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  1. Article ; Online: Cell death, therapeutics, and the immune response in cancer.

    Hänggi, Kay / Ruffell, Brian

    Trends in cancer

    2023  Volume 9, Issue 5, Page(s) 381–396

    Abstract: Induction of cell death is inexorably linked with cancer therapy, but this can also initiate wound-healing processes that have been linked to cancer progression and therapeutic resistance. Here we describe the contribution of apoptosis and the lytic cell ...

    Abstract Induction of cell death is inexorably linked with cancer therapy, but this can also initiate wound-healing processes that have been linked to cancer progression and therapeutic resistance. Here we describe the contribution of apoptosis and the lytic cell death pathways in the response to therapy (including chemotherapy and immunotherapy). We also discuss how necroptosis, pyroptosis, and ferroptosis function to promote tumor immunogenicity, along with emerging findings that these same forms of death can paradoxically contribute to immune suppression and tumor progression. Understanding the duality of cell death in cancer may allow for the development of therapeutics that shift the balance towards regression.
    MeSH term(s) Humans ; Cell Death ; Apoptosis ; Pyroptosis ; Neoplasms/drug therapy ; Immunity
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokines drive prostate cancer lineage plasticity.

    Li, Jie / Ruffell, Brian

    Immunity

    2022  Volume 55, Issue 10, Page(s) 1761–1763

    Abstract: Lineage plasticity is a critical mechanism of therapeutic resistance in cancer. In a recent issue of Science, Chan and colleagues demonstrate that early lineage plasticity in prostate cancer is driven by JAK-STAT inflammatory cytokine signaling. ...

    Abstract Lineage plasticity is a critical mechanism of therapeutic resistance in cancer. In a recent issue of Science, Chan and colleagues demonstrate that early lineage plasticity in prostate cancer is driven by JAK-STAT inflammatory cytokine signaling.
    MeSH term(s) Cytokines/metabolism ; Humans ; Janus Kinases/metabolism ; Male ; Prostatic Neoplasms ; STAT Transcription Factors/metabolism ; Signal Transduction
    Chemical Substances Cytokines ; STAT Transcription Factors ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2022-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.09.011
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  3. Article ; Online: Cavity macrophages stop anti-tumor T cells.

    Rodriguez, Paulo C / Ruffell, Brian

    Cancer cell

    2021  Volume 39, Issue 7, Page(s) 900–902

    Abstract: Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue of Cancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM- ... ...

    Abstract Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue of Cancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM-4
    MeSH term(s) Hepatitis A Virus Cellular Receptor 2 ; Immunotherapy ; Macrophages ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory
    Chemical Substances Hepatitis A Virus Cellular Receptor 2
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.06.007
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  4. Article: Metabolism in tumor-associated macrophages.

    Li, Jie / DeNicola, Gina M / Ruffell, Brian

    International review of cell and molecular biology

    2022  Volume 367, Page(s) 65–100

    Abstract: Macrophages functionally adapt to a diverse set of signals, a process that is critical for their role in maintaining or restoring tissue homeostasis. This process extends to cancer, where macrophages respond to a series of inflammatory and metabolic cues ...

    Abstract Macrophages functionally adapt to a diverse set of signals, a process that is critical for their role in maintaining or restoring tissue homeostasis. This process extends to cancer, where macrophages respond to a series of inflammatory and metabolic cues that direct a maladaptive healing response. Tumor-associated macrophages (TAMs) have altered glucose, amino acid, and lipid metabolic profiles, and interfering with this metabolic shift can blunt the ability of macrophages to promote tumor growth, metastasis, and the creation of an immunosuppressive microenvironment. Here we will review changes in metabolites and metabolic pathways in TAMs and link these with the phenotypic and functional properties of the cells. We will also discuss current strategies targeting TAM metabolism as a therapeutic intervention in cancer.
    MeSH term(s) Humans ; Macrophages ; Metabolic Networks and Pathways ; Neoplasms/metabolism ; Tumor Microenvironment ; Tumor-Associated Macrophages
    Language English
    Publishing date 2022-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2022.01.004
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  5. Article ; Online: Detection of exogenous DNA uptake by murine dendritic cells.

    Celias, Daiana P / de Mingo Pulido, Álvaro / Ruffell, Brian

    STAR protocols

    2022  Volume 3, Issue 3, Page(s) 101464

    Abstract: This protocol has been developed to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents. Inhibitors or antibodies that alter the ... ...

    Abstract This protocol has been developed to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents. Inhibitors or antibodies that alter the process can be added, and either flow cytometry or fluorescent microscopy can be used to measure DNA uptake
    MeSH term(s) Animals ; DNA ; Dendritic Cells ; Mice
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101464
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  6. Article ; Online: Oncogenic KRAS Drives Immune Suppression in Colorectal Cancer.

    Hänggi, Kay / Ruffell, Brian

    Cancer cell

    2019  Volume 35, Issue 4, Page(s) 535–537

    Abstract: In this issue of Cancer Cell, Liao et al. demonstrate that oncogenic KRAS drives an immune suppressive program in colorectal cancer by repressing IRF2 expression, which leads to downregulation of interferon responsive genes, enhanced expression of CXCL3 ... ...

    Abstract In this issue of Cancer Cell, Liao et al. demonstrate that oncogenic KRAS drives an immune suppressive program in colorectal cancer by repressing IRF2 expression, which leads to downregulation of interferon responsive genes, enhanced expression of CXCL3 and recruitment of suppressive myeloid cells, and subsequent resistance to immune checkpoint blockade.
    MeSH term(s) Colonic Neoplasms ; Colorectal Neoplasms/genetics ; Genes, ras ; Humans ; Interferon Regulatory Factor-2 ; Oncogenes ; Proto-Oncogene Proteins p21(ras)
    Chemical Substances IRF2 protein, human ; Interferon Regulatory Factor-2 ; KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2019.03.008
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  7. Article ; Online: moDCs, Less Problems.

    Gardner, Alycia / Ruffell, Brian

    Immunity

    2018  Volume 48, Issue 1, Page(s) 6–8

    Abstract: Type 1 conventional dendritic cells are necessary for the development of anti-tumor immunity. In this issue of Immunity, Sharma et al. (2018) identify a phenotypically similar monocyte-derived population within inflamed tumors that promotes T cell ... ...

    Abstract Type 1 conventional dendritic cells are necessary for the development of anti-tumor immunity. In this issue of Immunity, Sharma et al. (2018) identify a phenotypically similar monocyte-derived population within inflamed tumors that promotes T cell responses during therapy.
    MeSH term(s) Cell Differentiation ; Cells, Cultured ; Dendritic Cells ; Monocytes ; T-Lymphocytes
    Language English
    Publishing date 2018-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2017.12.017
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  8. Article ; Online: The Immune Microenvironment and Cancer Metastasis.

    El-Kenawi, Asmaa / Hänggi, Kay / Ruffell, Brian

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 4

    Abstract: The dynamic interplay between neoplastic cells and the immune microenvironment regulates every step of the metastatic process. Immune cells contribute to invasion by secreting a cornucopia of inflammatory factors that promote epithelial-to-mesenchymal ... ...

    Abstract The dynamic interplay between neoplastic cells and the immune microenvironment regulates every step of the metastatic process. Immune cells contribute to invasion by secreting a cornucopia of inflammatory factors that promote epithelial-to-mesenchymal transition and remodeling of the stroma. Cancer cells then intravasate to the circulatory system assisted by macrophages and use several pathways to avoid recognition by cytotoxtic lymphocytes and phagocytes. Circulating tumor cells that manage to adhere to the vasculature and encounter premetastic niches are able to use the associated myeloid cells to extravasate into ectopic organs and establish a dormant microscopic colony. If successful at avoiding repetitive immune attack, dormant cells can subsequently grow into overt, clinically detectable metastatic lesions, which ultimately account to most cancer-related deaths. Understanding how disseminated tumor cells evade and corrupt the immune system during the final stages of metastasis will be pivotal in developing new therapeutic modalities that combat metastasis.
    MeSH term(s) Cell Adhesion ; Epithelial-Mesenchymal Transition ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Neoplasm Metastasis/immunology ; Neoplasm Metastasis/pathology ; Neoplastic Cells, Circulating/immunology ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a037424
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  9. Article ; Online: Dendritic Cells and Their Role in Immunotherapy.

    Gardner, Alycia / de Mingo Pulido, Álvaro / Ruffell, Brian

    Frontiers in immunology

    2020  Volume 11, Page(s) 924

    Abstract: Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role in ... ...

    Abstract Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past. With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic. Dendritic cells are also emerging as critical regulators of the immune response within tumors. Understanding how to augment the function of these intratumoral dendritic cells could offer new approaches to enhance immunotherapy, in addition to improving the cytotoxic and targeted therapies that are partially dependent upon a robust immune response for their efficacy. Here we will discuss the role of specific dendritic cell subsets in regulating the anti-tumor immune response, as well as the current status of dendritic cell-based immunotherapies, in order to provide an overview for future lines of research and clinical trials.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Cancer Vaccines/adverse effects ; Cancer Vaccines/therapeutic use ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/transplantation ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy, Adoptive/adverse effects ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy ; Phenotype ; Signal Transduction ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Immunological ; Cancer Vaccines ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-05-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00924
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  10. Article ; Online: Detection of exogenous DNA uptake by murine dendritic cells

    Daiana P. Celias / Álvaro de Mingo Pulido / Brian Ruffell

    STAR Protocols, Vol 3, Iss 3, Pp 101464- (2022)

    2022  

    Abstract: Summary: This protocol has been developed to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents. Inhibitors or antibodies that ... ...

    Abstract Summary: This protocol has been developed to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents. Inhibitors or antibodies that alter the process can be added, and either flow cytometry or fluorescent microscopy can be used to measure DNA uptake. This is intended to mimic the exposure of DCs to dying cells in the tumor microenvironment or other pathological conditions of high cellular death.For complete details on the use and execution of this protocol, please refer to de Mingo Pulido et al. (2021). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Cancer ; Cell Biology ; Cell isolation ; Flow Cytometry/Mass Cytometry ; Immunology ; Microscopy ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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