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  1. Article ; Online: Salmonella

    Teafatiller, Trevor / Subramanya, Sandeep B / Lambrecht, Nils / Subramanian, Veedamali S

    Mediators of inflammation

    2023  Volume 2023, Page(s) 2629262

    Abstract: ... ...

    Abstract Salmonella
    MeSH term(s) Humans ; Animals ; Mice ; Ascorbic Acid/metabolism ; Ascorbic Acid/pharmacology ; Salmonella typhimurium/metabolism ; Caco-2 Cells ; NLR Family, Pyrin Domain-Containing 3 Protein ; Intestines ; Salmonella Infections ; Inflammasomes/metabolism ; Cytokines/pharmacology ; RNA, Messenger
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Cytokines ; RNA, Messenger
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2023/2629262
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  2. Article ; Online: The basic immunology of asthma.

    Hammad, Hamida / Lambrecht, Bart N

    Cell

    2021  Volume 184, Issue 6, Page(s) 1469–1485

    Abstract: In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as eosinophilia, mucus hypersecretion, bronchial hyperresponsiveness (BHR), ... ...

    Abstract In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as eosinophilia, mucus hypersecretion, bronchial hyperresponsiveness (BHR), IgE production, and susceptibility to exacerbations. However, only half the asthmatics have this "type 2-high" signature, and "type 2-low" asthma is more associated with obesity, presence of neutrophils, and unresponsiveness to corticosteroids, the mainstay asthma therapy. Here, we review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.
    MeSH term(s) Adaptive Immunity ; Alveolar Epithelial Cells/pathology ; Animals ; Asthma/immunology ; Asthma/physiopathology ; Asthma/therapy ; Asthma/virology ; B-Lymphocytes/immunology ; Biological Therapy ; Humans ; Immunoglobulin E/immunology
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.02.016
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  3. Article ; Conference proceedings: [No title information]

    Eisenmann, S / Böhm, S / Vogt, I / Wollschläger, B / Lambrecht, N

    Pneumologie

    2022  Volume 76, Issue 02

    Event/congress 22. Jahrestagung der Mitteldeutschen Gesellschaft für Pneumologie und Thoraxchirurgie e.V., virtuell, 2020-12-19
    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0041-1741127
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  4. Article ; Online: The state of complement in COVID-19.

    Afzali, Behdad / Noris, Marina / Lambrecht, Bart N / Kemper, Claudia

    Nature reviews. Immunology

    2021  Volume 22, Issue 2, Page(s) 77–84

    Abstract: Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute ... ...

    Abstract Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their currently known relationships to hyperinflammation and thrombosis. We also provide an update on early clinical findings and emerging clinical trial evidence that suggest potential therapeutic benefit of complement inhibition in severe COVID-19.
    MeSH term(s) Blood Coagulation ; COVID-19/immunology ; Complement Activation ; Complement System Proteins ; Humans ; Inflammation ; Thrombosis
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-12-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00665-1
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  5. Article ; Online: Wild foods contribute to women's higher dietary diversity in India.

    Cheek, Jennifer Zavaleta / Lambrecht, Nathalie J / den Braber, Bowy / Akanchha, Nirali / Govindarajulu, Dhanapal / Jones, Andrew D / Chhatre, Ashwini / Rasmussen, Laura Vang

    Nature food

    2023  Volume 4, Issue 6, Page(s) 476–482

    Abstract: Wild foods, from forests and common lands, can contribute to food and nutrition security. Most previous studies have established correlations between wild food consumption and children's dietary diversity in Africa, but other groups and geographic ... ...

    Abstract Wild foods, from forests and common lands, can contribute to food and nutrition security. Most previous studies have established correlations between wild food consumption and children's dietary diversity in Africa, but other groups and geographic contexts remain understudied. Here a rigorous quasi-experimental method was combined with monthly interval data to assess the contribution of wild foods to women's diets. We collected 24 h diet recall data monthly, from November 2016 to November 2017, from 570 households in East India. We found that wild foods contributed positively to diets, especially in June and July (when consumption of wild foods was highest). Women who consumed wild foods had higher average dietary diversity scores (13% and 9% higher in June and July, respectively) and were more likely to consume nutrient-dense, dark-green leafy vegetables than those who did not. Our results underscore the importance of policies that increase knowledge of wild foods and protect people's rights to access forests and other common lands for improved nutrition.
    MeSH term(s) Child ; Humans ; Female ; Diet ; Vegetables ; Nutritional Status ; Nutrients ; India
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ISSN 2662-1355
    ISSN (online) 2662-1355
    DOI 10.1038/s43016-023-00766-1
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  6. Article ; Online: Patient-reported outcomes after personalised dose-escalation for stage II-III non-small-cell lung cancer patients: Results from the randomised ARTFORCE PET-Boost trial.

    Cooke, Saskia A / Belderbos, José S A / Reymen, Bart / Lambrecht, Maarten / Fredberg Persson, Gitte / Faivre-Finn, Corinne / Dieleman, Edith M T / van Diessen, Judi N A / Sonke, Jan-Jakob / de Ruysscher, Dirk

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 196, Page(s) 110312

    Abstract: Background and purpose: The ultimate challenge in dose-escalation trials lies in finding the balance between benefit and toxicity. We examined patient-reported outcomes (PROs), including health-related quality of life (HRQoL) in patients with locally ... ...

    Abstract Background and purpose: The ultimate challenge in dose-escalation trials lies in finding the balance between benefit and toxicity. We examined patient-reported outcomes (PROs), including health-related quality of life (HRQoL) in patients with locally advanced non-small cell lung cancer (LA-NSCLC), treated with dose-escalated radiotherapy.
    Materials and methods: The international, randomised, phase 2 ARTFORCE PET-Boost study (NCT01024829) aimed to improve 1-year freedom from local failure rates in patients with stage II-III NSCLC, with a ≥ 4 cm primary tumour. Treatment consisted of an individualised, escalated fraction dose, either to the primary tumour as a whole or to its most FDG-avid subvolume (24 x 3.0-5.4 Gy). Patients received sequential or concurrent chemoradiotherapy, or radiotherapy only. Patients were asked to complete the EORTC QLQ-C30, QLQ-LC13, and the EuroQol-5D at eight timepoints. We assessed the effect of dose-escalation on C30 sum score through mixed-modelling and evaluated clinically meaningful changes for all outcomes.
    Results: Between Apr-2010 and Sep-2017, 107 patients were randomised; 102 were included in the current analysis. Compliance rates: baseline 86.3%, 3-months 85.3%, 12-months 80.3%; lowest during radiation treatment 35.0%. A linear mixed-effect (LME) model revealed no significant change in overall HRQoL over time, and no significant difference between the two treatment groups. Physical functioning showed a gradual decline in both groups during treatment and at 18-months follow-up, while clinically meaningful worsening of dyspnoea was seen mainly at 3- and 6-months.
    Conclusion: In patients with LA-NSCLC treated with two dose-escalation strategies, the average patient-reported HRQoL remained stable in both groups, despite frequent patient-reported symptoms, including dyspnoea, dysphagia, and fatigue.
    Language English
    Publishing date 2024-04-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110312
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    Zs.A 1926: Show issues Location:
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  7. Article ; Online: CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.

    Rawat, Kavita / Tewari, Anita / Li, Xin / Mara, Arlind B / King, William T / Gibbings, Sophie L / Nnam, Chinaza F / Kolling, Fred W / Lambrecht, Bart N / Jakubzick, Claudia V

    The Journal of experimental medicine

    2023  Volume 220, Issue 6

    Abstract: Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory DCs express this chemokine receptor, it is unclear how monocytes reach the ... ...

    Abstract Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory DCs express this chemokine receptor, it is unclear how monocytes reach the LN. In steady-state and following inhalation of several PAMPs, scRNA-seq identified LN mononuclear phagocytes as monocytes, resident, or migratory type 1 and type 2 conventional (c)DCs, despite the downregulation of Xcr1, Clec9a, H2-Ab1, Sirpa, and Clec10a transcripts on migratory cDCs. Migratory cDCs, however, upregulated Ccr7, Ccl17, Ccl22, and Ccl5. Migratory monocytes expressed Ccr5, a high-affinity receptor for Ccl5. Using two tracking methods, we observed that both CD88hiCD26lomonocytes and CD88-CD26hi cDCs captured inhaled antigens in the lung and migrated to LNs. Antigen exposure in mixed-chimeric Ccl5-, Ccr2-, Ccr5-, Ccr7-, and Batf3-deficient mice demonstrated that while antigen-bearing DCs use CCR7 to reach the LN, monocytes use CCR5 to follow CCL5-secreting migratory cDCs into the LN, where they regulate DC-mediated immunity.
    MeSH term(s) Mice ; Animals ; Monocytes ; Dendritic Cells ; Receptors, CCR7 ; Lung ; Antigens ; Lymph Nodes ; Cell Movement ; Mice, Inbred C57BL
    Chemical Substances Receptors, CCR7 ; Antigens
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20222129
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  8. Article ; Online: Regulators of A20 (TNFAIP3): new drug-able targets in inflammation.

    Momtazi, G / Lambrecht, B N / Naranjo, J R / Schock, B C

    American journal of physiology. Lung cellular and molecular physiology

    2018  Volume 316, Issue 3, Page(s) L456–L469

    Abstract: Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the pathogenesis of many inflammatory disorders, including those of the lung such as cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease (COPD). ...

    Abstract Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the pathogenesis of many inflammatory disorders, including those of the lung such as cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease (COPD). Despite recent advances in treatment, management of the inflammatory component of these diseases still remains suboptimal. A20 is an endogenous negative regulator of NF-κB signaling, which has been widely described in several autoimmune and inflammatory disorders and more recently in terms of chronic lung disorders. However, the underlying mechanism for the apparent lack of A20 in CF, COPD, and asthma has not been investigated. Transcriptional regulation of A20 is complex and requires coordination of different transcription factors. In this review we examine the existing body of research evidence on the regulation of A20, concentrating on pulmonary inflammation. Special focus is given to the repressor downstream regulatory element antagonist modulator (DREAM) and its nuclear and cytosolic action to regulate inflammation. We provide evidence that would suggest the A20-DREAM axis to be an important player in (airway) inflammatory responses and point to DREAM as a potential future therapeutic target for the modification of phenotypic changes in airway inflammatory disorders. A schematic summary describing the role of DREAM in inflammation with a focus on chronic lung diseases as well as the possible consequences of altered DREAM expression on immune responses is provided.
    MeSH term(s) Animals ; Chronic Disease/drug therapy ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Lung Diseases/drug therapy ; Phenotype ; Tumor Necrosis Factor alpha-Induced Protein 3/drug effects ; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism
    Chemical Substances TNFAIP3 protein, human (EC 3.4.19.12) ; Tumor Necrosis Factor alpha-Induced Protein 3 (EC 3.4.19.12)
    Language English
    Publishing date 2018-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00335.2018
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  9. Article ; Conference proceedings: Vaskuläre Indikationen für den endobronchialen Ultraschall

    Lambrecht, N / Vogt, I / Böhm, S / Wollschläger, B / Eisenmann, S

    Pneumologie

    2019  Volume 73, Issue S 01

    Event/congress 60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., München, 2019-03-13
    Language English
    Publishing date 2019-02-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0039-1678290
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  10. Article ; Conference proceedings: Immuntherapie und Radiatio – eine sinnvolle Kombination?

    Lambrecht, N / Vogt, I / Böhm, S / Wollschläger, B / Eisenmann, S

    Pneumologie

    2019  Volume 73, Issue S 01

    Event/congress 60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., München, 2019-03-13
    Language English
    Publishing date 2019-02-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0039-1678252
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