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  1. Article ; Online: Imaging patients with stable chest pain special feature: introductory editorial.

    Oudkerk, Matthijs / van Beek, Edwin Jr

    The British journal of radiology

    2020  Volume 93, Issue 1113, Page(s) 20209005

    MeSH term(s) Chest Pain/diagnosis ; Chest Pain/etiology ; Diagnostic Imaging/methods ; Heart/diagnostic imaging ; Heart Diseases/complications ; Heart Diseases/diagnostic imaging ; Humans
    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20209005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.11: Show issues Location:
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  2. Article ; Online: Imaging biomarkers in the clinic.

    van Beek, Edwin Jr

    Biomarkers in medicine

    2016  Volume 10, Issue 10, Page(s) 1073–1079

    Abstract: Multimodality medical imaging offers a key role in disease diagnosis, while providing accurate staging and defining disease extent in many instances. Recent developments are increasingly leading to quantitative assessment of medical images, allowing both ...

    Abstract Multimodality medical imaging offers a key role in disease diagnosis, while providing accurate staging and defining disease extent in many instances. Recent developments are increasingly leading to quantitative assessment of medical images, allowing both definition of disease extent, giving insight into the phenotypes of diseases and offering capabilities of monitoring response to therapy. Combined with other tools, such as genetic profiling, this is a powerful way of improving diagnosis and treatment of patients, enabling a personalized approach to delivering healthcare. It is highly likely that software tools will become integrated into the routine workflow of radiology reports. This special report describes some of the crucial areas where applications are being introduced and speculate on the potential impact on radiologists and clinicians.
    MeSH term(s) Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/pathology ; Aortic Valve Stenosis/therapy ; Biomarkers/analysis ; Contrast Media/chemistry ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers ; Contrast Media
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2016-0151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The vascular nature of COVID-19.

    Oudkerk, Matthijs / Kuijpers, Dirkjan / Oudkerk, Sytse F / van Beek, Edwin Jr

    The British journal of radiology

    2020  Volume 93, Issue 1113, Page(s) 20200718

    Abstract: A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in COVID-19 patients. The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of ... ...

    Abstract A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in COVID-19 patients. The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19 with a new vascular disease concept. The analysis of all available current medical, laboratory and imaging data on COVID-19 confirms that symptoms and diagnostic tests can not be explained by impaired pulmonary ventilation. Further imaging and pathological investigations confirm that the COVID-19 syndrome is explained by perfusion disturbances first in the lung, but consecutively in all organs of the body. Damage of the microvasculature by SARS 1 and SARS 2 (COVID-19) viruses causes microthrombotic changes in the pulmonary capillaries and organs leading to macrothrombosis and emboli. Therefore anticoagulant profylaxis, close lab and CT imaging monitoring and early anticoagulant therapy are indicated.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Computed Tomography Angiography/methods ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/blood supply ; Lung/diagnostic imaging ; Netherlands ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20200718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Pulmonary embolism severity before and during the COVID-19 pandemic.

    Tilliridou, Vicky / Kirkbride, Rachael / Dickinson, Rebecca / Tiernan, James / Yong, Guo Liang / van Beek, Edwin Jr / Murchison, John T / Williams, Michelle Claire

    The British journal of radiology

    2021  Volume 94, Issue 1123, Page(s) 20210264

    Abstract: Objectives: Early in the coronavirus 2019 (COVID-19) pandemic, a high frequency of pulmonary embolism was identified. This audit aims to assess the frequency and severity of pulmonary embolism in 2020 compared to 2019.: Methods: In this retrospective ...

    Abstract Objectives: Early in the coronavirus 2019 (COVID-19) pandemic, a high frequency of pulmonary embolism was identified. This audit aims to assess the frequency and severity of pulmonary embolism in 2020 compared to 2019.
    Methods: In this retrospective audit, we compared computed tomography pulmonary angiography (CTPA) frequency and pulmonary embolism severity in April and May 2020, compared to 2019. Pulmonary embolism severity was assessed with the Modified Miller score and the presence of right heart strain was assessed. Demographic information and 30-day mortality was identified from electronic health records.
    Results: In April 2020, there was a 17% reduction in the number of CTPA performed and an increase in the proportion identifying pulmonary embolism (26%,
    Conclusion: During the COVID-19 pandemic, there was a reduction in the number of CTPA scans performed and an increase in the frequency of CTPA scans positive for pulmonary embolism. Patients with both COVID-19 and pulmonary embolism had an increased risk of 30-day mortality compared to those without COVID-19.
    Advances in knowledge: During the COVID-19 pandemic, the number of CTPA performed decreased and the proportion of positive CTPA increased. Patients with both pulmonary embolism and COVID-19 had worse outcomes compared to those with pulmonary embolism alone.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/mortality ; Computed Tomography Angiography/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/etiology ; Pulmonary Embolism/mortality ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20210264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.11: Show issues Location:
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  5. Article: The vascular nature of COVID-19

    Oudkerk, Matthijs / Kuijpers, Dirkjan / Oudkerk, Sytse F / van Beek, Edwin Jr

    Br J Radiol

    Abstract: A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in COVID-19 patients. The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of ... ...

    Abstract A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in COVID-19 patients. The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19 with a new vascular disease concept. The analysis of all available current medical, laboratory and imaging data on COVID-19 confirms that symptoms and diagnostic tests can not be explained by impaired pulmonary ventilation. Further imaging and pathological investigations confirm that the COVID-19 syndrome is explained by perfusion disturbances first in the lung, but consecutively in all organs of the body. Damage of the microvasculature by SARS 1 and SARS 2 (COVID-19) viruses causes microthrombotic changes in the pulmonary capillaries and organs leading to macrothrombosis and emboli. Therefore anticoagulant profylaxis, close lab and CT imaging monitoring and early anticoagulant therapy are indicated.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690928
    Database COVID19

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  6. Article: Lung cancer screening: Computed tomography or chest radiographs?

    van Beek, Edwin Jr / Mirsadraee, Saeed / Murchison, John T

    World journal of radiology

    2015  Volume 7, Issue 8, Page(s) 189–193

    Abstract: Worldwide, lung cancer is the leading cause of mortality due to malignancy. The vast majority of cases of lung cancer are smoking related and the most effective way of reducing lung cancer incidence and mortality is by smoking cessation. In the Western ... ...

    Abstract Worldwide, lung cancer is the leading cause of mortality due to malignancy. The vast majority of cases of lung cancer are smoking related and the most effective way of reducing lung cancer incidence and mortality is by smoking cessation. In the Western world, smoking cessation policies have met with limited success. The other major means of reducing lung cancer deaths is to diagnose cases at an earlier more treatable stage employing screening programmes using chest radiographs or low dose computed tomography. In many countries smoking is still on the increase, and the sheer scale of the problem limits the affordability of such screening programmes. This short review article will evaluate the current evidence and potential areas of research which may benefit policy making across the world.
    Language English
    Publishing date 2015-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573705-3
    ISSN 1949-8470
    ISSN 1949-8470
    DOI 10.4329/wjr.v7.i8.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging techniques in atherosclerosis imaging.

    Syed, Maaz Bj / Fletcher, Alexander J / Forsythe, Rachael O / Kaczynski, Jakub / Newby, David E / Dweck, Marc R / van Beek, Edwin Jr

    The British journal of radiology

    2019  Volume 92, Issue 1103, Page(s) 20180309

    Abstract: Atherosclerosis is a chronic immunomodulated disease that affects multiple vascular beds and results in a significant worldwide disease burden. Conventional imaging modalities focus on the morphological features of atherosclerotic disease such as the ... ...

    Abstract Atherosclerosis is a chronic immunomodulated disease that affects multiple vascular beds and results in a significant worldwide disease burden. Conventional imaging modalities focus on the morphological features of atherosclerotic disease such as the degree of stenosis caused by a lesion. Modern CT, MR and positron emission tomography scanners have seen significant improvements in the rapidity of image acquisition and spatial resolution. This has increased the scope for the clinical application of these modalities. Multimodality imaging can improve cardiovascular risk prediction by informing on the constituency and metabolic processes within the vessel wall. Specific disease processes can be targeted using novel biological tracers and "smart" contrast agents. These approaches have the potential to inform clinicians of the metabolic state of atherosclerotic plaque. This review will provide an overview of current imaging techniques for the imaging of atherosclerosis and how various modalities can provide information that enhances the depiction of basic morphology.
    MeSH term(s) Aortic Diseases/diagnosis ; Atherosclerosis/diagnosis ; Carotid Artery Diseases/diagnosis ; Contrast Media ; Coronary Disease/diagnosis ; Diagnostic Imaging/trends ; Humans ; Magnetic Resonance Angiography/trends ; Magnetic Resonance Spectroscopy ; Magnetite Nanoparticles ; Molecular Imaging/trends ; Spectrophotometry, Infrared/trends ; Tomography, Optical Coherence/trends ; Tomography, X-Ray Computed/trends ; Ultrasonography, Interventional/trends ; Vascular Calcification/diagnosis
    Chemical Substances Contrast Media ; Magnetite Nanoparticles
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20180309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.11: Show issues Location:
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  8. Article: The International Association for the Study of Lung Cancer Lymph Node Map: A Radiologic Atlas and Review.

    Kim, Jin Hwan / van Beek, Edwin Jr / Murchison, John T / Marin, Aleksander / Mirsadraee, Saeed

    Tuberculosis and respiratory diseases

    2015  Volume 78, Issue 3, Page(s) 180–189

    Abstract: Accurate lymph node staging of lung cancer is crucial in determining optimal treatment plans and predicting patient outcome. Currently used lymph node maps have been reconciled to the internationally accepted International Association for the Study of ... ...

    Abstract Accurate lymph node staging of lung cancer is crucial in determining optimal treatment plans and predicting patient outcome. Currently used lymph node maps have been reconciled to the internationally accepted International Association for the Study of Lung Cancer (IASLC) map published in the seventh edition of TNM classification system of malignant tumours. This article provides computed tomographic illustrations of the IASLC nodal map, to facilitate its application in day-to-day clinical practice in order to increase the appropriate classification in lung cancer staging.
    Language English
    Publishing date 2015-06-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2015.78.3.180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5937: Show issues Location:
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  9. Article ; Online: Computed tomography aortic valve calcium scoring for the assessment of aortic stenosis progression.

    Doris, Mhairi Katrina / Jenkins, William / Robson, Philip / Pawade, Tania / Andrews, Jack Patrick / Bing, Rong / Cartlidge, Timothy / Shah, Anoop / Pickering, Alice / Williams, Michelle Claire / Fayad, Zahi A / White, Audrey / van Beek, Edwin Jr / Newby, David E / Dweck, Marc R

    Heart (British Cardiac Society)

    2020  Volume 106, Issue 24, Page(s) 1906–1913

    Abstract: Objective: CT quantification of aortic valve calcification (CT-AVC) is useful in the assessment of aortic stenosis severity. Our objective was to assess its ability to track aortic stenosis progression compared with echocardiography.: Methods: ... ...

    Abstract Objective: CT quantification of aortic valve calcification (CT-AVC) is useful in the assessment of aortic stenosis severity. Our objective was to assess its ability to track aortic stenosis progression compared with echocardiography.
    Methods: Subjects were recruited in two cohorts: (1) a
    Results: A total of 33 (age 71±8) and 81 participants (age 72±8) were recruited to the reproducibility and progression cohorts, respectively. Ten CT scans (16%) were excluded from the progression cohort due to non-diagnostic image quality. Scan-rescan reproducibility was excellent for CT-AVC (limits of agreement -12% to 10 %, intraclass correlation (ICC) 0.99), peak velocity (-7% to +17%; ICC 0.92) mean gradient (-25% to 27%, ICC 0.96) and dimensionless index (-11% to +15%; ICC 0.98). Repeat measurements of aortic valve area (AVA) were less reliable (-44% to +28%, ICC 0.85).CT-AVC progressed by 152 (65-375) AU/year. For echocardiography, the median annual change in peak velocity was 0.1 (0.0-0.3) m/s/year, mean gradient 2 (0-4) mm Hg/year and AVA -0.1 (-0.2-0.0) cm
    Conclusion: CT-AVC is reproducible and demonstrates larger increases over time normalised to measurement repeatability compared with echocardiographic measures.
    MeSH term(s) Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/metabolism ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/metabolism ; Calcium/metabolism ; Echocardiography, Doppler ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Reproducibility of Results ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-317125
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  10. Article: Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging.

    Tsuchiya, Nanae / van Beek, Edwin Jr / Ohno, Yoshiharu / Hatabu, Hiroto / Kauczor, Hans-Ulrich / Swift, Andrew / Vogel-Claussen, Jens / Biederer, Jürgen / Wild, James / Wielpütz, Mark O / Schiebler, Mark L

    World journal of radiology

    2018  Volume 10, Issue 6, Page(s) 52–64

    Abstract: Pulmonary contrast enhanced magnetic resonance angiography (CE-MRA) is useful for the primary diagnosis of pulmonary embolism (PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher ... ...

    Abstract Pulmonary contrast enhanced magnetic resonance angiography (CE-MRA) is useful for the primary diagnosis of pulmonary embolism (PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography (CTA). In this review, we discuss the strengths and weaknesses of CE-MRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multi-institutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women (< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness (patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE.
    Language English
    Publishing date 2018-08-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573705-3
    ISSN 1949-8470
    ISSN 1949-8470
    DOI 10.4329/wjr.v10.i6.52
    Database MEDical Literature Analysis and Retrieval System OnLINE

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