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Article ; Online: Parinaud's syndrome: a stroke chameleon.

Barbato, Francesco / Allocca, Roberto / Bosso, Giorgio / Numis, Fabio Giuliano

2023 Volume 19, Issue 1, Page(s) 145–146

MeSH term(s)	Humans ; Ocular Motility Disorders ; Stroke ; Syndrome
Language	English
Publishing date	2023-11-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03455-w
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Article ; Online: Simple detecting of elevated ICP through liquor flow after lumbar puncture.

Barbato, Francesco / Troise, Augusta / Allocca, Roberto / Sansone, Gennaro / Bosso, Giorgio / Numis, Fabio Giuliano

The American journal of emergency medicine

2023 Volume 75, Page(s) 128–130

Abstract: Elevated intracranial pressure (ICP) is defined as a cerebrospinal fluid (CSF) opening pressure (OP) greater than 25 cmH2O. When a diagnostic lumbar puncture is performed it is useful to estimate also intracranial pressure. To do this it is required a ... ...

Abstract	Elevated intracranial pressure (ICP) is defined as a cerebrospinal fluid (CSF) opening pressure (OP) greater than 25 cmH2O. When a diagnostic lumbar puncture is performed it is useful to estimate also intracranial pressure. To do this it is required a presence of pressure gauges, which are currently the gold standard, not available in most resource-constrained contexts. We decided to evaluate whether it is possible to estimate it simply by counting the drops of cerebrospinal liquor, which are collected after lumbar puncture, according to Poiseuille's law. Was examined a sample of 52 patients, aged between 18 and 85 years, belonging to the emergency room of "Santa Maria delle Grazie" Hospital in Pozzuoli (Naples) who needed a diagnostic lumbar puncture (LP). The ICP was initially measured using a standard narrow-gauge manometer by attaching it to the spinal needle. After removing the pressure gauge, the number of drops of cerebrospinal fluid flowing from the spinal needle in 30 seconds was counted. A statistical analysis was made with linear regression and ROC analysis. OP as measured by standard manometry was raised on 17 occasions with CSF drop rate median of 47 drops/30 seconds and range 30-74 drops/30 seconds. OP was normal on 35 occasions with CSF drop rate median of 23 drops/30 seconds with range of 14-34 drops/30 seconds. A linear regression analysis was performed which resulted in a Pearson correlation of 0.936 an adjusted R square of 0.874 (see Fig. 1). Analysis through ANOVA documented an F of 355.301 with p < 0.01 and Dubin Watson of 1.642. The analysis through ROC showed an AUC of 0.980, with a sensitivity of 100% and a specificity of 91% if chosen as a limit, 29 drops in 30 seconds (Youden Index of 0.9140). Therefore, we have concluded, that although there are several precautions, like patient's position, it is technically feasible to indirectly estimate cerebrospinal fluid pressure with good accuracy by counting the drops of cerebrospinal fluid flowing from a 22 G spinal needle.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Spinal Puncture/methods ; Intracranial Pressure ; Intracranial Hypertension/diagnosis ; ROC Curve ; Manometry/methods
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.10.029
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Article ; Online: Spontaneous eye movements in myxedematous coma.

Barbato, Francesco / Allocca, Roberto / Serra, Claudia / Bosso, Giorgio / Numis, Fabio Giuliano

Internal and emergency medicine

2022 Volume 17, Issue 7, Page(s) 2063–2064

MeSH term(s)	Coma/etiology ; Eye Movements ; Humans
Language	English
Publishing date	2022-08-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-022-03064-z
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Article ; Online: Echocardiographic assessment of aortic pulse wave velocity for left ventricular diastolic dysfunction.

Bosso, Giorgio / DE Luca, Mariarosaria / Oliviero, Ugo

Minerva cardiology and angiology

2020 Volume 69, Issue 1, Page(s) 9–11

MeSH term(s)	Echocardiography ; Humans ; Prognosis ; Pulse Wave Analysis ; Ventricular Dysfunction, Left/diagnostic imaging
Language	English
Publishing date	2020-05-29
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.20.05314-1
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Article ; Online: Effects of three-months folate supplementation on early vascular abnormalities in hyperhomocysteinemic patients with epilepsy.

De Luca, Mariarosaria / Valvano, Antonio / Striano, Pasquale / Bosso, Giorgio / Pirone, Daniela / Trinchillo, Assunta / Bilo, Leonilda / Oliviero, Ugo

Seizure

2022 Volume 103, Page(s) 120–125

Abstract: Background: Epilepsy has been associated with an increased risk of cardiovascular events. Anti-seizure medication (ASM) may contribute to vascular risk by several mechanisms, including increased homocysteine levels. This study aims to assess the global ... ...

Abstract	Background: Epilepsy has been associated with an increased risk of cardiovascular events. Anti-seizure medication (ASM) may contribute to vascular risk by several mechanisms, including increased homocysteine levels. This study aims to assess the global vascular burden in hyperhomocysteinemic people with epilepsy (PWE) on long-term ASM before and after folic acid supplementation and in subgroups of PWE treated with single enzyme-inducing or single non-enzyme inducing ASM. Methods: One hundred and seventy-four hyperhomocysteinemic (HHcy) PWE who met the inclusion criteria were enrolled. Carotid Doppler ultrasonography, FMD and ultrasound assessment of the brachial artery properties at the baseline and after 90 days of folic acid supplementation were performed. The vascular biomarkers MMP-9 and TIMP-1 were also detected. Results: After folic acid supplementation, in HHcy patients homocysteine levels reduced from 26.8 ± 10.5 to 20.2 ± 5.3 μmol/L, carotid Intima-Media-Thickness reduced from 0.83+0.06 mm to 0.79±0.05 mm, and FMD, distensibility coefficient and β-stiffness improved (p < 0.05). Moreover, MMP-9 and TIMP-1 reduced after supplementation (p < 0.05). PWE treated with a single enzyme-inducing ASM showed an impairment of vascular parameters compared to patients treated with non-enzyme inducing ASM. Conclusions: The results highlight the importance of assessing homocysteine levels and estimating the cardiovascular risk of PWE, preferring non-enzyme inducing ASM in high cardiovascular-risk patients. An adequate correction of homocysteine levels with folate supplementation should be considered to improve the cardiovascular profile.
MeSH term(s)	Humans ; Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 ; Epilepsy/complications ; Epilepsy/drug therapy ; Dietary Supplements ; Homocysteine ; Folic Acid/therapeutic use
Chemical Substances	Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2022.11.009
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Article ; Online: Lung ultrasound-guided PEEP titration in COVID-19 patients treated with CPAP.

Bosso, Giorgio / Sansone, Gennaro / Papillo, Martina / Giaquinto, Alessandro / Orefice, Silvia / Allegorico, Enrico / Serra, Claudia / Minerva, Valentina / Mercurio, Valentina / Cannavacciuolo, Francesca / Dello Vicario, Ferdinando / Porta, Giovanni / Pagano, Antonio / Numis, Fabio Giuliano

Journal of basic and clinical physiology and pharmacology

2023 Volume 34, Issue 5, Page(s) 677–682

Abstract: Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 ... ...

Abstract	Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 patients requiring CPAP. Methods: This is a single center, prospective, randomized clinical study. Sixty-three COVID-19 patients with hypoxemic respiratory failure and bilateral pneumonia were randomized in two Groups: Group A received CPAP with fixed PEEP of 10 cm H Results: Thirty-two patients were enrolled in Conclusions: Lung ultrasound-guided PEEP trial is associated with lower mortality in COVID-19 patients treated with CPAP. Identifying the best PEEP is useful to increase oxygenation and reduce the incidence of complications.
MeSH term(s)	Humans ; Pneumothorax ; Prospective Studies ; COVID-19/therapy ; Lung/diagnostic imaging ; Ultrasonography, Interventional
Language	English
Publishing date	2023-07-20
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2023-0165
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Article: The rise and fall of an alien: why the successful colonizer Littorina saxatilis failed to invade the Mediterranean Sea

Bosso, Luciano / Smeraldo, Sonia / Russo, Danilo / Chiusano, Maria Luisa / Bertorelle, Giorgio / Johannesson, Kerstin / Butlin, Roger K. / Danovaro, Roberto / Raffini, Francesca

Biological invasions. 2022 Oct., v. 24, no. 10

2022

Abstract: Understanding what determines range expansion or extinction is crucial to predict the success of biological invaders. We tackled this long-standing question from an unparalleled perspective using the failed expansions in Littorina saxatilis and ... ...

Abstract	Understanding what determines range expansion or extinction is crucial to predict the success of biological invaders. We tackled this long-standing question from an unparalleled perspective using the failed expansions in Littorina saxatilis and investigated its present and past habitat suitability in Europe through Ecological Niche Modelling. This intertidal snail is a typically successful Atlantic colonizer and the earliest confirmed alien species in the Mediterranean Sea, where, however, it failed to thrive despite its high dispersal ability and adaptability. We explored the environmental constraints affecting its biogeography, identified potential glacial refugia in Europe that fuelled its post-glacial colonisations and tested whether the current gaps in its distribution are linked to local ecological features. Our results suggested that L. saxatilis is unlikely to be a glacial relict in the Mediterranean basin. Multiple Atlantic glacial refugia occurred in the Last Glacial Maximum, and abiotic environmental features such as salinity and water temperature have influenced the past and current distributions of this snail and limited its invasion of the Mediterranean Sea. The snail showed a significant overlap in geographic space and ecological niche with Carcinus maenas, the Atlantic predator, but distinct from Pachygrapsus marmoratus, the Mediterranean predator, further pointing to Atlantic-like habitat requirements for this species. Abiotic constrains during introduction rather than dispersal abilities have shaped the past and current range of L. saxatilis and help explaining why some invasions have not been successful. Our findings contribute to clarifying the processes constraining or facilitating shifts in species’ distributions and biological invasions.
Keywords	Carcinus maenas ; Littorina ; biogeography ; extinction ; introduced species ; littoral zone ; niches ; refuge habitats ; salinity ; snails ; water temperature ; Europe ; Mediterranean Sea ; Mediterranean region
Language	English
Dates of publication	2022-10
Size	p. 3169-3187.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	1438729-3
ISSN	1573-1464 ; 1387-3547
ISSN (online)	1573-1464
ISSN	1387-3547
DOI	10.1007/s10530-022-02838-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Alert-LDL-2: adherence to guidelines and goals attainment in the treatment of diabetic patients with dyslipidemia.

DE Luca, Mariarosaria / Bosso, Giorgio / Alma, Giovanni / Carbone, Vincenzo / Ferrara, Ferdinando / Fimiani, Biagio / Guarnaccia, Franco / Iandolo, Alessandro / Murolo, Sabato / Olivares, Maurizio / Romeo, Emanuele / Santoro, Giosuè / Valvano, Antonio / Zito, Giovanni / Oliviero, Ugo

Minerva cardiology and angiology

2023 Volume 71, Issue 3, Page(s) 249–256

Abstract: Background: Type 2 diabetes mellitus is associated with a cluster of lipid and apolipoprotein abnormalities which increase the risk for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the adherence to guidelines-oriented ... ...

Abstract	Background: Type 2 diabetes mellitus is associated with a cluster of lipid and apolipoprotein abnormalities which increase the risk for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the adherence to guidelines-oriented dyslipidemia treatment in diabetic patients and to assess the efficacy of a territorial goal-oriented program. Methods: One thousand seventy-one diabetic patients at very high cardiovascular risk were enrolled in this prospective study. They performed a clinical-laboratory follow-up program, received lifestyle recommendations and optimization of their antihyperlipidemic therapies. At the beginning and the 3-month follow-up visit, LDL-c data were collected, and further therapies were prescribed to the patients that did not reach the target. After 12 month follow-up, LDL-c data were collected again. Results: Diabetic patients significantly improved mean LDL cholesterol levels during one-year follow-up (LDLc mean value 135 mg/dL at baseline, 60 mg/dL at the end of the study), obtaining a greater reduction compared to non-diabetic patients participating in the same program. Accordingly, the percentage of patients that reached the lipid target was significantly higher in diabetic patients after 3-months and 12- follow-ups (P<0.05). Diabetic patients assuming statins, both in monotherapy and in combination with ezetimibe, increased during the follow-up (74.1% at the enrolment vs. 88.2% one year later). GLP1ra-treated patients achieved the greatest reduction in cholesterol levels compared to baseline. Conclusions: The results of the study recommend encouraging strategies and appropriate treatments to achieve a targeted lipid profile in diabetic patients at very high cardiovascular risk.
MeSH term(s)	Humans ; Goals ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Cholesterol, LDL ; Prospective Studies ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-01-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.22.06189-0
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Article ; Online: The impact of a non-restrictive Antimicrobial Stewardship Program in the emergency department of a secondary-level Italian hospital.

Monari, Caterina / Onorato, Lorenzo / Allegorico, Enrico / Minerva, Valentina / Macera, Margherita / Bosso, Giorgio / Calò, Federica / Pagano, Antonio / Russo, Teresa / Sansone, Gennaro / D'Isanto, Marina / Casciotta, Antonio / Vanni, Monica / Numis, Fabio Giuliano / Coppola, Nicola

Internal and emergency medicine

2023 Volume 19, Issue 2, Page(s) 493–500

Abstract: Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation ... ...

Abstract	Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation unit. The intervention included periodic prospective audits (twice a week), conducted by four infectious disease consultants. Primary outcomes included the difference in the hospital mortality rate, antibiotic consumption, and the incidence of bloodstream infections (BSI) caused by multidrug resistant (MDR) bacteria, before March 2020-February 2021 and after March 2021-February 2022 when the program was implemented. Interrupted time-series analysis was performed to assess the effect of our program. During the 12-month program, we performed 152 audits and evaluated 366 antibiotic therapies out of a total of 853 patients admitted. In the intervention period, we observed a non-statistically significant decrease in total antibiotic consumption, with a change in level of - 31.2 defined daily dose/100 patient-days (PD) (p = 0.71). Likewise, we found no significant variations in the rate of BSI due to MDR Gram-positive (CT - 0.02 events/PD, p = 0.84), MDR Gram-negative bacteria (CT 0.08, p = 0.71), or Candida spp. (CT 0.008, p = 0.86). Conversely, we found a significant decrease in the mortality rate between the pre- and post-intervention periods (- 1.98 deaths/100 PD, CI - 3.9 to - 0.007, p = 0.049). The Antibiotic Stewardship Program in the ED was associated with a significant decrease in the mortality rate. More high-quality studies are needed to determine the most effective ASP strategies in this unique setting.
MeSH term(s)	Humans ; Antimicrobial Stewardship ; Prospective Studies ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Emergency Service, Hospital ; Italy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03418-1
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Article ; Online: From Nucleotides to Satellite Imagery

Francesca Raffini / Giorgio Bertorelle / Roberto Biello / Guido D’Urso / Danilo Russo / Luciano Bosso

Sustainability, Vol 12, Iss 4508, p

Approaches to Identify and Manage the Invasive Pathogen Xylella fastidiosa and Its Insect Vectors in Europe

2020 Volume 4508

Abstract: Biological invasions represent some of the most severe threats to local communities and ecosystems. Among invasive species, the vector-borne pathogen Xylella fastidiosa is responsible for a wide variety of plant diseases and has profound environmental, ... ...

Abstract	Biological invasions represent some of the most severe threats to local communities and ecosystems. Among invasive species, the vector-borne pathogen Xylella fastidiosa is responsible for a wide variety of plant diseases and has profound environmental, social and economic impacts. Once restricted to the Americas, it has recently invaded Europe, where multiple dramatic outbreaks have highlighted critical challenges for its management. Here, we review the most recent advances on the identification, distribution and management of X. fastidiosa and its insect vectors in Europe through genetic and spatial ecology methodologies. We underline the most important theoretical and technological gaps that remain to be bridged. Challenges and future research directions are discussed in the light of improving our understanding of this invasive species, its vectors and host–pathogen interactions. We highlight the need of including different, complimentary outlooks in integrated frameworks to substantially improve our knowledge on invasive processes and optimize resources allocation. We provide an overview of genetic, spatial ecology and integrated approaches that will aid successful and sustainable management of one of the most dangerous threats to European agriculture and ecosystems.
Keywords	ecological niche model ; epidemiology ; genetic diversity ; genomic ; GIS ; insect vector ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333 ; 580
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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