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  1. Article: Thrombotic complications in children with first-episode steroid-sensitive nephrotic syndrome: A single-center experience.

    Such-Gruchot, Agnieszka / Szymanik-Grzelak, Hanna / Pańczyk-Tomaszewska, Małgorzata / Poźniak, Agata / Brzewski, Michał

    Clinical nephrology

    2023  Volume 100, Issue 1, Page(s) 1–11

    Abstract: Objective: The aim of the study was to evaluate the clinical course and risk factors of venous thromboembolic complications (VTEC) in children with a first episode of steroid-sensitive nephrotic syndrome (SSNS).: Materials and methods: We ... ...

    Abstract Objective: The aim of the study was to evaluate the clinical course and risk factors of venous thromboembolic complications (VTEC) in children with a first episode of steroid-sensitive nephrotic syndrome (SSNS).
    Materials and methods: We retrospectively analyzed the medical records of children hospitalized due to SSNS in one pediatric nephrology unit between 2012 and 2019. Demographic data, clinical symptoms at the onset of NS, and laboratory parameters were compared between patients with and without VTEC.
    Results: Among 106 children (4.7 ± 3.06 years of age) with a first episode of SSNS, 5 VTEC were diagnosed during 2 - 60 days after onset of NS, on the basis of clinical symptoms and/or results of imaging studies. These were thromboses of femoral vein, central part of the kidney, dorsal veins of the hand, venous sinuses of the brain, and superficial vein in the popliteal fossa region. We found significant higher serum fibrinogen level (p = 0.022) and D-dimers (p = 0.0001) in children with VTEC vs. those without VTEC, but AUC analysis showed that only D-dimers significantly differentiate thrombosis. The clinical risk factors of VTEC were vascular cannulation (100%), infections (80%), and diuretics (80%). In children with VTEC, low molecular weight heparin was used. The outcome was a full recovery in all patients.
    Conclusion: VTEC occurs in 4.72% of children with a first episode of SSNS. The course of VTEC in children with SSNS may be asymptomatic. The clinical risk factors of VTEC in children with SSNS are vascular cannulation, infections, and diuretics. High D-dimer levels are a sensitive indicator of thrombosis.
    MeSH term(s) Child ; Humans ; Infant, Newborn ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/drug therapy ; Retrospective Studies ; Kidney ; Thrombosis/etiology ; Risk Factors
    Language English
    Publishing date 2023-06-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN110932
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  2. Article: Epidemiology and Risk Factors of UTIs in Children-A Single-Center Observation.

    Daniel, Maria / Szymanik-Grzelak, Hanna / Sierdziński, Janusz / Podsiadły, Edyta / Kowalewska-Młot, Magdalena / Pańczyk-Tomaszewska, Małgorzata

    Journal of personalized medicine

    2023  Volume 13, Issue 1

    Abstract: Urinary tract infections (UTIs) are one of childhood’s most common bacterial infections. The study aimed to determine the clinical symptoms, laboratory tests, risk factors, and etiology of different UTIs in children admitted to pediatric hospitals for ... ...

    Abstract Urinary tract infections (UTIs) are one of childhood’s most common bacterial infections. The study aimed to determine the clinical symptoms, laboratory tests, risk factors, and etiology of different UTIs in children admitted to pediatric hospitals for three years. Methods: Patients with positive urine cultures diagnosed with acute pyelonephritis (APN) or cystitis (CYS) were analyzed for clinical symptoms, laboratory tests, risk factors, and etiology, depending on their age and sex. Results: We studied 948 children with UTIs (531 girls and 417 boys), with a median age of 12 (IQR 5−48 months). A total of 789 children had clinical symptoms; the main symptom was fever (63.4% of patients). Specific symptoms of UTIs were presented only in 16.3% of patients. Children with APN had shown significantly more frequent loss of appetite, vomiting, lethargy, seizures, and less frequent dysuria and haematuria than children with CYS. We found significantly higher median WBC, CRP, and leukocyturia in children with APN than with CYS. The risk factors of UTIs were presented in 46.6% of patients, of which 35.6% were children with APN and 61.7% with CYS. The main risk factor was CAKUT, more frequently diagnosed in children with CYS than APN, mainly in children <2 years. The most commonly isolated bacteria were Escherichia coli (74%). There was a higher percentage of urine samples with E. coli in girls than in boys. Other bacteria found were Klebsiella species, Pseudomonas aeruginosa, Proteus mirabilis, and Enterococcus species. Conclusions: Patients with APN were younger and had higher inflammatory markers. Often, fever is the only symptom of UTI in children, and other clinical signs are usually non-specific. The most common UTI etiology is E. coli, regardless of the clinical presentation and risk factors.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010138
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  3. Article: Odległe wyniki leczenia hiperkalciurii nerkowej – prezentacja dwóch przypadków.

    Sawicka-Kamińska, Anna / Szymanik-Grzelak, Hanna / Szymanik-Grzelak, Małgorzata

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

    2017  Volume 42, Issue 252, Page(s) 260–263

    Abstract: In recent years there can be observed a growing number of cases of urolithialis, both in children and in adults. Many pathogenic mechanisms of forming stones have been recognized and there is possible profounder diagnostics. Facing increasing problem of ... ...

    Title translation The long-term results of the treatment of renal hypercalciuria - a report of two cases.
    Abstract In recent years there can be observed a growing number of cases of urolithialis, both in children and in adults. Many pathogenic mechanisms of forming stones have been recognized and there is possible profounder diagnostics. Facing increasing problem of urolithialis in children, it is necessary to seek all possible causes of the disease to prevent forming stones, relapses and its further consequences. In most cases it is possible to diagnose metabolic abnormalities, of which the most frequent is hypercalciuria (excessive excretion of calcium in urine). In children, idiopathic hypercalciuria occurs the most frequently. It is possible to diagnose different types of hypercalciuria (absorptive, renal or resorptive) and apply appropriate treatment.
    A case report: We present two cases of patients with urolithialis and diagnosed renal hypercalciuria. Time of observation of the first patient was more than 6 years, of the second one - 9 years. In both cases there has been applied appropriate treatment, however it was the proper realization of the recommendations that influenced long-term results of the treatment. Even the most detailed examination cannot assure effectiveness if the patient and the parents do not have positive approach to the treatment.
    MeSH term(s) Adolescent ; Child ; Female ; Humans ; Hypercalciuria/therapy ; Long-Term Care ; Male ; Treatment Outcome
    Language Polish
    Publishing date 2017-06-29
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 1388406-2
    ISSN 1426-9686
    ISSN 1426-9686
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  4. Article ; Online: Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus placebo as a prophylaxis for recurrence urinary tract infections in children: a study protocol for a randomised controlled trial.

    Daniel, Maria / Szymanik-Grzelak, Hanna / Turczyn, Agnieszka / Pańczyk-Tomaszewska, Małgorzata

    BMC urology

    2020  Volume 20, Issue 1, Page(s) 168

    Abstract: Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in children. In children < 7 years of age, the prevalence of one episode of symptomatic UTI has been estimated at 3-7% in girls and 1-2% in boys, whereas 8-30% ... ...

    Abstract Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in children. In children < 7 years of age, the prevalence of one episode of symptomatic UTI has been estimated at 3-7% in girls and 1-2% in boys, whereas 8-30% of them will have one or more episodes of UTI. The use of some probiotics appears to reduce the risk of recurrence of UTIs. Since the effects of probiotics are strain-specific, the efficacy and safety of each strain has to be assessed. The main aim of this study is to determine whether probiotics (containing Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1) therapy are effective in preventing UTI in children compared to placebo.
    Method: A superiority, double-blind, randomised, controlled trial is being conducted. One hundred and six patients aged 3 to 18 years with recurrent UTIs in last year (defined as: ≥ 2 episodes of UTI with acute pyelonephritis/upper UTI; or 1 episode of UTI with acute pyelonephritis and ≥ 1 episodes of UTI with cystitis/lower UTI; or ≥ 3 episodes of UTI with cystitis/lower UTI) or children with ≥ 1 infection in the upper urinary tract and ≥ 1 of recurrent UTIs risk factors (congenital anomalies of the kidney and urinary tract, constipation, bladder dysfunction, myelomeningocele, sexual activity in girls) will be randomly assigned to receive a 90-day prophylaxis arm (probiotic containing L. rhamnosus PL1 and L. plantarum PM1) or a 90-day placebo arm. The primary outcome measure will be the frequency of recurrence of UTI during the intervention and in the period 9 months after the intervention.
    Discussion: The findings of this randomised controlled trial (RCT), whether positive or negative, will contribute to the formulation of further recommendations on prevention of recurrent UTIs in children.
    Trial registration number: NCT03462160, date of trial registration 12th March 2018.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Humans ; Lactobacillus plantarum ; Lactobacillus rhamnosus ; Male ; Probiotics/therapeutic use ; Randomized Controlled Trials as Topic/methods ; Recurrence ; Urinary Tract Infections/prevention & control
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-020-00723-1
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  5. Article: Acute tubulointerstitial nephritis following aciclovir treatment for chickenpox in children with nephrotic syndrome - a report of two cases.

    Pańczyk-Tomaszewska, Małgorzata / Kuźma-Mroczkowska, Elżbieta / Skrzypczyk, Piotr / Szymanik-Grzelak, Hanna / Małdyk, Jadwiga

    Central-European journal of immunology

    2021  Volume 45, Issue 4, Page(s) 494–497

    Abstract: Tubulointerstitial nephritis (TIN) is an inflammatory process primarily involving the renal interstitium and is the cause of acute kidney injury (AKI) in 3-7% of cases confirmed by renal biopsy in children. Aciclovir may have a nephrotoxic effect by ... ...

    Abstract Tubulointerstitial nephritis (TIN) is an inflammatory process primarily involving the renal interstitium and is the cause of acute kidney injury (AKI) in 3-7% of cases confirmed by renal biopsy in children. Aciclovir may have a nephrotoxic effect by crystallization in renal tubules or by inducing an immunologic process that leads to development of TIN. We report 2 male patients, aged 10 and 8 years, with nephrotic syndrome (NS), in whom disease relapse was triggered by varicella zoster infection. The patients received intravenous aciclovir which resulted in AKI due to acute TIN with the glomerular filtration rate 19.5 and 24.9 ml/min/1.73 m
    Language English
    Publishing date 2021-01-30
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 1336421-2
    ISSN 1644-4124 ; 1426-3912
    ISSN (online) 1644-4124
    ISSN 1426-3912
    DOI 10.5114/ceji.2020.103426
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  6. Article: Diagnostic difficulties in a patient with paroxysmal cold haemoglobinuria and acute kidney injury.

    Daniel, Maria / Adamowicz-Salach, Anna / Szymanik-Grzelak, Hanna

    Central-European journal of immunology

    2017  Volume 42, Issue 4, Page(s) 404–406

    Abstract: Paroxysmal cold haemoglobinuria (PCH) is a form of autoimmune haemolytic anaemia (AIHA) characterised by a sudden onset of haemoglobinuria, either spontaneously or following exposure to cold. In children, it is commonly seen following a viral illness or ... ...

    Abstract Paroxysmal cold haemoglobinuria (PCH) is a form of autoimmune haemolytic anaemia (AIHA) characterised by a sudden onset of haemoglobinuria, either spontaneously or following exposure to cold. In children, it is commonly seen following a viral illness or after immunisation. Diagnosis of PCH is confirmed by a positive Donath Landsteiner (DL) test in which biphasic haemolysins are detected. However, in a real clinical setting, the serological diagnosis of PCH is not always easy. PCH can cause tubular renal injury, which in turn can lead to renal impairment. We describe a case of a two-year-old boy who was admitted to the hospital with pallor, jaundice, dehydration, and dark urine. Two weeks before admission, the child had an upper respiratory tract infection. Laboratory tests showed severe anaemia (haemoglobin 4.5g/dl, haematocrit 11.5%, LDH 8525 U/l), hyperbilirubinaemia (104 μmol/l), haemoglobinuria, and acute kidney injury: GFR 43.9 ml/min/1.73 m
    Language English
    Publishing date 2017-12-30
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 1336421-2
    ISSN 1644-4124 ; 1426-3912
    ISSN (online) 1644-4124
    ISSN 1426-3912
    DOI 10.5114/ceji.2017.72816
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  7. Article ; Online: Acute tubulointerstitial nephritis following aciclovir treatment for chickenpox in children with nephrotic syndrome – a report of two cases

    Małgorzata Pańczyk-Tomaszewska / Elżbieta Kuźma-Mroczkowska / Piotr Skrzypczyk / Hanna Szymanik-Grzelak / Jadwiga Małdyk

    Central European Journal of Immunology, Vol 45, Iss 4, Pp 494-

    2021  Volume 497

    Abstract: Tubulointerstitial nephritis (TIN) is an inflammatory process primarily involving the renal interstitium and is the cause of acute kidney injury (AKI) in 3-7% of cases confirmed by renal biopsy in children. Aciclovir may have a nephrotoxic effect by ... ...

    Abstract Tubulointerstitial nephritis (TIN) is an inflammatory process primarily involving the renal interstitium and is the cause of acute kidney injury (AKI) in 3-7% of cases confirmed by renal biopsy in children. Aciclovir may have a nephrotoxic effect by crystallization in renal tubules or by inducing an immunologic process that leads to development of TIN. We report 2 male patients, aged 10 and 8 years, with nephrotic syndrome (NS), in whom disease relapse was triggered by varicella zoster infection. The patients received intravenous aciclovir which resulted in AKI due to acute TIN with the glomerular filtration rate 19.5 and 24.9 ml/min/1.73 m2, respectively. The diagnosis was confirmed by kidney biopsy in one of these patients. Initiation of glucocorticosteroids and withdrawal of aciclovir resulted in resolution of proteinuria and symptoms of AKI. In children with active NS treated with intravenous aciclovir, a possibility of AKI due to TIN should be taken into account.
    Keywords children ; nephrotic syndrome (ns) ; acute tubulointerstitial nephritis (tin) ; acyclovir ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
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  8. Article: Is copeptin a reliable biomarker of primary monosymptomatic nocturnal enuresis?

    Szymanik-Grzelak, Hanna / Daniel, Maria Urszula / Skrzypczyk, Piotr / Kotuła, Iwona / Pańczyk-Tomaszewska, Małgorzata

    Central-European journal of immunology

    2019  Volume 44, Issue 1, Page(s) 38–44

    Abstract: Introduction: The position of copeptin (C-terminal fragment of antidiuretin propeptide) as a marker of primary monosymptomatic nocturnal enuresis (PMNE) is under debate, and there are no data on the relation between copeptin and clinical and biochemical ...

    Abstract Introduction: The position of copeptin (C-terminal fragment of antidiuretin propeptide) as a marker of primary monosymptomatic nocturnal enuresis (PMNE) is under debate, and there are no data on the relation between copeptin and clinical and biochemical parameters in these patients. Aim of the study was to assess the level of serum copeptin in children with PMNE and to look for a relation between copeptin and selected clinical and biochemical parameters in these children.
    Material and methods: Twenty-five children recruited for the trial fulfilled the following criteria: clinical diagnosis of PMNE, age 5-15 years, normal creatinine level, normal ultrasonographic image of kidneys and urinary tract. The following parameters were evaluated: serum copeptin, creatinine, sodium, potassium, hematocrit and urine specific gravity. Twenty healthy children were included in the control group.
    Results: Children from study and control groups did not differ in serum copeptin, sex, age creatinine, sodium, hematocrit and specific gravity. Serum potassium level remained normal in subjects but was significantly higher in the study group. In children with PMNE we found no relation between serum copeptin level and sex, kidney function, sodium, and urinary specific gravity. We found a negative correlation between copeptin and bladder capacity and trends towards positive relations between copeptin and age, as well as hemoglobin. In the subgroup of children with normal bladder capacity a trend towards a positive correlation between copeptin and potassium was found.
    Conclusions: Copeptin may be a marker of hydration status in children with PMNE. The relation between potassium and copeptin levels and the clinical significance of the relation require further studies.
    Language English
    Publishing date 2019-04-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1336421-2
    ISSN 1644-4124 ; 1426-3912
    ISSN (online) 1644-4124
    ISSN 1426-3912
    DOI 10.5114/ceji.2019.84013
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  9. Article ; Online: Is copeptin a reliable biomarker of primary monosymptomatic nocturnal enuresis?

    Hanna Szymanik-Grzelak / Maria Urszula Daniel / Piotr Skrzypczyk / Iwona Kotuła / Małgorzata Pańczyk-Tomaszewska

    Central European Journal of Immunology, Vol 44, Iss 1, Pp 38-

    2019  Volume 44

    Keywords children ; copeptin ; nocturnal enuresis ; Medicine ; R
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Thrombotic thrombocytopenic purpura in the course of systemic lupus erythematosus in a 15-year-old girl.

    Szymanik-Grzelak, Hanna / Przychodzeń, Joanna / Stelmaszczyk-Emmel, Anna / Pańczyk-Tomaszewska, MaŁgorzata

    Central-European journal of immunology

    2017  Volume 42, Issue 4, Page(s) 407–408

    Abstract: Systemic lupus erythematosus (SLE) concomitant with thrombotic thrombocytopenic purpura (TTP) in children is rarely diagnosed. We report a case of a 15-year-old girl with butterfly patch, generalized edema, leg pain, anemia (Hb 74 g/l), thrombocytopenia ( ...

    Abstract Systemic lupus erythematosus (SLE) concomitant with thrombotic thrombocytopenic purpura (TTP) in children is rarely diagnosed. We report a case of a 15-year-old girl with butterfly patch, generalized edema, leg pain, anemia (Hb 74 g/l), thrombocytopenia (5 x 10
    Language English
    Publishing date 2017-12-30
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 1336421-2
    ISSN 1644-4124 ; 1426-3912
    ISSN (online) 1644-4124
    ISSN 1426-3912
    DOI 10.5114/ceji.2017.72822
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