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Article ; Online: Very important pharmacogenetic variants landscape and potential clinical relevance in the Zhuang population from Yunnan province.

Li, Yujie / Chang, Yanting / Yan, Yan / Ma, Xiaoya / Zhou, Wenqian / Zhang, Huan / Guo, Jinping / Wei, Jie / Jin, Tianbo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7495

Abstract: ... variants that differ in Zhuang population compared with other populations and investigate their potential ... were genotyped in 200 Zhuang subjects using the Agena MassARRAY platform. The allele frequencies and ... between the Zhuang population and the other 26 populations. It was also found that the Chinese Dai ...

Abstract	The gradual evolution of pharmacogenomics has shed light on the genetic basis for inter-individual drug response variations across diverse populations. This study aimed to identify pharmacogenomic variants that differ in Zhuang population compared with other populations and investigate their potential clinical relevance in gene-drug and genotypic-phenotypic associations. A total of 48 variants from 24 genes were genotyped in 200 Zhuang subjects using the Agena MassARRAY platform. The allele frequencies and genotype distribution data of 26 populations were obtained from the 1000 Genomes Project, followed by a comparison and statistical analysis. After Bonferroni correction, significant differences in genotype frequencies were observed of CYP3A5 (rs776746), ACE (rs4291), KCNH2 (rs1805123), and CYP2D6 (rs1065852) between the Zhuang population and the other 26 populations. It was also found that the Chinese Dai in Xishuangbanna, China, Han Chinese in Beijing, China, and Southern Han Chinese, China showed least deviation from the Zhuang population. The Esan in Nigeria, Gambian in Western Division, The Gambia, and Yoruba in Ibadan, Nigeria exhibited the largest differences. This was also proved by structural analysis, Fst analysis and phylogenetic tree. Furthermore, these differential variants may be associated with the pharmacological efficacy and toxicity of Captopril, Amlodipine, Lisinopril, metoclopramide, and alpha-hydroxymetoprolol in the Zhuang population. Our study has filled the gap of pharmacogenomic information in the Zhuang population and has provided a theoretical framework for the secure administration of drugs in the Zhuang population.
MeSH term(s)	Humans ; Pharmacogenomic Variants ; Phylogeny ; Clinical Relevance ; Polymorphism, Single Nucleotide ; China ; Nigeria ; Gene Frequency ; Genotype
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58092-w
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Article: Prevalence and contributing factors of malocclusion in Zhuang children aged 7-8 years in southern China.

Mai, Wenjia / Xiao, Lijuan / Chen, Shaoyong / Chen, Shuang / Li, Andi / Zhang, Tingting / He, Haoyu / Zeng, Xiaojuan

Frontiers in pediatrics

2024 Volume 12, Page(s) 1308039

Abstract: ... its contributing factors in Chinese Zhuang children aged 7-8 years.: Methods: Overall, 2,281 Zhuang children ... of malocclusion in Zhuang children aged 7-8 years was 58.5%, with the highest prevalence of anterior crossbite ... to malocclusion in Zhuang children.: Conclusion: Malocclusion is a common oral problem among Zhuang children ...

Abstract	Introduction: Malocclusion, a common oral health problem in children, is associated with several contributing factors. This study aimed to investigate the prevalence of mixed dentition stage malocclusion and its contributing factors in Chinese Zhuang children aged 7-8 years. Methods: Overall, 2,281 Zhuang children, about 7-8 years old, were randomly selected using a stratified whole-cluster sampling method from schools in counties in Northwestern Guangxi, China. The children were examined on-site for malocclusion and caries by trained dentists, and basic data on the children were collected using questionnaires, including age, sex, parental education, parental accompaniment, and children's knowledge of malocclusion and treatment needs. Data were analyzed using the chi-square test and logistic regression analysis. Results: The total prevalence of malocclusion in Zhuang children aged 7-8 years was 58.5%, with the highest prevalence of anterior crossbite tendency, and the prevalence of anterior crossbite and anterior edge-to-edge occlusion was 15.1% and 7.7%, respectively. This was followed by an anterior increased overjet of 13.3% and an inter-incisor spacing of 10.3%. The lowest prevalence was 2.7% for anterior open bite. Sex, parental accompaniment, parental education, and decayed, missing, and filled teeth of the first primary molar were factors that contributed to malocclusion in Zhuang children. Conclusion: Malocclusion is a common oral problem among Zhuang children. Therefore, more attention must be paid to the intervention and prevention of malocclusion. The impact factors should be controlled as early as possible.
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1308039
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Article ; Online: Application of human data to predict hamstring tendon autograft diameter in Zhuang population.

Huang, Xiao-Li / Zheng, Hong-Yu / Yang, Hui-Hui / Shi, Ze-Feng / Zhang, Bing / Lan, Bei / Wang, Hong / Tan, Ru-Xin

International journal of rheumatic diseases

2022 Volume 26, Issue 3, Page(s) 464–470

Abstract: Background: To explore the value of human data from the Zhuang population via predicting ... determining the feasibility of preoperative ultrasound for prediction.: Methods: In total, 24 Zhuang ... In Zhuang patients undergoing ACL reconstruction with 4 S-STG, body weight more accurately predicted graft ...

Abstract	Background: To explore the value of human data from the Zhuang population via predicting the diameter of the hamstring tendon autograft in anterior cruciate ligament (ACL) reconstruction and determining the feasibility of preoperative ultrasound for prediction. Methods: In total, 24 Zhuang patients who underwent ACL reconstruction with a 4-strand semitendinosus and gracilis tendon autograft (4 S-STG) were enrolled in this study. Before the operation, the affected semitendinosus tendon (ST) was examined by ultrasonography, and its length, diameter, cross-sectional area, and circumference were measured. The patients' basic information and body data, ie, height, weight, body mass index, lower limb length injured, and thigh circumference injured, were recorded. Their ST and gracilis tendon lengths and diameters and 4 S-STG diameter were measured during the operation. A correlation analysis was conducted between the ultrasound measurement results and human data and intraoperative tendon measurements. Results: The ST diameter measured by ultrasound was correlated with the ST length and ST diameter measured during operation, and the ST circumference measured by ultrasound was correlated with the ST diameter measured during operation. The patients' body weight can be used to distinguish a 4 S-STG diameter of ≥8 mm (P < .01, mean difference = 11.59). The area under the receiver operating characteristic curve of body weight was 0.829. The final graft diameter ≥8 mm could be predicted with a body weight of 61.5 kg as the cutoff point; the sensitivity and specificity were 72.2% and 83.3%, respectively. Conclusion: In Zhuang patients undergoing ACL reconstruction with 4 S-STG, body weight more accurately predicted graft diameter than preoperative semitendinosus diameter.
MeSH term(s)	Humans ; Hamstring Tendons/transplantation ; Autografts ; Transplantation, Autologous ; Tendons ; Body Weight
Language	English
Publishing date	2022-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14545
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Article ; Online: Spatio-temporal heterogeneity and coupling effect of mining economy, social governance and environmental conservation: Evidence from Guangxi Zhuang Autonomous Region, China.

Liu, Mingkai / Zhang, Hongyan / Hou, Kaixin / Gong, Xiaoju / Liu, Changxin

PloS one

2024 Volume 19, Issue 4, Page(s) e0301585

Abstract: ... and environmental conservation in global resource-based cities, we choose Guangxi Zhuang Autonomous ...

Abstract	In order to solve the problem of coordinated development among mining economy, social governance and environmental conservation in global resource-based cities, we choose Guangxi Zhuang Autonomous Region as the research area. The advantage of resource endowment and resource industry was measured by location quotient and input-output method. The panel data related to mining governance from 2010 to 2021 were selected to build the evaluation and coupling analysis model between mining economic, social governance and environmental conservation, and the spatial-temporal heterogeneity and coupling effect of them were analyzed by comprehensive empowerment evaluation, spatial autocorrelation analysis and barrier degree methods. The results show that: (1) Except for the overall upward trend of social governance, the development level of mining economy and environmental conservation are basically stable; (2) The resource-rich areas have obvious mining economic advantages, and the central cities have good social governance capabilities, and the environmental conservation effectiveness is uncertain; (3) The coupling effect between mining economy and social governance is stronger than that between mining economy and environment conservation, and the synergistic coupling effect of the three is relatively random. Finally, we put forward some policy response strategies to Guangxi, and theoretical and practical reference would be provided for resource-based cities around the world.
MeSH term(s)	China ; Cities ; Urbanization ; Economic Development ; Industry ; Conservation of Natural Resources
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301585
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Article ; Online: Exploring the forensic effectiveness and population genetic differentiation by self-constructed 41 multi-InDel panel in Yunnan Zhuang group.

Mei, Shuyan / Yi, Shaohua / Cai, Meiming / Zhang, Yunying / Cui, Wei / Xu, Hui / Lan, Qiong / Zhu, Bofeng

Gene

2023 Volume 860, Page(s) 147180

Abstract: Yunnan is one of the main residences of the Zhuang group which is one of the 55 ethnic minorities ... of the Yunnan Zhuang group. Therefore, this study used a self-constructed panel containing 41 multi-InDel ... markers to analyze the genetic polymorphisms of 173 individuals from Yunnan Zhuang group. The results ...

Abstract	Yunnan is one of the main residences of the Zhuang group which is one of the 55 ethnic minorities in China. At present, there are relatively few researches on population genetics and forensic science of the Yunnan Zhuang group. Therefore, this study used a self-constructed panel containing 41 multi-InDel markers to analyze the genetic polymorphisms of 173 individuals from Yunnan Zhuang group. The results indicated that these 41 multi-InDels in Yunnan Zhuang group were highly polymorphic markers expect for three markers. The cumulative match probability and combined exclusion probability values of the 40 multi-InDels (MI38 marker was excluded) were 8.0671E-26 and 0.9999995959, respectively. In addition, population genetic analyses were performed on genotyping data of 41 multi-InDel markers among the Yunnan Zhuang and 26 reference populations, revealing that the Yunnan Zhuang group was genetically close to the five populations in East Asia. According to the STRUCTURE analysis, the Yunnan Zhuang group presented similar ancestral compositions to the five populations from East Asia, and when the K value was three, the five intercontinental populations showed their different genetic structures. In conclusion, the 41 multi-InDel markers could be used as an effective tool for individual identification and paternity testing of the Zhuang group in Yunnan province, as well as for their ancestry information inference studies.
MeSH term(s)	Humans ; Asian People/genetics ; China ; Genetics, Population ; Polymorphism, Genetic ; Genetic Drift ; Forensic Genetics/methods ; INDEL Mutation ; Gene Frequency
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147180
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Article ; Online: Genetic polymorphisms of 19 X-STRs in populations of Hubei Han and Guangxi Zhuang and their comparisons with 13 other Chinese populations.

Long, Fei / Fang, Hui / Zhang, Chunmei / Chen, Shengjie / Huang, Daixin / Xiao, Chao

Annals of human biology

2023 Volume 50, Issue 1, Page(s) 8–14

Abstract: ... in Hubei Province, Central China, and the Zhuang people residing in the Guangxi Zhuang Autonomous Region ... Subjects and methods: In total, 509 unrelated Han males and 266 unrelated Zhuang males were genotyped ... in the Hubei Han and Guangxi Zhuang populations, and the AGCU X19 STR kit was shown to be suitable for forensic ...

Abstract	Background: A prerequisite for applying short tandem repeat (STR) kits is obtaining population allele and/or haplotype frequencies and forensic parameters. Aim: Firstly, we aimed to investigate the population data of 19 X-chromosomal STRs (X-STRs) included in the AGCU X19 STR kit in the Han people residing in Hubei Province, Central China, and the Zhuang people residing in the Guangxi Zhuang Autonomous Region of South China. Furthermore, we compared these population data with those for other Chinese populations. Subjects and methods: In total, 509 unrelated Han males and 266 unrelated Zhuang males were genotyped using the AGCU X19 STR kit. Allele frequencies, haplotype frequencies, and forensic parameters were computed, and genetic differences among 15 Chinese populations were analysed. Results: The 19 X-STRs showed a high power of discrimination and high mean chance of exclusion, whether calculated using allele or haplotype frequencies. Major differences were found between Han and Oroqen, Uyghur, Mongolian, Tibetan, Li, and Yi populations. Aberrant biallelic patterns at DXS10159, DXS10134, and DXS10079 and allelic dropouts at DXS10164 were observed. Conclusion: The 19 X-STRs were highly polymorphic in the Hubei Han and Guangxi Zhuang populations, and the AGCU X19 STR kit was shown to be suitable for forensic casework.
MeSH term(s)	Male ; Humans ; Genetics, Population ; East Asian People ; China ; Chromosomes, Human, X/genetics ; Polymorphism, Genetic ; Gene Frequency ; Microsatellite Repeats/genetics
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460.2023.2166990
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Article: Predicting autologous hamstring graft diameter and finding reliable measurement levels in the Zhuang population using preoperative ultrasonography.

Huang, Xiao-Li / Zheng, Hong-Yu / Shi, Ze-Feng / Yang, Hui-Hui / Zhang, Bing / Yang, Xiao-Chun / Wang, Hong / Tan, Ru-Xin

Frontiers in physiology

2022 Volume 13, Page(s) 916438

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.916438
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Article: Epidemiology of childhood trauma and its association with insomnia and psychotic-like experiences in Chinese Zhuang adolescents.

Wei, Qiaoyue / Pan, Yuli / Zhang, Shengjie / Yin, Wenwen / Lin, Qinghong / Pan, Shuibo / Dai, Chenyangzi / Zhou, Linhua / Wu, Junduan

Frontiers in psychiatry

2022 Volume 13, Page(s) 974674

Abstract: ... its relationship with insomnia and PLEs in Chinese Zhuang adolescents, focusing on the role of a specific type ... CCAPE- 8) were all completed by 1,493 Chinese Zhuang adolescents. Chi-square and multivariate ...

Abstract	Background: Adolescents who have experienced childhood trauma are more likely to have insomnia and psychotic-like experiences (PLEs) than adolescents from other ethnic groups. However, little is known about the youth of ethnic minorities. This study aimed to investigate the epidemiology of childhood trauma and its relationship with insomnia and PLEs in Chinese Zhuang adolescents, focusing on the role of a specific type of trauma and accumulation. Methods: A questionnaire of Childhood Trauma Questionnaire-Short Form (CTQ-SF), Athens Insomnia Scale (AIS), and Chinese Version Community assessment psychic experiences-8 (CCAPE- 8) were all completed by 1,493 Chinese Zhuang adolescents. Chi-square and multivariate logistic regression analyses examined the association between childhood trauma and insomnia/PLEs. Results: The incidences of emotional abuse (EA), physical abuse (PA), sexual abuse (SA), emotional neglect (EN), and physical neglect (PN) occurred at rates of 5.63, 5.02, 6.56, 23.98, and 33.15%, respectively. EA, SA, EN, and PN were all positively related to insomnia (OR: 1.314-7.720, all Conclusion: The most common type of childhood trauma is PN. Childhood trauma has the primary effect on insomnia/PLE. A significant dose-response relationship was found between Childhood trauma and insomnia/ PLEs. This association varied depending on the type and accumulation of exposure.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.974674
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Article ; Online: Metallogenic mechanism of the Houge’zhuang gold deposit, Jiaodong, China

Naijie Chi / Zuozhen Han / Chuan’e Liu / Wei Zhang / Yanhui Zhang / Wei Shan / Zengsheng Li / Min Li / Xiufeng Wang / Yuqin Sun

Frontiers in Earth Science, Vol

Evidence from fluid inclusion, in situ trace element, and sulfur isotope compositions

2022 Volume 10

Abstract: The Houge’zhuang gold deposit, located in the Penglai–Qixia gold belt of the Jiaodong peninsula, is ... shows complex textures in the Houge’zhuang gold deposit. Study of ore-related pyrite is of great ...

Abstract	The Houge’zhuang gold deposit, located in the Penglai–Qixia gold belt of the Jiaodong peninsula, is a representative auriferous quartz vein-style deposit. Pyrite is the most common and main gold-bearing mineral and shows complex textures in the Houge’zhuang gold deposit. Study of ore-related pyrite is of great significance for understanding the metallogenesis of this deposit, especially the gold precipitation mechanism. The present study applied systematic microscopic observation, fluid inclusion analysis, electron microprobes,in situ LA-ICP-MS trace-element analysis, and in situ sulfur isotope analyses. Three types of fluid inclusions were identified, among which the ore-forming fluids exhibited medium–low salinity and temperature, with the fluid inclusions mainly comprising H2O and CO2. Three types of pyrites were identified: 1) Py0, characterized by low concentrations of As and Au and low δ34S values (5.51–6.86‰). 2) Py1, found in the gold-quartz-pyrite veins and homogeneous in chemical composition with no obvious zonal growth but with notably more gold and chalcopyrite inclusions. Py1 contained medium and uniform concentrations of As and was Au-rich, with δ34S values ranging from 7.13 to 7.89‰ (mean 7.44‰). 3) Py2 contained arsenic-bearing pyrite and was found in quartz-polymetallic sulfide veins, with distinct As enrichment and As-rich rims of pyrite and growth zoning. Consequently, the primary ore-forming fluids passed through some arsenic and δ34S-rich sedimentary rocks, such as the Jingshan, Fenzishan, and Penglai groups. With the occurrence of stable water-rock interaction, the extracted fluids were enriched for As and δ34S. Furthermore, Au was closely associated with As, visible gold grains tended to occur in association with Py1 at stage II, and invisible gold was related to the Au-As-rich Py2 of stage III. The As-bearing pyrites shared a close spatiotemporal relationship with gold, playing an important role in the formation and exploration of high-grade gold deposits.
Keywords	Houge’zhuang gold deposit ; ore-related pyrite ; in situ trace element ; lattice gold ; in situ sulfur isotope ; Science ; Q
Subject code	669
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: The impact of MCM6 on hepatocellular carcinoma in a Southern Chinese Zhuang population.

Jia, Wenxian / Xie, Li / Wang, Xiao / Zhang, Qinle / Wei, Bing / Li, Hongwen / Qin, Shouxu / Chen, Suixia / Liu, Jiayi / Tan, Yanjun / Zheng, Shengfeng / Liang, Xiaonan / Yang, Xiaoli

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 127, Page(s) 110171

Abstract: ... the impact of MCM6 on HCC in Southern Chinese Zhuang population. In addition to assessing the global mRNA ... in these databases. Furthermore, the mRNA and protein expression of MCM6 in the Guangxi Zhuang population was ... The results showed that MCM6 levels were up-regulated in the Zhuang population with HCC. Higher MCM6 protein ...

Abstract	Minichromosome maintenance complex component 6 (MCM6) is involved in tumorigenesis of hepatocellular carcinoma (HCC). Because its effect on different populations remains unclear, this study investigated the impact of MCM6 on HCC in Southern Chinese Zhuang population. In addition to assessing the global mRNA levels of MCM6 based on The Cancer Genome Atlas database (TCGA) and The Gene Expression Omnibus database (GEO), associations between MCM6 mRNA levels and clinicopathological features were analyzed. High MCM6 levels were associated with high alpha-fetoprotein (AFP) (>20 ng/mL in serum) (P < 0.0001) and advanced clinical stage (III + IV) (P < 0.001). Higher MCM6 was associated with poorer outcomes (P < 0.01) in these databases. Furthermore, the mRNA and protein expression of MCM6 in the Guangxi Zhuang population was detected by quantitative polymerase chain reaction (qPCR), western blot, and immunohistochemistry (IHC). The results showed that MCM6 levels were up-regulated in the Zhuang population with HCC. Higher MCM6 protein levels were correlated with larger tumor size (>5 cm) (P = 0.038) and advanced clinical stage (III + IV) (p = 0.023). Bioinformatic enrichment analysis of MCM6 and its interacting proteins (CDT1,WEE1,TRIM28 and MKI67) suggested that in addition to being involved in the cell cycle process, these complexes could also be involved in protein binding, pre-replication complex assemble, and nucleus metabolism. Based on the protein-protein interaction (PPI) network with module screen, the interactions between MCM6 and its potential interacting proteins were further studied through protein docking with hot spot analysis. Additionally, the results of the algorithms combining the ROC of MCM6 and its interacting proteins showed that combination biomarker analysis has better HCC diagnosis ability than the single MCM6 test. The combination of MCM6 and TRIM28 was more suitable for the Guangxi Zhuang population. Overall, our study suggests that MCM6 plays an important role in the growth of HCC. MCM6 could be an optimal biomarker for diagnosing HCC and a potential molecular target for HCC therapy in the Zhuang population.
MeSH term(s)	Adult ; Asian Continental Ancestry Group ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; China ; Computational Biology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Minichromosome Maintenance Complex Component 6/genetics ; Neoplasm Staging ; Protein Interaction Maps ; RNA, Messenger/genetics ; Tripartite Motif-Containing Protein 28/genetics ; alpha-Fetoproteins/metabolism
Chemical Substances	AFP protein, human ; Biomarkers, Tumor ; RNA, Messenger ; alpha-Fetoproteins ; TRIM28 protein, human (EC 2.3.2.27) ; Tripartite Motif-Containing Protein 28 (EC 2.3.2.27) ; MCM6 protein, human (EC 3.6.4.12) ; Minichromosome Maintenance Complex Component 6 (EC 3.6.4.12)
Language	English
Publishing date	2020-05-08
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110171
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