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  1. Article ; Online: Imagination is the Power of Myth, the Rest is Painted with a Touch of Science Fiction

    Sanjukta Chakraborty

    Comparative Literature: East & West, Pp 1-

    A Study of Mythology and Science Fiction

    2022  Volume 9

    Abstract: At the beginning of human existence, myths functioned as realizations of the fundamental mysteries of life. In the absence of scientific information of any kind, societies devised creation myths, resurrection myths, and complicated systems of ... ...

    Abstract At the beginning of human existence, myths functioned as realizations of the fundamental mysteries of life. In the absence of scientific information of any kind, societies devised creation myths, resurrection myths, and complicated systems of supernatural beings, each with specific powers and stories regarding their actions. At its best, science fiction generally tries to free the imagination and also opens up new avenues of perception. Its validity lies in its efforts to convey an exhilarating and life-enhancing appreciation of the mystery of the universe, of existence. The first science fiction was very much utopian; the following concerned a heavenly body and celestial body travel. As an effect, the genre arose out of the intensifying tenets that typify science and as initiative, and resourcefulness comprises the spirit of science. Through this paper, I will show how mythology and science fiction amalgamate and interconnect together. In the beginning, the inspiration for science fiction came from mythology, which means imagination changes into the reality of life.
    Keywords Scientific spirit ; mythology ; technological change ; science fiction ; cosmic abstraction ; 科学精神 ; Literature (General) ; PN1-6790
    Subject code 820
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
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  2. Article ; Online: The Cellular, Molecular, and Pathologic Consequences of Stress on the Liver.

    Maiers, Jessica L / Chakraborty, Sanjukta

    The American journal of pathology

    2023  Volume 193, Issue 10, Page(s) 1353–1354

    MeSH term(s) Humans ; Liver/pathology ; Liver Neoplasms/pathology
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2023.07.003
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  3. Article ; Online: To Go or Not to Go?-Targeting Tregs Traveling in Tumors.

    Chakraborty, Sanjukta / Zappasodi, Roberta

    Cancer research

    2021  Volume 81, Issue 11, Page(s) 2817–2819

    Abstract: Regulatory T cells (Treg) are one of the major impediments to effective antitumor immunity and successful immunotherapy. Elevated intratumoral Treg frequencies, observed in a variety of malignancies, have been associated with poor prognosis. In this ... ...

    Abstract Regulatory T cells (Treg) are one of the major impediments to effective antitumor immunity and successful immunotherapy. Elevated intratumoral Treg frequencies, observed in a variety of malignancies, have been associated with poor prognosis. In this issue of
    MeSH term(s) Animals ; Humans ; Mice ; Neoplasms/therapy ; Receptors, G-Protein-Coupled
    Chemical Substances Gpr15 protein, mouse ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-21-1203
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  4. Article ; Online: Oxidative Stress-Induced Liver Damage and Remodeling of the Liver Vasculature.

    Banerjee, Priyanka / Gaddam, Niyanshi / Chandler, Vanessa / Chakraborty, Sanjukta

    The American journal of pathology

    2023  Volume 193, Issue 10, Page(s) 1400–1414

    Abstract: As an organ critically important for targeting and clearing viruses, bacteria, and other foreign material, the liver operates via immune-tolerant, anti-inflammatory mechanisms indispensable to the immune response. Stress and stress-induced factors ... ...

    Abstract As an organ critically important for targeting and clearing viruses, bacteria, and other foreign material, the liver operates via immune-tolerant, anti-inflammatory mechanisms indispensable to the immune response. Stress and stress-induced factors disrupt the homeostatic balance in the liver, inflicting tissue damage, injury, and remodeling. These factors include oxidative stress (OS) induced by viral infections, environmental toxins, drugs, alcohol, and diet. A recurrent theme seen among stressors common to multiple liver diseases is the induction of mitochondrial dysfunction, increased reactive oxygen species expression, and depletion of ATP. Inflammatory signaling additionally exacerbates the condition, generating a proinflammatory, immunosuppressive microenvironment and activation of apoptotic and necrotic mechanisms that disrupt the integrity of liver morphology. These pathways initiate signaling pathways that significantly contribute to the development of liver steatosis, inflammation, fibrosis, cirrhosis, and liver cancers. In addition, hypoxia and OS directly enhance angiogenesis and lymphangiogenesis in chronic liver diseases. Late-stage consequences of these conditions often narrow the outcomes for liver transplantation or result in death. This review provides a detailed perspective on various stress-induced factors and the specific focus on role of OS in different liver diseases with special emphasis on different molecular mechanisms. It also highlights how resultant changes in the liver vasculature correlate with pathogenesis.
    MeSH term(s) Humans ; Oxidative Stress ; Liver/pathology ; Liver Cirrhosis/pathology ; Fatty Liver/pathology ; Liver Neoplasms/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2023.06.002
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  5. Article ; Online: Lymphatic Pathophysiology.

    Chakraborty, Sanjukta / Dixon, Brandon J / Rutkowski, Joseph M / Castorena-Gonzalez, Jorge A / Breslin, Jerome W

    Microcirculation (New York, N.Y. : 1994)

    2023  Volume 30, Issue 2-3, Page(s) e12806

    MeSH term(s) Lymphatic Vessels/physiology ; Lymphatic System
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217758-1
    ISSN 1549-8719 ; 1073-9688
    ISSN (online) 1549-8719
    ISSN 1073-9688
    DOI 10.1111/micc.12806
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  6. Article ; Online: Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis.

    Banerjee, Priyanka / Gaddam, Niyanshi / Pandita, Tej K / Chakraborty, Sanjukta

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Cellular senescence-the irreversible cell cycle arrest driven by a variety of mechanisms and, more specifically, the senescence-associated secretory phenotype (SASP)-is an important area of research in the context of different age-related diseases, such ... ...

    Abstract Cellular senescence-the irreversible cell cycle arrest driven by a variety of mechanisms and, more specifically, the senescence-associated secretory phenotype (SASP)-is an important area of research in the context of different age-related diseases, such as cardiovascular disease and cancer. SASP factors play both beneficial and detrimental roles in age-related disease progression depending on the source of the SASPs, the target cells, and the microenvironment. The impact of senescence and the SASP on different cell types, the immune system, and the vascular system has been widely discussed. However, the impact of replicative or stress-induced senescence on lymphatic biology and pathological lymphangiogenesis remains underexplored. The lymphatic system plays a crucial role in the maintenance of body fluid homeostasis and immune surveillance. The perturbation of lymphatic function can hamper normal physiological function. Natural aging or stress-induced premature aging influences the lymphatic vessel structure and function, which significantly affect the role of lymphatics in tumor dissemination and metastasis. In this review, we focus on the role of senescence on lymphatic pathobiology, its impact on cancer, and potential therapeutic interventions to manipulate the aged or senescent lymphatic system for disease management.
    MeSH term(s) Humans ; Lymphatic Metastasis ; Cellular Senescence/genetics ; Cell Cycle Checkpoints ; Tumor Microenvironment
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032877
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  7. Article ; Online: Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis

    Priyanka Banerjee / Niyanshi Gaddam / Tej K. Pandita / Sanjukta Chakraborty

    International Journal of Molecular Sciences, Vol 24, Iss 2877, p

    2023  Volume 2877

    Abstract: Cellular senescence—the irreversible cell cycle arrest driven by a variety of mechanisms and, more specifically, the senescence-associated secretory phenotype (SASP)—is an important area of research in the context of different age-related diseases, such ... ...

    Abstract Cellular senescence—the irreversible cell cycle arrest driven by a variety of mechanisms and, more specifically, the senescence-associated secretory phenotype (SASP)—is an important area of research in the context of different age-related diseases, such as cardiovascular disease and cancer. SASP factors play both beneficial and detrimental roles in age-related disease progression depending on the source of the SASPs, the target cells, and the microenvironment. The impact of senescence and the SASP on different cell types, the immune system, and the vascular system has been widely discussed. However, the impact of replicative or stress-induced senescence on lymphatic biology and pathological lymphangiogenesis remains underexplored. The lymphatic system plays a crucial role in the maintenance of body fluid homeostasis and immune surveillance. The perturbation of lymphatic function can hamper normal physiological function. Natural aging or stress-induced premature aging influences the lymphatic vessel structure and function, which significantly affect the role of lymphatics in tumor dissemination and metastasis. In this review, we focus on the role of senescence on lymphatic pathobiology, its impact on cancer, and potential therapeutic interventions to manipulate the aged or senescent lymphatic system for disease management.
    Keywords senescence ; senescence-associated secretory phenotype (SASP) ; lymphatics ; lymphangiogenesis cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  8. Article ; Online: Recent advancement of imaging strategies of the lymphatic system: Answer to the decades old questions.

    Banerjee, Priyanka / Roy, Sukanya / Chakraborty, Sanjukta

    Microcirculation (New York, N.Y. : 1994)

    2022  Volume 29, Issue 6-7, Page(s) e12780

    Abstract: The role of the lymphatic system in maintaining tissue homeostasis and a number of different pathophysiological conditions has been well established. The complex and delicate structure of the lymphatics along with the limitations of conventional imaging ... ...

    Abstract The role of the lymphatic system in maintaining tissue homeostasis and a number of different pathophysiological conditions has been well established. The complex and delicate structure of the lymphatics along with the limitations of conventional imaging techniques make lymphatic imaging particularly difficult. Thus, in-depth high-resolution imaging of lymphatic system is key to understanding the progression of lymphatic diseases and cancer metastases and would greatly benefit clinical decisions. In recent years, the advancement of imaging technologies and development of new tracers suitable for clinical applications has enabled imaging of the lymphatic system in both clinical and pre-clinical settings. In this current review, we have highlighted the advantages and disadvantages of different modern techniques such as near infra-red spectroscopy (NIRS), positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI) and fluorescence optical imaging, that has significantly impacted research in this field and has led to in-depth insights into progression of pathological states. This review also highlights the use of current imaging technologies, and tracers specific for immune cell markers to identify and track the immune cells in the lymphatic system that would help understand disease progression and remission in immune therapy regimen.
    MeSH term(s) Lymphatic System/diagnostic imaging ; Positron-Emission Tomography ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed/methods ; Lymphatic Vessels/diagnostic imaging
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217758-1
    ISSN 1549-8719 ; 1073-9688
    ISSN (online) 1549-8719
    ISSN 1073-9688
    DOI 10.1111/micc.12780
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  9. Article ; Online: Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.

    Medford, Abigail / Childs, Jonathan / Little, Ashleigh / Chakraborty, Sanjukta / Baiocchi, Leonardo / Alpini, Gianfranco / Glaser, Shannon

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 4, Page(s) 949–957

    Abstract: The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated ... ...

    Abstract The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00398
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  10. Article ; Online: Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow.

    Selahi, Amirali / Chakraborty, Sanjukta / Muthuchamy, Mariappan / Zawieja, David C / Jain, Abhishek

    The Analyst

    2022  Volume 147, Issue 13, Page(s) 2953–2965

    Abstract: The lymphatic vascular function is regulated by pulsatile shear stresses through signaling mediated by intracellular calcium [ ... ...

    Abstract The lymphatic vascular function is regulated by pulsatile shear stresses through signaling mediated by intracellular calcium [Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling ; Coculture Techniques ; Endothelial Cells ; Mechanotransduction, Cellular ; Muscle Cells/metabolism ; Pulsatile Flow
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d2an00396a
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