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  1. Article ; Online: An Overview of Lyme Disease in Europe.

    Higgs, Stephen / Brissette, Catherine A

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2023  Volume 23, Issue 4, Page(s) 137–138

    MeSH term(s) Animals ; Lyme Disease/epidemiology ; Lyme Disease/veterinary ; Europe/epidemiology
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2023.29006.hig
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Lyme Disease: Recent Advances and Perspectives

    Brissette, Catherine A / Ocwieja, Tanja Petnicki

    2015  

    Abstract: The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with ... ...

    Abstract The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance.-

    The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors.-

    Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology.-
    Keywords Science (General) ; Infectious and parasitic diseases
    Size 1 electronic resource (114 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090502
    ISBN 9782889195572 ; 2889195570
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Erp and Rev Adhesins of the Lyme Disease Spirochete's Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection.

    Stevenson, Brian / Brissette, Catherine A

    Infection and immunity

    2023  Volume 91, Issue 3, Page(s) e0025022

    Abstract: Almost all spirochetes in the ... ...

    Abstract Almost all spirochetes in the genus
    MeSH term(s) Animals ; Borrelia burgdorferi/genetics ; Borrelia burgdorferi/metabolism ; Prophages/genetics ; Prophages/metabolism ; Base Sequence ; Bacterial Outer Membrane Proteins/genetics ; Lyme Disease/microbiology ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Vertebrates/metabolism ; Bacterial Proteins/genetics
    Chemical Substances Bacterial Outer Membrane Proteins ; Adhesins, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00250-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Borrelia miyamotoi

    Cleveland, Dawn W / Anderson, Cassidy C / Brissette, Catherine A

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: ... Borrelia ... ...

    Abstract Borrelia miyamotoi
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: TICK TOCK-Time Is Running Out, as the United States Is Being Invaded by the Longhorned Tick!

    Brissette, Catherine A

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2019  Volume 19, Issue 5, Page(s) 307–308

    MeSH term(s) Animals ; Arachnid Vectors/virology ; Bunyaviridae Infections/epidemiology ; Bunyaviridae Infections/transmission ; Bunyaviridae Infections/virology ; Humans ; Introduced Species ; Ixodidae/virology ; Phlebovirus/physiology ; RNA, Viral/isolation & purification ; United States/epidemiology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2019-04-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2019.2473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Brilliance of

    Anderson, Cassidy / Brissette, Catherine A

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent, ...

    Abstract Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent,
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10030281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity.

    Thompson, Derick / Odufuwa, Abiodun E / Brissette, Catherine A / Watt, John A

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1223273

    Abstract: The age-dependent loss of neuronal plasticity is a well-known phenomenon that is poorly understood. The loss of this capacity for axonal regeneration is emphasized following traumatic brain injury, which is a major cause of disability and death among ... ...

    Abstract The age-dependent loss of neuronal plasticity is a well-known phenomenon that is poorly understood. The loss of this capacity for axonal regeneration is emphasized following traumatic brain injury, which is a major cause of disability and death among adults in the US. We have previously shown the intrinsic capacity of magnocellular neurons within the supraoptic nucleus to undergo axonal regeneration following unilateral axotomization in an age-dependent manner. The aim of this research was to determine the age-dependent molecular mechanisms that may underlie this phenomenon. As such, we characterized the transcriptome and DNA methylome of the supraoptic nucleus in uninjured 35-day old rats and 125-day old rats. Our data indicates the downregulation of a large number of axonogenesis related transcripts in 125-day old rats compared to 35-day old rats. Specifically, several semaphorin and ephrin genes were downregulated, as well as growth factors including FGF's, insulin-like growth factors (IGFs), and brain-derived neurotrophic factor (BDNF). Differential methylation analysis indicates enrichment of biological processes involved in axonogenesis and axon guidance. Conversely, we observed a robust and specific upregulation of MHCI related transcripts. This may involve the activator protein 1 (AP-1) transcription factor complex as motif analysis of differentially methylated regions indicate enrichment of AP-1 binding sites in hypomethylated regions. Together, our data suggests a loss of pro-regenerative capabilities with age which would prevent axonal growth and appropriate innervation following injury.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1223273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The choroid plexus and its role in the pathogenesis of neurological infections.

    Thompson, Derick / Brissette, Catherine A / Watt, John A

    Fluids and barriers of the CNS

    2022  Volume 19, Issue 1, Page(s) 75

    Abstract: The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system. In contrast to the ... ...

    Abstract The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system. In contrast to the blood-brain barrier, the choroid plexus and its epithelial barrier have received considerably less attention. As the main producer of cerebrospinal fluid, the secretory functions of the epithelial cells aid in the maintenance of CNS homeostasis and are capable of relaying inflammatory signals to the brain. The choroid plexus acts as an immunological niche where several types of peripheral immune cells can be found within the stroma including dendritic cells, macrophages, and T cells. Including the epithelia cells, these cells perform immunosurveillance, detecting pathogens and changes in the cytokine milieu. As such, their activation leads to the release of homing molecules to induce chemotaxis of circulating immune cells, driving an immune response at the choroid plexus. Research into the barrier properties have shown how inflammation can alter the structural junctions and promote increased bidirectional transmigration of cells and pathogens. The goal of this review is to highlight our foundational knowledge of the choroid plexus and discuss how recent research has shifted our understanding towards viewing the choroid plexus as a highly dynamic and important contributor to the pathogenesis of neurological infections. With the emergence of several high-profile diseases, including ZIKA and SARS-CoV-2, this review provides a pertinent update on the cellular response of the choroid plexus to these diseases. Historically, pharmacological interventions of CNS disorders have proven difficult to develop, however, a greater focus on the role of the choroid plexus in driving these disorders would provide for novel targets and routes for therapeutics.
    MeSH term(s) Blood-Brain Barrier/physiology ; Brain ; COVID-19 ; Choroid Plexus/physiology ; Humans ; SARS-CoV-2 ; Zika Virus ; Zika Virus Infection
    Language English
    Publishing date 2022-09-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-022-00372-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An Expert Panel Discussion Lyme Disease in Europe.

    Brissette, Catherine / Moniuszko-Malinowska, Anna / Nuttens, Charles / Lindgren, Per-Eric / Angulo, Frederick J

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2023  Volume 23, Issue S1, Page(s) i–S8

    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2023.29009.bri
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Brilliance of Borrelia

    Cassidy Anderson / Catherine A. Brissette

    Pathogens, Vol 10, Iss 3, p

    Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes

    2021  Volume 281

    Abstract: Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent, Borrelia burgdorferi sensu lato, is capable of establishing a persistent infection within the host. This is despite the activation of both ... ...

    Abstract Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent, Borrelia burgdorferi sensu lato, is capable of establishing a persistent infection within the host. This is despite the activation of both the innate and adaptive immune responses. B. burgdorferi utilizes several immune evasion tactics ranging from the regulation of surface proteins, tick saliva, antimicrobial peptide resistance, and the disabling of the germinal center. This review aims to cover the various methods by which B. burgdorferi evades detection and destruction by the host immune response, examining both the innate and adaptive responses. By understanding the methods employed by B. burgdorferi to evade the host immune response, we gain a deeper knowledge of B. burgdorferi pathogenesis and Lyme disease, and gain insight into how to create novel, effective treatments.
    Keywords Lyme disease ; Borrelia ; immune response ; innate ; adaptive ; complement ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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