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Artikel: Erratum: Author correction to 'Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis

Deng, Linglong / Petrek, Hannah / Tu, Mei-Juan / Batra, Neelu / Yu, Ai-Xi / Yu, Ai-Ming

Acta pharmaceutica Sinica. B

2023 Band 13, Heft 8, Seite(n) 3577–3578

Abstract: This corrects the article DOI: 10.1016/j.apsb.2021.07.027.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.apsb.2021.07.027.].
Sprache	Englisch
Erscheinungsdatum	2023-07-05
Erscheinungsland	Netherlands
Dokumenttyp	Published Erratum
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2023.07.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association between sarcoidosis and HLA polymorphisms in a Czech population from Central Europe: focus on a relationship with clinical outcome and treatment.

Sikorova, K / Osoegawa, K / Kocourkova, L / Strnad, A / Petrkova, J / Fernández-Viña, M A / Doubkova, M / Petrek, M

Frontiers in medicine

2023 Band 10, Seite(n) 1094843

Abstract: Background: Sarcoidosis is an immune-mediated systemic disease with unknown etiology affecting the lung predominantly. The clinical manifestation of sarcoidosis is rather diverse ranging from Löfgren's syndrome to fibrotic disease. Also, it differs ... ...

Abstract	Background: Sarcoidosis is an immune-mediated systemic disease with unknown etiology affecting the lung predominantly. The clinical manifestation of sarcoidosis is rather diverse ranging from Löfgren's syndrome to fibrotic disease. Also, it differs among patients with distinct geographical and ethnic origins, consistent with environmental and genetic factors' role in its pathogenesis. Of those, the polymorphic genes of the HLA system have been previously implicated in sarcoidosis. Therefore, we have performed an association study in a well-defined cohort of Czech patients aiming to define how variation in HLA genes, may contribute to disease origin and development. Materials and methods: Total of the 301 Czech unrelated sarcoidosis patients were diagnosed according to international guidelines. In those, HLA typing was performed using next-generation sequencing. The allele frequencies at six HLA loci ( Results: We report two variants, HLA-DQB106:02, and HLA-DQB106:04, as risk factors for sarcoidosis, and three variants, HLA-DRB101:01, HLA-DQA103:01, and HLA-DQB103:02 as protective factors. HLA-B08:01, HLA-C07:01, HLA-DRB103:01, HLA-DQA105:01, and HLA-DQB102:01 variants associated with Löfgren's syndrome, a more benign phenotype. HLA- DRB103:01 and HLA-DQA105:01 alleles were connected with better prognosis-chest X-ray (CXR) stage 1, disease remission, and non-requirement of corticosteroid treatment. The alleles HLA-DRB111:01 and HLA-DQA105:05 are associated with more advanced disease represented by the CXR stages 2-4. HLA-DQB105:03 associated with sarcoidosis extrapulmonary manifestation. Conclusion:* In our Czech cohort, we document some associations between sarcoidosis and HLA previously described in other populations. Further, we suggest novel susceptibility factors for sarcoidosis, such as HLA-DQB106:04, and characterize associations between HLA and sarcoidosis clinical phenotypes in Czech patients. Our study also extends the role of the 8.1 ancestral haplotype (HLA-A01:01∼HLA-B08:01∼HLA-C07:01∼HLA-DRB103:01∼HLA-DQA105:01∼HLA-DQB1*02:01), already implicated in autoimmune diseases, as a possible predictor of better prognosis in sarcoidosis. The general translational application of our newly reported findings for personalized patient care should be validated by an independent study from another, international referral center.
Sprache	Englisch
Erscheinungsdatum	2023-04-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1094843
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of genetic risk, its clinical manifestation and disease management based on 18 susceptibility gene markers among West-Slavonic patients with sarcoidosis.

Kishore, Amit / Sikorova, Katerina / Kocourkova, Lenka / Petrkova, Jana / Doubkova, Martina / Jakubec, Petr / Rębała, Krzysztof / Dubaniewicz, Anna / Petrek, Martin

Gene

2023 Band 878, Seite(n) 147577

Abstract: Sarcoidosis is a heterogenous, multisystemic inflammatory disease that primarily affects lungs. In this study, we multiplex genotyped 18 single-nucleotide polymorphisms (SNPs) to replicate the findings from previous genome-wide association studies (GWAS) ...

Abstract	Sarcoidosis is a heterogenous, multisystemic inflammatory disease that primarily affects lungs. In this study, we multiplex genotyped 18 single-nucleotide polymorphisms (SNPs) to replicate the findings from previous genome-wide association studies (GWAS) and candidate gene studies, and extended analyses to different clinical manifestations (Löfgren's syndrome and chest X-ray [CXR] stages) including treatment response among West-Slavonic subjects (564 sarcoidosis patients and 301 healthy controls). We confirm the replication (with Bonferroni's correction) of ANXA11 rs1049550 as protective variant for sarcoidosis (odds ratio [OR] = 0.71, p = 1.33 × 10
Mesh-Begriff(e)	Humans ; HLA-DR alpha-Chains/genetics ; Genome-Wide Association Study ; Sarcoidosis/genetics ; Genotype ; Polymorphism, Single Nucleotide ; Disease Management ; Genetic Predisposition to Disease
Chemische Substanzen	HLA-DR alpha-Chains
Sprache	Englisch
Erscheinungsdatum	2023-06-17
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147577
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association between sarcoidosis and HLA polymorphisms in a Czech population from Central Europe

K. Sikorova / K. Osoegawa / L. Kocourkova / A. Strnad / J. Petrkova / M. A. Fernández-Viña / M. Doubkova / M. Petrek

Frontiers in Medicine, Vol

focus on a relationship with clinical outcome and treatment

2023 Band 10

Abstract: BackgroundSarcoidosis is an immune-mediated systemic disease with unknown etiology affecting the lung predominantly. The clinical manifestation of sarcoidosis is rather diverse ranging from Löfgren’s syndrome to fibrotic disease. Also, it differs among ... ...

Abstract	BackgroundSarcoidosis is an immune-mediated systemic disease with unknown etiology affecting the lung predominantly. The clinical manifestation of sarcoidosis is rather diverse ranging from Löfgren’s syndrome to fibrotic disease. Also, it differs among patients with distinct geographical and ethnic origins, consistent with environmental and genetic factors’ role in its pathogenesis. Of those, the polymorphic genes of the HLA system have been previously implicated in sarcoidosis. Therefore, we have performed an association study in a well-defined cohort of Czech patients aiming to define how variation in HLA genes, may contribute to disease origin and development.Materials and methodsTotal of the 301 Czech unrelated sarcoidosis patients were diagnosed according to international guidelines. In those, HLA typing was performed using next-generation sequencing. The allele frequencies at six HLA loci (HLA-A,-B,-C,-DRB1,-DQA1, and -DQB1) observed in the patients were compared with HLA allele distribution determined in 309 unrelated healthy Czech subjects; sub-analyses of relationships between HLA and distinct sarcoidosis clinical phenotypes were performed. Associations were assessed by two-tailed Fischer’s exact test with correction for multiple comparisons.ResultsWe report two variants, HLA-DQB106:02, and HLA-DQB106:04, as risk factors for sarcoidosis, and three variants, HLA-DRB101:01, HLA-DQA103:01, and HLA-DQB103:02 as protective factors. HLA-B08:01, HLA-C07:01, HLA-DRB103:01, HLA-DQA105:01, and HLA-DQB102:01 variants associated with Löfgren’s syndrome, a more benign phenotype. HLA- DRB103:01 and HLA-DQA105:01 alleles were connected with better prognosis—chest X-ray (CXR) stage 1, disease remission, and non-requirement of corticosteroid treatment. The alleles HLA-DRB111:01 and HLA-DQA105:05 are associated with more advanced disease represented by the CXR stages 2−4. HLA-DQB1*05:03 associated with sarcoidosis extrapulmonary manifestation.ConclusionIn our Czech cohort, we document some associations ...
Schlagwörter	sarcoidosis ; HLA ; Czech ; clinical course ; Löfgren’s syndrome ; biomarker ; Medicine (General) ; R5-920
Thema/Rubrik (Code)	570 ; 610
Sprache	Englisch
Erscheinungsdatum	2023-04-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Effect of genotype on the disease course in idiopathic pulmonary fibrosis despite antifibrotic treatment.

Sterclova, Martina / Kishore, Amit / Sikorova, Katerina / Skibova, Jelena / Petrek, Martin / Vasakova, Martina

Biomedical reports

2021 Band 15, Heft 5, Seite(n) 87

Abstract: A genetic predisposition has been identified in 30% of idiopathic pulmonary fibrosis (IPF) cases. Although it is highly probable that the genotype affects the disease susceptibility and course in almost all patients, the specific genotype goes undetected. ...

Abstract	A genetic predisposition has been identified in 30% of idiopathic pulmonary fibrosis (IPF) cases. Although it is highly probable that the genotype affects the disease susceptibility and course in almost all patients, the specific genotype goes undetected. The aim of the present study was to explore the effects of variants of the genes encoding interleukin-4 (IL-4), mucin 5B (MUC5B), toll interacting protein (TOLLIP), surfactant protein A (SFPTA), transforming growth factor-β (TGF-β) and transporters associated with antigen processing (TAP1 and TAP2) on the course of IPF. A total of 50 patients with IPF were enrolled, and variants of these genes were assessed. Lung function at the time of diagnosis and after 6, 12 and 18 months, and the number of acute exacerbations and deaths in each observation period were measured. ANOVA was used to test the association between gene polymorphisms and the decrease in lung function. There was no significant effect of the gene polymorphisms on the outcomes of patients up to 6 months during the observation period. After 12 months, an effect of an IL-4 single nucleotide polymorphism (SNP) (rs 2070874) on patient outcomes was observed [relative risk (RR) for T allele: 5.6; 95% confidence interval (CI), 0.79-39.0; P=0.053]. The RR of progression in patients with the IL-4 SNP (rs 2243250) and the CT and TT genotypes was 4.3 (95% CI, 1.1-17.5; P=0.046). A total of 18 months after the diagnosis of IPF, an effect of the TOLLIP polymorphism on patient outcome was detected (rs 111521887; risk allele GC; RR: 7.2; 95% CI, 0.97-53.6; P=0.052). Thus, IL-4 and TOLLIP gene polymorphisms may represent disease course-modifying factors, but not drivers of IPF.
Sprache	Englisch
Erscheinungsdatum	2021-08-23
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2021.1463
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: TP53 rs1042522 and rs8064946 variants in myocardial infarction.

Hakobjanyan, A / Stahelova, A / Mrazek, F / Petrkova, J / Navratilova, Z / Petrek, M

Bratislavske lekarske listy

2019 Band 119, Heft 12, Seite(n) 747–751

Abstract: Objective: This study investigated the hypothesis that the single nucleotide polymorphisms (SNPs) of TP53 gene are related to a risk of myocardial infarction.: Methods: The coding SNP at codon 72 (rs1042522) and non-coding rs8064946 SNP were ... ...

Abstract	Objective: This study investigated the hypothesis that the single nucleotide polymorphisms (SNPs) of TP53 gene are related to a risk of myocardial infarction. Methods: The coding SNP at codon 72 (rs1042522) and non-coding rs8064946 SNP were genotyped by polymerase chain reaction with sequence specific primers in 205 Czech patients with myocardial infarction and 148 Czech control subjects. Results: The distribution of both SNPs was in agreement with the Hardy-Weinberg equilibrium and was similar to other European populations. Our power analysis showed 96 % of probability to detect an odd ratio equal to 2. Neither rs1042522 nor rs8064946 were associated with the risk of myocardial infarction. The haplotypes combined of rs1042522 and rs8064946 were not associated with myocardial infarction in the present study. Conclusion: The TP53 SNPs are not strongly associated with genetic predisposition to myocardial infarction (Tab. 3, Fig. 3, Ref. 23).
Mesh-Begriff(e)	Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Myocardial Infarction/genetics ; Polymorphism, Single Nucleotide ; Tumor Suppressor Protein p53/genetics
Chemische Substanzen	TP53 protein, human ; Tumor Suppressor Protein p53
Sprache	Englisch
Erscheinungsdatum	2019-01-24
Erscheinungsland	Slovakia
Dokumenttyp	Journal Article
ZDB-ID	127421-1
ISSN	0006-9248
ISSN	0006-9248
DOI	10.4149/BLL_2018_136
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Aktivita mozku pri zpracování jazyka.

Petrek, J

Ceskoslovenska fysiologie

2004 Band 53, Heft 3, Seite(n) 125–131

Abstract: The neural system, responsible for language comprehension, must quickly process and integrate a large amount of heterogenous linguistic data. There is no appropriate and generally acceptable description of the architecture of this system. This means that ...

Titelübersetzung	Brain activity during language processing.
Abstract	The neural system, responsible for language comprehension, must quickly process and integrate a large amount of heterogenous linguistic data. There is no appropriate and generally acceptable description of the architecture of this system. This means that no model of language processing is available that will allow, without problems, to interpret the wide range of disorders of language functions in neurological patients with focal lesions and explain the no less inconsistent results of experiments dealing with various aspects of language processing both in healthy people and in patients. In this paper are summed up the main findings from works of several authors who with electrophysiological recording techniques and metabolic imaging techniques (PET and MRI) sought answers to the question "where" and "how" in the brain are processed open class words and closed class words, nouns and verbs, or perhaps what is the temporal co-ordination and laterality of semantic and syntactic processes in language processing. The frequent contradictions in the findings, which a reader may quickly discover, are probably due to the design of the experiment, the properties of the stimulus applied, the type of the task to be solved during the experiment by its participants. In patients it may be also due to the accuracy of the determination of the anatomical localization and the extent of the lesions in nervous structures. In this context, however, it is necessary to be reminded that applied methods have their strong as well as weak points. Metabolic imaging techniques reliably inform of the exact localization of metabolically active brain structures, but they only give a rough picture of temporal dynamics of brain processes. On the other hand, electrophysiological techniques reflect precisely the temporal dynamics of neuronal activation near the recording electrode, but they say little about the activity of neuronal assemblies in areas remote from the site of registration.
Mesh-Begriff(e)	Brain/physiology ; Brain Mapping ; Evoked Potentials ; Humans ; Language
Sprache	Tschechisch
Erscheinungsdatum	2004
Erscheinungsland	Czech Republic
Dokumenttyp	English Abstract ; Journal Article ; Review
ZDB-ID	419220-5
ISSN	1210-6313 ; 0009-0557
ISSN	1210-6313 ; 0009-0557
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Toward a Quantitative Relationship between Nanoscale Spatial Organization and Hybridization Kinetics of Surface Immobilized Hairpin DNA Probes.

Gu, Qufei / Cao, Huan H / Zhang, Yehan / Wang, Haiyang / Petrek, Zachary J / Shi, Fukun / Josephs, Eric A / Ye, Tao

ACS sensors

2020 Band 6, Heft 2, Seite(n) 371–379

Abstract: Hybridization of DNA probes immobilized on a solid support is a key process for DNA biosensors and microarrays. Although the surface environment is known to influence the kinetics of DNA hybridization, so far it has not been possible to quantitatively ... ...

Abstract	Hybridization of DNA probes immobilized on a solid support is a key process for DNA biosensors and microarrays. Although the surface environment is known to influence the kinetics of DNA hybridization, so far it has not been possible to quantitatively predict how hybridization kinetics is influenced by the complex interactions of the surface environment. Using spatial statistical analysis of probes and hybridized target molecules on a few electrochemical DNA (E-DNA) sensors, functioning through hybridization-induced conformational change of redox-tagged hairpin probes, we developed a phenomenological model that describes how the hybridization rates for single probe molecules are determined by the local environment. The predicted single-molecule rate constants, upon incorporation into numerical simulation, reproduced the overall kinetics of E-DNA sensor surfaces at different probe densities and different degrees of probe clustering. Our study showed that the nanoscale spatial organization is a major factor behind the counterintuitive trends in hybridization kinetics. It also highlights the importance of models that can account for heterogeneity in surface hybridization. The molecular level understanding of hybridization at surfaces and accurate prediction of hybridization kinetics may lead to new opportunities in development of more sensitive and reproducible DNA biosensors and microarrays.
Mesh-Begriff(e)	Biosensing Techniques ; DNA/genetics ; DNA Probes/genetics ; Kinetics ; Nucleic Acid Hybridization
Chemische Substanzen	DNA Probes ; DNA (9007-49-2)
Sprache	Englisch
Erscheinungsdatum	2020-10-02
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.0c01278
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis.

van der Vis, Joanne J / Prasse, Antje / Renzoni, Elisabetta A / Stock, Carmel J W / Caliskan, Canay / Maher, Toby M / Bonella, Francesco / Borie, Raphael / Crestani, Bruno / Petrek, Martin / Wuyts, Wim A / Wind, Anne E / Molyneaux, Philip L / Grutters, Jan C / van Moorsel, Coline H M

Respirology (Carlton, Vic.)

2022 Band 28, Heft 5, Seite(n) 455–464

Abstract: Background and objective: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor ... ...

Abstract	Background and objective: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association between MUC5B rs35705950, survival and patient characteristics in a real-world population of European IPF patients. Methods: In this retrospective study, 1751 patients with IPF from 8 European centres were included. MUC5B rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed. Results: In a multi-variate Cox proportional hazard model the MUC5B minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. MUC5B minor allele carriers were significantly older at diagnosis (p = 0.001). The percentage of MUC5B minor allele carriers increased significantly with age from 44% in patients aged <56 year, to 63% in patients aged >75. In IPF patients aged <56, the MUC5B minor allele was not associated with survival. In IPF patients aged ≥56, survival was significantly better for MUC5B minor allele carriers (45 months [CI: 42-49]) compared to non-carriers (29 months [CI: 26-33]; p = 4 × 10 Conclusion: MUC5B minor allele carriage associates with a better median transplant-free survival of 16 months in the European IPF population aged over 56 years. MUC5B genotype status might aid disease prognostication in clinical management of IPF patients.
Mesh-Begriff(e)	Humans ; Aged ; Retrospective Studies ; Idiopathic Pulmonary Fibrosis/genetics ; Polymorphism, Genetic ; Genotype ; Alleles ; Mucin-5B/genetics ; Genetic Predisposition to Disease
Chemische Substanzen	Mucin-5B ; MUC5B protein, human
Sprache	Englisch
Erscheinungsdatum	2022-12-26
Erscheinungsland	Australia
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14440
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis

Vis, Joanne J. van der / Prasse, Antje / Renzoni, Elisabetta A. / Stock, Carmel J.W. / Caliskan, Canay / Maher, Toby M. / Bonella, Francesco / Borie, Raphael / Crestani, Bruno / Petrek, Martin / Wuyts, Wim A. / Wind, Anne E. / Molyneaux, Philip L. / Grutters, Jan C. / Moorsel, Coline H.M. van

2023

Abstract: 455 ... 464 ... Background and objective: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B ... ...

Abstract	455 464 Background and objective: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association between MUC5B rs35705950, survival and patient characteristics in a real-world population of European IPF patients. Methods: In this retrospective study, 1751 patients with IPF from 8 European centres were included. MUC5B rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed. Results: In a multi-variate Cox proportional hazard model the MUC5B minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. MUC5B minor allele carriers were significantly older at diagnosis (p = 0.001). The percentage of MUC5B minor allele carriers increased significantly with age from 44% in patients aged <56 year, to 63% in patients aged >75. In IPF patients aged <56, the MUC5B minor allele was not associated with survival. In IPF patients aged ≥56, survival was significantly better for MUC5B minor allele carriers (45 months [CI: 42-49]) compared to non-carriers (29 months [CI: 26-33]; p = 4 × 10-12 ). Conclusion: MUC5B minor allele carriage associates with a better median transplant-free survival of 16 months in the European IPF population aged over 56 years. MUC5B genotype status might aid disease prognostication in clinical management of IPF patients. 28 5
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsland	de
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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