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  1. Article: Emeriti: Hintergrund & Interview mit Klaus Rajewsky

    Rajewsky, Klaus

    Laborjournal

    2012  Volume 19, Issue 3, Page(s) 22

    Language German
    Document type Article
    ZDB-ID 1237282-1
    ISSN 1612-8354
    Database Current Contents Medicine

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    Zs.A 4842: Show issues Location:
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  2. Article ; Online: The advent and rise of monoclonal antibodies.

    Rajewsky, Klaus

    Nature

    2019  Volume 575, Issue 7781, Page(s) 47–49

    MeSH term(s) Allergy and Immunology/history ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; History, 20th Century ; Hybridomas/metabolism ; Immunologic Techniques/history ; Mice ; Neoplasms/drug therapy ; Neoplasms, Plasma Cell/metabolism
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2019-11-04
    Publishing country England
    Document type Historical Article ; News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-02840-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  3. Article ; Online: George Klein: 1925-2016.

    Rajewsky, Klaus

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 13, Page(s) 3275–3277

    Language English
    Publishing date 2017-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1702501114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

    Iwakoshi, Neal N / Lee, Ann-Hwee / Vallabhajosyula, Prasanth / Otipoby, Kevin L / Rajewsky, Klaus / Glimcher, Laurie H

    Nature immunology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01827-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The DNA deamination model of somatic antibody diversification.

    Rajewsky, Klaus

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Volume 194, Issue 5, Page(s) 2041–2042

    MeSH term(s) Allergy and Immunology/history ; Cytidine Deaminase/genetics ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Genetic Engineering/history ; Humans ; Immunoglobulins/genetics
    Chemical Substances Escherichia coli Proteins ; Immunoglobulins ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2015-03-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1403252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Herzenberg lecture: how to make a B-1 cell?

    Rajewsky, Klaus

    Annals of the New York Academy of Sciences

    2015  Volume 1362, Page(s) 6–7

    Abstract: This essay presents a short historical perspective on B-1 cells and a synopsis of contemporary work in my laboratory on generating B-1 from B-2 cells via B cell receptor exchange. ...

    Abstract This essay presents a short historical perspective on B-1 cells and a synopsis of contemporary work in my laboratory on generating B-1 from B-2 cells via B cell receptor exchange.
    MeSH term(s) Animals ; B-Lymphocyte Subsets/physiology ; Humans ; Laboratory Personnel/trends ; Receptors, Antigen, B-Cell/physiology
    Chemical Substances Receptors, Antigen, B-Cell
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Lectures ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.12767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Michael S. Neuberger 1953-2013.

    Rajewsky, Klaus

    Proceedings of the National Academy of Sciences of the United States of America

    2014  Volume 111, Issue 8, Page(s) 2862–2863

    MeSH term(s) Antibodies/immunology ; History, 20th Century ; History, 21st Century ; Hybridomas/immunology ; Molecular Biology/history
    Chemical Substances Antibodies
    Language English
    Publishing date 2014-02-14
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1401334111
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  8. Article ; Online: Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety.

    Tran, Ngoc Tung / Lebedin, Mikhail / Danner, Eric / Kühn, Ralf / Rajewsky, Klaus / Chu, Van Trung

    Bio-protocol

    2023  Volume 13, Issue 8, Page(s) e4661

    Abstract: The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern. In contrast to Cas9 nuclease, ... ...

    Abstract The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern. In contrast to Cas9 nuclease, Cas9 nickases with a pair of short-distance (38-68 bp) PAM-out single-guide RNAs (sgRNAs) preserve gene repair efficiency while strongly reducing off-target effects. However, this approach still leads to efficient unwanted on-target mutations that may cause tumorigenesis or abnormal hematopoiesis. We establish a precise and safe
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Years in Cologne.

    Rajewsky, Klaus

    Annual review of immunology

    2013  Volume 31, Page(s) 1–29

    Abstract: This review describes the building and scientific activity of the Immunology Department at the Institute for Genetics in Cologne, cofounded by Max Delbrück in post-World War II Germany. The protagonist, a child of Russian emigrants, became interested in ... ...

    Abstract This review describes the building and scientific activity of the Immunology Department at the Institute for Genetics in Cologne, cofounded by Max Delbrück in post-World War II Germany. The protagonist, a child of Russian emigrants, became interested in antibodies as a postdoc at the Pasteur Institute in Paris and a proponent of the antigen-bridge model of T-B cell collaboration during his early time in Cologne. He was challenged by the gap between cellular immunology and molecular genetics and profited from the advances of the latter as well as postwar economic growth in Germany. The Immunology Department became a place, and little universe in itself, where young scientists from all over the world came together to study cellular and molecular mechanisms of antibody formation. This included work on normal and malignant B cells in the human, particularly the origin of Hodgkin lymphoma, but the main focus was on B cell development and homeostasis, the germinal center reaction, and immunological memory, developing recombinase-assisted and conditional gene targeting in mice as a main technical tool.
    MeSH term(s) Animals ; Antibody Formation/genetics ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocyte Subsets/pathology ; Germany ; History, 20th Century ; History, 21st Century ; Humans ; Immunity, Cellular/genetics ; Lymphocyte Cooperation/genetics ; Lymphocyte Cooperation/immunology ; Molecular Biology/history ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/pathology
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev.immunol.021908.132646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.

    Li, Xun / Wirtz, Tristan / Weber, Timm / Lebedin, Mikhail / Lowenstein, Elijah D / Sommermann, Thomas / Zach, Andreas / Yasuda, Tomoharu / de la Rosa, Kathrin / Chu, Van Trung / Schulte, Johannes H / Müller, Ingo / Kocks, Christine / Rajewsky, Klaus

    Science immunology

    2024  Volume 9, Issue 92, Page(s) eadi0042

    Abstract: Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently ... ...

    Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently needed. FHL is caused by inactivating mutations in proteins that regulate cellular immunity. Here, we used an adeno-associated virus-based CRISPR-Cas9 system with an inhibitor of nonhomologous end joining to repair such mutations in potentially long-lived T cells ex vivo. Repaired CD8 memory T cells efficiently cured lethal hyperinflammation in a mouse model of Epstein-Barr virus-triggered FHL2, a subtype caused by perforin-1 (
    MeSH term(s) Animals ; Mice ; Humans ; Lymphohistiocytosis, Hemophagocytic/genetics ; Lymphohistiocytosis, Hemophagocytic/therapy ; CRISPR-Cas Systems ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/therapy ; Memory T Cells ; Herpesvirus 4, Human ; Membrane Proteins/genetics
    Chemical Substances UNC13D protein, human ; Membrane Proteins
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adi0042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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