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Article ; Online: Drosophila melanogaster as a model of systemic dermatophytosis.

da Costa, Bárbara / Pippi, Bruna / Merkel, Simone / Agostinetto, Giovanna / Zanette, Régis A / Fuentefria, Alexandre M

2023 Volume 66, Issue 10, Page(s) 906–910

Abstract: Background: Dermatophytosis is one of the most common fungal infections worldwide. The distribution of dermatophytes varies across continents, but the genera Trichophyton and Microsporum have emerged as the main isolated agents in humans and animals.: ...

Abstract	Background: Dermatophytosis is one of the most common fungal infections worldwide. The distribution of dermatophytes varies across continents, but the genera Trichophyton and Microsporum have emerged as the main isolated agents in humans and animals. Objectives: To validate Drosophila melanogaster flies as a fast and feasible model to study dermatophytic infections. Methods: Wild-type (WT) and Toll-deficient D. melanogaster flies were infected by Trichophyton rubrum, T. mentagrophytes, Microsporum canis and Nannizzia gypsea by pricking with a needle previously dipped in inoculum concentrations ranging from 10 Results: WT flies were predominantly resistant to the infection, whereas Toll-deficient flies succumbed to the four dermatophyte genera tested. The antifungal drugs protected flies from the infection, except for N. gypsea whose survival curves did not differ from the untreated group. Conclusions: This pilot study confirms that D. melanogaster is a suitable model to study the virulence and antifungal drug efficacy in dermatophyte species.
MeSH term(s)	Humans ; Animals ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Drosophila melanogaster ; Pilot Projects ; Arthrodermataceae ; Itraconazole ; Trichophyton ; Tinea/drug therapy ; Tinea/microbiology
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4)
Language	English
Publishing date	2023-07-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13630
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Article: Anti-Inflammatory Activity of

da Silva, Pablo Rayff / Apolinário, Nadjaele de Melo / Silva, Simone Ângela Soares da / Araruna, Maria Elaine Cristina / Costa, Thássia Borges / E Silva, Yvnni M S de Medeiros / da Silva, Teresinha Gonçalves / de Moura, Ricardo Olímpio / Dos Santos, Vanda Lucia

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 10

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16101415
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Article ; Online: Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach.

Silva, Simone S / Rodrigues, Luísa C / Fernandes, Emanuel M / Soares da Costa, Diana / Villalva, Denise G / Loh, Watson / Reis, Rui L

Marine drugs

2023 Volume 21, Issue 7

Abstract: Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin ... ...

Abstract	Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 µm, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 ± 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 ± 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway.
MeSH term(s)	Chitosan ; Emulsions ; Diclofenac ; Plant Oils/chemistry ; Coconut Oil/chemistry
Chemical Substances	Chitosan (9012-76-4) ; Emulsions ; Diclofenac (144O8QL0L1) ; Plant Oils ; Coconut Oil (Q9L0O73W7L)
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21070394
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Article ; Online: Age-related Morphofunctional Changes in Sickle Cell Mice Bone Marrow Mesenchymal Stromal Cells.

Rós, Felipe A / da Costa, Péricles N M / Milhomens, Jonathan / de La-Roque, Débora G L / Ferreira, Fernanda U / de Matos Maçonetto, Juliana / de Oliveira Menezes Bonaldo, Camila C / de Carvalho, Julianne V / Palma, Patrícia V B / El Nemer, Wassim / Covas, Dimas T / Kashima, Simone

Hematology/oncology and stem cell therapy

2024 Volume 17, Issue 2, Page(s) 120–129

Abstract: Background and objectives: Bone marrow mesenchymal stromal cells (BM-MSCs) are key elements of the hematopoietic niche and participate in the regulatory mechanisms of hematopoietic stem cells (HSCs). Hematological diseases can affect MSCs and their ... ...

Abstract	Background and objectives: Bone marrow mesenchymal stromal cells (BM-MSCs) are key elements of the hematopoietic niche and participate in the regulatory mechanisms of hematopoietic stem cells (HSCs). Hematological diseases can affect MSCs and their functions. However, the dysregulations caused by sickle cell disease (SCD) are not fully elucidated. This work explored changes in BM-MSCs and their relationship with age using sickle cell mice (Townes-SS). Materials and methods: BM-MSCs were isolated from Townes-SS, and control groups 30- and 60-day-old Townes-AA and C57BL/6 J. Results: The BM-MSCs showed no morphological differences in culture and demonstrated a murine MSC-like immunophenotypic profile (Sca-1+, CD29+, CD44+, CD90.2+, CD31-, CD45-, and CD117-). Subsequently, all BM-MSCs were able to differentiate into adipocytes and osteocytes in vitro. Finally, 30-day-old BM-MSCs of Townes-SS showed higher expression of genes related to the maintenance of HSCs (Cxcl12, Vegfa, and Angpt1) and lower expression of pro-inflammatory genes (Tnfa and Il-6). However, 60-day-old BM-MSCs of Townes-SS started to show expression of genes related to reduced HSC maintenance and increased expression of pro-inflammatory genes. Conclusion: These results indicates age as a modifying factor of gene expression of BM-MSCs in the context of SCD.
MeSH term(s)	Humans ; Animals ; Mice ; Bone Marrow ; Mice, Inbred C57BL ; Hematopoietic Stem Cells/metabolism ; Mesenchymal Stem Cells/metabolism ; Anemia, Sickle Cell ; Bone Marrow Cells/metabolism ; Cell Differentiation
Language	English
Publishing date	2024-04-01
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2651893-4
ISSN	2589-0646 ; 1658-3876
ISSN (online)	2589-0646
ISSN	1658-3876
DOI	10.56875/2589-0646.1115
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Article: Transcription Landscape of the Early Developmental Biology in Pigs.

Teixeira, Susana A / Marques, Daniele B D / Costa, Thaís C / Oliveira, Haniel C / Costa, Karine A / Carrara, Eula R / Silva, Walmir da / Guimarães, José D / Neves, Mariana M / Ibelli, Adriana M G / Cantão, Maurício E / Ledur, Mônica C / Peixoto, Jane O / Guimarães, Simone E F

Animals : an open access journal from MDPI

2021 Volume 11, Issue 5

Abstract: Since pre- and postnatal development are programmed during early prenatal life, studies addressing the complete transcriptional landscape during organogenesis are needed. Therefore, we aimed to disentangle differentially expressed (DE) genes between ... ...

Abstract	Since pre- and postnatal development are programmed during early prenatal life, studies addressing the complete transcriptional landscape during organogenesis are needed. Therefore, we aimed to disentangle differentially expressed (DE) genes between fetuses (at 35 days old) and embryos (at 25 days old) through RNA-sequencing analysis using the pig as model. In total, 1705 genes were DE, including the top DE
Language	English
Publishing date	2021-05-18
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11051443
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Article: Evaluation of the Photocatalytic Activity of Distinctive-Shaped ZnO Nanocrystals Synthesized Using Latex of Different Plants Native to the Amazon Rainforest.

Matos, Robert S / Attah-Baah, John M / Monteiro, Michael D S / Costa, Benilde F O / Mâcedo, Marcelo A / Da Paz, Simone P A / Angélica, Rômulo S / de Souza, Tiago M / Ţălu, Ştefan / Oliveira, Rosane M P B / Ferreira, Nilson S

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 16

Abstract: ZnO nanocrystals with three different morphologies have been synthesized via a simple sol-gel-based method ... ...

Abstract	ZnO nanocrystals with three different morphologies have been synthesized via a simple sol-gel-based method using
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12162889
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Article ; Online: Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection.

Adamoski, Douglas / Dias, Marilia Meira / Quesñay, Jose Edwin Neciosup / Yang, Zhengyi / Zagoriy, Ievgeniia / Steyer, Anna M / Rodrigues, Camila Tanimoto / da Silva Bastos, Alliny Cristiny / da Silva, Bianca Novaes / Costa, Renna Karoline Eloi / de Abreu, Flávia Mayumi Odahara / Islam, Zeyaul / Cassago, Alexandre / van Heel, Marin Gerard / Consonni, Sílvio Roberto / Mattei, Simone / Mahamid, Julia / Portugal, Rodrigo Villares / Ambrosio, Andre Luis Berteli /

Dias, Sandra Martha Gomes

Nature structural & molecular biology

2023 Volume 30, Issue 12, Page(s) 1902–1912

Abstract: Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS filamentation and activation, the molecular basis of this mechanism is unknown. Here ...

Abstract	Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS filamentation and activation, the molecular basis of this mechanism is unknown. Here we aimed to determine the molecular mechanism of Pi-induced mouse GLS filamentation and its impact on mitochondrial physiology. Single-particle cryogenic electron microscopy revealed an allosteric mechanism in which Pi binding at the tetramer interface and the activation loop is coupled to direct nucleophile activation at the active site. The active conformation is prone to enzyme filamentation. Notably, human GLS filaments form inside tubulated mitochondria following glutamine withdrawal, as shown by in situ cryo-electron tomography of cells thinned by cryo-focused ion beam milling. Mitochondria with GLS filaments exhibit increased protection from mitophagy. We reveal roles of filamentous GLS in mitochondrial morphology and recycling.
MeSH term(s)	Mice ; Humans ; Animals ; Glutaminase/chemistry ; Glutaminase/metabolism ; Mitophagy ; Glutamine/metabolism ; Mitochondria/metabolism
Chemical Substances	Glutaminase (EC 3.5.1.2) ; Glutamine (0RH81L854J)
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-023-01118-0
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Zs.A 4101: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Position Statement on Ischemic Heart Disease - Women-Centered Health Care - 2023.

Oliveira, Gláucia Maria Moraes de / Almeida, Maria Cristina Costa de / Rassi, Daniela do Carmo / Bragança, Érika Olivier Vilela / Moura, Lidia Zytynski / Arrais, Magaly / Campos, Milena Dos Santos Barros / Lemke, Viviana Guzzo / Avila, Walkiria Samuel / Lucena, Alexandre Jorge Gomes de / Almeida, André Luiz Cerqueira de / Brandão, Andréa Araujo / Ferreira, Andrea Dumsch de Aragon / Biolo, Andreia / Macedo, Ariane Vieira Scarlatelli / Falcão, Breno de Alencar Araripe / Polanczyk, Carisi Anne / Lantieri, Carla Janice Baister / Marques-Santos, Celi /

Freire, Claudia Maria Vilas / Pellegrini, Denise / Alexandre, Elizabeth Regina Giunco / Braga, Fabiana Goulart Marcondes / Oliveira, Fabiana Michelle Feitosa de / Cintra, Fatima Dumas / Costa, Isabela Bispo Santos da Silva / Silva, José Sérgio Nascimento / Carreira, Lara Terra F / Magalhães, Lucelia Batista Neves Cunha / Matos, Luciana Diniz Nagem Janot de / Assad, Marcelo Heitor Vieira / Barbosa, Marcia M / Silva, Marconi Gomes da / Rivera, Maria Alayde Mendonça / Izar, Maria Cristina de Oliveira / Costa, Maria Elizabeth Navegantes Caetano / Paiva, Maria Sanali Moura de Oliveira / Castro, Marildes Luiza de / Uellendahl, Marly / Oliveira Junior, Mucio Tavares de / Souza, Olga Ferreira de / Costa, Ricardo Alves da / Coutinho, Ricardo Quental / Silva, Sheyla Cristina Tonheiro Ferro da / Martins, Sílvia Marinho / Brandão, Simone Cristina Soares / Buglia, Susimeire / Barbosa, Tatiana Maia Jorge de Ulhôa / Nascimento, Thais Aguiar do / Vieira, Thais / Campagnucci, Valquíria Pelisser / Chagas, Antonio Carlos Palandri

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 7, Page(s) e20230303

Title translation	Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023.
MeSH term(s)	Humans ; Female ; Delivery of Health Care ; Myocardial Ischemia
Language	Portuguese
Publishing date	2023-08-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20230303
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Article ; Online: Construct validity and reliability of the Canadian Eating Practices Screener to assess eating practices based on 2019 Canada's Food Guide recommendations.

Perreault, Maude / Wallace, Angela / Martin, Alicia / Sadowski, Adam / Laila, Amar / Lemieux, Simone / Hutchinson, Joy M / Kirkpatrick, Sharon I / Simpson, Janis Randall / Guenther, Patricia M / Lamarche, Benoît / Jessri, Mahsa / Louzada, Maria Laura da Costa / Olstad, Dana Lee / Prowse, Rachel / Vatanparast, Hassan / Haines, Jess

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2023 Volume 48, Issue 12, Page(s) 919–931

Abstract: For the first time since its introduction, the 2019 Canada's Food Guide (2019-CFG) highlighted specific guidance on eating practices, i.e., recommendations on where, when, why, and how to eat. The Canadian Eating Practices Screener / Questionnaire court ... ...

Abstract	For the first time since its introduction, the 2019 Canada's Food Guide (2019-CFG) highlighted specific guidance on eating practices, i.e., recommendations on where, when, why, and how to eat. The Canadian Eating Practices Screener / Questionnaire court canadien sur les pratiques alimentaires was developed to assess eating practices based on the 2019-CFG healthy eating recommendations. The objective of this cross-sectional study was to assess the construct validity and reliability of the Canadian Eating Practices Screener. From July to December 2021, adults (
MeSH term(s)	Canada ; Cross-Sectional Studies ; Reproducibility of Results ; Feeding Behavior ; Fruit ; Surveys and Questionnaires ; Eating
Language	English
Publishing date	2023-10-03
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2023-0080
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Article ; Online: IgA quantification as a good predictor of the neutralizing antibodies levels after vaccination against SARS-CoV-2.

Fernandes-Siqueira, Lorena O / Sousa, Bruna G / Cleto, Carlos E / Wermelinger, Luciana S / Caetano, Beatriz L L / Pacheco, Agatha R / Costa, Simone M / Almeida, Fabio C L / Ferreira, Gustavo C / Salmon, Didier / Alves, Ada M B / Da Poian, Andrea T

Journal of clinical virology plus

2022 Volume 2, Issue 4, Page(s) 100121

Abstract: Background: Vaccination against COVID-19 was implemented very quickly, but the emergence of new variants that can evade the previous acquired immunological protection highlights the importance of understanding the mechanisms involved in the immune ... ...

Abstract	Background: Vaccination against COVID-19 was implemented very quickly, but the emergence of new variants that can evade the previous acquired immunological protection highlights the importance of understanding the mechanisms involved in the immune response generated after SARS-CoV-2 infection or vaccination. Objectives: Since most of our knowledge on the humoral immunity generated against SARS-CoV-2 has been obtained from studies with infected patients before vaccination, our goal here was to evaluate seroconversion and its correlation with the titers of neutralizing antibodies (NAbs) in individuals who received the complete initial recommended vaccination schedule with three different vaccines. Study design: We analyzed serum IgG, IgA and total NAbs against the trimeric SARS-CoV-2 Spike (S) protein or its receptor binding domain (RBD) in blood samples collected from 118 healthy individuals without known previous infection, before and after receiving the first and the second dose of CoronaVac ( Results: We found that although IgG titers were high in all sera collected after the two doses of these vaccines, NAbs amounts varies among the groups. In contrast, serum NAbs concentrations were much more comparable to the IgA levels, indicating that these antibodies would have a major neutralizing capacity against SARS-CoV-2. Conclusions: Altogether our data suggest that quantification of serum anti-S or anti-RBD IgA, rather than IgG, may be a valuable tool to screen NAbs and may be considered for surveillance of vaccine coverage.
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article
ISSN	2667-0380
ISSN (online)	2667-0380
DOI	10.1016/j.jcvp.2022.100121
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