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Article ; Online: With Gratitude to Michael L. Callaham, MD.

Green, Steven M / Cooper, Richelle J / Dart, Richard C / Schriger, David L / Yealy, Donald M

2022 Volume 79, Issue 5, Page(s) 419

Language	English
Publishing date	2022-04-23
Publishing country	United States
Document type	Editorial
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2022.02.007
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Article ; Online: Effects of cigarette butts on marine keystone species (Ulva lactuca L. and Mytilus edulis L.) and sediment microphytobenthos.

Green, Dannielle Senga / Kregting, Louise / Boots, Bas

Marine pollution bulletin

2021 Volume 165, Page(s) 112152

Abstract: ... cellulose acetate, or biodegradable, cellulose, smoked cigarette butts were added at densities of 0.25 or 1 butt L ...

Abstract	Outdoor mesocosms with constantly flowing natural seawater were used to test the effects of littered cigarette butts on the filter feeder Mytilus edulis (blue mussel), the macroalga, Ulva lactuca (sea lettuce) and sediment microphytobenthos in a semi-natural marine setting. Either conventional, cellulose acetate, or biodegradable, cellulose, smoked cigarette butts were added at densities of 0.25 or 1 butt L
MeSH term(s)	Animals ; Mytilus edulis ; Smoking ; Tobacco Products ; Ulva
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2021.112152
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Article ; Online: L-selectin regulates human neutrophil transendothelial migration.

Rahman, Izajur / Collado Sánchez, Aida / Davies, Jessica / Rzeniewicz, Karolina / Abukscem, Sarah / Joachim, Justin / Hoskins Green, Hannah L / Killock, David / Sanz, Maria Jesus / Charras, Guillaume / Parsons, Maddy / Ivetic, Aleksandar

Journal of cell science

2021 Volume 134, Issue 3

Abstract: ... to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils ... For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering ... for L-selectin contributing to neutrophil transendothelial migration (TEM). We show that L-selectin co ...

Abstract	The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and rolling - the initial stages of the multi-step adhesion cascade. Here, we provide direct evidence for L-selectin contributing to neutrophil transendothelial migration (TEM). We show that L-selectin co-clusters with PECAM-1 - a well-characterised cell adhesion molecule involved in regulating neutrophil TEM. This co-clustering behaviour occurs specifically during TEM, which serves to augment ectodomain shedding of L-selectin and expedite the time taken for TEM (TTT) to complete. Blocking PECAM-1 signalling (through mutation of its cytoplasmic tail), PECAM-1-dependent adhesion or L-selectin shedding, leads to a significant delay in the TTT. Finally, we show that co-clustering of L-selectin with PECAM-1 occurs specifically across TNF- but not IL-1β-activated endothelial monolayers - implying unique adhesion interactomes forming in a cytokine-specific manner. To our knowledge, this is the first report to implicate a non-canonical role for L-selectin in regulating neutrophil TEM.
MeSH term(s)	Cell Adhesion ; Cell Movement ; Endothelium, Vascular ; Humans ; L-Selectin/genetics ; Neutrophils ; Transendothelial and Transepithelial Migration
Chemical Substances	SELL protein, human ; L-Selectin (126880-86-2)
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.250340
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Article ; Online: Correction: L-selectin regulates human neutrophil transendothelial migration.

Rahman, Izajur / Sánchez, Aida Collado / Davies, Jessica / Rzeniewicz, Karolina / Abukscem, Sarah / Joachim, Justin / Hoskins Green, Hannah L / Killock, David / Sanz, Maria Jesus / Charras, Guillaume / Parsons, Maddy / Ivetic, Aleksandar

Journal of cell science

2022 Volume 135, Issue 20

Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Published Erratum
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.260658
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Article ; Online: Volatilome evolution during storage and in vitro starch digestibility of high-power ultrasonication pretreated wholegrain Oryza sativa L.

Yang, Caijiao / Zheng, Yuanrong / Green, Brian D / Zhou, Changyu / Pan, Daodong / Cao, Jinxuan / Wang, Libin / Cai, Zhendong / Xia, Qiang

Food research international (Ottawa, Ont.)

2022 Volume 162, Issue Pt B, Page(s) 112127

Abstract: The potential of high-power ultrasonication (HPU) to enhance the physicochemical stability of bran-containing cereal products has been demonstrated, but the information concerning how the wholegrain volatilome and key quality-related chemical reactions ... ...

Abstract	The potential of high-power ultrasonication (HPU) to enhance the physicochemical stability of bran-containing cereal products has been demonstrated, but the information concerning how the wholegrain volatilome and key quality-related chemical reactions evolve responding to HPU remains scarcely reported. The objective of this work was to examine the headspace volatile fingerprinting features of sonicated wholegrain brown rice (WBR; 400 W, 28 kHz, 30 min) following an accelerated storage testing (37 °C, 20 days), and simultaneously to identify the key chemical reactions induced by ultrasonication. A total of 70 aroma compounds were identified by the untargeted headspace GC-MS, including 9 alkanes, 6 alkenes, 15 aldehydes, 6 furans, 12 ketones, 9 alcohols and 13 miscellaneous compounds. Multivariate statistical analysis demonstrated that HPU pretreatments before a storage process significantly influenced the volatilome evolution, as revealed by a clear classification between sonicated and unsonicated grains. Supervised orthogonal partial least squares discriminant analysis identified the volatiles including acetic acid, pentanoic acid, hexanal, ethyl hexanoate and 2-pentyl-furan as HPU-related markers, inferring that HPU mainly modified the chemical reactions involving lipid decomposition, free fatty acids oxidation and esterification. This was further confirmed by targeted monitoring of lipid peroxidation products, with 13.22-14.84 % of MDA contents reduced (p < 0.05) in sonicated samples after storage. Besides, the ultrasonic effects resulted in a slight improvement of in vitro starch digestibility of WBR samples depending on the rice ecotype. This investigation demonstrated the potential of HPU pretreatments for prolonging the oxidative stability of WBR grains, without significantly compromising digestion properties.
MeSH term(s)	Starch ; Oryza ; Whole Grains ; Edible Grain ; Esterification
Chemical Substances	Starch (9005-25-8)
Language	English
Publishing date	2022-11-11
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.112127
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Article ; Online: l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo.

Lange, Shannon M / McKell, Melanie C / Schmidt, Stephanie M / Zhao, Junfang / Crowther, Rebecca R / Green, Lisa C / Bricker, Rebecca L / Arnett, Eusondia / Köhler, S Eleonore / Schlesinger, Larry S / Setchell, Kenneth D R / Qualls, Joseph E

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 202, Issue 6, Page(s) 1747–1754

Abstract: ... infection. Targeting l-arginine metabolism is intriguing, considering this amino acid is the substrate ... for antimicrobial NO production by macrophages. The importance of l-arginine during infection is supported ... by the finding that inhibiting its synthesis from its precursor l-citrulline blunts host defense. During ...

Abstract	Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting l-arginine metabolism is intriguing, considering this amino acid is the substrate for antimicrobial NO production by macrophages. The importance of l-arginine during infection is supported by the finding that inhibiting its synthesis from its precursor l-citrulline blunts host defense. During the first few weeks following pulmonary mycobacterial infection, we found a drastic increase in l-citrulline in the lung, even though serum concentrations were unaltered. This correlated with increased gene expression of the l-citrulline-generating (i.e., iNOS) and l-citrulline-using (i.e., Ass1) enzymes in key myeloid populations. Eliminating l-arginine synthesis from l-citrulline in myeloid cells via conditional deletion of either
MeSH term(s)	Animals ; Arginine/immunology ; Arginine/metabolism ; Citrulline/immunology ; Citrulline/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mycobacterium Infections/immunology ; Mycobacterium Infections/metabolism ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/metabolism
Chemical Substances	Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1801569
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Discontinuous L-binding motifs in the transactivation domain of the vesicular stomatitis virus P protein are required for terminal

Gupta, Nirmala / Ogino, Minako / Watkins, Dean E / Yu, Tiffany / Green, Todd J / Ogino, Tomoaki

Journal of virology

2023 Volume 97, Issue 8, Page(s) e0024623

Abstract: The phospho- (P) protein, the co-factor of the RNA polymerase large (L) protein ...

Abstract	The phospho- (P) protein, the co-factor of the RNA polymerase large (L) protein, of vesicular stomatitis virus (VSV, a prototype of nonsegmented negative-strand RNA viruses) plays pivotal roles in transcription and replication. However, the precise mechanism underlying the transcriptional transactivation by the P protein has remained elusive. Here, using an
MeSH term(s)	Animals ; Vesicular Stomatitis/genetics ; Transcriptional Activation ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Vesiculovirus/metabolism ; Vesicular stomatitis Indiana virus/genetics ; Vesicular stomatitis Indiana virus/metabolism ; RNA, Messenger/genetics ; Amino Acids/genetics ; Transcription, Genetic ; Virus Replication/genetics
Chemical Substances	RNA, Viral ; RNA, Messenger ; Amino Acids
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00246-23
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Article ; Online: Odors Attracting the Long-Legged Predator Medetera signaticornis Loew to Ips typographus L. Infested Norway Spruce Trees.

Sousa, Maria / Birgersson, Göran / Karlsson Green, Kristina / Pollet, Marc / Becher, Paul G

Journal of chemical ecology

2023 Volume 49, Issue 7-8, Page(s) 451–464

Abstract: Predatory long-legged flies of the genus Medetera are important, but currently understudied, natural enemies of Scolytinae bark beetles such as Ips typographus. Medetera flies lay eggs on beetle-infested trees, where the developing larvae find their prey, ...

Abstract	Predatory long-legged flies of the genus Medetera are important, but currently understudied, natural enemies of Scolytinae bark beetles such as Ips typographus. Medetera flies lay eggs on beetle-infested trees, where the developing larvae find their prey, but the chemical cues used by Medetera to locate infested trees are currently unknown. To identify odors attracting Medetera signaticornis, a species in Europe, headspace samples were collected at several time-points through different stages of I. typographus attacks on logs of Norway spruce (Picea abies). The headspace samples were analyzed using combined gas chromatography and mass spectrometry (GC-MS), and gas chromatography coupled with electroantennographic detection (GC-EAD) to determine compounds that stimulate M. signaticornis antennae. Antennae of M. signaticornis males and females were found to detect (-)-cis-verbenol, ( +)-trans-verbenol and myrtenol, which are known to be produced by bark beetles. Antennal responses were also observed for verbenene, isoterpinolene, α-pinene oxide, camphor, pinocamphone, terpinene-4-ol, myrtenal, borneol, α-terpineol, geranyl acetone, and verbenone, which are primarily produced by microorganisms, and α-pinene, α-fenchene, β-pinene, camphene, 3-carene, limonene, γ-terpinene, and terpinolene, known spruce tree compounds. In field experiments testing two synthetic blends containing 18 antennal active and two additional compounds 2-methyl-3-buten-2-ol and ipsdienol we observed significant attraction of M. signaticornis within 24 h. These attractive blends can form the basis for development of Medetera monitoring lures for use in future forest and pest management.
MeSH term(s)	Male ; Animals ; Female ; Picea/chemistry ; Odorants ; Gas Chromatography-Mass Spectrometry ; Weevils ; Coleoptera/physiology ; Diptera ; Trees
Chemical Substances	verbenol (G0F32F922S)
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	800130-3
ISSN	1573-1561 ; 0098-0331
ISSN (online)	1573-1561
ISSN	0098-0331
DOI	10.1007/s10886-023-01405-6
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Article ; Online: Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD

Weeks, Ryan D / Banack, Sandra A / Howell, Shaunacee / Thunga, Preethi / Metcalf, James S / Green, Adrian J / Cox, Paul A / Planchart, Antonio

Neurotoxicity research

2023 Volume 41, Issue 5, Page(s) 496

Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00664-1
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Zs.A 5749: Show issues

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Article ; Online: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD

Weeks, Ryan D / Banack, Sandra A / Howell, Shaunacee / Thunga, Preethi / Metcalf, James S / Green, Adrian J / Cox, Paul A / Planchart, Antonio

Neurotoxicity research

2023 Volume 41, Issue 5, Page(s) 481–495

Abstract: β-N-Methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid produced by cyanobacteria ...

Abstract	β-N-Methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid produced by cyanobacteria, which has been implicated in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). It is postulated that chronic exposure to BMAA can lead to formation of protein aggregates, oxidative stress, and/or excitotoxicity, which are mechanisms involved in the etiology of ALS. While specific genetic mutations are identified in some instances of ALS, it is likely that a combination of genetic and environmental factors, such as exposure to the neurotoxin BMAA, contributes to disease. We used a transgenic zebrafish with an ALS-associated mutation, compared with wild-type fish to explore the potential neurotoxic effects of BMAA through chronic long-term exposures. While our results revealed low concentrations of BMAA in the brains of exposed fish, we found no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. Further research is needed to determine if chronic BMAA exposure in adult zebrafish is a suitable model to study neurodegenerative disease initiation and/or progression.
MeSH term(s)	Animals ; Zebrafish ; Neurodegenerative Diseases/etiology ; Amyotrophic Lateral Sclerosis/chemically induced ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/complications ; Amino Acids, Diamino/toxicity ; Animals, Genetically Modified ; Neurotoxins/toxicity ; Superoxide Dismutase
Chemical Substances	beta-N-methylamino-L-alanine (108SA6URTV) ; Amino Acids, Diamino ; Neurotoxins ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00658-z
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