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  1. Article ; Online: Editorial Comment: Novel Immunotherapies for Alzheimer Disease and Cerebral Amyloid Angiopathy Create New Challenges and Opportunities in Neuroimaging.

    Özütemiz, Can

    AJR. American journal of roentgenology

    2022  Volume 220, Issue 4, Page(s) 575

    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/therapy ; Cerebral Amyloid Angiopathy/diagnostic imaging ; Cerebral Amyloid Angiopathy/therapy ; Neuroimaging/methods
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.22.28721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.57: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Vigabatrin Neurotoxicity in Pediatric Brain.

    Dinçer, Ceren / Özütemiz, Can

    Radiology

    2024  Volume 310, Issue 1, Page(s) e231603

    MeSH term(s) Humans ; Child ; Vigabatrin/adverse effects ; Brain/diagnostic imaging ; Head
    Chemical Substances Vigabatrin (GR120KRT6K)
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.231603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Case report: Delayed posttraumatic cortical laminar necrosis secondary to spreading depolarization induced spreading ischemia from old subarachnoid hemorrhage.

    Irfanullah, Zakariya / Özütemiz, Ayça Özbek / Robertson, Jetter / Özütemiz, Can

    Radiology case reports

    2022  Volume 17, Issue 6, Page(s) 2220–2226

    Abstract: Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case ... ...

    Abstract Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case of trauma. We report a unique case of delayed post-traumatic CLN which occurred 30 days after the initial trauma, without any proven cause apart from possible spreading depolarization induced spreading ischemia from adjacent subarachnoid hemorrhage with distinct radiologic features.
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Images in Vascular Medicine: Radiologic confirmation of Pemberton's sign.

    Hofstedt, Daniel / Elkadi, Ghassan H / Özütemiz, Ayça Özbek / Özütemiz, Can

    Vascular medicine (London, England)

    2022  Volume 27, Issue 5, Page(s) 513–514

    MeSH term(s) Humans ; Cardiology ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Thyroid Gland/surgery ; Thyroidectomy ; Phlebography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X221093399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Lymphadenopathy after the third Covid-19 vaccine.

    Özütemiz, Can / Potter, David A / Özütemiz, Ayça Özbek / Steinberger, Daniel

    Current problems in cancer. Case reports

    2021  Volume 4, Page(s) 100127

    Abstract: Axillary lymphadenopathy ipsilateral to the vaccination site has been clinically and radiologically reported after administration of COVID-19 vaccines. This can be an important diagnostic dilemma, particularly in cancer patients who are being staged or ... ...

    Abstract Axillary lymphadenopathy ipsilateral to the vaccination site has been clinically and radiologically reported after administration of COVID-19 vaccines. This can be an important diagnostic dilemma, particularly in cancer patients who are being staged or re-staged, as this benign entity may mimic metastasis, cause unnecessary biopsies and changes in therapy. Here we present a breast cancer patient and a patient with squamous cell carcinoma of the head and neck, who had already received the first two doses of mRNA type COVID-19 vaccines before, now presenting with new hypermetabolic reactive lymphadenopathy on FDG PET/CT after the third booster dose.
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Case Reports
    ISSN 2666-6219
    ISSN (online) 2666-6219
    DOI 10.1016/j.cpccr.2021.100127
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  6. Article ; Online: Lumbar puncture under fluoroscopy guidance: a technical review for radiologists.

    Özütemiz, Can / Rykken, Jeffrey B

    Diagnostic and interventional radiology (Ankara, Turkey)

    2019  Volume 25, Issue 2, Page(s) 144–156

    Abstract: There are many differences in fluoroscopy-guided lumbar puncture (FG-LP) technique among radiologists. Even within the same institution, there are a variety of preferences among proceduralists with individual perspectives based on the literature, ... ...

    Abstract There are many differences in fluoroscopy-guided lumbar puncture (FG-LP) technique among radiologists. Even within the same institution, there are a variety of preferences among proceduralists with individual perspectives based on the literature, training, and/or experience. Our aim is to provide familiarity with various techniques involved in FG-LP and provide insight on how to improve patient outcomes. The pertinent anatomy and physiology, indications, contraindications, patient management, complications of the procedure, and procedural techniques for performing an FG-LP are reviewed in detail. Potentially controversial topics regarding FG-LP are also addressed. There are many differences in fluoroscopy-guided lumbar puncture (FG-LP) technique among radiologists (1). Even within the same institution, there are a variety of individual preferences among physicians with different perspectives based on a combination of literature familiarity, training, and personal experience. Our aim is to provide familiarity with various techniques involved in FG-LP, improve efficiency, and improve patient outcomes. We will also address possible controversial issues regarding FG-LPs using an evidence-based approach.
    MeSH term(s) Anatomy ; Cerebrospinal Fluid/physiology ; Female ; Fluoroscopy/methods ; Humans ; Intracranial Pressure/physiology ; Male ; Needles ; Post-Dural Puncture Headache/epidemiology ; Radiologists/statistics & numerical data ; Radiology, Interventional ; Spinal Puncture/adverse effects ; Spinal Puncture/methods ; Young Adult
    Language English
    Publishing date 2019-02-18
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2184145-7
    ISSN 1305-3612 ; 1305-3825
    ISSN (online) 1305-3612
    ISSN 1305-3825
    DOI 10.5152/dir.2019.18291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stability of serial platelet and urine protein measurements in patients receiving nusinersen for spinal muscular atrophy.

    Nagarajan, Eric K / Özütemiz, Can / Rubin, Nathan / Nascene, David R

    Muscle & nerve

    2022  Volume 66, Issue 1, Page(s) 76–79

    Abstract: Introduction/aims: Patients undergoing nusinersen treatment for spinal muscular atrophy are subject to measurements of platelet count and urine protein before each injection due to concern for platelet depletion and renal dysfunction according to the ... ...

    Abstract Introduction/aims: Patients undergoing nusinersen treatment for spinal muscular atrophy are subject to measurements of platelet count and urine protein before each injection due to concern for platelet depletion and renal dysfunction according to the prescribing information. These tests may be uncomfortable or inconvenient and may cause delays in treatment. However, it is still unclear whether these values have been significantly affected by nusinersen treatment. Our aim in this study was to determine whether these measurements ever reached critical values that necessitated withholding treatment at our center.
    Methods: Records from 57 patients treated with nusinersen at our institution between 2017 and 2020 were retrospectively analyzed. Laboratory values for platelet count, random urine protein, and total urine protein:creatinine ratio were collected from all patients before each procedure.
    Results: Mean patient age was 28.9 years (range, 2-76 years). Mean platelet count was 307 × 10
    Discussion: Although further study on a larger cohort is warranted for more definitive conclusions, it may not be necessary to measure platelet count and urine protein before each nusinersen treatment, particularly in the maintenance phase.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Creatinine/urine ; Humans ; Injections, Spinal ; Middle Aged ; Muscular Atrophy, Spinal/drug therapy ; Oligonucleotides/administration & dosage ; Oligonucleotides/adverse effects ; Oligonucleotides/therapeutic use ; Platelet Count ; Proteinuria/urine ; Retrospective Studies ; Spinal Muscular Atrophies of Childhood/drug therapy ; Young Adult
    Chemical Substances Oligonucleotides ; nusinersen (5Z9SP3X666) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 551: Show issues

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  8. Article ; Online: Case report

    Zakariya Irfanullah, MD / Ayça Özbek Özütemiz, MD / Jetter Robertson, DO / Can Özütemiz, MD

    Radiology Case Reports, Vol 17, Iss 6, Pp 2220-

    Delayed posttraumatic cortical laminar necrosis secondary to spreading depolarization induced spreading ischemia from old subarachnoid hemorrhage

    2022  Volume 2226

    Abstract: Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case ... ...

    Abstract Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case of trauma. We report a unique case of delayed post-traumatic CLN which occurred 30 days after the initial trauma, without any proven cause apart from possible spreading depolarization induced spreading ischemia from adjacent subarachnoid hemorrhage with distinct radiologic features.
    Keywords Trauma ; Cortical laminar necrosis ; Subarachnoid hemorrhage ; Spreading depolarization ; Spreading ischemia ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Intracranial MRI Findings in a Patient with FBXO11-Related Disorder

    Chandra, Vishal / Aggarwal, Anjali / Moen, Amanda / Strul, Sasha / Özütemiz, Can

    Journal of Pediatric Neurology

    2023  

    Abstract: FBXO11- related intellectual developmental disorder with dysmorphic facies and behavioral abnormalities is a rare genetic disorder. Brain magnetic resonance imaging (MRI) findings associated with this disorder have been sparsely described in literature. ... ...

    Abstract FBXO11- related intellectual developmental disorder with dysmorphic facies and behavioral abnormalities is a rare genetic disorder. Brain magnetic resonance imaging (MRI) findings associated with this disorder have been sparsely described in literature. This case report describes and depicts brain MRI of a patient with FBXO11 -related disorder. The radiologic findings within this report aim to improve the knowledge of the radiologists and clinicians in the detection of this rare condition.
    Keywords brain ; MRI ; radiology
    Language English
    Publishing date 2023-08-28
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1875-9041 ; 1304-2580
    ISSN (online) 1875-9041
    ISSN 1304-2580
    DOI 10.1055/s-0043-1772491
    Database Thieme publisher's database

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  10. Article ; Online: Nusinersen injections in adults and children with spinal muscular atrophy: a single-center experience.

    Özütemiz, Can / Karachunski, Peter / Nascene, David R

    Diagnostic and interventional radiology (Ankara, Turkey)

    2020  Volume 26, Issue 6, Page(s) 596–602

    Abstract: Purpose: Nusinersen is a drug approved in December 2016 for treatment of spinal muscular atrophy (SMA). We want to share our initial experience with image-guided, non-image-guided, and port-delivered nusinersen injections in a large single-center SMA ... ...

    Abstract Purpose: Nusinersen is a drug approved in December 2016 for treatment of spinal muscular atrophy (SMA). We want to share our initial experience with image-guided, non-image-guided, and port-delivered nusinersen injections in a large single-center SMA patient cohort, treating both pediatric and adult patients with focus on technical considerations and other patient concerns from a combined perspective of patient, neurologist, and radiologist.
    Methods: All nusinersen injections between February 2017 and September 2018 were retrospectively reviewed. We obtained age, sex, SMA type and technical details of the injections and postprocedure complications for each procedure.
    Results: A total of 52 patients (24 women [46%]; 4 patients with SMA-1 [7.6%]; 30 patients with SMA-2 [57.8%]; 18 patients with SMA-3 [34.6%]; mean age, 25.5 years [7 months to 62 years]) with a total of 265 injections were included. Of the 265 injections, 206 (77.9%) were performed with local anesthetic, 25 (9.4%) with moderate sedation, and 23 (8.6%) under general anesthesia. We performed 65 CT-guided transforaminal injections in 13 patients, 106 fluoroscopy-guided lumbar punctures in 24 patients and 83 lumbar punctures in 16 patients using conventional technique. Only 6 of 265 injections (2.2%) ended up with a post-lumbar puncture headache (PLPH) requiring medical treatment. None required an epidural blood patch. Fourteen PLPH (5.2%) occurred and resolved at the same day without any treatment. After 6 of 265 injections (2.2%), patients reported soreness at the injection site which resolved spontaneously. Three elected to have an intrathecal reservoir placement (2 lumbar, 1 intraventricular) with a total of 11 injections. One patient with lumbar catheter developed infection after surgery with subsequent meningitis and treatment delay. After the resolution of meningitis, a new intraventricular reservoir was placed without any complication in the following injections.
    Conclusion: With the introduction of nusinersen treatment, neurologists and radiologists play an important role in treatment of SMA patients and therefore should be familiar with different techniques and complications of drug administration. Using good technique, it is possible to have very low complication rates even in this complex patient population, and various image-guided procedures can be a safe alternative to surgical approach, even in the most difficult cases.
    MeSH term(s) Adult ; Child ; Female ; Humans ; Injections, Spinal ; Muscular Atrophy, Spinal/drug therapy ; Oligonucleotides/therapeutic use ; Retrospective Studies
    Chemical Substances Oligonucleotides ; nusinersen (5Z9SP3X666)
    Language English
    Publishing date 2020-05-21
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2184145-7
    ISSN 1305-3612 ; 1305-3612
    ISSN (online) 1305-3612
    ISSN 1305-3612
    DOI 10.5152/dir.2020.19607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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