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Article ; Online: Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis.

Julé, Amélie M / Lam, Ki Pui / Taylor, Maria / Hoyt, Kacie J / Wei, Kevin / Gutierrez-Arcelus, Maria / Case, Siobhan M / Chandler, Mia / Chang, Margaret H / Cohen, Ezra M / Dedeoglu, Fatma / Halyabar, Olha / Hausmann, Jonathan / Hazen, Melissa M / Janssen, Erin / Lo, Jeffrey / Lo, Mindy S / Meidan, Esra / Roberts, Jordan E /

Wobma, Holly / Son, Mary Beth F / Sundel, Robert P / Lee, Pui Y / Sage, Peter T / Chatila, Talal A / Nigrovic, Peter A / Rao, Deepak A / Henderson, Lauren A

Frontiers in immunology

2023 Volume 13, Page(s) 1068399

Abstract: ... arthritis, drive B cell maturation and antibody production in non-lymphoid tissues. We sought to determine ... if similarly dysregulated T cell-B cell interactions underlie another form of inflammatory arthritis, juvenile ... oligoarthritis (oligo JIA). Clonally expanded Tph cells able to promote B cell antibody production preferentially ...

Abstract	T peripheral helper (Tph) cells, identified in the synovium of adults with seropositive rheumatoid arthritis, drive B cell maturation and antibody production in non-lymphoid tissues. We sought to determine if similarly dysregulated T cell-B cell interactions underlie another form of inflammatory arthritis, juvenile oligoarthritis (oligo JIA). Clonally expanded Tph cells able to promote B cell antibody production preferentially accumulated in the synovial fluid (SF) of oligo JIA patients with antinuclear antibodies (ANA) compared to autoantibody-negative patients. Single-cell transcriptomics enabled further definition of the Tph gene signature in inflamed tissues and showed that Tph cells from ANA-positive patients upregulated genes associated with B cell help to a greater extent than patients without autoantibodies. T cells that co-expressed regulatory T and B cell-help factors were identified. The phenotype of these Tph-like Treg cells suggests an ability to restrain T cell-B cell interactions in tissues. Our findings support the central role of disordered T cell-help to B cells in autoantibody-positive arthritides.
MeSH term(s)	Humans ; Autoantibodies ; Arthritis, Rheumatoid ; T-Lymphocytes, Helper-Inducer ; Arthritis, Juvenile ; B-Lymphocytes
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1068399
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Article: Experiences in Patent Ductus Arteriosus Closure of Preterm Infants Transported to Another Center for Surgical Ligation.

Dedeoğlu, Savaş / Şaşmazel, Ahmet

Turkish archives of pediatrics

2023 Volume 58, Issue 5, Page(s) 503–508

Abstract: ... gestation weeks, respectively. The birth age of the sub-groups were A: ≤28 weeks and B: >28 weeks and ...

Abstract	Objective: The timing of surgical patent ductus arteriosus ligation in preterm infants remains controversial. Early ligation (<2 or 3 weeks of life) benefits preterm infants with a lower incidence of bronchopulmonary dysplasia and necrotizing enterocolitis. We present patent ductus arteriosus ligation experience in premature infants who had been transported for closure to an outside centre other than the hospital they were hospitalized. Materials and methods: We retrospectively evaluated 17 consecutive patients who had undergone surgery of premature infant patent ductus arteriosus closure during the period of March 2009-December 2020. Patent ductus arteriosus had been clipped in 17 patients. Results: The median birth weight and age were 930 g and 28 gestation weeks, respectively. The birth age of the sub-groups were A: ≤28 weeks and B: >28 weeks and birthweight were group I: ≤800 g and group II: >800 g. The median day of PDA ligation wasa 20 days, and patients with birthweight ≤800 g were ligated later than patients weighing >800 g. Two patients had intracranial hemorrhage, 6 had bronchopulmonary dysplasia, and 2 were dead. We found that exposure to large patent ductus arteriosus and low birth age in preterm babies was associated with longer hospitalization duration, preoperative mechanical ventilation time, and sepsis. Conclusion: Infants exposed to moderate-to-large patent ductus arteriosus requiring intubation and resistant to medical therapy for more than 2 weeks should have surgical ligation as soon as possible.
Language	English
Publishing date	2023-08-11
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2023.23066
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Article: Ultrasonographic evaluation of the masseter muscle in patients with temporomandibular joint degeneration.

Arıkan, Büşra / Dedeoğlu, Numan / Keskinrüzgar, Aydın

Imaging science in dentistry

2023 Volume 53, Issue 4, Page(s) 355–363

Abstract: Purpose: Sonographic elastography can be used to evaluate the hardness of muscle tissue through the application of compression. Strain elastography gauges hardness through the comparison of echo sets before and after compression. This study utilized ... ...

Abstract	Purpose: Sonographic elastography can be used to evaluate the hardness of muscle tissue through the application of compression. Strain elastography gauges hardness through the comparison of echo sets before and after compression. This study utilized ultrasonography to measure the thickness and hardness of the masseter muscle in individuals with temporomandibular joint (TMJ) osteoarthritis. Materials and methods: This study included 40 patients who presented with joint pain and were diagnosed with TMJ osteoarthritis via diagnostic cone-beam computed tomography, along with 40 healthy individuals. The thickness and hardness of each individual's masseter muscle were evaluated both at rest and at maximum bite using ultrasonography. The Mann-Whitney Results: The mean thickness of the resting masseter muscle was 0.91 cm in patients with osteoarthritis, versus 1.00 cm in healthy individuals. The mean thickness of the masseter muscle at maximum bite was 1.28 cm in osteoarthritis patients and 1.36 cm in healthy individuals. The mean masseter elasticity index ratio at maximum bite was 4.51 in patients with osteoarthritis and 3.16 in healthy controls. Significant differences were observed between patients with osteoarthritis and healthy controls in both the masseter muscle thickness and the masseter elasticity index ratio, at rest and at maximum bite ( Conclusion: The thickness of the masseter muscle in patients with TMJ osteoarthritis was less than that in healthy controls. Additionally, the hardness of the masseter muscle was greater in patients with TMJ osteoarthritis.
Language	English
Publishing date	2023-09-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2631801-5
ISSN	2233-7830 ; 2233-7822
ISSN (online)	2233-7830
ISSN	2233-7822
DOI	10.5624/isd.20230134
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Article ; Online: Minimally invasive plate osteosynthesiswith the application of a superior anatomic locking plate; is it a suitable treatment approach for AO-OTA Type B clavicular midshaft fractures?

Suleyman Semih Dedeoglu

Medicine Science, Vol 6, Iss 4, Pp 737-

2017 Volume 742

Abstract: ... osteosynthesis (MIPO) technique, on clinical and radiological outcomes in the surgical treatment of AO-OTA Type B ... option for the management of acute, displaced AO OTA Type B clavicular midshaft fractures. [Med-Science ...

Abstract	The minimally invasive osteosynthesis technique has gained attention in fracture treatment in recent years. The aim of this study was to evaluate the effects of the minimally invasive plate osteosynthesis (MIPO) technique, on clinical and radiological outcomes in the surgical treatment of AO-OTA Type B (wedge) clavicular midshaft fractures. This prospective study included twenty-three patients who were diagnosed with acute clavicular midshaft fracture where surgical intervention was indicatedand MIPO was performed between February 2014 and April 2016.Exclusion criteria were patients with non-displaced fractures, pathological fractures, open fractures, cases where theindex trauma was three weeks ago, or those with concomitant neurovascular injuries.The patients comprised of 16 males and 7 females with a mean age of 36.5 years (range, 18-65 years).The mean time from trauma to surgery was 6.1 days (range, 3-12 days).The mean follow-up period was 15.3 months (range: 12-18 months). The mean duration of surgery was 65.5 mins (range: 50-80 mins). Anatomic reduction was obtained in 11 (47%) patients, of whom 7 were Type B1, 4 were Type B2, and 1 was Type B3. The mean time to union was found to be 15.9 weeks (range: 10-24 weeks). After union was confirmed, the mean Constant Murley score was 83 (range: 68-92) and the mean UCLA score was 29.95 (range: 23-34). The mean proportional length difference in the clavicle was 0.32% (range:-0.55 to +1.63).There was no statistically significant difference for the Constant Murley score and UCLA score between patients with anatomic reduction achieved and not achieved (p=0.36, p=0.43 respectively). Osteosynthesis with a minimally invasive percutaneously applied plate (MIPO) could be a successful therapeutic option for the management of acute, displaced AO OTA Type B clavicular midshaft fractures. [Med-Science 2017; 6(4.000): 737-742]
Keywords	Minimal invasive surgery ; clavicle fracture ; plate fixation ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article ; Online: Morphometric Analysis of Cleft Lip Palate and Prognathic Mandibles in Relation to Mandibular Canal Course.

Sancar, Bahadir / Dedeoğlu, Numan

The Journal of craniofacial surgery

2021 Volume 32, Issue 2, Page(s) 694–697

Abstract: Introduction: This study aimed to evaluate the mandibular canal course in individuals with cleft lip palate (CLP) and mandibular prognathism in terms of the sagittal split-ramus osteotomy using cone-beam computed tomography.: Materials and methods: ... ...

Abstract	Introduction: This study aimed to evaluate the mandibular canal course in individuals with cleft lip palate (CLP) and mandibular prognathism in terms of the sagittal split-ramus osteotomy using cone-beam computed tomography. Materials and methods: Individuals with CLP older than 16 years of age and planned to undergo Le fort I + SSR osteotomies and those with class III occlusion planned to undergo Le fort I + SSR osteotomies were included. The measurements on the cleft side of CLP patients were compared with both their noncleft sides and those with class III occlusion. The course of the inferior alveolar nerve and its position in the mandible were evaluated starting from the mandibular foramen, the first entrance to the mandible, to the mental foramen, the exit from the mandible. Results: The distance between the mandibular canal and the buccal surface of the mandible (B3) on the plane tangent to the distal of the mandibular first molar and perpendicular to the occlusal plane was found to be greater in individuals with CLP (P = 0.011). Buccal cortex thickness (C4) at the level of the mandibular canal on the plane tangent to the distal of the mandibular second molar and perpendicular to the occlusal plane was found to be lower in individuals with CLP (P = 0.021). Conclusions: The buccal cortex thickness of the mandible corpus and the distance of the mandibular canal to the buccal surface is different in patients with CLP compared to class III individuals' posterior to the mandible. Surgeons should take these differences into consideration during mandibular osteotomy.
MeSH term(s)	Cleft Lip/diagnostic imaging ; Cleft Lip/surgery ; Cone-Beam Computed Tomography ; Humans ; Mandible/diagnostic imaging ; Osteotomy, Sagittal Split Ramus ; Palate ; Prognathism/diagnostic imaging ; Prognathism/surgery
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000007502
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Article ; Online: Triggers and clinical changes of childhood primary headache characteristics during COVID-19 pandemic lockdown.

Dedeoglu, Özge / Konuşkan, Bahadır

Acta neurologica Belgica

2022 Volume 123, Issue 1, Page(s) 215–220

Abstract: Objective: Children with primary headache are particularly vulnerable to the negative impacts of the pandemic due to factors like increased social isolation, disruption of sleep and impairment of healthy diet. We aimed to investigate the clinical ... ...

Abstract	Objective: Children with primary headache are particularly vulnerable to the negative impacts of the pandemic due to factors like increased social isolation, disruption of sleep and impairment of healthy diet. We aimed to investigate the clinical changes and triggering factors for childhood primary headaches to demonstrate the impact of the pandemic lockdown. Method: Children aged between 60 months and 18 years with headache complaint attending the general outpatient clinic between December 2019 and December 2020 were included in the study. Patients were classified according to ICHD-3 regarding clinical and laboratory data. Primary headaches diagnosed before (December 2019-March 2020) and during the pandemic lockdown (April 2020-December 2020) were divided into two groups as migraine and tension-type headache (TTH). Clinical picture and triggering factors were compared between groups to illustrate the effect of the lockdown. Results: The study included 612 subjects, with 463 patients (76%) classified in the primary headache group and 149 (24%) in the secondary headache group. Among the first group, 267 patients (58%) had migraine and 196 patients (42%) had TTH. Comparisons between before and during the pandemic lockdown showed significant increased frequency of TTH, but no difference in the frequency and duration of migraine. Both screen exposure and sleep pattern changes were found to be significantly increased in the TTH group during the pandemic lockdown. Discussion: We found a significant increase in the attack frequency for TTH patients during the pandemic lockdown. Reduction in screen time is an important strategy in preventing primary headache attacks in children.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Pandemics ; COVID-19 ; Communicable Disease Control ; Headache ; Tension-Type Headache/diagnosis ; Migraine Disorders/diagnosis
Language	English
Publishing date	2022-12-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02150-5
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Article ; Online: Feasibility of diagnosing osteoporosis using routine computed tomography scans for hip fractures: Correlation with histopathological diagnosis of head and neck regions.

Imren, Yunus / Karslioğlu, Bulent / Semih Dedeoğlu, Suleyman / Keskin, Ahmet / Firat Berkay, Ahmet / Cagri Tekin, Ali

Acta orthopaedica et traumatologica turcica

2024 Volume 57, Issue 6, Page(s) 384–388

Abstract: Objective: The aim of this study was to demonstrate the feasibility of diagnosing osteoporosis through routine computed tomography (CT) by assessing the association between the histopathological assessment of femoral head specimens extracted from ... ...

Abstract	Objective: The aim of this study was to demonstrate the feasibility of diagnosing osteoporosis through routine computed tomography (CT) by assessing the association between the histopathological assessment of femoral head specimens extracted from patients who underwent surgery for intertrochanteric fractures and the Hounsfield unit (HU) measurements derived from preoperative CT scans. Methods: Forty-eight patients who presented to our clinic between November 2019 and May 2020 with hip fractures and underwent partial prosthesis fixation were included in this retrospective study. Hounsfield unit measurements were performed on the head and neck regions using dual-energy x-ray absorptiometry (DEXA) and CT scans, respectively. The trabecular ratio per unit area was calculated using the Nikon Imaging Software (NIS-Elements ) program in the pathology laboratory from digitally captured images of the removed head and neck specimens. Results: The mean HU receiver operating characteristic analysis had a sensitivity of 77% and a specificity of 87%, with a cutoff value of 77.68. There was a moderate correlation between the mean trabecular density and the mean HU of the femoral head (P=0.013, r=0.340). Additionally, there was a significant correlation between the mean HU and the T-score of the head, although this correlation was not found with the maximum-minimum HU. Although there was a significant correlation between trabecular density and mean HU, the correlation coefficient indicated a moderate relationship. This relationship was also observed between the inferior sections of the head and the trabecular density and HU (P=.018). However, no significant correlation was found between the T-score and the trabecular structure of the head (P=.977). Conclusion: The results of the present study suggest that conventional CT has the potential to serve as a diagnostic tool for osteoporosis and may offer a more precise and accurate method for evaluating the success of intraosseous implants when compared to T-scores without the need for additional tests or procedures.
MeSH term(s)	Humans ; Bone Density ; Retrospective Studies ; Feasibility Studies ; Osteoporosis/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Absorptiometry, Photon/methods ; Hip Fractures/diagnostic imaging ; Hip Fractures/surgery ; Lumbar Vertebrae
Language	English
Publishing date	2024-03-07
Publishing country	Turkey
Document type	Journal Article
ISSN	2589-1294
ISSN (online)	2589-1294
DOI	10.5152/j.aott.2023.23126
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Article ; Online: New-Onset Vision Impairment in Children: Magnetic Resonance Imaging Findings by Age Groups.

Çıvgın, Esra / Duran, Semra / Parlak, Izzet Selçuk / Gülleroğlu, Başak / Timur, İnci Elif Erbahçeci / Dedeoğlu, Özge / Ekşioğlu, Ayşe Seçil Yücel

Journal of child neurology

2024 , Page(s) 8830738241239696

Abstract: Introduction: Non-traumatic visual impairment is rare in the pediatric population, but early diagnosis and treatment of the cause is crucial to prevent long-term consequences affecting children's neurocognitive development. The authors aim to determine ... ...

Abstract	Introduction: Non-traumatic visual impairment is rare in the pediatric population, but early diagnosis and treatment of the cause is crucial to prevent long-term consequences affecting children's neurocognitive development. The authors aim to determine the most common causes of non-traumatic visual impairment in pediatric patients according to age groups by magnetic resonance imaging (MRI). Methods: Images of patients who underwent contrast-enhanced cranial and orbital MRI for new-onset visual impairment between June 2019 and June 2022 were retrospectively reviewed. MRI findings were categorized as tumors, idiopathic intracranial hypertension, demyelinating disorders, infections, isolated optic neuritis, and others. The patients were grouped according to age as preschoolers, schoolchildren, and adolescents. Demographic features of patients and MRI findings were collected and compared among age groups. Results: One hundred seventeen of the 238 patients had pathologic MRI findings. The most common pathologies were tumors (26.4%), idiopathic intracranial hypertension (24.7%), demyelinating disorders (18.8%), infections (11.1%), and isolated optic neuritis (7.6%). Tumors (69.2%) in preschool children, idiopathic intracranial hypertension (36.3%) in schoolchildren, and demyelinating disorders (32.7%) in adolescents were the most common cause of vision impairment by age group. Conclusion: Children with acute vision impairment could have severe pathologies. Tumors in preschool children, idiopathic intracranial hypertension in schoolchildren, and demyelinating disorders in adolescents were the most common causes of new-onset vision impairment detected with MRI. Because of the difficulty of performing optimal ophthalmologic and neurologic examinations, especially in young children, cranial and orbital MRI should be considered to detect life-threatening pathologies.
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738241239696
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Article: The chemical and electrochemical stimuli viologen substituted phthalocyanine with tunable optical features1.

Ateş, Özge Dilara / Tunç, Gülenay / Şenocak, Ahmet / Dedeoğlu, Burcu / Ayhan, Mehmet Menaf / Gürek, Ayşe Gül

Turkish journal of chemistry

2023 Volume 47, Issue 5, Page(s) 1149–1159

Abstract: In this study, viologen-tetrasubstituted Zn(II) phthalocyanines ( ...

Abstract	In this study, viologen-tetrasubstituted Zn(II) phthalocyanines (
Language	English
Publishing date	2023-05-22
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046471-X
ISSN	1303-6130 ; 1300-0527
ISSN (online)	1303-6130
ISSN	1300-0527
DOI	10.55730/1300-0527.3601
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Article: Comparison of Functional Outcomes and Complications of Inlay and Onlay Reverse Shoulder Arthroplasty in Neer Type 4 Proximal Humerus Fractures and Cuff Tear Arthropathy: A Multicentric Study.

Kahraman, Sinan / Karslioglu, Bulent / Imren, Yunus / Keskin, Ahmet / Bilsel, Kerem / Dedeoglu, Suleyman Semih

Indian journal of orthopaedics

2024 Volume 58, Issue 3, Page(s) 263–270

Abstract: ... Group A received inlay humeral components, while Group B received onlay humeral components. Functional ... The study included 67 patients in Group A and 62 patients in Group B. Group A had significantly better ...

Abstract	Background: This multicenter retrospective study was conducted with the objective of comparing the outcomes and complications between inlay and onlay reverse shoulder arthroplasty (RSA) in patients presenting Neer Type 4 proximal humerus fractures and cuff tear arthropathy. The primary aim of this investigation was to assess and juxtapose the clinical as well as functional outcomes of individuals who underwent onlay reverse shoulder arthroplasty with those who underwent inlay reverse shoulder arthroplasty. Methods: A retrospective cohort study was conducted, involving patients who had undergone reverse shoulder arthroplasty between the period of 2016 and 2022. The study divided the population into two groups: Group A received inlay humeral components, while Group B received onlay humeral components. Functional outcomes were evaluated using the American Shoulder and Elbow Surgeons (ASES) and Constant scores. Range of motion, infection, periprosthetic fractures, and nerve injuries were also assessed. Results: The study included 67 patients in Group A and 62 patients in Group B. Group A had significantly better functional outcomes, as indicated by higher ASES and Constant scores ( Conclusion: Inlay humeral components in reverse shoulder arthroplasty for Neer Type 4 fractures and cuff tear arthropathy resulted in better functional outcomes, increased range of motion, and lower incidence of periprosthetic fractures compared to onlay components. Onlay components showed potential advantages in reducing instability rates. Further studies with larger samples and standardized protocols are needed to confirm these findings.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-01084-1
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