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Article ; Online: Binary and ternary logic-in-memory using nanosheet feedback field-effect transistors with triple-gated structure.

Han, Jongseong / Son, Jaemin / Ryu, Seungho / Cho, Kyoungah / Kim, Sangsig

2024 Volume 14, Issue 1, Page(s) 6446

Abstract: In this study, we demonstrate binary and ternary logic-in-memory (LIM) operations of inverters and NAND and NOR gates comprising nanosheet (NS) feedback field-effect transistors (FBFETs) with a triple-gated structure. The NS FBFETs are reconfigured in p- ...

Abstract	In this study, we demonstrate binary and ternary logic-in-memory (LIM) operations of inverters and NAND and NOR gates comprising nanosheet (NS) feedback field-effect transistors (FBFETs) with a triple-gated structure. The NS FBFETs are reconfigured in p- or n-channel modes depending on the polarity of the gate bias voltage and exhibit steep switching characteristics with an extremely low subthreshold swing of 1.08 mV dec
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57290-w
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Article ; Online: Antibody-Conjugated Nanogel with Two Immune Checkpoint Inhibitors for Enhanced Cancer Immunotherapy.

Chae, Yun Jin / Lee, Kang-Gon / Oh, Doogie / Lee, Su-Kyoung / Park, Yongdoo / Kim, Jongseong

Advanced healthcare materials

2024 , Page(s) e2400235

Abstract: Cancer immunotherapy by immune checkpoint inhibitors (ICIs) acts on antitumor responses by stimulating the immune system to attack cancer cells. However, this powerful therapy is hampered by its high treatment cost and limited efficacy. Here, it is shown ...

Abstract	Cancer immunotherapy by immune checkpoint inhibitors (ICIs) acts on antitumor responses by stimulating the immune system to attack cancer cells. However, this powerful therapy is hampered by its high treatment cost and limited efficacy. Here, it is shown that the development of an antibody-conjugated nanogel (ANGel), consisting of N-isopropylacrylamide-co-acrylic acid and antibody-binding protein (protein A), potentiates the efficacy of two ICI monoclonal antibodies (mAbs) (cytotoxic-T-lymphocyte-associated antigen 4 and programmed death ligand-1 mAbs). Compared with mAb treatment alone, treatment with a bispecific ANGel surface-conjugated with the mAbs significantly decreases both the survival of Michigan Cancer Foundation-7 (MCF-7) and M D Anderson-Metastatic Breast-231 (MDA-MB-231) breast cancer cells in vitro and the burden of 4T1-luciferase-2-derived orthotopic syngeneic tumors in vivo. The bispecific ANGel is also more potent than the conventional treatment at prolonging survival in animals with triple-negative breast cancer. The advantage of the bispecific ANGel over other engineered bispecific antibodies arises not only from the adaptability to link multiple antibodies quickly and easily, but also from the capability to maintain the anticancer effect steadily at subcutaneously delivered tumor site. This finding has an important implication for cancer immunotherapy, opening a new paradigm to treat solid tumors.
Language	English
Publishing date	2024-04-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202400235
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Article ; Online: Detection of α-Thrombin with Platelet Glycoprotein Ibα (GP1bα) for the Development of a Coagulation Marker.

Oh, Doogie / Chae, Yun Jin / Teoh, Jie Ying / Yim, Bora / Yoo, Dongwon / Park, Yongdoo / Kim, Jongseong

ACS omega

2024 Volume 9, Issue 11, Page(s) 13418–13426

Abstract: The detection of prothrombotic markers is crucial for understanding thromboembolism and assessing the effectiveness of anticoagulant drugs. α-Thrombin is a marker that plays a critical role in the coagulation cascade process. However, the detection of ... ...

Abstract	The detection of prothrombotic markers is crucial for understanding thromboembolism and assessing the effectiveness of anticoagulant drugs. α-Thrombin is a marker that plays a critical role in the coagulation cascade process. However, the detection of this enzymatic molecule was hindered by the absence of an efficient modality in the clinical environment. Previously, we reported that one α-thrombin interacts with two α-chains of glycoprotein Ib (GPIbα), i.e., multivalent protein binding (MPB), using bioresponsive hydrogel nanoparticles (nanogels) and optical microscopy. In this study, we demonstrated that GPIbα-mediated platforms led to the highly sensitive and quantitative detection of α-thrombin in various diagnostic systems. Initially, a bioresponsive nanogel-based surface plasmon resonance (nSPR) assay was developed that responds to the MPB of α-thrombin to GPIbα. The use of GPIbα for the detection of α-thrombin was further validated using the enzyme-linked immunosorbent assay, which is a gold-standard protein detection technique. Additionally, GPIbα-functionalized latex beads were developed to perform latex agglutination (LA) assays, which are widely used with hospital diagnostic instruments. Notably, the nSPR and LA assays exhibited a nearly 1000-fold improvement in sensitivity for α-thrombin detection compared to our previous optical microscopy method. The superiority of our GPIbα-mediated platforms lies in their stability for α-thrombin detection through protein-protein interactions. By contrast, assays relying on α-thrombin enzymatic activity using substrates face the challenge of a rapid decrease in postsample collection. These results suggested that the MPB of α-thrombin to GPIbα is an ideal mode for clinical α-thrombin detection, particularly in outpatient settings.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00010
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Book ; Online: Decompose, Adjust, Compose

Lee, Sangrok / Bae, Jongseong / Kim, Ha Young

Effective Normalization by Playing with Frequency for Domain Generalization

2023

Abstract: Domain generalization (DG) is a principal task to evaluate the robustness of computer vision models. Many previous studies have used normalization for DG. In normalization, statistics and normalized features are regarded as style and content, ... ...

Abstract	Domain generalization (DG) is a principal task to evaluate the robustness of computer vision models. Many previous studies have used normalization for DG. In normalization, statistics and normalized features are regarded as style and content, respectively. However, it has a content variation problem when removing style because the boundary between content and style is unclear. This study addresses this problem from the frequency domain perspective, where amplitude and phase are considered as style and content, respectively. First, we verify the quantitative phase variation of normalization through the mathematical derivation of the Fourier transform formula. Then, based on this, we propose a novel normalization method, PCNorm, which eliminates style only as the preserving content through spectral decomposition. Furthermore, we propose advanced PCNorm variants, CCNorm and SCNorm, which adjust the degrees of variations in content and style, respectively. Thus, they can learn domain-agnostic representations for DG. With the normalization methods, we propose ResNet-variant models, DAC-P and DAC-SC, which are robust to the domain gap. The proposed models outperform other recent DG methods. The DAC-SC achieves an average state-of-the-art performance of 65.6% on five datasets: PACS, VLCS, Office-Home, DomainNet, and TerraIncognita. Comment: 10 pages,6 figures, Conference on Computer Vision and Pattern Recognition 2023
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-03-04
Publishing country	us
Document type	Book ; Online
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Article ; Online: A magnetically powered nanomachine with a DNA clutch.

Lin, Mouhong / Lee, Jung-Uk / Kim, Youngjoo / Kim, Gooreum / Jung, Yunmin / Jo, Ala / Park, Mansoo / Lee, Sol / Lah, Jungsu David / Park, Jongseong / Noh, Kunwoo / Lee, Jae-Hyun / Kwak, Minsuk / Lungerich, Dominik / Cheon, Jinwoo

Nature nanotechnology

2024

Abstract: Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dynein, myosin or bacterial flagellar motors, ... ...

Abstract	Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dynein, myosin or bacterial flagellar motors, allows for temporary disengagement of the moving parts from the running engine. However, such sophistication is still challenging to achieve in artificial nanomachines. Here we present a spherical rotary nanomotor with a reversible clutch system based on precise molecular recognition of built-in DNA strands. The clutch couples and decouples the engine from the machine's rotor in response to encoded inputs such as DNA or RNA. The nanomotor comprises a porous nanocage as a spherical rotor to confine the magnetic engine particle within the nanospace (∼0.004 μm
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2254964-X
ISSN	1748-3395 ; 1748-3387
ISSN (online)	1748-3395
ISSN	1748-3387
DOI	10.1038/s41565-023-01599-6
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Article ; Online: Method for the Rapid Detection of SARS-CoV-2-Neutralizing Antibodies Using a Nanogel-Based Surface Plasmon Resonance Biosensor.

Lee, Su-Kyoung / Yim, Bora / Park, Jinseul / Kim, Nam-Gun / Kim, Byung-Soo / Park, Yongdoo / Yoon, Young Kyung / Kim, Jongseong

ACS applied polymer materials

2023 Volume 5, Issue 3, Page(s) 2195–2202

Abstract: The efficacy of coronavirus disease 2019 (COVID-19) vaccination is closely related to the serum levels of SARS-CoV-2-neutralizing antibodies (NAb) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Therefore, the rapid and ... ...

Abstract	The efficacy of coronavirus disease 2019 (COVID-19) vaccination is closely related to the serum levels of SARS-CoV-2-neutralizing antibodies (NAb) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Therefore, the rapid and quantitative measurement of SARS-CoV-2 NAb in the sera of vaccinated individuals is essential to develop an effective vaccine and further achieve population immunity, that is, herd immunity. The plaque reduction neutralization test, the gold standard for NAb effectiveness in serological tests, is accurate but requires biosafety level 3 facilities because of the use of the virus, which hampers its application in common laboratories and clinical practice. Here, we developed a bioresponsive nanogel-based surface plasmon resonance (nSPR) platform that detects SARS-CoV-2 NAb in clinical samples without complicated pretreatment. We found that multivalent protein binding (MPB) between the nanogel-conjugated RBD protein and SARS-CoV-2 NAb yields significantly enhanced SPR signals compared to the nonspecific interference from serum proteins in the nSPR assay. The excellence of our nanogel-based SARS-CoV-2 NAb test is due to its selectivity for NAb, with resistance to all other proteins, allowing the rapid detection and quantification of NAbs in each individual. Importantly, this nSPR assay provides a NAb detection platform for easier and safer COVID-19 vaccination strategies.
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ISSN	2637-6105
ISSN (online)	2637-6105
DOI	10.1021/acsapm.2c02187
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Article ; Online: Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA.

Yoon, Jung-Ki / Ahn, Jongseong / Kim, Sheehyun / Kim, Hwang-Phil / Kang, Jun-Kyu / Bang, Duhee / Lim, Yoojoo / Kim, Tae-You

Cancer research and treatment

2023 Volume 55, Issue 3, Page(s) 1048–1052

Abstract: Poly(ADP-ribose) polymerase inhibitors have been shown dramatic responses in patients with BRCAness. However, clinical studies have been limited to breast cancer patients with germline mutations. Here, we describe a patient with metastatic breast cancer ... ...

Abstract	Poly(ADP-ribose) polymerase inhibitors have been shown dramatic responses in patients with BRCAness. However, clinical studies have been limited to breast cancer patients with germline mutations. Here, we describe a patient with metastatic breast cancer who had a rare BRCA1 somatic mutation (BRCA1 c.4336G>T (p.E1446)) detected by cell-free DNA analysis after failing standard therapies. This tier III variant of unknown significance was predicted to be a pathogenic variant in our assessment, leading us to consider off-label treatment with olaparib. The patient responded well to olaparib for several months, with a decrease in allele frequency of this BRCA1 somatic mutation in cell-free DNA. Olaparib resistance subsequently developed with an increase in the allele frequency and new BRCA1 reversion mutations. To our knowledge, this is the first report confirming BRCA1 c.4336G>T (p.E1446) as a mutation sensitive to olaparib in breast cancer and describing the dynamic changes in the associated mutations using liquid biopsy.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Circulating Tumor DNA/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Mutation ; Cell-Free Nucleic Acids/therapeutic use
Chemical Substances	Circulating Tumor DNA ; olaparib (WOH1JD9AR8) ; Poly(ADP-ribose) Polymerase Inhibitors ; Cell-Free Nucleic Acids
Language	English
Publishing date	2023-01-31
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2133613-1
ISSN	2005-9256 ; 1598-2998
ISSN (online)	2005-9256
ISSN	1598-2998
DOI	10.4143/crt.2022.1529
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Zs.A 7043: Show issues

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Article ; Online: Spatio-temporal structures of satellite-derived water quality indicators along the Korean South Coast

Kim, Hae-Cheol / Son, Seunghyun / Ok Jo, Chun / Hoon Kim, Yong / Park, Mingyu / Park, Young-Gyu / Ryu, Jongseong

Environment International. 2023 Aug., v. 178 p.108083-

2023

Abstract: The structure of 9-year time series data for Sea Surface Temperature (SST), Chlorophyll a (Chl-a) and Total Suspended Solids (TSS), derived from the Visible Infrared Imaging Radiometer Suite (VIIRS), was examined in this study. Authors found that there ... ...

Abstract	The structure of 9-year time series data for Sea Surface Temperature (SST), Chlorophyll a (Chl-a) and Total Suspended Solids (TSS), derived from the Visible Infrared Imaging Radiometer Suite (VIIRS), was examined in this study. Authors found that there exists strong seasonality among the three variables with spatial heterogeneity along the Korean South Coast (KSC). In specific, SST was in phase with Chl-a, but out of phase with TSS by six months. A strong inversed spectral power with six-month phase-lag was found between Chl-a and TSS. This could be attributed to different dynamics and environmental settings. For example, Chl-a concentration seemed to have strong positive correlation with SST indicating typical seasonality of marine biogeochemical processes such as primary production; while a strong negative correlation between TSS and SST might have been influenced by changes in physical oceanographic processes, such as stratification and monsoonal wind-driven vertical mixing. In addition, the strong east–west heterogeneity of Chl-a suggests that the marine coastal environments are predominantly governed by distinct local hydrological conditions and human activities associated with land cover and land use, while the east–west spatial pattern revealed in TSS timeseries was associated with the gradient of tidal forcings and topographical changes keeping tidally induced resuspension low eastward.
Keywords	chlorophyll ; coasts ; environment ; humans ; hydrology ; land cover ; land use ; primary productivity ; spatial variation ; surface water temperature ; time series analysis ; water quality ; VIIRS ; Sea Surface Temperature ; Chlorophyll a ; Total Suspended Solids ; Principal Component Analysis ; Cross Spectral Analysis
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.108083
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Spatio-temporal structures of satellite-derived water quality indicators along the Korean South Coast.

Kim, Hae-Cheol / Son, Seunghyun / Ok Jo, Chun / Hoon Kim, Yong / Park, Mingyu / Park, Young-Gyu / Ryu, Jongseong

Environment international

2023 Volume 178, Page(s) 108083

Abstract	The structure of 9-year time series data for Sea Surface Temperature (SST), Chlorophyll a (Chl-a) and Total Suspended Solids (TSS), derived from the Visible Infrared Imaging Radiometer Suite (VIIRS), was examined in this study. Authors found that there exists strong seasonality among the three variables with spatial heterogeneity along the Korean South Coast (KSC). In specific, SST was in phase with Chl-a, but out of phase with TSS by six months. A strong inversed spectral power with six-month phase-lag was found between Chl-a and TSS. This could be attributed to different dynamics and environmental settings. For example, Chl-a concentration seemed to have strong positive correlation with SST indicating typical seasonality of marine biogeochemical processes such as primary production; while a strong negative correlation between TSS and SST might have been influenced by changes in physical oceanographic processes, such as stratification and monsoonal wind-driven vertical mixing. In addition, the strong east-west heterogeneity of Chl-a suggests that the marine coastal environments are predominantly governed by distinct local hydrological conditions and human activities associated with land cover and land use, while the east-west spatial pattern revealed in TSS timeseries was associated with the gradient of tidal forcings and topographical changes keeping tidally induced resuspension low eastward.
MeSH term(s)	Humans ; Chlorophyll A ; Chlorophyll/analysis ; Quality Indicators, Health Care ; Water Quality ; Seasons ; Republic of Korea ; Environmental Monitoring/methods
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y) ; Chlorophyll (1406-65-1)
Language	English
Publishing date	2023-07-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.108083
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Article ; Online: Spatio-temporal structures of satellite-derived water quality indicators along the Korean South Coast

Hae-Cheol Kim / Seunghyun Son / Chun Ok Jo / Yong Hoon Kim / Mingyu Park / Young-Gyu Park / Jongseong Ryu

Environment International, Vol 178, Iss , Pp 108083- (2023)

2023

Abstract	The structure of 9-year time series data for Sea Surface Temperature (SST), Chlorophyll a (Chl-a) and Total Suspended Solids (TSS), derived from the Visible Infrared Imaging Radiometer Suite (VIIRS), was examined in this study. Authors found that there exists strong seasonality among the three variables with spatial heterogeneity along the Korean South Coast (KSC). In specific, SST was in phase with Chl-a, but out of phase with TSS by six months. A strong inversed spectral power with six-month phase-lag was found between Chl-a and TSS. This could be attributed to different dynamics and environmental settings. For example, Chl-a concentration seemed to have strong positive correlation with SST indicating typical seasonality of marine biogeochemical processes such as primary production; while a strong negative correlation between TSS and SST might have been influenced by changes in physical oceanographic processes, such as stratification and monsoonal wind-driven vertical mixing. In addition, the strong east–west heterogeneity of Chl-a suggests that the marine coastal environments are predominantly governed by distinct local hydrological conditions and human activities associated with land cover and land use, while the east–west spatial pattern revealed in TSS timeseries was associated with the gradient of tidal forcings and topographical changes keeping tidally induced resuspension low eastward.
Keywords	VIIRS ; Sea Surface Temperature ; Chlorophyll a ; Total Suspended Solids ; Principal Component Analysis ; Cross Spectral Analysis ; Environmental sciences ; GE1-350
Subject code	551
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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