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  1. Article ; Online: Hodgkin lymphoma: outsmarting HRS cells.

    Connors, Joseph M

    Blood

    2020  Volume 136, Issue 21, Page(s) 2362–2364

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Hodgkin Disease/therapy ; Humans ; Reed-Sternberg Cells
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  2. Article ; Online: Immunotherapy for older patients with classic Hodgkin lymphoma.

    Connors, Joseph M

    The Lancet. Haematology

    2020  Volume 7, Issue 11, Page(s) e776–e777

    MeSH term(s) Hodgkin Disease ; Humans ; Immunologic Factors ; Immunotherapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30321-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: To treat or not to treat, that is the NLPHL question.

    Connors, Joseph M

    Blood

    2019  Volume 133, Issue 20, Page(s) 2113–2114

    MeSH term(s) Diagnosis, Differential ; Hodgkin Disease ; Humans ; Immunophenotyping ; Lymphocytes ; Watchful Waiting
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2019-02-900811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Introduction From the Guest Editor: Hodgkin Lymphoma: Integrating New Therapies to Improve Outcomes.

    Connors, Joseph M

    Cancer journal (Sudbury, Mass.)

    2018  Volume 24, Issue 5, Page(s) 205

    MeSH term(s) Hodgkin Disease/pathology ; Hodgkin Disease/therapy ; Humans ; Molecular Targeted Therapy ; Prognosis
    Language English
    Publishing date 2018-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 163: Show issues

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  5. Article ; Online: Advanced-Stage Hodgkin Lymphoma: New Approaches Based on Novel Therapeutic Agents or Treatment Intensification.

    Connors, Joseph M

    Cancer journal (Sudbury, Mass.)

    2018  Volume 24, Issue 5, Page(s) 230–236

    Abstract: Depending on a variety of prognostic factors including age, stage, laboratory abnormalities, and initial response to treatment, from 70% to 90% of patients with advanced-stage Hodgkin lymphoma can be cured with modern multiagent chemotherapy. Two ... ...

    Abstract Depending on a variety of prognostic factors including age, stage, laboratory abnormalities, and initial response to treatment, from 70% to 90% of patients with advanced-stage Hodgkin lymphoma can be cured with modern multiagent chemotherapy. Two effective strategies offer the promise to improve on those results. Early intensification of treatment, typically by increasing the doses and frequency of administration of standard chemotherapy agents, induces higher initial response rates but has the major drawback of causing unacceptably severe acute toxicity, increased numbers of secondary neoplasms, and infertility due to oligospermia in men and premature menopause in women. Alternatively, integration of novel therapeutic agents into primary treatment is attractive, especially when the introduction not only improves the frequency and durability of disease response but also does not unacceptably increase acute or long-term toxicity. Finally, widespread availability of functional imaging with positron emission tomography now enables response-adapted therapy, a separate innovation in the treatment of Hodgkin lymphoma that can be incorporated with either intensified chemotherapy or addition of novel agents. This article discusses these exciting new developments in the treatment of advanced-stage Hodgkin lymphoma.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Humans ; Molecular Targeted Therapy ; Prognosis
    Language English
    Publishing date 2018-09-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 163: Show issues

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  6. Article ; Online: Is the lymphoma better? Not easy to determine.

    Connors, Joseph M

    Blood

    2016  Volume 128, Issue 21, Page(s) 2481–2482

    MeSH term(s) Humans ; Lymphoma
    Language English
    Publishing date 2016-11-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-09-738815
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  7. Article ; Online: Immune Checkpoint Inhibition: A New Era in Lymphoma Treatment.

    Connors, Joseph M

    Journal of oncology practice

    2016  Volume 12, Issue 2, Page(s) 109–110

    MeSH term(s) Humans ; Lymphoma
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2236338-5
    ISSN 1935-469X ; 1554-7477
    ISSN (online) 1935-469X
    ISSN 1554-7477
    DOI 10.1200/JOP.2015.009506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: I. Hodgkin lymphoma: special challenges and solutions.

    Connors, Joseph M

    Hematological oncology

    2015  Volume 33 Suppl 1, Page(s) 21–24

    MeSH term(s) Female ; Hodgkin Disease/diagnosis ; Hodgkin Disease/mortality ; Hodgkin Disease/pathology ; Hodgkin Disease/therapy ; Humans ; Male
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2210
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  9. Article ; Online: Risk assessment in the management of newly diagnosed classical Hodgkin lymphoma.

    Connors, Joseph M

    Blood

    2015  Volume 125, Issue 11, Page(s) 1693–1702

    Abstract: Treatment of Hodgkin lymphoma is associated with 2 major types of risk: that the treatment may fail to cure the disease or that the treatment will prove unacceptably toxic. Careful assessment of the amount of the lymphoma (tumor burden), its behavior ( ... ...

    Abstract Treatment of Hodgkin lymphoma is associated with 2 major types of risk: that the treatment may fail to cure the disease or that the treatment will prove unacceptably toxic. Careful assessment of the amount of the lymphoma (tumor burden), its behavior (extent of invasion or specific organ compromise), and host related factors (age; coincident systemic infection; and organ dysfunction, especially hematopoietic, cardiac, or pulmonary) is essential to optimize outcome. Elaborately assembled prognostic scoring systems, such as the International Prognostic Factors Project score, have lost their accuracy and value as increasingly effective chemotherapy and supportive care have been developed. Identification of specific biomarkers derived from sophisticated exploration of Hodgkin lymphoma biology is bringing promise of further improvement in targeted therapy in which effectiveness is increased at the same time off-target toxicity is diminished. Parallel developments in functional imaging are providing additional potential to evaluate the efficacy of treatment while it is being delivered, allowing dynamic assessment of risk during chemotherapy and adaptation of the therapy in real time. Risk assessment in Hodgkin lymphoma is continuously evolving, promising ever greater precision and clinical relevance. This article explores the past usefulness and the emerging potential of risk assessment for this imminently curable malignancy.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/metabolism ; Disease-Free Survival ; Female ; Hodgkin Disease/diagnosis ; Hodgkin Disease/metabolism ; Hodgkin Disease/therapy ; Humans ; Male ; Prognosis ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Tumor Burden
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-07-537480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Brentuximab Vedotin for Stage III or IV Hodgkin's Lymphoma.

    Connors, Joseph M / Radford, John A

    The New England journal of medicine

    2018  Volume 378, Issue 16, Page(s) 1560–1561

    MeSH term(s) Antineoplastic Agents ; Antineoplastic Combined Chemotherapy Protocols ; Hodgkin Disease ; Humans ; Immunoconjugates
    Chemical Substances Antineoplastic Agents ; Immunoconjugates ; brentuximab vedotin (7XL5ISS668)
    Language English
    Publishing date 2018--19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1802363
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