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Article ; Online: Predicting the Hard to Predict: How Mitral Regurgitation, General Anesthesia, and 3D TEE Can Form a Reliable Team.

Couture, Etienne J / Royer, Olivier / Nabzdyk, Christoph G S

Journal of cardiothoracic and vascular anesthesia

2021 Volume 36, Issue 4, Page(s) 983–985

MeSH term(s)	Anesthesia, General ; Echocardiography, Three-Dimensional ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery
Language	English
Publishing date	2021-11-14
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2021.11.019
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Article ; Online: Clinical and bacteriological specificities of Escherichia coli bloodstream infections from biliary portal of entries.

Sokal, Aurélien / Royer, Guilhem / Esposito-Farese, Marina / Clermont, Olivier / Condamine, Bénédicte / Laouénan, Cedric / Lefort, Agnès / Denamur, Erick / de Lastours, Victoire

The Journal of infectious diseases

2024

Abstract: Background: Escherichia coli is frequently responsible for bloodstream infections (BSI). Among digestive BSI, biliary infections appear to be less severe. Respective roles of host factors, bacterial determinants (phylogroups, virulence and antibiotic ... ...

Abstract	Background: Escherichia coli is frequently responsible for bloodstream infections (BSI). Among digestive BSI, biliary infections appear to be less severe. Respective roles of host factors, bacterial determinants (phylogroups, virulence and antibiotic resistance) and portal of entry on outcome are unknown. Methods: Clinical characteristics and prognosis of 770 episodes of E. coli BSI were analyzed and isolates sequenced (Illumina technology) comparing phylogroups, MLST, virulence and resistance gene content. BSI isolates were compared with 362 commensal E. coli from healthy subjects. Results: Among 770 episodes, 135 were biliary, 156 non-biliary digestive and 479 urinary. Compared to urinary, BSI of digestive origin occurred significantly more in men, comorbid and immunocompromised patients. Digestive portal of entry was significantly associated with septic shock and death. Among digestive infections, patients with biliary infections were dies less (P=0.032), despite comparable initial severity. Biliary E. coli resembled commensals (phylogroup distribution, ST group and few virulence-associated genes) whereas non-biliary digestive and urinary strains carried many virulence-associated genes. Conclusions: E. coli strains responsible for biliary infections exhibit commensal characteristics and are associatedd with lower mortality rates, despite similar initial severity than other digestive BSI. Biliary drainage in addition to antibiotics in the management of biliary infections may explain improved outcome.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad586
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Zs.MO 445: Show issues

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Article ; Online: Sepsis-Induced Cardiomyopathy Reviewed: The Case for Early Consideration of Mechanical Support.

Plack, Daniel L / Royer, Olivier / Couture, Etienne J / Nabzdyk, Christoph G S

Journal of cardiothoracic and vascular anesthesia

2022 Volume 36, Issue 10, Page(s) 3916–3926

Abstract: Sepsis-induced cardiomyopathy (SCM) is an increasingly recognized problem encountered in critical care medicine. It generally is characterized as a decrease in left, right, or biventricular ejection fraction followed by a recovery of function over a ... ...

Abstract	Sepsis-induced cardiomyopathy (SCM) is an increasingly recognized problem encountered in critical care medicine. It generally is characterized as a decrease in left, right, or biventricular ejection fraction followed by a recovery of function over a period of days to weeks. Venoarterial extracorporeal membrane oxygenation (ECMO) has been used for the treatment of adults with various etiologies of shock, including cardiogenic and septic shock. This review summarizes current pathophysiologic mechanisms leading to SCM and provides a detection and treatment algorithm for SCM, as well as a discussion about the rationale and recent clinical data surrounding the use of ECMO and other forms of mechanical circulatory support for SCM.
MeSH term(s)	Adult ; Cardiomyopathies/complications ; Cardiomyopathies/therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Sepsis/complications ; Sepsis/therapy ; Shock, Cardiogenic/etiology ; Treatment Outcome
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.04.025
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Zs.MO 31: Show issues

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Article ; Online: Lung Ultrasound Evolution in a Patient with COVID-19.

Royer, Olivier / Couture, Etienne J / Langevin, Stephan

American journal of respiratory and critical care medicine

2020 Volume 202, Issue 9, Page(s) 1297–1298

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Lung/diagnostic imaging ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Ultrasonography/methods ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-09-24
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202006-2572IM
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Article ; Online: The Population Genomics of Increased Virulence and Antibiotic Resistance in Human Commensal Escherichia coli over 30 Years in France.

Marin, Julie / Clermont, Olivier / Royer, Guilhem / Mercier-Darty, Mélanie / Decousser, Jean Winoc / Tenaillon, Olivier / Denamur, Erick / Blanquart, François

Applied and environmental microbiology

2022 Volume 88, Issue 15, Page(s) e0066422

Abstract: Escherichia coli is a commensal species of the lower intestine but is also a major pathogen causing intestinal and extraintestinal infections that is increasingly prevalent and resistant to antibiotics. Most studies on genomic evolution of E. coli used ... ...

Abstract	Escherichia coli is a commensal species of the lower intestine but is also a major pathogen causing intestinal and extraintestinal infections that is increasingly prevalent and resistant to antibiotics. Most studies on genomic evolution of E. coli used isolates from infections. Here, instead, we whole-genome sequenced a collection of 403 commensal E. coli isolates from fecal samples of healthy adult volunteers in France (1980 to 2010). These isolates were distributed mainly in phylogroups A and B2 (30% each) and belonged to 152 sequence types (STs), the five most frequent being ST10 (phylogroup A; 16.3%), ST73 and ST95 (phylogroup B2; 6.3 and 5.0%, respectively), ST69 (phylogroup D; 4.2%), and ST59 (phylogroup F; 3.9%), and 224 O:H serotypes. ST and serotype diversity increased over time. The O1, O2, O6, and O25 groups used in bioconjugate O-antigen vaccine against extraintestinal infections were found in 23% of the strains of our collection. The increase in frequency of virulence-associated genes and antibiotic resistance was driven by two evolutionary mechanisms. Evolution of virulence gene frequency was driven by both clonal expansion of STs with more virulence genes ("ST-driven") and increases in gene frequency within STs independent of changes in ST frequencies ("gene-driven"). In contrast, the evolution of resistance was dominated by increases in frequency within STs ("gene-driven"). This study provides a unique picture of the phylogenomic evolution of E. coli in its human commensal habitat over 30 years and will have implications for the development of preventive strategies.
MeSH term(s)	Aged ; Animals ; Drug Resistance, Multiple, Bacterial/genetics ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/microbiology ; Humans ; Metagenomics ; Phylogeny ; Prospective Studies ; Virulence/genetics ; Virulence Factors/genetics
Chemical Substances	Virulence Factors
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.00664-22
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Article ; Online: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence.

Royer, Guilhem / Clermont, Olivier / Marin, Julie / Condamine, Bénédicte / Dion, Sara / Blanquart, François / Galardini, Marco / Denamur, Erick

Nature communications

2023 Volume 14, Issue 1, Page(s) 3667

Abstract: The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as adhesins, toxins, and iron capture systems. However, the respective ... ...

Abstract	The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as adhesins, toxins, and iron capture systems. However, the respective contribution to virulence of those genes seems to depend on the genetic background and is poorly understood. Here, we analyze genomes of 232 strains of sequence type complex STc58 and show that virulence (quantified in a mouse model of sepsis) emerged in a sub-group of STc58 due to the presence of the siderophore-encoding high-pathogenicity island (HPI). When extending our genome-wide association study to 370 Escherichia strains, we show that full virulence is associated with the presence of the aer or sit operons, in addition to the HPI. The prevalence of these operons, their co-occurrence and their genomic location depend on strain phylogeny. Thus, selection of lineage-dependent specific associations of virulence-associated genes argues for strong epistatic interactions shaping the emergence of virulence in E. coli.
MeSH term(s)	Animals ; Mice ; Escherichia coli ; Virulence/genetics ; Iron ; Escherichia coli Infections/pathology ; Genomic Islands/genetics ; Genome-Wide Association Study ; Phylogeny
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39428-y
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Article ; Online: Polyclonal antibodies selectively inhibit tumor growth and invasion and synergize with immune checkpoint inhibitors.

Ciron, Carine / Morice, Pierre / Rousse, Juliette / Roy, Patrice / Royer, Pierre-Joseph / Gauthier, Olivier / Brouard, Sophie / Duvaux, Odile / Bassissi, Firas / Vanhove, Bernard

JCI insight

2024 Volume 9, Issue 3

Abstract: Heterologous polyclonal antibodies (pAb) were shown to possess oncolytic properties a century ago with reported clinical responses. More recent preclinical models confirmed pAb efficacy, though their ability to tackle complex target antigens reduces ... ...

Abstract	Heterologous polyclonal antibodies (pAb) were shown to possess oncolytic properties a century ago with reported clinical responses. More recent preclinical models confirmed pAb efficacy, though their ability to tackle complex target antigens reduces susceptibility to tumor escape. Owing to the recent availability of glyco-humanized pAb (GH-pAb) with acceptable clinical toxicology profile, we revisited use of pAb in oncology and highlighted their therapeutic potential against multiple cancer types. Murine antitumor pAb were generated after repeated immunization of rabbits with murine tumor cell lines from hepatocarcinoma, melanoma, and colorectal cancers. Antitumor pAb recognized and showed cytotoxicity against their targets without cross-reactivity with healthy tissues. In vivo, pAb are effective alone; moreover, these pAb synergize with immune checkpoint inhibitors like anti-PD-L1 in several cancer models. They elicited an antitumor host immune response and prevented metastases. The anticancer activity of pAb was also confirmed in xenografted NMRI nude mice using GH-pAb produced by repeated immunization of pigs with human tumor cell lines. In conclusion, the availability of bioengineered GH-pAb allows for revisiting of passive immunotherapy with oncolytic pAb to fight against solid tumor and cancer metastasis.
MeSH term(s)	Humans ; Rabbits ; Animals ; Mice ; Swine ; Immune Checkpoint Inhibitors ; Mice, Nude ; Immunization ; Melanoma/therapy ; Cell Line, Tumor ; Antibodies, Neoplasm/pharmacology
Chemical Substances	Immune Checkpoint Inhibitors ; Antibodies, Neoplasm
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.166231
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Article ; Online: Importance of cytochrome 3A4 and 2D6-mediated drug-drug interactions in oxycodone consumption among older adults hospitalized for hip fracture: a cross-sectional study.

Decaix, Théodore / Gautier, Sylvain / Royer, Luca / Laprévote, Olivier / Tritz, Thomas / Siguret, Virginie / Teillet, Laurent / Sellier, Cyril / Pépin, Marion

Aging clinical and experimental research

2023 Volume 35, Issue 11, Page(s) 2471–2481

Abstract: Hip fracture is a common injury and represents a major health problem with an increasing incidence. In older adults, opioids such as oxycodone are often preferred to other analgesics such as tramadol because of a lower risk of delirium. Different ... ...

Abstract	Hip fracture is a common injury and represents a major health problem with an increasing incidence. In older adults, opioids such as oxycodone are often preferred to other analgesics such as tramadol because of a lower risk of delirium. Different parameters, such as inhibition of cytochrome P450 (CYP450) 2D6 and/or 3A4, can potentially lead to pharmacokinetic variations of oxycodone representing a risk of adverse drugs effects or lack of drug response. There is a risk of drug-drug interactions involving CYP450 in older adults due to the high prevalence of polypharmacy. This study sought to identify patient characteristics that influence oxycodone administration. A single-center observational study included 355 patients with a hip fracture hospitalized in a geriatric postoperative unit. Composite endpoint based on form, duration, and timing to intake separated patients into three groups: "no oxycodone", "low oxycodone ", and "high oxycodone ". CYP450 interactions were studied based on a composite variable defining the most involved CYP450 pathways between CYP2D6 and CYP3A4. CYP450 interactions with CYP2D6 pathway involved were associated with the risk of "high oxycodone" [odds ratio adjusted on age and the type of hip fracture (OR) 4.52, 95% confidence interval (CI) 1.39-16.83, p = 0.02)], as well as serum albumin levels (OR 1.09, 95% CI 1.02-1.17, p = 0.01). Cognitive impairment was negatively associated with the risk of "high oxycodone" (OR* 0.38, 95% CI 0.18-0.77, p = 0.02). This study showed an association between CYP2D6 interactions and higher oxycodone consumption indirectly reflecting the existence of uncontrolled postoperative pain.
MeSH term(s)	Humans ; Aged ; Oxycodone/adverse effects ; Cross-Sectional Studies ; Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 CYP2D6 Inhibitors ; Analgesics, Opioid/adverse effects ; Drug Interactions ; Hip Fractures
Chemical Substances	Oxycodone (CD35PMG570) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 CYP2D6 Inhibitors ; Analgesics, Opioid
Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02569-7
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Article ; Online: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence

Guilhem Royer / Olivier Clermont / Julie Marin / Bénédicte Condamine / Sara Dion / François Blanquart / Marco Galardini / Erick Denamur

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as adhesins, toxins, and iron capture systems. However, the respective ... ...

Abstract	Abstract The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as adhesins, toxins, and iron capture systems. However, the respective contribution to virulence of those genes seems to depend on the genetic background and is poorly understood. Here, we analyze genomes of 232 strains of sequence type complex STc58 and show that virulence (quantified in a mouse model of sepsis) emerged in a sub-group of STc58 due to the presence of the siderophore-encoding high-pathogenicity island (HPI). When extending our genome-wide association study to 370 Escherichia strains, we show that full virulence is associated with the presence of the aer or sit operons, in addition to the HPI. The prevalence of these operons, their co-occurrence and their genomic location depend on strain phylogeny. Thus, selection of lineage-dependent specific associations of virulence-associated genes argues for strong epistatic interactions shaping the emergence of virulence in E. coli.
Keywords	Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A taphonomic investigation of small vertebrate accumulations produced by the snowy owl (Bubo scandiacus) and its implications for fossil studies

Royer, Aurélien / Sophie Montuire / Olivier Gilg / Véronique Laroulandie

Palaeogeography, palaeoclimatology, palaeoecology. 2019 Jan. 15, v. 514

2019

Abstract: The action of predators, such as diurnal raptors, owls, mammals or humans, influence the nature of small vertebrate fossil assemblages but currently their taphonomic features are still poorly understood. In this study, we investigate the taphonomic ... ...

Abstract	The action of predators, such as diurnal raptors, owls, mammals or humans, influence the nature of small vertebrate fossil assemblages but currently their taphonomic features are still poorly understood. In this study, we investigate the taphonomic signature of the snowy owl (Bubo scandiacus) based on an analysis of pellets collected at breeding sites located in Greenland and the Canadian Arctic. This taxon is widely distributed through the North Hemisphere and was an important predator in Pleistocene times. Taphonomic parameters suggest that, contrary to previous assumptions, B. scandiacus produces, on average, moderate digestion of incisors, molars and post-cranial elements, and should be classed as a Category 3 or Category 3/4 predator according to the terminology established by Andrews. Significant inter-site variability was observed for some of the damage considered (in particular, digestion on incisors), and a key finding is that variability and the associated statistical confidence intervals are crucial notions that should be taken into account when assessing taphonomical features, in order to reliably identify the potential predator(s) responsible for small vertebrate fossil accumulations.
Keywords	Bubo scandiacus ; birds of prey ; breeding sites ; confidence interval ; digestion ; fossils ; humans ; pellets ; terminology ; Arctic region ; Greenland
Language	English
Dates of publication	2019-0115
Size	p. 189-205.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2018.10.018
Database	NAL-Catalogue (AGRICOLA)

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