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Article ; Online: Characterization and Management of Amicrobial Pustulosis of the Folds, Aseptic Abscess Syndrome, Behçet Disease, Neutrophilic Eccrine Hidradenitis, and Pyostomatitis Vegetans-Pyodermatitis Vegetans.

Nguyen, Giang Huong / Camilleri, Michael J / Wetter, David A

2024 Volume 42, Issue 2, Page(s) 231–245

Abstract: Neutrophilic dermatoses are a broadly heterogeneous group of inflammatory skin disorders. This article reviews 5 conditions: amicrobial pustulosis of the folds, aseptic abscess syndrome, Behçet disease, neutrophilic eccrine hidradenitis, and ... ...

Abstract	Neutrophilic dermatoses are a broadly heterogeneous group of inflammatory skin disorders. This article reviews 5 conditions: amicrobial pustulosis of the folds, aseptic abscess syndrome, Behçet disease, neutrophilic eccrine hidradenitis, and pyostomatitis vegetans-pyodermatitis vegetans.The authors include up-to-date information about their epidemiology, pathogenesis, clinicopathologic features, diagnosis, and management.
MeSH term(s)	Humans ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Abscess/diagnosis ; Abscess/drug therapy ; Skin/pathology ; Hidradenitis/pathology ; Pemphigus ; Organic Chemicals
Chemical Substances	vegetan (105478-66-8) ; Organic Chemicals
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2023.12.003
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Article ; Online: Blue-black hyperpigmentation on the extremities.

Ali, Nora S / Jin, Mauricio F / Wetter, David A

The Journal of family practice

2023 Volume 71, Issue 10, Page(s) 445–447

Abstract: In some cases, diagnosis entails less "what is it?" and more "what caused it?" ...

Abstract	In some cases, diagnosis entails less "what is it?" and more "what caused it?"
MeSH term(s)	Humans ; Hyperpigmentation/chemically induced ; Hyperpigmentation/diagnosis ; Extremities
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	197883-4
ISSN	1533-7294 ; 0094-3509
ISSN (online)	1533-7294
ISSN	0094-3509
DOI	10.12788/jfp.0520
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Article ; Online: Personal reflections on mentorship as a pathway toward sustaining a joyful dermatologic practice: Part I: Influential mentors during training and early career.

Wetter, David A

Clinics in dermatology

2019 Volume 38, Issue 1, Page(s) 126–128

Abstract: The greatest mentors model career paths that are personally fulfilling and intellectually stimulating, provide tangible guidance and boundless encouragement to help mentees discern and achieve their goals, and inspire self-confidence in mentees that ... ...

Abstract	The greatest mentors model career paths that are personally fulfilling and intellectually stimulating, provide tangible guidance and boundless encouragement to help mentees discern and achieve their goals, and inspire self-confidence in mentees that translate to success in a variety of areas, including patient care, education, research, and overall life purpose. Mentorship is a readily available resource to all of us and embodies many of the qualities that initially attracted us to the medical profession. Helping others to achieve their goals is inherently joyful and immensely gratifying, and it provides clarity of purpose that we are part of a community greater than ourselves.
MeSH term(s)	Career Choice ; Dermatology/education ; Goals ; Humans ; Job Satisfaction ; Mentors ; Physicians/psychology ; Self Concept
Language	English
Publishing date	2019-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2019.06.005
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Article ; Online: Personal reflections on mentorship as a pathway toward sustaining a joyful dermatologic practice: Part II: Our colleagues, our students, and our patients.

Wetter, David A

Clinics in dermatology

2019 Volume 37, Issue 5, Page(s) 604–606

Abstract: Mentorship has always been an important part of dermatology. Clinical dermatologic practice is increasingly busy, and it is paramount that we seek out occasions for joy that will imbue our work with meaning. I have had the privilege of experiencing ... ...

Abstract	Mentorship has always been an important part of dermatology. Clinical dermatologic practice is increasingly busy, and it is paramount that we seek out occasions for joy that will imbue our work with meaning. I have had the privilege of experiencing wonderful mentorship along my dermatologic pathway, and I hope that the personal stories contained herein galvanize readers to search for opportunities for mentorship as a means of creating and sustaining a joyful dermatologic practice.
MeSH term(s)	Dermatology ; Happiness ; Humans ; Internship and Residency ; Interprofessional Relations ; Job Satisfaction ; Mentoring ; Patients ; Students, Medical
Language	English
Publishing date	2019-06-15
Publishing country	United States
Document type	Journal Article ; Personal Narrative
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2019.06.006
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Article ; Online: Cutaneous manifestations of monoclonal gammopathy.

Claveau, Jean-Sebastien / Wetter, David A / Kumar, Shaji

Blood cancer journal

2022 Volume 12, Issue 4, Page(s) 58

Abstract: Monoclonal gammopathy associated with dermatological manifestations are a well-recognized complication. These skin disorders can be associated with infiltration and proliferation of a malignant plasma cells or by a deposition of the monoclonal ... ...

Abstract	Monoclonal gammopathy associated with dermatological manifestations are a well-recognized complication. These skin disorders can be associated with infiltration and proliferation of a malignant plasma cells or by a deposition of the monoclonal immunoglobulin in a nonmalignant monoclonal gammopathy. These disorders include POEMS syndrome, light chain amyloidosis, Schnitzler syndrome, scleromyxedema and TEMPI syndrome. This article provides a review of clinical manifestations, diagnostics criteria, natural evolution, pathogenesis, and treatment of these cutaneous manifestations.
MeSH term(s)	Amyloidosis ; Humans ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Paraproteinemias/complications ; Paraproteinemias/diagnosis ; Plasma Cells ; Skin Diseases/complications ; Skin Diseases/etiology
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-022-00661-1
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Article ; Online: Chronic non-healing facial ulcer: Trigeminal trophic syndrome from underlying paraneoplastic antibodies.

Berry, Nicholas A / Kumar, Anagha B / Wetter, David A

International journal of dermatology

2021 Volume 61, Issue 11, Page(s) e452–e453

MeSH term(s)	Facial Dermatoses/complications ; Humans ; Skin Ulcer/etiology ; Ulcer
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.15918
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Article ; Online: Histopathologic features predictive of perivascular deposition of IgA on direct immunofluorescence in cases of leukocytoclastic vasculitis: A retrospective study of 112 specimens.

Xie, Fangyi / Johnson, Emma F / Wetter, David A / Camilleri, Michael J / Todd, Austin / Lehman, Julia S

Journal of cutaneous pathology

2023 Volume 50, Issue 7, Page(s) 681–686

Abstract: IgA vasculitis is a small-vessel vasculitis subtype with increased risk of systemic involvement. We aimed to investigate if any light-microscopic features can predict the presence of perivascular granular IgA deposits on direct immunofluorescence (DIF) ... ...

Abstract	IgA vasculitis is a small-vessel vasculitis subtype with increased risk of systemic involvement. We aimed to investigate if any light-microscopic features can predict the presence of perivascular granular IgA deposits on direct immunofluorescence (DIF) microscopy. We performed a retrospective search of cutaneous pathology reports from our internal and consultation practice (January 1, 2010-October 5, 2021) with a diagnosis of leukocytoclastic vasculitis and accompanying DIF. A blinded dermatopathologist reviewed standard microscopy slides for predetermined histopathological features. Fifty-six biopsies (48 patients) and 56 biopsies (42 patients) met inclusion criteria for IgA+ and IgA-, respectively. The presence of eosinophils and mid and deep dermal inflammation were statistically more associated with IgA- (41/56 [73.2%] and 31/56 [55.4%], respectively) than IgA+ cases (28/56 [50.0%] and 14/56 [25.0%]; p = 0.049 and 0.006, respectively, chi-squared test). Other microscopic criteria recorded were not significantly different between the two groups (p > 0.05, chi-squared and Fisher's exact tests). In this retrospective study of 112 cases, we found that while the absence of eosinophils and absence of mid- and deep inflammation were correlated with increased likelihood of IgA perivascular deposition on DIF, no other histopathological features on light microscopy tested could reliably predict the presence of IgA perivascular deposition on DIF. Therefore, DIF remains a necessary component for the accurate diagnosis of cutaneous IgA vasculitis.
MeSH term(s)	Humans ; IgA Vasculitis/diagnosis ; Retrospective Studies ; Fluorescent Antibody Technique, Direct ; Vasculitis, Leukocytoclastic, Cutaneous/pathology ; Inflammation/complications ; Immunoglobulin A
Chemical Substances	Immunoglobulin A
Language	English
Publishing date	2023-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14436
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Article ; Online: Editorial: Digital technology for tobacco control: Novel data collection, study designs, and interventions.

Potter, Lindsey N / Nahum-Shani, Inbal / Wetter, David W

Frontiers in digital health

2023 Volume 5, Page(s) 1341759

Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Editorial
ISSN	2673-253X
ISSN (online)	2673-253X
DOI	10.3389/fdgth.2023.1341759
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Article ; Online: Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.

Cappel, Mark A / Cappel, Jonathan A / Wetter, David A

Mayo Clinic proceedings

2021 Volume 96, Issue 4, Page(s) 989–1005

Abstract: Pernio or chilblains is characterized by erythema and swelling at acral sites (eg, toes and fingers), typically triggered by cold exposure. Clinical and histopathologic features of pernio are well described, but the pathogenesis is not entirely ... ...

Abstract	Pernio or chilblains is characterized by erythema and swelling at acral sites (eg, toes and fingers), typically triggered by cold exposure. Clinical and histopathologic features of pernio are well described, but the pathogenesis is not entirely understood; vasospasm and a type I interferon (IFN-I) immune response are likely involved. During the coronavirus disease 2019 (COVID-19) pandemic, dermatologists have observed an increase in pernio-like acral eruptions. Direct causality of pernio due to COVID-19 has not been established in many cases because of inconsistent testing methods (often negative results) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a form of COVID-19‒associated pernio (also called COVID toes) is probable because of increased occurrence, frequently in young patients with no cold exposure or a history of pernio, and reports of skin biopsies with positive SARS-CoV-2 immunohistochemistry. PubMed was searched between January 1, 2020, and December 31, 2020 for publications using the following keywords: pernio, chilblain, and acral COVID-19. On the basis of our review of the published literature, we speculate that several unifying cutaneous and systemic mechanisms may explain COVID-19‒associated pernio: (1) SARS-CoV-2 cell infection occurs through the cellular receptor angiotensin-converting enzyme 2 mediated by transmembrane protease serine 2, subsequently affecting the renin-angiotensin-aldosterone system with an increase in the vasoconstricting, pro-inflammatory, and prothrombotic angiotensin II pathway. (2) Severe acute respiratory syndrome coronavirus 2 cell infection triggers an immune response with robust IFN-I release in patients predisposed to COVID-19‒associated pernio. (3) Age and sex discrepancies correlated with COVID-19 severity and manifestations, including pernio as a sign of mild disease, are likely explained by age-related immune and vascular differences influenced by sex hormones and genetics, which affect susceptibility to viral cellular infection, the renin-angiotensin-aldosterone system balance, and the IFN-I response.
MeSH term(s)	COVID-19/immunology ; COVID-19/physiopathology ; Chilblains/immunology ; Chilblains/physiopathology ; Chilblains/virology ; Disease Susceptibility ; Fingers/blood supply ; Humans ; Renin-Angiotensin System/physiology ; SARS-CoV-2/pathogenicity ; Toes/blood supply ; Vasoconstriction
Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2021.01.009
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Article ; Online: Use of implementation mapping in the planning of a hybrid type 1 pragmatic clinical trial: the BeatPain Utah study.

Fritz, Julie M / Gibson, Bryan / Wetter, David W / Del Fiol, Guilherme / Solis, Victor / Ford, Isaac / Lundberg, Kelly / Thackeray, Anne

Implementation science communications

2024 Volume 5, Issue 1, Page(s) 3

Abstract: Background: Considerable disparities in chronic pain management have been identified. Persons in rural, lower income, and minoritized communities are less likely to receive evidence-based, nonpharmacologic care. Telehealth delivery of nonpharmacologic, ... ...

Abstract	Background: Considerable disparities in chronic pain management have been identified. Persons in rural, lower income, and minoritized communities are less likely to receive evidence-based, nonpharmacologic care. Telehealth delivery of nonpharmacologic, evidence-based interventions for persons with chronic pain is a promising strategy to lessen disparities, but implementation comes with many challenges. The BeatPain Utah study is a hybrid type 1 effectiveness-implementation pragmatic clinical trial investigating telehealth strategies to provide nonpharmacologic care from physical therapists to persons with chronic back pain receiving care in ommunity health centers (CHCs). CHCs provide primary care to all persons regardless of ability to pay. This paper outlines the use of implementation mapping to develop a multifaceted implementation plan for the BeatPain study. Methods: During a planning year for the BeatPain trial, we developed a comprehensive logic model including the five-step implementation mapping process informed by additional frameworks and theories. The five iterative implementation mapping steps were addressed in the planning year: (1) conduct needs assessments for involved groups; (2) identify implementation outcomes, performance objectives, and determinants; (3) select implementation strategies; (4) produce implementation protocols and materials; and (5) evaluate implementation outcomes. Results: CHC leadership/providers, patients, and physical therapists were identified as involved groups. Barriers and assets were identified across groups which informed identification of performance objectives necessary to implement two key processes: (1) electronic referral of patients with back pain in CHC clinics to the BeatPain team and (2) connecting patients with physical therapists providing telehealth. Determinants of the performance objectives for each group informed our choice of implementation strategies which focused on training, education, clinician support, and tailoring physical therapy interventions for telehealth delivery and cultural competency. We selected implementation outcomes for the BeatPain trial to evaluate the success of our implementation strategies. Conclusions: Implementation mapping provided a comprehensive and systematic approach to develop an implementation plan during the planning phase for our ongoing hybrid effectiveness-implementation trial. We will be able to evaluate the implementation strategies used in the BeatPain Utah study to inform future efforts to implement telehealth delivery of evidence-based pain care in CHCs and other settings. Trial registration: ClinicalTrials.gov Identifier: NCT04923334 . Registered June 11, 2021.
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ISSN	2662-2211
ISSN (online)	2662-2211
DOI	10.1186/s43058-023-00542-z
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