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  1. Article ; Online: Cardiopulmonary exercise testing in children six months after COVID-19.

    Denina, Marco / Appendini, Lorenzo / Ronco, Lucia / Funiciello, Elisa / Bignamini, Elisabetta / Garazzino, Silvia

    Pediatric pulmonology

    2023  Volume 58, Issue 7, Page(s) 2154–2157

    MeSH term(s) Humans ; Child ; Exercise Test ; COVID-19 ; Exercise Tolerance ; Oxygen Consumption
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26406
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  2. Article ; Online: Acute intoxication by neurotropic agents in pediatric setting: a monocentre observational study.

    Chioma, Elisa / Castagno, Emanuele / Denina, Marco / Raffaldi, Irene / Bondone, Claudia

    European journal of emergency medicine : official journal of the European Society for Emergency Medicine

    2022  Volume 30, Issue 1, Page(s) 55–57

    MeSH term(s) Humans ; Child ; Alcoholic Intoxication
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Observational Study ; Letter
    ZDB-ID 1233544-7
    ISSN 1473-5695 ; 0969-9546
    ISSN (online) 1473-5695
    ISSN 0969-9546
    DOI 10.1097/MEJ.0000000000000976
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  3. Article ; Online: Long COVID-19/post-COVID condition in children: do we all speak the same language?

    Garazzino, Silvia / Denina, Marco / Pruccoli, Giulia / Funiciello, Elisa / Ramenghi, Ugo / Fagioli, Franca

    Italian journal of pediatrics

    2023  Volume 49, Issue 1, Page(s) 12

    Abstract: Post-COVID condition is a new and highly debated entity that is still to be outlined in its complexity, especially in the pediatric population. In response to the article by Trapani and colleagues, we report the results of a long-term follow-up conducted ...

    Abstract Post-COVID condition is a new and highly debated entity that is still to be outlined in its complexity, especially in the pediatric population. In response to the article by Trapani and colleagues, we report the results of a long-term follow-up conducted in the outpatient clinic of the Pediatric Infectious Diseases Unit on children admitted to our hospital with SARS-CoV-2 infection.
    MeSH term(s) Child ; Humans ; COVID-19 ; Cohort Studies ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Language
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-023-01417-8
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  4. Article ; Online: An unusual peak of febrile rhabdomyolysis.

    Denina, Marco / Castagno, Emanuele / Feyles, Francesca / Bruno, Ilaria / Delmonaco, Angelo G / Peruzzi, Licia / Bondone, Claudia

    Minerva pediatrics

    2023  Volume 76, Issue 2, Page(s) 294–295

    MeSH term(s) Humans ; Rhabdomyolysis/diagnosis ; Rhabdomyolysis/etiology ; Fever/etiology
    Language English
    Publishing date 2023-09-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.23.07346-9
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  5. Article ; Online: Nontunneled central venous catheter bloodstream infections in pediatric surgery.

    Denina, Marco / Curetti, Roberta / Garazzino, Silvia / Silvestro, Erika / Scolfaro, Carlo

    Infection control and hospital epidemiology

    2019  Volume 40, Issue 7, Page(s) 836–837

    MeSH term(s) Adolescent ; Bacteremia/epidemiology ; Bacteremia/etiology ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/etiology ; Catheterization, Central Venous/adverse effects ; Child ; Child, Preschool ; Female ; Hospitals, Pediatric ; Humans ; Infant ; Infant, Newborn ; Italy ; Male ; Prospective Studies ; Risk Factors ; Surgical Procedures, Operative/statistics & numerical data
    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Letter ; Observational Study
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2019.107
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  6. Article ; Online: Imported malaria in children: A 13 years retrospective study.

    Agagliati, Federica / Silvestro, Erika / Denina, Marco / Garazzino, Silvia / Mignone, Federica / Zoppo, Marisa / Pruccoli, Giulia / Scolfaro, Carlo

    Travel medicine and infectious disease

    2022  Volume 46, Page(s) 102273

    Abstract: Malaria is not endemic in Italy, however every year about 600-700 imported cases are detected in people born or living in Italy who return from a stay in their country of origin (visiting friends and relatives - VFR). Children account for 20% of this ... ...

    Abstract Malaria is not endemic in Italy, however every year about 600-700 imported cases are detected in people born or living in Italy who return from a stay in their country of origin (visiting friends and relatives - VFR). Children account for 20% of this population and they have an higher risk of severe disease. Socio-economic problems and deficiencies in the doctor-patient relationship often lead to a lack of awareness of the importance of prophylaxis, making the category of VFRs at increased risk of disease. The aim of this study is to analyze the characteristics of pediatric imported malaria, with a specific focus on prevention and risk factors for severe malaria. All malaria cases diagnosed from 2007 to 2019 in Ospedale Infantile Regina Margherita in Turin were retrospectively observed. Epidemiological and clinical data were described. A total of 72 patients were reported: 98.6% had African origins and 73.6% traveled as VFRs. Plasmodium falciparum was the species most commonly isolated (94.4%). Twenty-four patients (33.3%) underwent chemoprophylaxis and never appropriately. Patients not undergoing prophylaxis and those undergoing incomplete prophylaxis showed not statistically significant difference in term of disease severity (p = 0.26). Nineteen cases were considered severe, including 3 with cerebral malaria. High levels of parasitemia were statistically significantly correlated with severe anemia (p = 0.049) and severe thrombocytopenia (p = 0.036). In 25% of cases the first diagnosis was incorrect. The therapeutic use of artemisinin derivatives has resulted in a significant shortening of the parasitemia clearance time compared to the use of other drugs (p < 0.001). Families have to be educated about the serious implications of a malaria infection and the importance of a correct and complete prophylaxis. Clinicians should always consider malaria in the differential diagnoses in patients with fever and a history of a recent travel to an endemic area. Prompt diagnosis and use of appropriate drugs, according to the latest guidelines, could guarantee a better outcome for patients.
    MeSH term(s) Antimalarials/therapeutic use ; Child ; Humans ; Malaria, Cerebral ; Physician-Patient Relations ; Retrospective Studies ; Travel
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102273
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  7. Article ; Online: The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children

    Silvia Garazzino / Elena Altieri / Marco Denina

    Reports, Vol 2, Iss 3, p

    A Review

    2019  Volume 17

    Abstract: Sepsis is still related to high mortality and hospitalization rates in the paediatric population despite medical progress. Prompt recognition of sepsis and consequent initiation of an appropriate treatment are essential elements in securing a positive ... ...

    Abstract Sepsis is still related to high mortality and hospitalization rates in the paediatric population despite medical progress. Prompt recognition of sepsis and consequent initiation of an appropriate treatment are essential elements in securing a positive outcome in adults and children. In such scenario, various biomarkers have been studied to support the clinician in the diagnosis of severe infections, in the identification of patients at risk of progression towards sepsis as well as in the evaluation of the response to treatment. In children, the performance of C-reactive protein and procalcitonin has been largely investigated, whereas data on newer biomarkers of sepsis are scant. The aim of the present review is to summarise the available data on the use of pro-adrenomedullin in the paediatric age.
    Keywords adrenomedullin ; children ; neonates ; sepsis ; severe infections ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Peculiar immunophenotypic signature in MIS-C-affected children.

    Licciardi, Francesco / Baldini, Letizia / Denina, Marco / Ricotti, Emanuela / Covizzi, Carlotta / Dellepiane, Marta / Mignone, Federica / Zoppo, Marisa / Felici, Enrico / Montin, Davide

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2021  Volume 32, Issue 4, Page(s) 801–804

    MeSH term(s) COVID-19 ; Child ; Humans ; Immunophenotyping ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Letter
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13434
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  9. Article ; Online: SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children.

    Licciardi, Francesco / Pruccoli, Giulia / Denina, Marco / Parodi, Emilia / Taglietto, Manuela / Rosati, Sergio / Montin, Davide

    Pediatrics

    2020  Volume 146, Issue 2

    Abstract: We describe 2 children with persistent fever and profuse diarrhea who developed signs of mucocutaneous involvement (conjunctivitis, fissured lips, skin rash, erythema, and edema of the hands and feet). Blood tests revealed elevated markers of ... ...

    Abstract We describe 2 children with persistent fever and profuse diarrhea who developed signs of mucocutaneous involvement (conjunctivitis, fissured lips, skin rash, erythema, and edema of the hands and feet). Blood tests revealed elevated markers of inflammation, lymphopenia, thrombocytopenia, and complement consumption. Afterward, diffuse edema with hypoalbuminemia appeared in the context of a capillary leak syndrome. In both patients, repeated nasal swabs were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but each patient had high titers of immunoglobulin G and immunoglobulin M against the SARS-CoV-2 virus. The negative PCR results in the presence of immunoglobulin M and immunoglobulin G suggested that the inflammatory response developed in the late phase of viral infection, when SARS-CoV-2 was not detectable in the upper airway. In this report, we describe patients with what we propose to name as SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome. SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome seems to be caused by a delayed response to SARS-CoV-2. It resembles Kawasaki disease complicated by macrophage activation syndrome, although it has peculiar features, such as prodromal diarrhea, capillary leak syndrome, and myocardial dysfunction. Intravenous corticosteroid treatment appears to be helpful.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Phenotype ; Pneumonia, Viral ; SARS-CoV-2 ; Shock, Cardiogenic
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-1711
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  10. Article ; Online: Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department.

    Denina, Marco / Giannone, Virginia / Curtoni, Antonio / Zanotto, Elisa / Garazzino, Silvia / Urbino, Antonio Francesco / Bondone, Claudia

    Irish journal of medical science

    2021  Volume 191, Issue 4, Page(s) 1767–1770

    Abstract: Background: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.: Aims: To investigate Sars-CoV-2 antigen rapid test in children.: Methods: We compare the ... ...

    Abstract Background: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.
    Aims: To investigate Sars-CoV-2 antigen rapid test in children.
    Methods: We compare the performance of LumiraDx with molecular tests in a paediatric emergency department.
    Results: A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found.
    Conclusions: AT may be helpful in the initial screening of patients at PED.
    MeSH term(s) COVID-19/diagnosis ; Child ; Emergency Service, Hospital ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Sensitivity and Specificity
    Language English
    Publishing date 2021-09-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-021-02776-z
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