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Article: A Case Report of an Atypical Presentation of IgG4-Related Disease and Idiopathic CD4 Lymphocytopenia.

Rapisarda, Francesco / Zanoli, Luca / Portale, Grazia / Scuto, Salvo / Castellino, Pietro

2015 Volume 2015, Page(s) 512370

Abstract: The IgG4-related disease is a fibroinflammatory disease characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and, often but not always, elevated serum levels of IgG4. ... ...

Abstract	The IgG4-related disease is a fibroinflammatory disease characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and, often but not always, elevated serum levels of IgG4. Idiopathic CD4 lymphocytopenia is a heterogenic and rare syndrome characterized by the detection of a persistent absolute CD4 T cells count <300 cells/mm(3) (or <20% of total T cells) in more than one occasion and no evidence of HIV infection in absence of immunodeficiency or therapy associated with depressed levels of CD4 T cells. We report the case of a 50-year-old man with a multiorgan IgG4-related disease presenting in a temporal association with a profound and symptomatic idiopathic CD4 lymphocytopenia. Both clinical pictures improved after steroid treatment. Idiopathic CD4 lymphocytopenia has been associated with a number of autoimmune conditions but, to the best of our knowledge, this is the first case in which an association with the IgG4-related disease is reported.
Language	English
Publishing date	2015-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2015/512370
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Article ; Online: Review: UPDATE sul metabolismo del magnesio.

Fatuzzo, Pasquale / Zanoli, Luca / Scollo, Viviana / Portale, Grazia / Gaudio, Agostino / Pani, Alessandra / Granata, Antonio

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2016 Volume 33, Issue 6

Abstract: Magnesium is the second intracellular cation and the fourth most abundant mineral in the body. Low levels of magnesium have been associated with insulin resistance and type-2 diabetes mellitus, asthma, osteoporosis and chronic kidney disease (CKD). The ... ...

Title translation	Review: UPDATE on magnesium metabolism.
Abstract	Magnesium is the second intracellular cation and the fourth most abundant mineral in the body. Low levels of magnesium have been associated with insulin resistance and type-2 diabetes mellitus, asthma, osteoporosis and chronic kidney disease (CKD). The use of proton pump inhibitors (PPIs) represents the most common cause of hypomagnesemia. The risk of hypomagnesemia, and consequently worsening of the renal function, is increased when diuretics are added to therapy in subjects treated with PPIs. Interestingly, diuretics and PPIs are two of the most used drugs in subjects with CKD. In this review, we described the mechanisms at the basis of the hypomagnesemia and the effect of this electrolyte disturbance in subjects with CKD.
MeSH term(s)	Bone and Bones/metabolism ; Brain/physiology ; Heart/physiology ; Humans ; Hypercalciuria/chemically induced ; Magnesium/metabolism ; Magnesium/physiology ; Nephrocalcinosis/chemically induced ; Proton Pump Inhibitors/pharmacology ; Renal Tubular Transport, Inborn Errors/chemically induced
Chemical Substances	Proton Pump Inhibitors ; Magnesium (I38ZP9992A)
Language	Italian
Publishing date	2016-11
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography.

Portale, Grazia / Ciolina, Federica / Arcari, Luca / Giraldi, Gianluca Di Lazzaro / Danti, Massimiliano / Pietropaolo, Lorenzo / Camastra, Giovanni / Cordischi, Chiara / Urbani, Laura / Proietti, Lidia / Cacciotti, Luca / Santini, Claudio / Melandri, Serena / Ansalone, Gerardo / Sbarbati, Stefano / Sighieri, Cinzia

SN comprehensive clinical medicine

2021 Volume 3, Issue 10, Page(s) 2075–2081

Abstract: Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were ... ...

Abstract	Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were performed within 24 h upon admission. Both were analyzed according to semi-quantitative scoring systems. Subgroups were identified according to median LUS score. Patients within higher LUS score group were older (79 vs 60 years, p<0.001), had higher C-reactive protein (CRP) (7.2 mg/dl vs 1.3 mg/dl, p<0.001) and chest CT score (10 vs 4, p=0.027) as well as lower PaO2/FiO2 (286 vs 356, p=0.029) as compared to patients within lower scores. We found a significant correlation between scores (r=0.390, p=0.023). Both LUS and CT scores correlated directly with patients age (r=0.586, p<0.001 and r=0.399, p=0.021 respectively) and CRP (r=0.472, p=0.002 and r=0.518, p=0.002 respectively), inversely with PaO2/FiO2 (r=-0.485, p=0.003 and r=-0.440, p=0.017 respectively). LUS score only showed significant correlation with hs-troponin T, NT-pro-BNP, and creatinine (r=0.433, p=0.019; r=0.411, p=0.027, and r=0.497, p=0.001, respectively). Semi-quantitative bedside LUS is related to the severity of COVID-19 pneumonia similarly to chest CT. Correlation of LUS score with markers of cardiac and renal injury suggests that LUS might contribute to a more comprehensive evaluation of this heterogeneous population.
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2947211-8
ISSN	2523-8973 ; 2523-8973
ISSN (online)	2523-8973
ISSN	2523-8973
DOI	10.1007/s42399-021-00986-1
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Article ; Online: A Case Report of an Atypical Presentation of IgG4-Related Disease and Idiopathic CD4 Lymphocytopenia

Francesco Rapisarda / Luca Zanoli / Grazia Portale / Salvo Scuto / Pietro Castellino

Case Reports in Medicine, Vol

2015 Volume 2015

Abstract	The IgG4-related disease is a fibroinflammatory disease characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and, often but not always, elevated serum levels of IgG4. Idiopathic CD4 lymphocytopenia is a heterogenic and rare syndrome characterized by the detection of a persistent absolute CD4 T cells count <300 cells/mm3 (or <20% of total T cells) in more than one occasion and no evidence of HIV infection in absence of immunodeficiency or therapy associated with depressed levels of CD4 T cells. We report the case of a 50-year-old man with a multiorgan IgG4-related disease presenting in a temporal association with a profound and symptomatic idiopathic CD4 lymphocytopenia. Both clinical pictures improved after steroid treatment. Idiopathic CD4 lymphocytopenia has been associated with a number of autoimmune conditions but, to the best of our knowledge, this is the first case in which an association with the IgG4-related disease is reported.
Keywords	Medicine ; R
Subject code	570
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Magnesio, calcio e potassio: "Nessuno nasce solo o è nato per sé solo".

Rapisarda, Francesco / Portale, Grazia / Ferrario, Silvia / Sessa, Concetto / Aliotta, Roberta / Zanoli, Luca / Fatuzzo, Pasquale

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2016 Volume 33, Issue 1

Abstract: In contrast to other ions, magnesium is treated as an orphan by the body: there are no hormones that have a substantial role in regulating urinary magnesium excretion, and bone, the principal reservoir of magnesium, does not readily exchange with ... ...

Title translation	Magnesium, calcium and potassium: "no one was born alone".
Abstract	In contrast to other ions, magnesium is treated as an orphan by the body: there are no hormones that have a substantial role in regulating urinary magnesium excretion, and bone, the principal reservoir of magnesium, does not readily exchange with circulating magnesium.The Mg ++ is often overlooked by physicians in the differential diagnosis because it is considered insignificant, but its role is crucial for cells function, first of all neurons and cardiomyocytes. A condition of hypocalcemia associated with hypokalemia, especially in the presence of chronic renal failure, should raise suspicion of a lack of Mg ++.We report the case of an old man of 77 year with kidney transplant for 13 years, treated with cyclosporine, and sodium mycophenolate and steroid who, for about a month, accused impaired balance and walking instability, who fell accidentally down with wrist fracture.Blood tests showed hypocalcemia and hypokalemia, and so we required dosage of serum and urinary magnesium. A significant reduction in the ion plasma concentration was seen, associated to a fraction of excretion inappropriately high in relation to the degree of hypomagnesemia.The cause of this important renal loss is likely attributable to cyclosporine, a drug that has as a side effect the inhibition of the reabsorption of Mg ++ in the distal convoluted tubule. then, oral supplementation was started (244 mg of Mg ++ ion / day), with subsequent normalization, after a few days, not only of magnesiemia, but also in serum calcium and potassium levels, and improvement of neurological symptoms.Hypomagnesaemia is common in patients with renal transplantation in therapy with calcineurin inhibitors ICN, due to the effects of such drugs on the TRPM6 transporter present in the kidney distal convoluted tubule. To prevent complications caused by chronic and severe depletion of magnesium in this particular population, we recommend periodic monitoring of magnesium plasma levels.
MeSH term(s)	Aged ; Cyclosporine/adverse effects ; Humans ; Hypercalciuria/chemically induced ; Hypocalcemia/chemically induced ; Hypokalemia/chemically induced ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Male ; Nephrocalcinosis/chemically induced ; Renal Tubular Transport, Inborn Errors/chemically induced
Chemical Substances	Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
Language	Italian
Publishing date	2016-01
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Peritonite da Candida e sepsi da Acinetobacter baumannii in dialisi peritoneale: un'associazione con prognosi non sempre infausta.

Rapisarda, Francesco / Aliotta, Roberta / Pocorobba, Barbara / Portale, Grazia / Ferrario, Silvia / Zanoli, Luca / Fatuzzo, Pasquale

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2015 Volume 32, Issue 6

Abstract: Fungal infections have a high incidence in patients receiving peritoneal dialysis. (1) Peritoneal dialysis is often complicated by peritonitis which has only minimally mycotic etiology, but nonetheless it is associated with 15-45% mortality (8).  The ... ...

Title translation	Candida peritonitis and sepsis due to Acinetobacter baumannii in peritoneal dialysis: an association with prognosis not always unfavourable.
Abstract	Fungal infections have a high incidence in patients receiving peritoneal dialysis. (1) Peritoneal dialysis is often complicated by peritonitis which has only minimally mycotic etiology, but nonetheless it is associated with 15-45% mortality (8).  The opportunistic pathogens such as Candida can cause infection in immunocompromised conditions. Even the Acinetobacter tends to infect immunocompromised individuals and it has the same risk factors for infection as Candida: immunosuppression, malignancy, HIV positivity and all the other conditions of immunosuppression, central venous catheterization, mechanical ventilation and prolonged antibiotic therapy. The sepsis by Acinetobacter predicts a negative prognosis with the mortality rate between 20 to 60% (12), especially in cases of isolation of multi-resistant germs.  We present a case report of a CKD patient undergoing peritoneal dialysis therapy who was hospitalized for acute pancreatitis, later complicated by the development of pancreatic pseudocysts, C. albicans peritonitis with hematologic spread of the fungus, superimposed Acinetobacter baumannii sepsis and pneumonia. She has been subjected to percutaneous drainage of pseudocysts, to switch from peritoneal dialysis to hemodialysis, to various evacuative thoracentesis, and to polymicrobial therapy (meropenem, teicoplanina, tigeciclina, linezolid, colimicina, fluconazolo, etc.) that allowed the resolution of sepsis. The peculiarity of this case is represented by the numerous morbidity that the patient developed simultaneously, with the genesis of a complex clinical picture, by the combination of infections due to Candida albicans and Acinetobacter baumannii. Successful treatment strategies allowed to fight and cure a medical condition associated with a high mortality rate.
MeSH term(s)	Acinetobacter Infections/complications ; Acinetobacter baumannii ; Candidiasis/complications ; Female ; Humans ; Middle Aged ; Peritoneal Dialysis ; Peritonitis/microbiology ; Prognosis ; Sepsis/complications
Language	Italian
Publishing date	2015-11
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Monocyte-macrophage polarization and recruitment pathways in the tumour microenvironment of B-cell acute lymphoblastic leukaemia.

British journal of haematology

2021 Volume 193, Issue 6, Page(s) 1157–1171

Abstract: B-cell acute lymphoblastic leukaemia (B-ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia-supportive niche. To elucidate the contribution of immune cells to the leukaemic microenvironment, we investigated the involvement of ... ...

Abstract	B-cell acute lymphoblastic leukaemia (B-ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia-supportive niche. To elucidate the contribution of immune cells to the leukaemic microenvironment, we investigated the involvement of monocyte/macrophage compartments, as well as several recruitment pathways in B-ALL development. Immunohistochemistry analyses showed that CD68-expressing macrophages were increased in leukaemic BM biopsies, compared to controls and predominantly expressed the M2-like markers CD163 and CD206. Furthermore, the "non-classical" CD14
MeSH term(s)	Adolescent ; Adult ; Aged ; Antigens, CD/metabolism ; Coculture Techniques ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Middle Aged ; Monocytes/metabolism ; Monocytes/pathology ; Neoplasm Proteins/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Tumor Microenvironment
Chemical Substances	Antigens, CD ; Neoplasm Proteins
Language	English
Publishing date	2021-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17330
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Article ; Online: Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.

Masetti, Michela / Carriero, Roberta / Portale, Federica / Marelli, Giulia / Morina, Nicolò / Pandini, Marta / Iovino, Marta / Partini, Bianca / Erreni, Marco / Ponzetta, Andrea / Magrini, Elena / Colombo, Piergiuseppe / Elefante, Grazia / Colombo, Federico Simone / den Haan, Joke M M / Peano, Clelia / Cibella, Javier / Termanini, Alberto / Kunderfranco, Paolo /

Brummelman, Jolanda / Chung, Matthew Wai Heng / Lazzeri, Massimo / Hurle, Rodolfo / Casale, Paolo / Lugli, Enrico / DePinho, Ronald A / Mukhopadhyay, Subhankar / Gordon, Siamon / Di Mitri, Diletta

The Journal of experimental medicine

2021 Volume 219, Issue 2

Abstract: Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing ... ...

Abstract	Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used to profile the transcriptional landscape of TAMs in human PCa, leading to identification of a subset of macrophages characterized by dysregulation in transcriptional pathways associated with lipid metabolism. This subset of TAMs correlates positively with PCa progression and shorter disease-free survival and is characterized by an accumulation of lipids that is dependent on Marco. Mechanistically, cancer cell-derived IL-1β enhances Marco expression on macrophages, and reciprocally, cancer cell migration is promoted by CCL6 released by lipid-loaded TAMs. Moreover, administration of a high-fat diet to tumor-bearing mice raises the abundance of lipid-loaded TAMs. Finally, targeting lipid accumulation by Marco blockade hinders tumor growth and invasiveness and improves the efficacy of chemotherapy in models of PCa, pointing to combinatorial strategies that may influence patient outcomes.
MeSH term(s)	Animals ; Cell Plasticity/genetics ; Cell Plasticity/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Disease Progression ; Gene Expression Profiling ; Gene Knockdown Techniques ; Heterografts ; Humans ; Lipid Metabolism ; Lipids/chemistry ; Male ; Metabolic Networks and Pathways ; Mice ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Single-Cell Analysis ; Tumor Microenvironment ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism
Chemical Substances	Cytokines ; Lipids
Language	English
Publishing date	2021-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20210564
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Article ; Online: Early recognition of the 2009 pandemic influenza A (H1N1) pneumonia by chest ultrasound.

Testa, Americo / Soldati, Gino / Copetti, Roberto / Giannuzzi, Rosangela / Portale, Grazia / Gentiloni-Silveri, Nicolò

Critical care (London, England)

2012 Volume 16, Issue 1, Page(s) R30

Abstract: Introduction: The clinical picture of the pandemic influenza A (H1N1)v ranges from a self-limiting afebrile infection to a rapidly progressive pneumonia. Prompt diagnosis and well-timed treatment are recommended. Chest radiography (CRx) often fails to ... ...

Abstract	Introduction: The clinical picture of the pandemic influenza A (H1N1)v ranges from a self-limiting afebrile infection to a rapidly progressive pneumonia. Prompt diagnosis and well-timed treatment are recommended. Chest radiography (CRx) often fails to detect the early interstitial stage. The aim of this study was to evaluate the role of bedside chest ultrasonography (US) in the early management of the 2009 influenza A (H1N1)v infection. Methods: 98 patients who arrived in the Emergency Department complaining of influenza-like symptoms were enrolled in the study. Patients not displaying symptoms of acute respiratory distress were discharged without further investigations. Among patients with clinical suggestion of a community-acquired pneumonia, cases encountering other diagnoses or comorbidities were excluded from the study. Clinical history, laboratory tests, CRx, and computed tomography (CT) scan, if indicated, contributed to define the diagnosis of pneumonia in the remaining patients. Chest US was performed by an emergency physician, looking for presence of interstitial syndrome, alveolar consolidation, pleural line abnormalities, and pleural effusion, in 34 patients with a final diagnosis of pneumonia, in 16 having normal initial CRx, and in 33 without pneumonia, as controls. Results: Chest US was carried out without discomfort in all subjects, requiring a relatively short time (9 minutes; range, 7 to 13 minutes). An abnormal US pattern was detected in 32 of 34 patients with pneumonia (94.1%). A prevalent US pattern of interstitial syndrome was depicted in 15 of 16 patients with normal initial CRx, of whom 10 (62.5%) had a final diagnosis of viral (H1N1) pneumonia. Patients with pneumonia and abnormal initial CRx, of whom only four had a final diagnosis of viral (H1N1) pneumonia (22.2%; P<0.05), mainly displayed an US pattern of alveolar consolidation. Finally, a positive US pattern of interstitial syndrome was found in five of 33 controls (15.1%). False negatives were found in two (5.9%) of 34 cases, and false positives, in five (15.1%) of 33 cases, with sensitivity of 94.1%, specificity of 84.8%, positive predictive value of 86.5%, and negative predictive value of 93.3%. Conclusions: Bedside chest US represents an effective tool for diagnosing pneumonia in the Emergency Department. It can accurately provide early-stage detection of patients with (H1N1)v pneumonia having an initial normal CRx. Its routine integration into their clinical management is proposed.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Early Diagnosis ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Influenza, Human/diagnostic imaging ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Ultrasonography/methods
Language	English
Publishing date	2012-02-17
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/cc11201
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Article ; Online: Ultrasound M-mode assessment of diaphragmatic kinetics by anterior transverse scanning in healthy subjects.

Testa, Americo / Soldati, Gino / Giannuzzi, Rosangela / Berardi, Silvia / Portale, Grazia / Gentiloni Silveri, Nicolò

Ultrasound in medicine & biology

2011 Volume 37, Issue 1, Page(s) 44–52

Abstract: The purpose of this study was to set an effective standardized method to assess diaphragmatic kinetics by ultrasound. Forty healthy volunteers were submitted to a B- and M-mode ultrasound study using a convex transducer positioned in the subcostal ... ...

Abstract	The purpose of this study was to set an effective standardized method to assess diaphragmatic kinetics by ultrasound. Forty healthy volunteers were submitted to a B- and M-mode ultrasound study using a convex transducer positioned in the subcostal anterior area for transverse scanning. Ultrasound examination was completed in 38/40 cases (95%), spending on average <10 min for examination. The resting and forced diaphragmatic excursions were 18.4 ± 7.6 and 78.8 ± 13.3 mm, respectively, unrelated to demographic or anthropometric parameters: intraobserver variability on three successive measurements resulted in 6.0% and in 3.9%, respectively. An inexperienced sonographer completed the ultrasound examination in 37/40 cases, spending on average >15 min, with significant, although marginal, interobserver variability (31.9% and 14.7% for resting and forced diaphragmatic excursion, respectively). Bedside ultrasonography by an anterior subcostal transverse scanning on semi-recumbent patient proves to be a safe, feasible, reliable, fast, relatively easy and reproducible way to assess diaphragm movement.
MeSH term(s)	Adult ; Anthropometry ; Diaphragm/diagnostic imaging ; Diaphragm/physiology ; Female ; Humans ; Kinetics ; Linear Models ; Male ; Movement/physiology ; Posture/physiology ; Prospective Studies ; Reference Values ; Respiratory Mechanics/physiology ; Spirometry ; Transducers ; Ultrasonography
Language	English
Publishing date	2011-01
Publishing country	England
Document type	Journal Article
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2010.10.004
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