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  1. Article ; Online: Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience.

    Tuder, Rubin M

    Annals of the American Thoracic Society

    2019  Volume 15, Issue Suppl 4, Page(s) S227–S233

    Abstract: The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in the field have struggled to decipher the cellular and molecular processes underlying chronic bronchitis and emphysema. Studies in the past 20 years have ... ...

    Abstract The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in the field have struggled to decipher the cellular and molecular processes underlying chronic bronchitis and emphysema. Studies in the past 20 years have underscored that the tissue destruction, notably in emphysema, involves a multitude of injurious stresses, with progressive engagement of endogenous destructive processes triggered by decades of exposure to cigarette smoke and/or pollutants. These lead to an aged lung, with evidence of macromolecular damage that is unlikely to repair. Here we discuss these key pathogenetic elements in the context of organismal evolution as this concept may best capture the challenges facing chronic obstructive pulmonary disease.
    MeSH term(s) Animals ; Cellular Senescence ; Cigarette Smoking/adverse effects ; DNA Damage ; Disease Models, Animal ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Iron/metabolism ; Lung/metabolism ; Lung/pathology ; Mitochondria/metabolism ; Oxidative Stress ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/etiology ; Smoke/adverse effects
    Chemical Substances Smoke ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201808-583MG
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
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  2. Article ; Online: Bronchopulmonary Dysplasia: Endothelial Cells in the Driver's Seat.

    Vohwinkel, Christine U / Tuder, Rubin M

    American journal of respiratory cell and molecular biology

    2021  Volume 65, Issue 1, Page(s) 6–7

    MeSH term(s) Bronchopulmonary Dysplasia ; Endothelial Cells ; Humans ; Infant, Newborn
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0145ED
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  3. Article ; Online: Perspective: pathobiological paradigms in pulmonary hypertension, time for reappraisal.

    Tuder, Rubin M / Stenmark, Kurt R

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 318, Issue 6, Page(s) L1131–L1137

    Abstract: For the past 120 years, there has been a progressive evolution of the pathobiological concepts underlying pulmonary hypertension. Conceptual frameworks, build around the paradigms of excessive vasoconstriction (vs. vasodilation) and, more recently, of ... ...

    Abstract For the past 120 years, there has been a progressive evolution of the pathobiological concepts underlying pulmonary hypertension. Conceptual frameworks, build around the paradigms of excessive vasoconstriction (vs. vasodilation) and, more recently, of the cancer-like hypothesis of pulmonary hypertension, have served to consolidate key discoveries; moreover, they have and continue contributing to innovative advances that have been translated into either successful or potential new therapies. However, those frameworks do not fully address the complexity and challenges facing pulmonary hypertension, particularly those involving the marked heterogeneity of disease presentation and the dynamic changes occurring over time in affected tissues and cells. This is particularly relevant in regards to the molecular pathways of pulmonary hypertension; the ever growing understanding of molecular and cellular pathways requires clarification if they drive distinctive pulmonary vascular lesions in a given lung and disease patients with the same group pulmonary hypertension. Novel methodologies and approaches can start dissecting this key challenge in the field as it is critical to address the key angle of heterogeneity of the disease and reappraisal of disease-modifying therapies.
    MeSH term(s) Animals ; Humans ; Hypertension, Pulmonary/pathology ; Models, Biological ; Principal Component Analysis
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00067.2020
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  4. Article ; Online: Pulmonary vascular remodeling in pulmonary hypertension.

    Tuder, Rubin M

    Cell and tissue research

    2016  Volume 367, Issue 3, Page(s) 643–649

    Abstract: Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and ... ...

    Abstract Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.
    MeSH term(s) Animals ; Humans ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Inflammation/pathology ; Vascular Remodeling
    Language English
    Publishing date 2016-12-26
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-016-2539-y
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  5. Article ; Online: Pulmonary Arteries and Microcirculation in COPD With Pulmonary Hypertension: Bystander or Culprit?

    Tuder, Rubin M / Cool, Carlyne D

    Chest

    2019  Volume 156, Issue 1, Page(s) 4–6

    MeSH term(s) Humans ; Hypertension, Pulmonary ; Lung ; Microcirculation ; Pulmonary Artery ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.04.100
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: Peroxisome Proliferator-activated Receptor γ and Mitochondria: Drivers or Passengers on the Road to Pulmonary Hypertension?

    Stenmark, Kurt R / Tuder, Rubin M

    American journal of respiratory cell and molecular biology

    2018  Volume 58, Issue 5, Page(s) 555–557

    MeSH term(s) Cell Proliferation ; Humans ; Hypertension, Pulmonary ; Mitochondria ; Myocytes, Smooth Muscle ; PPAR gamma ; Pulmonary Artery
    Chemical Substances PPAR gamma
    Language English
    Publishing date 2018-04-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2017-0318ED
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  7. Article ; Online: Lung Histological Methods.

    Gandjeva, Aneta / Tuder, Rubin M

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1809, Page(s) 315–329

    Abstract: The lung is ideally suited to the application of histological methods to study its structure, cellular composition, and molecular characteristics of more than 30 types of cells. The key in these endeavors are proper tissue preservation/fixation, well- ... ...

    Abstract The lung is ideally suited to the application of histological methods to study its structure, cellular composition, and molecular characteristics of more than 30 types of cells. The key in these endeavors are proper tissue preservation/fixation, well-established protocols aimed at sectioning and staining, and understanding of lung morphology. Molecular studies can be performed in laser-captured cells and microscopic structures.
    MeSH term(s) Histological Techniques ; Humans ; Immunohistochemistry ; Laser Capture Microdissection ; Lung/cytology ; Lung/metabolism
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8570-8_20
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  8. Article: Pulmonary vascular remodeling in pulmonary hypertension

    Tuder, Rubin M

    Cell and tissue research. 2017 Mar., v. 367, no. 3

    2017  

    Abstract: Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and ... ...

    Abstract Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.
    Keywords animal pathology ; hypertension ; lungs ; pathogenicity
    Language English
    Dates of publication 2017-03
    Size p. 643-649.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-016-2539-y
    Database NAL-Catalogue (AGRICOLA)

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    Z 46/352: Show issues

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  9. Article ; Online: How do we measure pathology in PAH (lung and RV) and what does it tell us about the disease.

    Tuder, Rubin M

    Drug discovery today

    2014  Volume 19, Issue 8, Page(s) 1257–1263

    Abstract: The current understanding of the pathology that underlies pulmonary vascular and right ventricular remodeling in pulmonary hypertension is discussed. Although recent studies underscored the importance of intima and media remodeling and, for the first ... ...

    Abstract The current understanding of the pathology that underlies pulmonary vascular and right ventricular remodeling in pulmonary hypertension is discussed. Although recent studies underscored the importance of intima and media remodeling and, for the first time, the relevance of perivascular inflammation, much is needed to move the field forward. Reassessment of distribution and extension of the different vascular lesions requires state-of-the-art stereological tools, allied to three-dimensional casting and integration with data concerning cellular and molecular pathobiological processes. This integrated approach is ever more pressing in the right ventricle, because our understanding of key structural alterations of the failing right ventricle in pulmonary hypertension is lacking. This enterprise will enable better translation of pathogenetic processes to the human disease and provide key data to guide diagnostic and prognostic imaging approaches.
    MeSH term(s) Animals ; Heart Ventricles/pathology ; Humans ; Hypertension, Pulmonary/pathology ; Lung/pathology ; Ventricular Dysfunction, Right/pathology
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2014.05.022
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    Zs.A 4725: Show issues Location:
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  10. Article ; Online: Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension.

    Gu, Sue / Goel, Khushboo / Forbes, Lindsay M / Kheyfets, Vitaly O / Yu, Yen-Rei A / Tuder, Rubin M / Stenmark, Kurt R

    Comprehensive Physiology

    2023  Volume 13, Issue 1, Page(s) 4295–4319

    Abstract: In the over 100 years since the recognition of pulmonary hypertension (PH), immense progress and significant achievements have been made with regard to understanding the pathophysiology of the disease and its treatment. These advances have been mostly in ...

    Abstract In the over 100 years since the recognition of pulmonary hypertension (PH), immense progress and significant achievements have been made with regard to understanding the pathophysiology of the disease and its treatment. These advances have been mostly in idiopathic pulmonary arterial hypertension (IPAH), which was classified as Group 1 Pulmonary Hypertension (PH) at the Second World Symposia on PH in 1998. However, the pathobiology of PH due to chronic lung disease, classified as Group 3 PH, remains poorly understood and its treatments thus remain limited. We review the history of the classification of the five groups of PH and aim to provide a state-of-the-art review of the understanding of the pathogenesis of Group 1 PH and Group 3 PH including insights gained from novel high-throughput omics technologies that have revealed heterogeneities within these categories as well as similarities between them. Leveraging the substantial gains made in understanding the genomics, epigenomics, proteomics, and metabolomics of PAH to understand the full spectrum of the complex, heterogeneous disease of PH is needed. Multimodal omics data as well as supervised and unbiased machine learning approaches after careful consideration of the powerful advantages as well as of the limitations and pitfalls of these technologies could lead to earlier diagnosis, more precise risk stratification, better predictions of disease response, new sub-phenotype groupings within types of PH, and identification of shared pathways between PAH and other types of PH that could lead to new treatment targets. © 2023 American Physiological Society. Compr Physiol 13:4295-4319, 2023.
    MeSH term(s) Humans ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/therapy ; Lung Diseases ; Genomics
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c220010
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