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  1. Article ; Online: Visible-Light-Induced Siloxycarbene Addition to N═N of Azodicarboxylates: Synthesis of Acyl Hydrazides from Acylsilanes.

    Saleem, Mohammad / Ratwan, Akash / Yamini, Pokhriyal / Yadagiri, Dongari

    Organic letters

    2024  Volume 26, Issue 10, Page(s) 2039–2044

    Abstract: We report the synthesis of acyl hydrazides from acylsilanes in the presence of visible light without the aid of additives or transition metals. Acylsilanes underwent [1,2]-Brook rearrangement to generate the nucleophilic siloxycarbenes which on further ... ...

    Abstract We report the synthesis of acyl hydrazides from acylsilanes in the presence of visible light without the aid of additives or transition metals. Acylsilanes underwent [1,2]-Brook rearrangement to generate the nucleophilic siloxycarbenes which on further addition to N═N of azodicarboxylates produced the acyl hydrazides. Control experiments indicate that the reaction proceeds through the singlet carbene intermediate. Transformation of the acyl hydrazide functionality to other functional groups was demonstrated, including the synthesis of the drug candidate Moclobemide.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00185
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  2. Article ; Online: Extracorporeal Photopheresis in Dermatological Diseases.

    Terhaar, Hanna / Saleem, Mohammad / Yusuf, Nabiha

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Extracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary's syndrome and mycosis fungoides. Over the past three decades, its ... ...

    Abstract Extracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary's syndrome and mycosis fungoides. Over the past three decades, its immunotherapeutic properties have been tested on a variety of autoimmune conditions, including many dermatologic diseases. There is ample evidence of ECP's ability to modify leukocytes and alter cytokine production for certain dermatologic diseases that have been refractory to first-line treatments, such as atopic dermatitis. However, the evidence on the efficacy of ECP for the treatment of these dermatologic diseases is unclear and/or lacks sufficient evidence. The purpose of this paper is to review the literature on the utilization and clinical efficacy of ECP in the treatment of several [autoimmune] dermatologic diseases and discuss its applications, guidelines, recommendations, and future implementation for dermatologic diseases.
    MeSH term(s) Humans ; Photopheresis/methods ; Skin Neoplasms/pathology ; Mycosis Fungoides/pathology ; Blood Component Removal/methods ; Sezary Syndrome/therapy
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25053011
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  3. Article ; Online: COVID-19 and distribution centres operations

    Atif Saleem Butt / Mohammad Alghababsheh

    Heliyon, Vol 9, Iss 7, Pp e18000- (2023)

    The impacts and countermeasures

    2023  

    Abstract: COVID-19 has wreaked havoc on supply chains. This is particularly true for distribution centres as they struggle to bounce back amid the COVID-19 outbreak. While much literature has recently emerged on supply chain disruption, studies pertaining to the ... ...

    Abstract COVID-19 has wreaked havoc on supply chains. This is particularly true for distribution centres as they struggle to bounce back amid the COVID-19 outbreak. While much literature has recently emerged on supply chain disruption, studies pertaining to the impacts of COVID-19 on distribution centres and the countermeasures taken to mitigate such impacts are elusive and mute. Our study fills this important gap in the supply chain literature. This study employs a multiple-case methodology and conducts 40 semi-structured interviews with senior managers/executives from eight distribution centres in the United Arab Emirates. Our results exhibit that COVID-19 is adversely affecting the distribution centres in at least six distinct ways. For instance, distribution centres are encountering limited staff availability, inventory shortage, destabilized supply chains, excessive inventory, limited capacity and surge in demand. Results also demonstrate six corresponding strategies employed by distribution centres to mitigate the impact. For example, distribution centres enhance warehouse automation, increase hands-on inventory, reshoring manufacturing, use scalable processes and an automation retrieval system, and finally employ a picking strategy. Distribution centres can use the findings provided in this study. Particularly, they can learn how COVID-19 affects them and what corresponding strategies they should adopt to stay strong during this pandemic. This study demystifies its contribution to theory and practice alongside limitations and future research directions.
    Keywords Automation ; Case study ; Distribution centres ; COVID-19 ; Logistics ; Supply chain ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 380
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Designing gamified assistive apps

    Mohammad Abedrabbu Alkhawalde / Mohamad Ahmad Saleem Khasawneh

    International Journal of Data and Network Science, Vol 8, Iss 1, Pp 53-

    A novel approach to motivating and supporting students with learning disabilities

    2024  Volume 60

    Abstract: The present research endeavor delves into the profound effects of gamified assistive applications on the levels of user engagement, motivation, and academic attainment within the population of students grappling with learning disabilities in the esteemed ...

    Abstract The present research endeavor delves into the profound effects of gamified assistive applications on the levels of user engagement, motivation, and academic attainment within the population of students grappling with learning disabilities in the esteemed nation of Jordan. The study involved individuals who actively interacted with a gamified assistive application that was specifically developed to offer tailored educational opportunities and enhance their scholarly advancement. The analysis of descriptive statistics unveiled a noteworthy degree of app engagement, signifying the app's proficiency in captivating and maintaining students' focus. The utilization of paired-samples t-tests revealed noteworthy enhancements in both intrinsic and extrinsic motivation subsequent to the utilization of the application, thereby underscoring the favorable impact of gamified components on student motivation. Furthermore, a notable enhancement in scholastic attainment was noted, underscoring the application's influence on augmenting students' educational results. The findings of the correlational analysis unveiled a noteworthy association between the utilization of mobile applications, the presence of intrinsic motivation, and the attainment of academic success. This implies that heightened levels of engagement and motivation are linked to enhanced academic performance. The results of this study highlight the considerable promise of gamified assistive applications in fostering motivation and providing support to students who face challenges associated with learning disabilities. The incorporation of gamification into educational technologies presents educators with a promising strategy to cultivate active participation and elevate scholarly accomplishments within this demographic, ultimately advancing inclusivity and fostering educational triumph.
    Keywords Social Sciences ; H ; Management. Industrial management ; HD28-70
    Subject code 360
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Growing Science
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Review of the Performance of High-Voltage Composite Insulators.

    Saleem, Muhammad Zaheer / Akbar, Mohammad

    Polymers

    2022  Volume 14, Issue 3

    Abstract: In the present literature survey, we focused on the performance of polymeric materials encompassing silicone rubber (SiR), ethylene propylene diene monomer (EPDM) and epoxy resins loaded with micro, nano, and micro/nano hybrid fillers. These insulators ... ...

    Abstract In the present literature survey, we focused on the performance of polymeric materials encompassing silicone rubber (SiR), ethylene propylene diene monomer (EPDM) and epoxy resins loaded with micro, nano, and micro/nano hybrid fillers. These insulators are termed as composite insulators. The scope of the added fillers/additives was limited to the synthetic inorganic family. Special attention was directed to understanding the effect of fillers on the improvement of the thermal conductivity, dielectric strength, mechanical strength, corona discharge resistance, and tracking and erosion resistance performance of polymeric materials for use as high-voltage transmission line insulators. The survey showed that synthetic inorganic fillers, which include silica (SiO
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14030431
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  6. Article ; Online: Transition metal-catalyzed reactivity of carbenes with boronic acid derivatives for arylation (alkylation) and beyond.

    Babbar, Akanksha / Yamini, Pokhriyal / Saleem, Mohammad / Yadagiri, Dongari

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 35, Page(s) 7062–7078

    Abstract: This comprehensive review article discussed the reactivity of carbenes with boronic acid derivatives for the one-pot synthesis of diarylmethanes, difluoromethylated arenes, aryl and alkyl boron compounds, arylacetic acid derivatives, furan derivatives, ... ...

    Abstract This comprehensive review article discussed the reactivity of carbenes with boronic acid derivatives for the one-pot synthesis of diarylmethanes, difluoromethylated arenes, aryl and alkyl boron compounds, arylacetic acid derivatives, furan derivatives, and many other compounds. We have summarized the arylation, vinylation, and alkylation of carbenes utilizing various transition metals,
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00904a
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  7. Article: A Retrospective Study on the Outcome of Coronavirus Disease 2019 (COVID-19) Patients Admitted to a District General Hospital and Predictors of High Mortality.

    Khan, Zahid / Mlawa, Gideon / Islam, Saiful / Elshowaya, Suhier / Saleem, Mohammad

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53432

    Abstract: Background: The clinical features and severity of coronavirus disease 2019 (COVID-19) vary between patients and countries. Patients with certain conditions are predisposed to poor outcomes compared with those without medical conditions, such as diabetes, ...

    Abstract Background: The clinical features and severity of coronavirus disease 2019 (COVID-19) vary between patients and countries. Patients with certain conditions are predisposed to poor outcomes compared with those without medical conditions, such as diabetes, dementia, and hypertension (HTN).
    Methods: The aim of this retrospective study was to assess factors associated with higher mortality in patients with COVID-19 infections and to identify the reason for hospital admission in these patients. The study was performed on patients admitted between 1 and 31 March 2020. Data collection was done retrospectively from electronic medical records.
    Results: There were 269 patient admissions during this period, of which 147 were included in this audit. The mean age of COVID-19-positive patients was 62.8 years and 65.9 years for COVID-19-negative patients during this period. Forty-seven patients requiring hospital admission were COVID-19 positive and 93 were COVID-19 negative. There were no COVID-19 swabs in the seven patients included in the audit. Approximately 50% of the COVID-19-positive patients presented with fever and shortness of breath (sob), followed by dyspnea and cough (seven patients). The most common comorbidity was HTN, followed by type 2 diabetes mellitus (T2DM) and ischemic heart disease (IHD). The survival rate was 72.3% in COVID-19-positive patients and 80% in COVID-19-negative patients. The average length of stay was 14.4 days for COVID-19-positive survivors compared to 7.8 days for COVID-19-negative survivors. Most patients who tested positive for COVID-19 infection received oseltamivir vaccination and antibiotics. The presence of HTN, diabetes mellitus (DM), age, and organ failure was associated with a high mortality risk.
    Conclusion: Our study supports the findings of previous studies that diabetes, HTN, coronary artery disease, old age, and organ failure were associated with high mortality in patients admitted to hospitals with COVID-19 infections.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53432
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  8. Article: COVID-19 and distribution centres operations: The impacts and countermeasures.

    Butt, Atif Saleem / Alghababsheh, Mohammad

    Heliyon

    2023  Volume 9, Issue 7, Page(s) e18000

    Abstract: COVID-19 has wreaked havoc on supply chains. This is particularly true for distribution centres as they struggle to bounce back amid the COVID-19 outbreak. While much literature has recently emerged on supply chain disruption, studies pertaining to the ... ...

    Abstract COVID-19 has wreaked havoc on supply chains. This is particularly true for distribution centres as they struggle to bounce back amid the COVID-19 outbreak. While much literature has recently emerged on supply chain disruption, studies pertaining to the impacts of COVID-19 on distribution centres and the countermeasures taken to mitigate such impacts are elusive and mute. Our study fills this important gap in the supply chain literature. This study employs a multiple-case methodology and conducts 40 semi-structured interviews with senior managers/executives from eight distribution centres in the United Arab Emirates. Our results exhibit that COVID-19 is adversely affecting the distribution centres in at least six distinct ways. For instance, distribution centres are encountering limited staff availability, inventory shortage, destabilized supply chains, excessive inventory, limited capacity and surge in demand. Results also demonstrate six corresponding strategies employed by distribution centres to mitigate the impact. For example, distribution centres enhance warehouse automation, increase hands-on inventory, reshoring manufacturing, use scalable processes and an automation retrieval system, and finally employ a picking strategy. Distribution centres can use the findings provided in this study. Particularly, they can learn how COVID-19 affects them and what corresponding strategies they should adopt to stay strong during this pandemic. This study demystifies its contribution to theory and practice alongside limitations and future research directions.
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18000
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  9. Article: Anti-arthritic, anti-nociceptive and anti-inflammatory potential of Cassia absus: An ethanomedicinal plant of Febaceae family.

    Gul, Bazgha / Anwar, Rukhsana / Saleem, Mohammad

    Pakistan journal of pharmaceutical sciences

    2023  Volume 35, Issue 6(Special), Page(s) 1705–1711

    Abstract: Medicinal plants are becoming popular choice for treatment of chronic disease conditions. Cassia absus plant parts have been traditionally used to treat inflammatory conditions. This study was designed for evaluating anti-arthritic, anti-nociceptive and ... ...

    Abstract Medicinal plants are becoming popular choice for treatment of chronic disease conditions. Cassia absus plant parts have been traditionally used to treat inflammatory conditions. This study was designed for evaluating anti-arthritic, anti-nociceptive and anti-inflammatory potential of Cassia absus seeds. n- hexane, methanol, chloroform and aqueous extracts were prepared to be appraised for identification and quantitative determination of various phytochemicals. All the extracts were evaluated for anti-arthritic activity via protein denaturation, anti-nociceptive activity by hot plate method and anti-inflammatory potential through Carrageenan induced paw edema. Three doses; 100, 200 and 300mg/kg of each extract were given to Wistar rats. The results of the quantitative analysis revealed that Aqueous and n-hexane extracts contained the highest total flavonoid (104.2±0.24mg QE/g) and phenolic contents (187.4±0.65mg GA/g) respectively. All the extracts exhibited decrease in protein denaturation (n-hexane 66.66%, methanol 59.42%, chloroform 65.21% and aqueous extract 89.85%). Significant increase in mean latency time (secs) was observed in n-hexane, methanol and aqueous extract treated rats as compared to normal rats. All four extracts caused significant reduction in paw inflammation as compared to carrageenan control. It is therefore concluded that all the extracts of Cassia absus possessed significant anti-arthritic, anti-nociceptive and anti-inflammatory potential.
    MeSH term(s) Animals ; Rats ; Rats, Wistar ; Cassia ; Carrageenan ; Chloroform ; Methanol ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances n-hexane (2DDG612ED8) ; Carrageenan (9000-07-1) ; Chloroform (7V31YC746X) ; Methanol (Y4S76JWI15) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-02-27
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
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  10. Article: An Unexpected GIST Causing Life-Threatening Bleeding after an Elective Hernia Repair.

    Saleem, Athary / Husain, Fatemah / Boushehry, Reem / Alshamali, Mohammed / Fahim, Emad / Mohammad, Khaleel

    Surgery journal (New York, N.Y.)

    2023  Volume 9, Issue 1, Page(s) e18–e22

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2864275-2
    ISSN 2378-5136 ; 2378-5128
    ISSN (online) 2378-5136
    ISSN 2378-5128
    DOI 10.1055/s-0042-1760130
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