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  1. Article: Commensal bacteria increase invasion of intestinal epithelium by Salmonella enterica serovar Typhi.

    Lyczak, Jeffrey B

    Infection and immunity

    2003  Volume 71, Issue 11, Page(s) 6610–6614

    Abstract: The intestinal microflora consists of a heterogeneous population of microorganisms and has many effects on the health status of its human host. Here, it is shown that the products of certain strains of bacteria normally present in the intestinal ... ...

    Abstract The intestinal microflora consists of a heterogeneous population of microorganisms and has many effects on the health status of its human host. Here, it is shown that the products of certain strains of bacteria normally present in the intestinal microflora are able to trigger redistribution of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in epithelial cells. CFTR is used by Salmonella enterica serovar Typhi as a receptor on epithelial cells which mediate the translocation of this microorganism to the gastric submucosa. Serovar Typhi-epithelial cell adhesion and CFTR-dependent invasion by serovar Typhi of epithelial cells were increased following commensal-mediated CFTR redistribution. These data suggest that commensal microorganisms present in the intestinal lumen can affect the efficiency of serovar Typhi invasion of the intestinal submucosa. This could be a key factor influencing host susceptibility to typhoid fever.
    MeSH term(s) Animals ; Cell Line ; Cystic Fibrosis Transmembrane Conductance Regulator/physiology ; Dogs ; Intestinal Mucosa/microbiology ; Salmonella typhi/pathogenicity
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2003-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.71.11.6610-6614.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
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  2. Article: Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium.

    Lyczak, Jeffrey B / Pier, Gerald B

    Infection and immunity

    2001  Volume 70, Issue 11, Page(s) 6416–6423

    Abstract: The cystic fibrosis transmembrane conductance regulator (CFTR) protein is an epithelial receptor mediating the translocation of Salmonella enterica serovar Typhi to the gastric submucosa. Since the level of cell surface CFTR is directly related to the ... ...

    Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) protein is an epithelial receptor mediating the translocation of Salmonella enterica serovar Typhi to the gastric submucosa. Since the level of cell surface CFTR is directly related to the efficiency of serovar Typhi translocation, the goal of this study was to measure CFTR expression by the intestinal epithelium during infection. CFTR protein initially present in the epithelial cell cytoplasm was rapidly trafficked to the plasma membrane following exposure to live serovar Typhi or bacterial extracts. CFTR-dependent bacterial uptake by epithelial cells increased (>100-fold) following CFTR redistribution. The bacterial factor which triggers CFTR redistribution is heat and protease sensitive. These data suggest that serovar Typhi induces intestinal epithelial cells to increase membrane CFTR levels, leading to enhanced bacterial ingestion and submucosal translocation. This could be a key, early step in the infectious process leading to typhoid fever.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Female ; Humans ; Intestinal Mucosa/metabolism ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/analysis ; Salmonella typhi/pathogenicity ; Tumor Cells, Cultured
    Chemical Substances CFTR protein, human ; RNA, Messenger ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2001-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.70.11.6416-6423.2002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article: Lung infections associated with cystic fibrosis.

    Lyczak, Jeffrey B / Cannon, Carolyn L / Pier, Gerald B

    Clinical microbiology reviews

    2002  Volume 15, Issue 2, Page(s) 194–222

    Abstract: While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is now recognized as a single disease whose diverse symptoms stem from the wide tissue distribution of the gene product that is defective in CF, the ion channel and ...

    Abstract While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is now recognized as a single disease whose diverse symptoms stem from the wide tissue distribution of the gene product that is defective in CF, the ion channel and regulator, cystic fibrosis transmembrane conductance regulator (CFTR). Defective CFTR protein impacts the function of the pancreas and alters the consistency of mucosal secretions. The latter of these effects probably plays an important role in the defective resistance of CF patients to many pathogens. As the modalities of CF research have changed over the decades from empirical histological studies to include biophysical measurements of CFTR function, the clinical management of this disease has similarly evolved to effectively address the ever-changing spectrum of CF-related infectious diseases. These factors have led to the successful management of many CF-related infections with the notable exception of chronic lung infection with the gram-negative bacterium Pseudomonas aeruginosa. The virulence of P. aeruginosa stems from multiple bacterial attributes, including antibiotic resistance, the ability to utilize quorum-sensing signals to form biofilms, the destructive potential of a multitude of its microbial toxins, and the ability to acquire a mucoid phenotype, which renders this microbe resistant to both the innate and acquired immunologic defenses of the host.
    MeSH term(s) Bacterial Infections/microbiology ; Cystic Fibrosis/genetics ; Cystic Fibrosis/history ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Haemophilus influenzae/isolation & purification ; History, 20th Century ; Humans ; Lung/microbiology ; Mutation ; Pseudomonas aeruginosa/isolation & purification ; Staphylococcus aureus/isolation & purification
    Chemical Substances CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2002-04
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/CMR.15.2.194-222.2002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Book: Immunology, infection, and immunity

    Pier, Gerald Bryan / Lyczak, Jeffrey B / Wetzler, Lee M

    2004  

    Author's details edited by Gerald B. Pier, Jeffrey B. Lyczak, Lee M. Wetzler
    Keywords Immunology. ; Infection.
    Language English
    Size xxiii, 718 p. :, col. ill. ;, 29 cm.
    Publisher ASM Press
    Publishing place Washington, D.C
    Document type Book
    ISBN 1555812465 ; 9781555812461
    Database NAL-Catalogue (AGRICOLA)

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  5. Book: Immunology, infection, and immunity

    Pier, Gerald Bryan / Lyczak, Jeffrey B / Wetzler, Lee M

    2004  

    Author's details edited by Gerald B. Pier, Jeffrey B. Lyczak, Lee M. Wetzler
    MeSH term(s) Immune System ; Immune System Diseases ; Immunity, Cellular ; Infection
    Language English
    Size xxiii, 718 p., ill., port.
    Publisher ASM Press
    Publishing place Washington, D.C
    Document type Book
    ISBN 9781555812461 ; 1555812465
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book ; Online: Immunology, infection, and immunity

    Lyczak, Jeffrey B / Pier, Gerald Bryan / Wetzler, Lee M

    2004  

    Abstract: Covers the foundation concepts of immunology and their application to the real world of diseases and ... ...

    Author's details edited by Gerald B. Pier, Jeffrey B. Lyczak, Lee M. Wetzler
    Abstract Covers the foundation concepts of immunology and their application to the real world of diseases and health
    MeSH term(s) Immune System ; Immune System Diseases ; Immunity, Cellular ; Infection
    Keywords Immunology ; Infection
    Language English
    Size Online-Ressource (xxiii, 718 pages), color illustrations
    Publisher ASM Press
    Publishing place Washington, D.C
    Document type Book ; Online
    Note Includes bibliographical references and index ; Use copy Restrictions unspecified star MiAaHDL
    ISBN 1555816142 ; 1555812465 ; 9781555812461 ; 9781555816148
    Database Former special subject collection: coastal and deep sea fishing

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