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Article ; Online: Ultra-processed food consumption and risk of cardiovascular events: a systematic review and dose-response meta-analysis.

Qu, Yang / Hu, Wei / Huang, Jing / Tan, Bijun / Ma, Fenghui / Xing, Changyang / Yuan, Lijun

EClinicalMedicine

2024 Volume 69, Page(s) 102484

Abstract: Background: Ultra-processed food (UPF) consumption continues to increase worldwide. However, evidences from meta-analyses are limited regarding the effects on cardiovascular events (CVEs).: Methods: A meta-analysis was performed to assess the dose- ... ...

Abstract	Background: Ultra-processed food (UPF) consumption continues to increase worldwide. However, evidences from meta-analyses are limited regarding the effects on cardiovascular events (CVEs). Methods: A meta-analysis was performed to assess the dose-response relationship of UPF consumption and CVEs risk (including the morbidity and mortality of cardiovascular causes, and myocardial infarction, stroke, transient ischemic attack, coronary intervention). Databases (PubMed, EMBASE, Cochrane Library, and Web of Science) were searched for observational studies published in English language up to October 24, 2023. Generalized least squares regression and restricted cubic splines were used to estimate the linear/nonlinear relationship. PROSPERO CRD 42023391122. Findings: Twenty studies with 1,101,073 participants and 58,201 CVEs cases with a median follow-up of 12.2 years were included. A positive linear relationship between UPF intake and CVEs risk was identified. In addition, positive correlation between coronary heart disease and UPF consumption in terms of daily serving and daily energy proportion. No significant association of UPF consumption with the risk of cerebrovascular disease was observed. Briefly, 10% increase of UPF by daily weight proportion was associated with a 1.9% increase of CVEs risk (RR = 1.019; 95% CI, 1.007-1.031; Interpretation: UPF consumption were associated with a higher risk of CVEs in the positive linear relationship. Our findings highlight the importance of minimizing UPF consumption for cardiovascular health and might be help to pursue public health policies in control of UPF consumption. Funding: This work was supported by the Key Research and Development Program of Shaanxi Province (2023-ZDLSF-22), the Innovative Talent Support Program of Shaanxi Province (2022KJXX-106), and the Key Research and Development Program of Shaanxi Province (2023-YBSF-424).
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2024.102484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction.

Wang, Dingyi / Xing, Changyang / Liang, Yuan / Wang, Chen / Zhao, Ping / Liang, Xiao / Li, Qiuyang / Yuan, Lijun

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 18, Page(s) e2310421

Abstract: Vascular microenvironment is found to be closely related to immunotherapy efficacy. Identification and ultrasound imaging of the unique vascular characteristics, able to predict immune microenvironment, is important for immunotherapy decision-making. ... ...

Abstract	Vascular microenvironment is found to be closely related to immunotherapy efficacy. Identification and ultrasound imaging of the unique vascular characteristics, able to predict immune microenvironment, is important for immunotherapy decision-making. Herein, it is proved that high CD93 expression in the tumor vessels is closely related to the poor immune response of prostate cancer. For ultrasound molecular imaging of CD93, CD93-targeted microbubbles (MBs) consist a gaseous core and the MMRN2 (Multimerin-2) containing cell membrane (CM) /lipid hybrid membrane is then synthesized. In vitro and in vivo assays demonstrate that these MBs can recognize CD93 efficiently and then accumulate within tumor regions highly expressing CD93. Contrast-enhanced ultrasound (CEUS) imaging with CD93-targeted MBs demonstrates that targeted ultrasound intensity is negatively related to inflammatory tumor immune microenvironment (TIME) and cytotoxic T cell infiltration. Together, endothelial expression of CD93 in tumor is a unique predictor of immunosuppressive microenvironment and CD93-targeted MBs have a great potential to evaluate tumor immune status.
MeSH term(s)	Microbubbles ; Tumor Microenvironment ; Animals ; Ultrasonography/methods ; Mice ; Humans ; Cell Line, Tumor ; Male ; Contrast Media/chemistry ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/pathology
Chemical Substances	Contrast Media
Language	English
Publishing date	2024-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310421
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Article ; Online: AHNAK-modified microbubbles for the intracranial delivery of triptolide: In-vitro and in-vivo investigations.

Feng, Yang / An, Rui / Zhang, Yajun / Chen, Mingjun / Wang, Li / Duan, Yunyou / Xing, Changyang

International journal of pharmaceutics

2022 Volume 629, Page(s) 122351

Abstract: Autophagic dysfunction related cascade events might induce the accumulation of α-synuclein (αSyn) in Parkinson's disease (PD). Triptolide ( ... ...

Abstract	Autophagic dysfunction related cascade events might induce the accumulation of α-synuclein (αSyn) in Parkinson's disease (PD). Triptolide (T
MeSH term(s)	Animals ; Mice ; Microbubbles ; Phenanthrenes ; Diterpenes ; Epoxy Compounds ; Parkinson Disease ; Membrane Proteins ; Neoplasm Proteins
Chemical Substances	triptolide (19ALD1S53J) ; Phenanthrenes ; Diterpenes ; Epoxy Compounds ; Ahnak protein, mouse ; Membrane Proteins ; Neoplasm Proteins
Language	English
Publishing date	2022-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2022.122351
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Zs.A 1409: Show issues

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Article ; Online: Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE

Qiu, Shuo / Liu, Jiahan / Chen, Jianmei / Li, Yangni / Bu, Te / Li, Zhelong / Zhang, Liang / Sun, Wenqi / Zhou, Tian / Hu, Wei / Yang, Guodong / Yuan, Lijun / Duan, Yunyou / Xing, Changyang

Journal of nanobiotechnology

2024 Volume 22, Issue 1, Page(s) 178

Abstract: Background: Clearance of apoptotic cells by efferocytosis is crucial for prevention of atherosclerosis progress, and impaired efferocytosis contributes to the aggravated atherosclerosis.: Results: In this study, we found that diabetic ApoE: ... ...

Abstract	Background: Clearance of apoptotic cells by efferocytosis is crucial for prevention of atherosclerosis progress, and impaired efferocytosis contributes to the aggravated atherosclerosis. Results: In this study, we found that diabetic ApoE Conclusions: Our study indicates that MerTK decrease in macrophages contributes to the aggravated atherosclerosis in diabetic ApoE
MeSH term(s)	Humans ; Animals ; Mice ; Efferocytosis ; HEK293 Cells ; Cell Membrane ; Atherosclerosis ; Protein-Tyrosine Kinases ; Apolipoproteins E/genetics ; Magnetic Iron Oxide Nanoparticles ; Diabetes Mellitus
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Apolipoproteins E
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-024-02463-y
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Article: Exercise Improves Metabolism and Alleviates Atherosclerosis via Muscle-Derived Extracellular Vesicles.

Wang, Yixiao / Liu, Yunnan / Zhang, Siyan / Li, Na / Xing, Changyang / Wang, Chen / Wang, Jia / Wei, Mengying / Yang, Guodong / Yuan, Lijun

Aging and disease

2023 Volume 14, Issue 3, Page(s) 952–965

Abstract: Regular exercise maintains a healthy metabolic profile, while the underlying mechanisms have not been fully elucidated. Extracellular vesicles serve as an important mediator in intercellular communication. In this study, we aimed to explore whether ... ...

Abstract	Regular exercise maintains a healthy metabolic profile, while the underlying mechanisms have not been fully elucidated. Extracellular vesicles serve as an important mediator in intercellular communication. In this study, we aimed to explore whether exercise-induced extracellular vesicles (EVs) of skeletal muscle origins contribute to exercise-related protective effects on metabolism. We found that the twelve weeks of swimming training improved glucose tolerance, reduced visceral lipid accumulation, alleviated liver damage, and inhibited atherosclerosis progression in both obese WT mice and ApoE
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2022.1131
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Article ; Online: Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice.

Zhou, Tian / Qiu, Shuo / Zhang, Liang / Li, Yangni / Zhang, Jing / Shen, Donghua / Zhao, Ping / Yuan, Lijun / Zhao, Lianbi / Duan, Yunyou / Xing, Changyang

Diabetes & metabolism journal

2024

Abstract: Background: Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between ... ...

Abstract	Background: Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between the gut microbiota and vascular inflammation of diabetic mice. Methods: The db/db diabetic and wild-type (WT) mice were used in this study. We profiled gut microbiota and examined the and vascular function in both db/db group and WT group. Gut microbiota was analyzed by 16s rRNA sequencing. Vascular function was examined by ultrasonographic hemodynamics and histological staining. Clostridium butyricum (CB) was orally administered to diabetic mice by intragastric gavage every 2 days for 2 consecutive months. Reactive oxygen species (ROS) and expression of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were detected by fluorescence microscopy. The mRNA expression of inflammatory cytokines was tested by quantitative polymerase chain reaction. Results: Compared with WT mice, CB abundance was significantly decreased in the gut of db/db mice, together with compromised vascular function and activated inflammation in the arterial tissue. Meanwhile, ROS in the vascular tissue of db/db mice was also significantly increased. Oral administration of CB restored the protective microbiota, and protected the vascular function in the db/db mice via activating the Nrf2/HO-1 pathway. Conclusion: This study identified the potential link between decreased CB abundance in gut microbiota and vascular inflammation in diabetes. Therapeutic delivery of CB by gut transplantation alleviates the vascular lesions of diabetes mellitus by activating the Nrf2/HO-1 pathway.
Language	English
Publishing date	2024-02-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2602402-0
ISSN	2233-6087 ; 2233-6087
ISSN (online)	2233-6087
ISSN	2233-6087
DOI	10.4093/dmj.2023.0109
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Article ; Online: Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis

Wenqi Sun / Panpan Ji / Tian Zhou / Zhelong Li / Changyang Xing / Liang Zhang / Mengying Wei / Guodong Yang / Lijun Yuan

Advanced Science, Vol 10, Iss 19, Pp n/a-n/a (2023)

2023

Abstract: Abstract Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti‐tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. ...

Abstract	Abstract Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti‐tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. Here, a poly (lactic‐co‐glycolic acid) (PLGA)‐based cancer vaccine of nanoscale is designed, in which engineered tumor cell membrane proteins, mRNAs, and sonosensitizer chlorin e6 (Ce6) are encapsulated at high efficiency. The nanosized vaccine can be efficiently delivered into antigen presentation cells (APCs) in lymph nodes after subcutaneous injection. In the APCs, the encapsulated cell membrane and RNA from engineered cells, which have disturbed splicing resembling the metastatic cells, provide neoantigens of metastatic cancer in advance. Moreover, the sonosensitizer Ce6 together with ultrasound irradiation promotes mRNA escape from endosome, and augments antigen presentation. Through 4T1 syngeneic mouse model, it has been proved that the proposed nanovaccine is efficient to elicit antitumor immunity and thus prevent cancer metastasis.
Keywords	alternative splicing ; antigen presentation ; cancer vaccine ; sonosensitizer ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis.

Sun, Wenqi / Ji, Panpan / Zhou, Tian / Li, Zhelong / Xing, Changyang / Zhang, Liang / Wei, Mengying / Yang, Guodong / Yuan, Lijun

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 19, Page(s) e2301107

Abstract: Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti-tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. Here, a ... ...

Abstract	Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti-tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. Here, a poly (lactic-co-glycolic acid) (PLGA)-based cancer vaccine of nanoscale is designed, in which engineered tumor cell membrane proteins, mRNAs, and sonosensitizer chlorin e6 (Ce6) are encapsulated at high efficiency. The nanosized vaccine can be efficiently delivered into antigen presentation cells (APCs) in lymph nodes after subcutaneous injection. In the APCs, the encapsulated cell membrane and RNA from engineered cells, which have disturbed splicing resembling the metastatic cells, provide neoantigens of metastatic cancer in advance. Moreover, the sonosensitizer Ce6 together with ultrasound irradiation promotes mRNA escape from endosome, and augments antigen presentation. Through 4T1 syngeneic mouse model, it has been proved that the proposed nanovaccine is efficient to elicit antitumor immunity and thus prevent cancer metastasis.
MeSH term(s)	Animals ; Mice ; Polylactic Acid-Polyglycolic Acid Copolymer/metabolism ; Cancer Vaccines ; Dendritic Cells ; RNA/metabolism ; Neoplasms/therapy ; Neoplasms/metabolism ; Antigen Presentation ; Cell Membrane/metabolism ; Antigens, Neoplasm/metabolism
Chemical Substances	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Cancer Vaccines ; RNA (63231-63-0) ; Antigens, Neoplasm
Language	English
Publishing date	2023-04-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202301107
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Article ; Online: Clinical Value of TCCD for Evaluating the Prognosis of Patients with Severe Traumatic Brain Injury After Large Decompressive Craniectomy: A Retrospective Study.

Liang, Yuan / Duan, Yunyou / Xing, Changyang / Jin, Jinglan / Yan, Lingjuan / Liu, Xi / Wang, Jia

Advances in therapy

2022 Volume 39, Issue 10, Page(s) 4556–4567

Abstract: Introduction: It is challenging to assess the prognosis of patients with severe traumatic brain injury (sTBI) after large decompressive craniectomy (DC). The aim of this study was to evaluate the clinical value of transcranial color-coded duplex ... ...

Abstract	Introduction: It is challenging to assess the prognosis of patients with severe traumatic brain injury (sTBI) after large decompressive craniectomy (DC). The aim of this study was to evaluate the clinical value of transcranial color-coded duplex sonography (TCCD) for assessing the prognosis of sTBI patients 6 months after large DC. Methods: This was a retrospective observational study that consecutively enrolled 84 patients with sTBI who were followed up for prognosis until 6 months after large DC. The primary endpoint was the Glasgow Outcome Score (GOS). According to the GOS, patients were divided into an unfavorable prognosis group (GOS 1-3, n = 47) and a favorable prognosis group (GOS 4-5, n = 37). Results: Significant between-group differences were found in age and hemodynamic parameters (systolic peak blood flow velocity, end-diastolic blood flow velocity, mean blood flow velocity, pulsatility index and resistance index) of the middle cerebral artery detected by TCCD (P < 0.05 for all). Subsequently, ridge regression was used to build a prognostic model for patients with large DC. Based on the cerebral hemodynamic parameters measured by TCCD and age, the mean (± standard deviation) area under the curve of the prognostic model in patients with sTBI after large DC was 0.76 ± 0.22. The sensitivity and specificity were 82.08% and 74.17%, respectively. Conclusions: The cerebral hemodynamic parameters detected by TCCD, combined with age, may be used to predict the outcomes of patients with sTBI at 6 months after large DC. As a noninvasive method, TCCD has the potential to assess the prognosis of these patients. Trial registration: ChiCTR: ChiCTR1800019758. Registered 27 November 2018-retrospectively registered ( http://www.chictr.org.cn/index.aspx ).
MeSH term(s)	Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/surgery ; Decompressive Craniectomy/methods ; Humans ; Infant ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Treatment Outcome
Language	English
Publishing date	2022-08-07
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-022-02251-w
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Zs.A 2101: Show issues

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Article ; Online: Hierarchical cumulative network for unsupervised medical image registration.

Ma, Xinke / He, Jiang / Liu, Xing / Liu, Qin / Chen, Geng / Yuan, Bo / Li, Changyang / Xia, Yong

Computers in biology and medicine

2023 Volume 167, Page(s) 107598

Abstract: Unsupervised deep learning techniques have gained increasing popularity in deformable medical image registration However, existing methods usually overlook the optimal similarity position between moving and fixed images To tackle this issue, we propose a ...

Abstract	Unsupervised deep learning techniques have gained increasing popularity in deformable medical image registration However, existing methods usually overlook the optimal similarity position between moving and fixed images To tackle this issue, we propose a novel hierarchical cumulative network (HCN), which explicitly considers the optimal similarity position with an effective Bidirectional Asymmetric Registration Module (BARM). The BARM simultaneously learns two asymmetric displacement vector fields (DVFs) to optimally warp both moving images and fixed images to their optimal similar shape along the geodesic path. Furthermore, we incorporate the BARM into a Laplacian pyramid network with hierarchical recursion, in which the moving image at the lowest level of the pyramid is warped successively for aligning to the fixed image at the lowest level of the pyramid to capture multiple DVFs. We then accumulate these DVFs and up-sample them to warp the moving images at higher levels of the pyramid to align to the fixed image of the top level. The entire system is end-to-end and jointly trained in an unsupervised manner. Extensive experiments were conducted on two public 3D Brain MRI datasets to demonstrate that our HCN outperforms both the traditional and state-of-the-art registration methods. To further evaluate the performance of our HCN, we tested it on the validation set of the MICCAI Learn2Reg 2021 challenge. Additionally, a cross-dataset evaluation was conducted to assess the generalization of our HCN. Experimental results showed that our HCN is an effective deformable registration method and achieves excellent generalization performance.
MeSH term(s)	Algorithms ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Neuroimaging
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107598
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