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Book ; Online: Adam und Embryo

Eich, Thomas / Doroftei, Doru Constantin

Ein Beitrag zur Erforschung der Adamsgeschichte in jüdischen, christlichen und islamischen Texten bis zum Ende des ersten Jahrtausends

(Recht, Ethik und Gesellschaft im Vorderen Orient | Law, Ethics and Society in the Middle East ; 3)

2023

Series title	Recht, Ethik und Gesellschaft im Vorderen Orient \| Law, Ethics and Society in the Middle East ; 3
Keywords	HRAC ; HRJS ; 7th century ; Adam's story ; baptismal theology ; Christian texts ; creation ; early Islamic period ; embryo ; genesis of humankind ; intellectual history ; Islamic texts ; Jewish texts
Language	German
Size	1 electronic resource (340 pages)
Publisher	Nomos Verlagsgesellschaft mbH and Company KG
Publishing place	Baden-Baden
Document type	Book ; Online
Note	German
HBZ-ID	HT030609965
ISBN	9783987400643 ; 3987400641
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: ADAM

Thomas Dandekar / Zeeshan Ahmed / Saman Majeed

International Journal of Emerging Sciences, Vol 2, Iss 2, Pp 280-

Potential of PDM into Clinical Patient Data Management

2012 Volume 299

Abstract: The contributions of efficient PDM systems in industry for better product life cycle and data management is described. Presented are importance, architectural designs and implementation details of some existing commercial and academic PDM Systems i.e. ... ...

Abstract	The contributions of efficient PDM systems in industry for better product life cycle and data management is described. Presented are importance, architectural designs and implementation details of some existing commercial and academic PDM Systems i.e. Windchill, CIM DATABASE, CPDM, WPDM and Promise PLM. To implement a new PDM System, this paper presents major development guidelines, main components, mandatory functional requirements and some currently identified problems in PDM Systems. We support the medical community with the proposition and implementation of an innovative initiative, addressing major challenges of providing optimal management of a certain diagnosis, working rapidly under emergency conditions, protecting personal data, coupling individual patient data with general repositories, allowing therapy monitoring, analyzing individual variations with the and incorporation of golden standard therapy guidelines. The concepts of PDM transit the field of Bioinformatics for the implementation of an advanced clinical data analysis and management system. We propose layered conceptual and implementation architectures along with tools and technologies for the development of a prototype system.
Keywords	Product Data Management (PDM) ; Integrated System ; Bioinformatics ; Clinical Data Management. ; Science (General) ; Q1-390 ; Science ; Q ; DOAJ:Science (General) ; DOAJ:Science General ; Technology (General) ; T1-995 ; Technology ; T ; DOAJ:Technology (General) ; DOAJ:Technology and Engineering
Subject code	501
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	Islamia University of Bahawalpur
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors.

Ireland, Joanna / Segura, Jason / Shi, Genbin / Buchwald, Julianna / Roth, Gwynne / Shen, Thomas Juncheng / Wang, Ruipeng / Ji, Xinhua / Fischer, Elizabeth R / Moir, Susan / Chun, Tae-Wook / Sun, Peter D

Frontiers in microbiology

2024 Volume 15, Page(s) 1385775

Abstract: ... of both ADAM10 and 17 activities and expressions of these ADAMs were transiently induced during ...

Abstract	HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the shedding of CD62L. To systematically investigate CD62L-shedding mediated viral release and its potential inhibition, we screened compounds specific for serine-, cysteine-, aspartyl-, and Zn-dependent proteases for CD62L shedding inhibition and found that a subclass of Zn-metalloproteinase inhibitors, including BB-94, TAPI, prinomastat, GM6001, and GI25423X, suppressed CD62L shedding. Their inhibition of HIV-1 infections correlated with enzymatic suppression of both ADAM10 and 17 activities and expressions of these ADAMs were transiently induced during the viral infection. These metalloproteinase inhibitors are distinct from the current antiretroviral drug compounds. Using immunogold labeling of CD62L, we observed association between budding HIV-1 virions and CD62L by transmission electron microscope, and the extent of CD62L-tethering of budding virions increased when the receptor shedding is inhibited. Finally, these CD62L shedding inhibitors suppressed the release of HIV-1 virions by CD4 T cells of infected individuals and their virion release inhibitions correlated with their CD62L shedding inhibitions. Our finding reveals a new therapeutic approach targeted at HIV-1 viral release.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1385775
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vers un « nouvel Adam » ?

Thomas Hirsch

Revue d’Histoire des Sciences Humaines, Vol 37, Pp 235-

2020 Volume 258

Keywords	histoire des savoirs ; théorie de l’étiquetage ; behavioral sciences ; Geisteswissenschaften ; histoire transnationale ; Social Sciences ; H
Language	French
Publishing date	2020-12-01T00:00:00Z
Publisher	Éditions de la Sorbonne
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Adam et lAstragale : Essais danthropologie et dhistoire sur les limites de lhumain

Bartholeyns, Gil / Dittmar, Pierre-Olivier / Golsenne, Thomas / Har-Peled, Misgav / Jolivet, Vincent

2009

Abstract: Adam et l'astragale, deux faces d'une même question : celle de l'homme et de son humanité. Un homme ... de certains comportements et valeurs, qu'il devientntale, un humain.- ... dans la tradition occidentale, c'est d'évidence un fils d'Adam, qui fut créé de toutes pièces et d'un coup par Dieu ...

Abstract	Adam et l'astragale, deux faces d'une même question : celle de l'homme et de son humanité. Un homme, dans la tradition occidentale, c'est d'évidence un fils d'Adam, qui fut créé de toutes pièces et d'un coup par Dieu à son image. L'homme y est animé de raison, pour se distinguer de l'animal : celui-ci d'emblée et sa nature le sépare radicalement de son environnement. L'astragale, c'est ce petit os du pied présent chez tous les primates et chez l'homme. C'est parce que l'astragale humain forme un angle presque droit que l'homme peut se déplacer debout longtemps, libérer ses mains, développer son cerveau. Cet os minuscule, comme tant d'autre critère, incarne une vision plus continuiste de l'origine de l'homme : l'homme est ici animal parmi d'autres. Ce n'est que par l'apprentissage d'une culture spécifique, par l'acquisition de certains comportements et valeurs, qu'il devient un humain.- Face à une vision simpliste de l'histoire de l'idée d'humanité, qui expliquerait en termes de progrès unilatéral le passage d'Adam à l'astragale, d'une vision religieuse à une vision matérialiste, ce livre révèle l'imbrication voire les tensions des deux modèles à travers les époques. Au lieu de définir l'être d e l'humain en s'appuyant sur les seules références philosophiques ou dogmatiques, il interroge les discours et les pratiques qui ont déterminé et déterminent les limites de l'humain. Un tel questionnement demande une approche transversale, multidisciplinaire. L'humanité mise à l'épreuve, en tant que valeur communautaire, principe d'exclusion, modèle normatif de comportement, tel est le fil conducteur de ces essais d'histoire, de philosophie d'anthropologie et d'éthologie. L'Occident médiéval est ici leur centre de gravité.- Car c'est là qu'Adam, le chrétien, l'image de Dieu, qui nous semble si étranger, évidement triomphe. Mai c'est aussi à cette époque que sont clairement posés un certain nombre de problèmes qui rendront possible la pensée de l'astragale. Adam et l'astragale, deux faces d'une même question : celle de l'homme et de son humanité. Un homme, dans la tradition occidentale, c'est d'évidence un fils d'Adam, qui fut créé de toutes pièces et d'un coup par Dieu à son image. L'homme y est animé de raison, pour se distinguer de l'animal : celui-ci d'emblée et sa nature le sépare radicalement de son environnement. L'astragale, c'est ce petit os du pied présent chez tous les primates et chez l'homme. C'est parce que l'astragale humain forme un angle presque droit que l'homme peut se déplacer debout longtemps, libérer ses mains, développer son cerveau.-
Keywords	Social sciences (General)
Size	1 electronic resource ( pages)
Publisher	Éditions de la Maison des sciences de l'homme
Document type	Book ; Online
Note	French ; Open Access
HBZ-ID	HT020321176
ISBN	9782735116638 ; 2735116638
DOI	10.4000/books.editionsmsh.1696
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Exodex Adam-A Reconfigurable Dexterous Haptic User Interface for the Whole Hand.

Lii, Neal Y / Pereira, Aaron / Dietl, Julian / Stillfried, Georg / Schmidt, Annika / Beik-Mohammadi, Hadi / Baker, Thomas / Maier, Annika / Pleintinger, Benedikt / Chen, Zhaopeng / Elawad, Amal / Mentzer, Lauren / Pineault, Austin / Reisich, Philipp / Albu-Schäffer, Alin

Frontiers in robotics and AI

2022 Volume 8, Page(s) 716598

Abstract: ... they work in, whether virtual or a remote site through an avatar. We introduce the DLR Exodex Adam ... workspace. Exodex Adam uses a front-facing interface, with robotic fingers coupled to two of the user's ... the fingertips, thus realizing deeper immersion. Interaction using Exodex Adam can range from palpation ...

Abstract	Applications for dexterous robot teleoperation and immersive virtual reality are growing. Haptic user input devices need to allow the user to intuitively command and seamlessly "feel" the environment they work in, whether virtual or a remote site through an avatar. We introduce the DLR Exodex Adam, a reconfigurable, dexterous, whole-hand haptic input device. The device comprises multiple modular, three degrees of freedom (3-DOF) robotic fingers, whose placement on the device can be adjusted to optimize manipulability for different user hand sizes. Additionally, the device is mounted on a 7-DOF robot arm to increase the user's workspace. Exodex Adam uses a front-facing interface, with robotic fingers coupled to two of the user's fingertips, the thumb, and two points on the palm. Including the palm, as opposed to only the fingertips as is common in existing devices, enables accurate tracking of the whole hand without additional sensors such as a data glove or motion capture. By providing "whole-hand" interaction with omnidirectional force-feedback at the attachment points, we enable the user to experience the environment with the complete hand instead of only the fingertips, thus realizing deeper immersion. Interaction using Exodex Adam can range from palpation of objects and surfaces to manipulation using both power and precision grasps, all while receiving haptic feedback. This article details the concept and design of the Exodex Adam, as well as use cases where it is deployed with different command modalities. These include mixed-media interaction in a virtual environment, gesture-based telemanipulation, and robotic hand-arm teleoperation using adaptive model-mediated teleoperation. Finally, we share the insights gained during our development process and use case deployments.
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2021.716598
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adjunctive Medication Management and Contingency Management to enhance adherence to acamprosate for alcohol dependence: the ADAM trial RCT.

Donoghue, Kim / Boniface, Sadie / Brobbin, Eileen / Byford, Sarah / Coleman, Rachel / Coulton, Simon / Day, Edward / Dhital, Ranjita / Farid, Anum / Hermann, Laura / Jordan, Amy / Kimergård, Andreas / Koutsou, Maria-Leoni / Lingford-Hughes, Anne / Marsden, John / Neale, Joanne / O'Neill, Aimee / Phillips, Thomas / Shearer, James /

Sinclair, Julia / Smith, Joanna / Strang, John / Weinman, John / Whittlesea, Cate / Widyaratna, Kideshini / Drummond, Colin

Health technology assessment (Winchester, England)

2023 Volume 27, Issue 22, Page(s) 1–88

Abstract: Background: Acamprosate is an effective and cost-effective medication for alcohol relapse prevention but poor adherence can limit its full benefit. Effective interventions to support adherence to acamprosate are therefore needed.: Objectives: To ... ...

Abstract	Background: Acamprosate is an effective and cost-effective medication for alcohol relapse prevention but poor adherence can limit its full benefit. Effective interventions to support adherence to acamprosate are therefore needed. Objectives: To determine the effectiveness of Medication Management, with and without Contingency Management, compared to Standard Support alone in enhancing adherence to acamprosate and the impact of adherence to acamprosate on abstinence and reduced alcohol consumption. Design: Multicentre, three-arm, parallel-group, randomised controlled clinical trial. Setting: Specialist alcohol treatment services in five regions of England (South East London, Central and North West London, Wessex, Yorkshire and Humber and West Midlands). Participants: Adults (aged 18 years or more), an Interventions: (1) Standard Support, (2) Standard Support with adjunctive Medication Management provided by pharmacists via a clinical contact centre (12 sessions over 6 months), (3) Standard Support with adjunctive Medication Management plus Contingency Management that consisted of vouchers (up to £120) to reinforce participation in Medication Management. Consenting participants were randomised in a 2 : 1 : 1 ratio to one of the three groups using a stratified random permuted block method using a remote system. Participants and researchers were not blind to treatment allocation. Main outcome measures: Primary outcome: self-reported percentage of medication taken in the previous 28 days at 6 months post randomisation. Economic outcome: EuroQol-5 Dimensions, a five-level version, used to calculate quality-adjusted life-years, with costs estimated using the Adult Service Use Schedule. Results: Of the 1459 potential participants approached, 1019 (70%) were assessed and 739 (73 consented to participate in the study, 372 (50%) were allocated to Standard Support, 182 (25%) to Standard Support with Medication Management and 185 (25%) to Standard Support and Medication Management with Contingency Management. Data were available for 518 (70%) of participants at 6-month follow-up, 255 (68.5%) allocated to Standard Support, 122 (67.0%) to Standard Support and Medication Management and 141 (76.2%) to Standard Support and Medication Management with Contingency Management. The mean difference of per cent adherence to acamprosate was higher for those who received Standard Support and Medication Management with Contingency Management (10.6%, 95% confidence interval 19.6% to 1.6%) compared to Standard Support alone, at the primary end point (6-month follow-up). There was no significant difference in per cent days adherent when comparing Standard Support and Medication Management with Standard Support alone 3.1% (95% confidence interval 12.8% to -6.5%) or comparing Standard Support and Medication Management with Standard Support and Medication Management with Contingency Management 7.9% (95% confidence interval 18.7% to -2.8%). The primary economic analysis at 6 months found that Standard Support and Medication Management with Contingency Management was cost-effective compared to Standard Support alone, achieving small gains in quality-adjusted life-years at a lower cost per participant. Cost-effectiveness was not observed for adjunctive Medication Management compared to Standard Support alone. There were no serious adverse events related to the trial interventions reported. Limitations: The trial's primary outcome measure changed substantially due to data collection difficulties and therefore relied on a measure of self-reported adherence. A lower than anticipated follow-up rate at 12 months may have lowered the statistical power to detect differences in the secondary analyses, although the primary analysis was not impacted. Conclusions: Medication Management enhanced with Contingency Management is beneficial to patients for supporting them to take acamprosate. Future work: Given our findings in relation to Contingency Management enhancing Medication Management adherence, future trials should be developed to explore its effectiveness and cost-effectiveness with other alcohol interventions where there is evidence of poor adherence. Trial registration: This trial is registered as ISRCTN17083622 https://doi.org/10.1186/ISRCTN17083622. Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in
MeSH term(s)	Adult ; Humans ; Acamprosate/therapeutic use ; Alcoholism/drug therapy ; Medication Therapy Management ; Behavior Therapy ; England ; Cost-Benefit Analysis ; Quality of Life
Chemical Substances	Acamprosate (N4K14YGM3J)
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2006765-3
ISSN	2046-4924 ; 1366-5278
ISSN (online)	2046-4924
ISSN	1366-5278
DOI	10.3310/DQKL6124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exodex Adam—A Reconfigurable Dexterous Haptic User Interface for the Whole Hand

Neal Y. Lii / Aaron Pereira / Julian Dietl / Georg Stillfried / Annika Schmidt / Hadi Beik-Mohammadi / Thomas Baker / Annika Maier / Benedikt Pleintinger / Zhaopeng Chen / Amal Elawad / Lauren Mentzer / Austin Pineault / Philipp Reisich / Alin Albu-Schäffer

Frontiers in Robotics and AI, Vol

2022 Volume 8

Abstract: ... they work in, whether virtual or a remote site through an avatar. We introduce the DLR Exodex Adam ... workspace. Exodex Adam uses a front-facing interface, with robotic fingers coupled to two of the user’s ... the fingertips, thus realizing deeper immersion. Interaction using Exodex Adam can range from palpation ...

Abstract	Applications for dexterous robot teleoperation and immersive virtual reality are growing. Haptic user input devices need to allow the user to intuitively command and seamlessly “feel” the environment they work in, whether virtual or a remote site through an avatar. We introduce the DLR Exodex Adam, a reconfigurable, dexterous, whole-hand haptic input device. The device comprises multiple modular, three degrees of freedom (3-DOF) robotic fingers, whose placement on the device can be adjusted to optimize manipulability for different user hand sizes. Additionally, the device is mounted on a 7-DOF robot arm to increase the user’s workspace. Exodex Adam uses a front-facing interface, with robotic fingers coupled to two of the user’s fingertips, the thumb, and two points on the palm. Including the palm, as opposed to only the fingertips as is common in existing devices, enables accurate tracking of the whole hand without additional sensors such as a data glove or motion capture. By providing “whole-hand” interaction with omnidirectional force-feedback at the attachment points, we enable the user to experience the environment with the complete hand instead of only the fingertips, thus realizing deeper immersion. Interaction using Exodex Adam can range from palpation of objects and surfaces to manipulation using both power and precision grasps, all while receiving haptic feedback. This article details the concept and design of the Exodex Adam, as well as use cases where it is deployed with different command modalities. These include mixed-media interaction in a virtual environment, gesture-based telemanipulation, and robotic hand–arm teleoperation using adaptive model-mediated teleoperation. Finally, we share the insights gained during our development process and use case deployments.
Keywords	haptic user interface ; hand exoskeletons ; human–machine interface (HMI) ; human–robot interface (HRI) ; teleoperation ; Mechanical engineering and machinery ; TJ1-1570 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	629
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Adam Smith für Anfänger

Winter, Helen / Rommel, Thomas / Smith, Adam

der Wohlstand der Nationen ; eine Lese-Einführung

(Philosophie für Anfänger ; dtv ; 30708)

2013

Author's details	von Helen Winter und Thomas Rommel
Series title	Philosophie für Anfänger dtv ; 30708
Language	German
Size	222 S, 20 cm
Edition	Orig.-Ausg., 5. Aufl.
Publisher	Dt. Taschenbuch-Verl
Publishing place	München
Document type	Book
Note	Literaturverz. S. 221 - [223]
ISBN	9783423307086 ; 3423307080
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: The ADAM Trial: Visiting the Road Less Traveled.

Arulananda, Surein / John, Thomas

JAMA oncology

2016 Volume 3, Issue 1, Page(s) 66–67

MeSH term(s)	Arginine ; Argininosuccinate Synthase ; Humans ; Hydrolases ; Mesothelioma ; Polyethylene Glycols
Chemical Substances	Polyethylene Glycols (3WJQ0SDW1A) ; Arginine (94ZLA3W45F) ; Hydrolases (EC 3.-) ; ADI PEG20 (EC 3.5.3.6) ; Argininosuccinate Synthase (EC 6.3.4.5)
Language	English
Publishing date	2016-08-31
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2016.2854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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