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  1. Article ; Online: Targeting HER2 in Gastroesophageal Adenocarcinoma: Molecular Features and Updates in Clinical Practice.

    Bonomi, Maria / Spada, Daniele / Baiocchi, Gian Luca / Celotti, Andrea / Brighenti, Matteo / Grizzi, Giulia

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Gastroesophageal adenocarcinoma (GEA) is one of the principal causes of death related to cancer globally. Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor which is found to be overexpressed or amplified in approximately 20% ... ...

    Abstract Gastroesophageal adenocarcinoma (GEA) is one of the principal causes of death related to cancer globally. Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor which is found to be overexpressed or amplified in approximately 20% of GEA cases. In GEA, the identification of HER2-positive status is crucial to activate a specific anti-HER2 targeted therapy. The landmark ToGA trial demonstrated the superiority of adding trastuzumab to platinum-based chemotherapy, becoming the first-line standard of treatment. However, unlike breast cancer, the efficacy of other anti-HER2 drugs, such as lapatinib, pertuzumab, and T-DM1, has failed to improve outcomes in advanced and locally advanced resectable GEA. Recently, the combination of trastuzumab with pembrolizumab, along with chemotherapy, and the development of trastuzumab deruxtecan, with its specific bystander activity, demonstrated improved outcomes, renewing attention in the treatment of this disease. This review will summarise historical and emerging therapies for the treatment of HER2-positive GEA, with a section dedicated to the HER2 molecular pathway and the use of novel blood biomarkers, such as circulating tumour DNA and circulating tumour cells, which may be helpful in the future to guide treatment decisions.
    MeSH term(s) Humans ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Trastuzumab/therapeutic use ; Ado-Trastuzumab Emtansine ; Circulating Tumor DNA ; Lapatinib
    Chemical Substances Trastuzumab (P188ANX8CK) ; Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Circulating Tumor DNA ; Lapatinib (0VUA21238F)
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on "The Limit for Artificial Intelligence's Potentiality in Surgery Doesn't Have to Be the Surgeon".

    Gheza, Federico / Arru, Luca / Baiocchi, Gian Luca

    Annals of surgery

    2019  Volume 269, Issue 6, Page(s) e75–e77

    MeSH term(s) Artificial Intelligence ; Humans ; Surgeons
    Language English
    Publishing date 2019-05-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000002950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
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  3. Article ; Online: Further Considerations for Personalized Video Feedback in Laparoscopic Training.

    Gheza, Federico / Baiocchi, Gian Luca

    Academic medicine : journal of the Association of American Medical Colleges

    2018  Volume 93, Issue 8, Page(s) 1103–1104

    MeSH term(s) Feedback ; Laparoscopy
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000002275
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: A unique case of lymphoepithelioma-like HCC with osteoclast-like giant cells: CT imaging features with pathologic correlations.

    Frittoli, Barbara / Castaldo, Anna / Santarsiere, Marika / Ascione, Raffaele / Tanzi, Giulia / Ponsiglione, Andrea / Baiocchi, Gian Luca / Grazioli, Luigi

    Clinical journal of gastroenterology

    2023  Volume 17, Issue 1, Page(s) 112–117

    Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, with several histological variants being reported in literature. Hereby, we describe a case of a 77-year-old man with chronic liver disease referred to our department for ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, with several histological variants being reported in literature. Hereby, we describe a case of a 77-year-old man with chronic liver disease referred to our department for performing a computed tomography (CT) due to a liver mass discovered at an abdominal ultrasound follow-up. At CT, a large, ill-defined lesion in the third hepatic segment was detected, characterized by progressive and delayed enhancement with minimal retraction of the hepatic capsule, associated with perihepatic adipose tissue inhomogeneity, mimicking a cholangiocarcinoma. At histopathological evaluation, the lesion turned out to be an HCC with lymphoepithelioma-like component and osteoclastic-like giant cells. This report focuses on the clinicopathological and radiological features of this unique case.
    MeSH term(s) Male ; Humans ; Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Osteoclasts/pathology ; Tomography, X-Ray Computed ; Giant Cells/pathology ; Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology
    Language English
    Publishing date 2023-10-21
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01871-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Circulating Tumor DNA in Gastric Adenocarcinoma: Future Clinical Applications and Perspectives.

    Grizzi, Giulia / Salati, Massimiliano / Bonomi, Maria / Ratti, Margherita / Holladay, Lauren / De Grandis, Maria Caterina / Spada, Daniele / Baiocchi, Gian Luca / Ghidini, Michele

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Gastric cancer (GC) is still one of the most aggressive cancers with a few targetable alterations and a dismal prognosis. A liquid biopsy allows for identifying and analyzing the DNA released from tumor cells into the bloodstream. Compared to tissue- ... ...

    Abstract Gastric cancer (GC) is still one of the most aggressive cancers with a few targetable alterations and a dismal prognosis. A liquid biopsy allows for identifying and analyzing the DNA released from tumor cells into the bloodstream. Compared to tissue-based biopsy, liquid biopsy is less invasive, requires fewer samples, and can be repeated over time in order to longitudinally monitor tumor burden and molecular changes. Circulating tumor DNA (ctDNA) has been recognized to have a prognostic role in all the disease stages of GC. The aim of this article is to review the current and future applications of ctDNA in gastric adenocarcinoma, in particular, with respect to early diagnosis, the detection of minimal residual disease (MRD) following curative surgery, and in the advanced disease setting for treatment decision choice and therapeutic monitoring. Although liquid biopsies have shown potentiality, pre-analytical and analytical steps must be standardized and validated to ensure the reproducibility and standardization of the procedures and data analysis methods. Further research is needed to allow the use of liquid biopsy in everyday clinical practice.
    MeSH term(s) Humans ; Circulating Tumor DNA/genetics ; Circulating Tumor DNA/analysis ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Reproducibility of Results ; Biomarkers, Tumor/genetics ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics
    Chemical Substances Circulating Tumor DNA ; Biomarkers, Tumor
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119421
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  6. Article: Oral Antibiotics Alone versus Oral Antibiotics Combined with Mechanical Bowel Preparation for Elective Colorectal Surgery: A Propensity Score-Matching Re-Analysis of the iCral 2 and 3 Prospective Cohorts.

    Catarci, Marco / Guadagni, Stefano / Masedu, Francesco / Sartelli, Massimo / Montemurro, Leonardo Antonio / Baiocchi, Gian Luca / Tebala, Giovanni Domenico / Borghi, Felice / Marini, Pierluigi / Scatizzi, Marco / The Italian ColoRectal Anastomotic Leakage iCral Study Group

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: The evidence regarding the role of oral antibiotics alone (oA) or combined with mechanical bowel preparation (MoABP) for elective colorectal surgery remains controversial. A prospective database of 8359 colorectal resections gathered over a 32-month ... ...

    Abstract The evidence regarding the role of oral antibiotics alone (oA) or combined with mechanical bowel preparation (MoABP) for elective colorectal surgery remains controversial. A prospective database of 8359 colorectal resections gathered over a 32-month period from 78 Italian surgical units (the iCral 2 and 3 studies), reporting patient-, disease-, and procedure-related variables together with 60-day adverse events, was re-analyzed to identify a subgroup of 1013 cases (12.1%) that received either oA or MoABP. This dataset was analyzed using a 1:1 propensity score-matching model including 20 covariates. Two well-balanced groups of 243 patients each were obtained: group A (oA) and group B (MoABP). The primary endpoints were anastomotic leakage (AL) and surgical site infection (SSI) rates. Group A vs. group B showed a significantly higher AL risk [14 (5.8%) vs. 6 (2.5%) events; OR: 3.77; 95%CI: 1.22-11.67;
    Language English
    Publishing date 2024-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13030235
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  7. Article ; Online: A pancreatic stent to prevent post-ERCP acute pancreatitis: Is it always "true" prophylaxis?

    Grassia, Roberto / Mazza, Stefano / Drago, Andrea / Verga, Maria Chiara / Soro, Sara / Elvo, Biagio / Baiocchi, Gian Luca

    Gastrointestinal endoscopy

    2022  Volume 95, Issue 6, Page(s) 1271–1272

    MeSH term(s) Acute Disease ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Humans ; Pancreas ; Pancreatic Ducts/surgery ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Risk Factors ; Stents
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.02.045
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
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    Zs.MO 519: Show issues

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  8. Article ; Online: Defining benchmarks for total and distal gastrectomy: global multicentre analysis.

    Schneider, Marcel André / Kim, Jeesun / Berlth, Felix / Sugita, Yutaka / Grimminger, Peter P / Sano, Takeshi / Rosati, Riccardo / Baiocchi, Gian Luca / Bencivenga, Maria / De Manzoni, Giovanni / Nunobe, Souya / Yang, Han-Kwang / Gutschow, Christian Alexander

    The British journal of surgery

    2023  Volume 111, Issue 2

    MeSH term(s) Humans ; Benchmarking ; Gastroenterostomy ; Gastrectomy ; Stomach Neoplasms/surgery ; Laparoscopy
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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  9. Article ; Online: Re: Lee C. Zhao, Aaron C. Weinberg, Ziho Lee, et al. Robotic Ureteral Reconstruction Using Buccal Mucosa Grafts: A Multi-institutional Experience. Eur Urol 2018;73:419-26: Robotic Ureteral Reconstruction with Buccal Mucosal Graft: A Call Not To Lose Momentum.

    Gheza, Federico / Crivellaro, Simone / Baiocchi, Gian Luca

    European urology

    2018  Volume 73, Issue 5, Page(s) e127–e128

    MeSH term(s) Mouth Mucosa ; Reconstructive Surgical Procedures ; Robotic Surgical Procedures ; Robotics ; Ureter/surgery
    Language English
    Publishing date 2018-02-14
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.01.041
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  10. Article: Krukenberg Tumor Related to Gallbladder Cancer in a Young Woman: A Case Report and Review of the Literature.

    Grizzi, Giulia / Ghidini, Michele / Ratti, Margherita / D'Ercole, Marianna / Tanzi, Giulia / Abbiati, Annalisa / Celotti, Andrea / Spada, Daniele / Baiocchi, Gian Luca / Bonomi, Maria

    Journal of personalized medicine

    2023  Volume 13, Issue 6

    Abstract: A gallbladder tumor is a rare condition, which usually spreads to the liver, lymph nodes, and other organs. A Krukenberg tumor, derived from the biliary tract and gallbladder cancers (GBCs), is an uncommon finding in routine clinical practice. Here, a ... ...

    Abstract A gallbladder tumor is a rare condition, which usually spreads to the liver, lymph nodes, and other organs. A Krukenberg tumor, derived from the biliary tract and gallbladder cancers (GBCs), is an uncommon finding in routine clinical practice. Here, a case of a young woman with a Krukenberg tumor related to a previous diagnosis of GBC is reported. Differential diagnosis of an ovarian malignant lesion is challenging for both clinicians and pathologists. In order to provide a proper diagnosis, integrated multidisciplinary management is essential. The occurrence of Krukenberg tumors should be evaluated in the management of GBC, even if this is rare in clinical practice.
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13060957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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