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Article: Indirect formaldehyde exposure and the appearance of respiratory symptoms.

Benharroch, Daniel / Benharroch, Yane-Bianca

2020 Volume 31, Page(s) 101166

Abstract: This 70 year-old female patient, previously described as having undergone a toxicant-associated steatohepatitis during her childhood, now represents the core of a follow-up case report. After an apparent complete recovery at 13 years of age, she ... ...

Abstract	This 70 year-old female patient, previously described as having undergone a toxicant-associated steatohepatitis during her childhood, now represents the core of a follow-up case report. After an apparent complete recovery at 13 years of age, she developed a paroxysmal dry cough, predominantly nocturnal, starting at age 24, during her first pregnancy. A seasonal recurrence was observed and bouts of cough have been resurgent at every subsequent winter. Several diagnoses, including asthma, gastro-esophageal reflux, and chronic pertussis have been suggested, as well as a sequel of her severe scoliosis, but the consequent treatments were of no avail. Moreover, repeated lung function tests have remained normal ever since. We presently propose a possible explanation for the puzzle.
Language	English
Publishing date	2020-07-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2020.101166
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Article ; Online: A Nuphar lutea plant active ingredient, 6,6'-dihydroxythiobinupharidine, ameliorates kidney damage and inflammation in a mouse model of chronic kidney disease.

Landau, Daniel / Khalilia, Jannat / Arazi, Eden / Tobar, Ana Foigelman / Benharroch, Daniel / Golan-Goldhirsh, Avi / Gopas, Jacob / Segev, Yael

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7577

Abstract: Chronic Kidney Disease (CKD) associated complications are associated with increased inflammation through the innate immune response, which can be modulated with anti-inflammatory agents. An active ingredient derived from the Nuphar lutea aquatic plant, 6, ...

Abstract	Chronic Kidney Disease (CKD) associated complications are associated with increased inflammation through the innate immune response, which can be modulated with anti-inflammatory agents. An active ingredient derived from the Nuphar lutea aquatic plant, 6,6'-dihydroxythiobinupharidine (DTBN) has anti-inflammatory properties, mainly through the inhibition of NF-κB. We tested the effects of DTBN on mice with CKD. After preliminary safety and dosing experiments, we exposed 8 weeks old male C57BL/6J mice to adenine diet to induce CKD. Control and CKD animals were treated with IP injections of DTBN (25 μg QOD) or saline and sacrificed after 8 weeks. Serum urea and creatinine were significantly decreased in CKD-DTBN Vs CKD mice. Kidney histology showed a decrease in F4/80 positive macrophage infiltration, damaged renal area, as well as decreased kidney TGF-β in CKD-DTBN Vs CKD mice. Kidney inflammation indices (IL-1β, IL-6 and P-STAT3) were significantly decreased in CKD-DTBN as compared to CKD mice. DTBN treatment showed no apparent damage to tissues in control mice, besides a decrease in weight gain and mild hypoalbuminemia without proteinuria. Thus, DTBN significantly improved renal failure and inflammation indices in CKD mice. Therefore, this and similar substances may be considered as an additional treatment in CKD patients.
MeSH term(s)	Humans ; Mice ; Animals ; Nuphar ; Mice, Inbred C57BL ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/pathology ; Kidney/pathology ; Inflammation/pathology ; Anti-Inflammatory Agents/pharmacology ; Disease Models, Animal ; Alkaloids
Chemical Substances	dihydroxythiobinupharidine (30343-70-5) ; Anti-Inflammatory Agents ; Alkaloids
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58055-1
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Article: Transformation of low-grade follicular lymphoma with partial marginal zone differentiation: Two cases.

Nalbandyan, Karen / Benharroch, Daniel / Gurevitch, Anna / Levi, Itai

Hematology reports

2021 Volume 13, Issue 3, Page(s) 8896

Abstract: Two cases of low-grade follicular lymphoma, with marginal zone differentiation and/or with high proliferation rate in one of them, are reported with transformation into high grade B-cell and B-lymphoblastic lymphomas. The contribution of these features ... ...

Abstract	Two cases of low-grade follicular lymphoma, with marginal zone differentiation and/or with high proliferation rate in one of them, are reported with transformation into high grade B-cell and B-lymphoblastic lymphomas. The contribution of these features to the transforming process, although previously described, is infrequent, and has not been deciphered to date.
Language	English
Publishing date	2021-09-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.4081/hr.2021.8896
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Article ; Online: Splenic Micronodular T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: The Corticosteroid Pretreatment Hypothesis.

Samueli, Benzion / Nalbandyan, Karen / Benharroch, Daniel / Levi, Itai

Acta haematologica

2021 Volume 145, Issue 3, Page(s) 310–317

Abstract: Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is derived from diffuse large B-cell lymphoma N.O.S., perhaps with some affinity with nodal THRLBCL. Of note, in contrast with the latter, the only lymph nodes involved in ... ...

Abstract	Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is derived from diffuse large B-cell lymphoma N.O.S., perhaps with some affinity with nodal THRLBCL. Of note, in contrast with the latter, the only lymph nodes involved in association with the splenic micronodular pattern of the disease are the splenic hilar lymph nodes. The possibility that corticosteroids, when prescribed prior to splenectomy, cause histopathological and functional modulations, apoptosis, necrosis, tissue shrinkage, which may obscure the diagnostic morphological features of this variant lymphoma and cause an underdiagnosis of this condition. The indications for glucocorticoid therapy are either related to the lymphoma itself, or else to other comorbidities, like asthma and autoimmune disorders. We propose that patients with the splenic subset of the disease are likely to have been prescribed corticosteroids prior to histopathologic examination of the involved spleen, causing disparate morphologies. However, a reviewer might accidentally dismiss the corticosteroid pretreatment which is thus overlooked. Apoptosis, induced by corticosteroids, is hypothesized as the major mechanism initiating the histopathological and functional changes in the splenic micronodular variant of the lymphoma.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Histiocytes/pathology ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Spleen/pathology ; T-Lymphocytes
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2021-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000520791
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Article ; Online: Incidental Durotomy Following Transforaminal Lumbar Interbody Fusion Performed with the Modified Wiltse Approach.

Sheinis, Dimitri / Sheinis, Vadim / Benharroch, Daniel / Ohana, Nissim

Journal of neurological surgery. Part A, Central European neurosurgery

2020 Volume 81, Issue 5, Page(s) 399–403

Abstract: Purpose: Incidental durotomy is an intraoperative complication that occurs in 3 to 27% of lumbar spine surgeries. It has been reported more commonly following revision spinal procedures.: Study objectives: To investigate the frequency of incidental ...

Abstract	Purpose: Incidental durotomy is an intraoperative complication that occurs in 3 to 27% of lumbar spine surgeries. It has been reported more commonly following revision spinal procedures. Study objectives: To investigate the frequency of incidental durotomy while performing transforaminal lumbar interbody fusion (TLIF) using the modified Wiltse approach. A secondary goal was to compare the incidence of durotomy in patients undergoing primary spine surgery with those undergoing revision surgery. Methods: A group of consecutive patients who had undergone (TLIF) in the last 10 years ending in 2015 were enrolled in the study. All patients underwent TLIF via the modified Wiltse approach that included a central midline skin incision, followed by a paravertebral blunt dissection of the paraspinal muscles to reach the transverse processes. The deep paravertebral dissection was done conservatively, one side at a time. Demographic and clinical data were collected when relevant to the comparison. Results: The study cohort encompassed 257 patients: 200 primary cases and 57 revisions. The frequency of incidental durotomy was equal in both groups: 3.5% each (7/200 and 2/57). All durotomies were repaired primarily. No other immediate or late complications were observed during follow-up. Conclusion: The present study displays a limited incidence of durotomy in the primary interventions and to a lesser degree in the revisions, all of which had used a TLIF performed with the modified Wiltse approach. This procedure probably circumvented the need for further revisions.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Dura Mater/injuries ; Female ; Humans ; Incidence ; Intraoperative Complications/epidemiology ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Reoperation ; Retrospective Studies ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Young Adult
Language	English
Publishing date	2020-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2651663-9
ISSN	2193-6323 ; 2193-6315
ISSN (online)	2193-6323
ISSN	2193-6315
DOI	10.1055/s-0039-1698390
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Article: Multiple Myeloma with Foamy Mott Cells.

Nalbandyan, Karen / Benharroch, Daniel / Samueli, Benzion / Kafka, Michael / Gourevitch, Anna

Case reports in hematology

2021 Volume 2021, Page(s) 7391895

Abstract: Intracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report ... ...

Abstract	Intracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report the case of a patient who presented with skeletal pain and CT confirmed lytic lesions. A bone marrow biopsy revealed multiple myeloma with unusual foamy Mott cells. The patient was subsequently treated with four cycles of cyclophosphamide, bortezomib, and dexamethasone induction therapy, followed by 3 cycles of lenalidomide with dexamethasone. A biopsy performed following initial biological and immunomodulatory drugs revealed different morphological and clonal characteristics. These features were modified again, five years later, and again, after two years of close monitoring. Hematopathologists should be aware of this morphologic variant of myeloma as well as for the capacity of clonal characteristics, such as light chain monotype, to fluctuate subsequent to treatment.
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627639-2
ISSN	2090-6579 ; 2090-6560
ISSN (online)	2090-6579
ISSN	2090-6560
DOI	10.1155/2021/7391895
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Article: Toxicant-associated steatohepatitis: à propos a case of benzene exposure.

Benharroch, Daniel / Talalay, Boris

International medical case reports journal

2017 Volume 10, Page(s) 73–75

Abstract: An attempted interpretation of recurrent episodes of hepatitis in a girl at ages 6 and 13 years, which were followed by an interval of 35 years of apparent good health, is reported. A subsequent transient incidence of a halothane hypersensitivity ... ...

Abstract	An attempted interpretation of recurrent episodes of hepatitis in a girl at ages 6 and 13 years, which were followed by an interval of 35 years of apparent good health, is reported. A subsequent transient incidence of a halothane hypersensitivity reaction at age 48 years led to the disclosure of negative hepatitis A, B and C antigenicity. A tentative diagnosis may be reached if we accept, at its face value, the statement that a toy that the child played with before each hepatitis episode carried a very high benzene content. The toy was a "pate-à-ballon" or "magic balloon," and it can carry a benzene content that is seven to nine times higher than the traditionally authorized concentration.
Language	English
Publishing date	2017-03-06
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495077-4
ISSN	1179-142X
ISSN	1179-142X
DOI	10.2147/IMCRJ.S120422
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Article ; Online: Pleural Dural Fistula After Anterior Excision of Thoracic Disc Hernia: Suggested Repair Procedure.

Ohana, Nissim / Benharroch, Daniel / Sheinis, Dimitri

The Annals of thoracic surgery

2018 Volume 107, Issue 3, Page(s) e191–e193

Abstract: A young woman displayed a dural tear during thoracic spine surgery. The corpectomy was by anterior approach, after thoracotomy. The dural defect was plastered by a fatty flap and a pleural layer. One month later, she exhibited a right pleural effusion. ... ...

Abstract	A young woman displayed a dural tear during thoracic spine surgery. The corpectomy was by anterior approach, after thoracotomy. The dural defect was plastered by a fatty flap and a pleural layer. One month later, she exhibited a right pleural effusion. No consensual intervention is available for this complication. This dural fistula was sealed by a triple patch comprising a flap of intercostal muscles. The incidence of dural leaks following an anterior thoracic spinal surgery is infrequent but not rare. A long delay from the index surgery is unusual. Three years after the repair, the patient is free from complaints.
MeSH term(s)	Adult ; Arthrodesis/adverse effects ; Female ; Fistula/diagnosis ; Fistula/etiology ; Fistula/surgery ; Humans ; Intercostal Muscles/transplantation ; Intervertebral Disc Displacement/diagnosis ; Intervertebral Disc Displacement/surgery ; Magnetic Resonance Imaging ; Pleural Diseases/diagnosis ; Pleural Diseases/etiology ; Pleural Diseases/surgery ; Postoperative Complications ; Radiography, Thoracic ; Reoperation ; Surgical Flaps ; Thoracic Vertebrae ; Thoracotomy/methods
Language	English
Publishing date	2018-09-25
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2018.07.065
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Article ; Online: Challenge of handling a Charcot spinal arthropathy with a novel hybrid fibular autograft and expandable cage.

Ohana, Nissim / Benharroch, Daniel / Sheinis, Dimitri

Journal of neurosurgery. Spine

2018 Volume 29, Issue 1, Page(s) 34–39

Abstract: A 26-year-old man, who was paraplegic for 6 years due to a motor vehicle accident, presented to the authors' clinic following his incapacity to withstand a sitting posture, the frequent sensation of "clicks" in his back, and a complaint of back pain ... ...

Abstract	A 26-year-old man, who was paraplegic for 6 years due to a motor vehicle accident, presented to the authors' clinic following his incapacity to withstand a sitting posture, the frequent sensation of "clicks" in his back, and a complaint of back pain while in his wheelchair. On imaging, his dorsal spine showed a complete arthrodesis of the primarily fused vertebrae. However, distal to this segment, a Charcot spinal arthropathy with subluxation of T12-L1 was evident. Repair of this complex, uncommon, late complication of his paraplegia by the frequently used fusion techniques was shown to be inappropriate. A novel and elaborate surgical procedure is presented by which a complete fusion of the affected spine was secured. A left retrodiaphragmatic approach was used. Complete corpectomy of both the T-12 and L-1 vertebrae to the preserved endplates was performed. Most of the patient's fibula was resected and shaped for engrafting. The segment of the fibula was introduced into a mesh cage, before its intramedullary implantation into the T-12 and L-1 vertebrae. This 2-step procedure combined the hybrid use of a fibular autograft and an expandable mesh cage, incorporated one into the other, in an innovative intramedullary position. This intervention allowed the patient to resume his former condition as an extremely physically active patient with paraplegia. Nine years later, an asymptomatic early-stage Charcot spine was found at L5-S1, but no treatment is planned at this point.
MeSH term(s)	Adult ; Arthropathy, Neurogenic/diagnostic imaging ; Arthropathy, Neurogenic/surgery ; Autografts ; Humans ; Internal Fixators ; Male ; Spinal Diseases/diagnostic imaging ; Spinal Diseases/surgery
Language	English
Publishing date	2018-04-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2158643-3
ISSN	1547-5646 ; 1547-5654
ISSN (online)	1547-5646
ISSN	1547-5654
DOI	10.3171/2017.10.SPINE17606
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Article ; Online: Traumatic glioblastoma: commentary and suggested mechanism.

Ohana, Nissim / Benharroch, Daniel / Sheinis, Dimitri / Cohen, Abraham

The Journal of international medical research

2018 Volume 46, Issue 6, Page(s) 2170–2176

Abstract: The role of head trauma in the development of glioblastoma is highly controversial and has been minimized since first put forward. This is not unexpected because skull injuries are overwhelmingly more common than glioblastoma. This paper presents a ... ...

Abstract	The role of head trauma in the development of glioblastoma is highly controversial and has been minimized since first put forward. This is not unexpected because skull injuries are overwhelmingly more common than glioblastoma. This paper presents a commentary based on the contributions of James Ewing, who established a major set of criteria for the recognition of an official relationship between trauma and cancer. Ewing's criteria were very stringent. The scholars who succeeded Ewing have facilitated the characterization of traumatic brain injuries since the introduction of computed tomography and magnetic resonance imaging. Discussions of the various criteria that have since developed are now being conducted, and those of an unnecessarily limiting nature are being highlighted. Three transcription factors associated with traumatic brain injury have been identified: p53, hypoxia-inducible factor-1α, and c-MYC. A role for these three transcription factors in the relationship between traumatic brain injury and glioblastoma is suggested; this role may support a cause-and-effect link with the subsequent development of glioblastoma.
MeSH term(s)	Brain Injuries/complications ; Brain Injuries/history ; Brain Injuries/metabolism ; Brain Injuries/physiopathology ; Brain Neoplasms/etiology ; Brain Neoplasms/history ; Brain Neoplasms/metabolism ; Brain Neoplasms/physiopathology ; Glioblastoma/etiology ; Glioblastoma/history ; Glioblastoma/metabolism ; Glioblastoma/physiopathology ; History, 20th Century ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Patient Selection ; Proto-Oncogene Proteins c-myc/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; MYC protein, human ; Proto-Oncogene Proteins c-myc ; Tumor Suppressor Protein p53
Language	English
Publishing date	2018-04-30
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Review
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/0300060518771265
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