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Article ; Online: Lysophosphatidic acid (LPA) and angiogenesis.

Rivera-Lopez, Carol M / Tucker, Amy L / Lynch, Kevin R

2008 Volume 11, Issue 3, Page(s) 301–310

Abstract: Lysophosphatidic acid (LPA) is a simple lipid with many important biological functions such as the regulation of cellular proliferation, cellular migration, differentiation, and suppression of apoptosis. Although a direct angiogenic effect of LPA has not ...

Abstract	Lysophosphatidic acid (LPA) is a simple lipid with many important biological functions such as the regulation of cellular proliferation, cellular migration, differentiation, and suppression of apoptosis. Although a direct angiogenic effect of LPA has not been reported to date, there are indications that LPA promotes angiogenesis. In addition, LPA is a chemoattractant for cultured endothelial cells and promotes barrier function in such cultures. To test the hypothesis that LPA is angiogenic, we used the chicken chorio-allantoic membrane (CAM) assay. Sequence analysis of the cloned, full-length chicken LPA receptor cDNAs revealed three receptor types that are orthologous to the mammalian LPA(1), LPA(2), and LPA(3) receptors. We document herein that LPA is angiogenic in the CAM system and further that synthetic LPA receptor agonists and antagonists mimic or block this response, respectively. Our results predict that LPA receptor antagonists are a possible therapeutic route to interdicting angiogenesis.
MeSH term(s)	Amino Acid Sequence ; Angiogenesis Inhibitors/pharmacology ; Animals ; Chick Embryo ; Drug Evaluation, Preclinical ; Lysophospholipids/pharmacology ; Molecular Sequence Data ; Neovascularization, Physiologic/drug effects ; Organophosphates/pharmacology ; Pyridines/pharmacology ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/physiology ; Sequence Homology, Amino Acid ; Sphingosine/analogs & derivatives ; Sphingosine/pharmacology ; Substrate Specificity ; Vascular Endothelial Growth Factor A/pharmacology
Chemical Substances	Angiogenesis Inhibitors ; Lysophospholipids ; Organophosphates ; Pyridines ; Receptors, Lysophosphatidic Acid ; VPC32183 ; Vascular Endothelial Growth Factor A ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42) ; lysophosphatidic acid (PG6M3969SG)
Language	English
Publishing date	2008-05-27
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1484717-6
ISSN	1573-7209 ; 0969-6970
ISSN (online)	1573-7209
ISSN	0969-6970
DOI	10.1007/s10456-008-9113-5
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Article: Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi.

Cuebas-Irizarry, Mara F / Irizarry-Caro, Ricardo A / López-Morales, Carol / Badillo-Rivera, Keyla M / Rodríguez-Minguela, Carlos M / Montalvo-Rodríguez, Rafael

Life (Basel, Switzerland)

2017 Volume 7, Issue 4

Abstract: We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the ... ...

Abstract	We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon
Language	English
Publishing date	2017-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life7040046
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Article: Prevalence of Dementia and Associated Factors among Older Adults in Latin America during the COVID-19 Pandemic.

Soto-Añari, Marcio / Camargo, Loida / Ramos-Henderson, Miguel / Rivera-Fernández, Claudia / Denegri-Solís, Lucia / Calle, Ursula / Mori, Nicanor / Ocampo-Barbá, Ninoska / López, Fernanda / Porto, Maria / Caldichoury-Obando, Nicole / Saldías, Carol / Gargiulo, Pascual / Castellanos, Cesar / Shelach-Bellido, Salomon / López, Norman

Dementia and geriatric cognitive disorders extra

2021 Volume 11, Issue 3, Page(s) 213–221

Abstract: Background: The COVID-19 pandemic has had a great impact on cognitive health in Latin American older adults, increasing the risk of cognitive impairment and dementia. Our objective was to analyze the prevalence of dementia and the associated factors in ... ...

Abstract	Background: The COVID-19 pandemic has had a great impact on cognitive health in Latin American older adults, increasing the risk of cognitive impairment and dementia. Our objective was to analyze the prevalence of dementia and the associated factors in Latin American older adults during SARS-CoV-2 pandemic. Methods: A multicentric first phase cross-sectional observational study was conducted during the SARS-CoV-2 pandemic. Five thousand two hundred and forty-five Latin American adults over 60 years of age were studied in 10 countries: Argentina, Bolivia, Chile, Colombia, Ecuador, Guatemala, Mexico, Peru, the Dominican Republic, and Venezuela. We used the telephone version of Montreal Cognitive Assessment, the "Alzheimer Disease 8" scale for functional and cognitive changes, and the abbreviated version of the Yesavage depression scale. We also asked for sociodemographic and lockdown data. All the evaluation was made by telephone. Cross-tabulations and χ Results: We observed that the prevalence of dementia in Latin America is 15.6%, varying depending on the country (Argentine = 7.83 and Bolivia = 28.5%). The variables most associated with dementia were race and age. It does not seem to be associated with the pandemic but with social and socio-health factors. Conclusion: The prevalence of dementia shows a significant increase in Latin America, attributable to a constellation of ethnic, demographic, and socioeconomic factors.
Language	English
Publishing date	2021-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2621464-7
ISSN	1664-5464
ISSN	1664-5464
DOI	10.1159/000518922
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Article ; Online: Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi

Mara F. Cuebas-Irizarry / Ricardo A. Irizarry-Caro / Carol López-Morales / Keyla M. Badillo-Rivera / Carlos M. Rodríguez-Minguela / Rafael Montalvo-Rodríguez

Life, Vol 7, Iss 4, p

2017 Volume 46

Abstract: ... at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3–4 M ... KCl. However, specific activity values were two-fold higher in the presence of 3–4 M KCl when compared ...

Abstract	We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon Haloquadratum walsbyi. A 2349 bp region (Hqrw_2071) from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+), expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3–4 M KCl. However, specific activity values were two-fold higher in the presence of 3–4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41%) to alpha-glucosidases and alpha-xylosidases of Halorubrum. Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.
Keywords	alpha-glucosidase ; halophilic Archaea ; Haloquadratum ; Science ; Q
Subject code	572
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Defining and Scoping Participatory Health Informatics: An eDelphi Study.

Denecke, Kerstin / Romero, Octavio Rivera / Petersen, Carolyn / Benham-Hutchins, Marge / Cabrer, Miguel / Davies, Shauna / Grainger, Rebecca / Hussein, Rada / Lopez-Campos, Guillermo / Martin-Sanchez, Fernando / McKillop, Mollie / Merolli, Mark / Miron-Shatz, Talya / Trigo, Jesús Daniel / Wright, Graham / Wynn, Rolf / Hullin Lucay Cossio, Carol / Gabarron, Elia

Methods of information in medicine

2023 Volume 62, Issue 3-04, Page(s) 90–99

Abstract: Background: Health care has evolved to support the involvement of individuals in decision making by, for example, using mobile apps and wearables that may help empower people to actively participate in their treatment and health monitoring. While the ... ...

Abstract	Background: Health care has evolved to support the involvement of individuals in decision making by, for example, using mobile apps and wearables that may help empower people to actively participate in their treatment and health monitoring. While the term "participatory health informatics" (PHI) has emerged in literature to describe these activities, along with the use of social media for health purposes, the scope of the research field of PHI is not yet well defined. Objective: This article proposes a preliminary definition of PHI and defines the scope of the field. Methods: We used an adapted Delphi study design to gain consensus from participants on a definition developed from a previous review of literature. From the literature we derived a set of attributes describing PHI as comprising 18 characteristics, 14 aims, and 4 relations. We invited researchers, health professionals, and health informaticians to score these characteristics and aims of PHI and their relations to other fields over three survey rounds. In the first round participants were able to offer additional attributes for voting. Results: The first round had 44 participants, with 28 participants participating in all three rounds. These 28 participants were gender-balanced and comprised participants from industry, academia, and health sectors from all continents. Consensus was reached on 16 characteristics, 9 aims, and 6 related fields. Discussion: The consensus reached on attributes of PHI describe PHI as a multidisciplinary field that uses information technology and delivers tools with a focus on individual-centered care. It studies various effects of the use of such tools and technology. Its aims address the individuals in the role of patients, but also the health of a society as a whole. There are relationships to the fields of health informatics, digital health, medical informatics, and consumer health informatics. Conclusion: We have proposed a preliminary definition, aims, and relationships of PHI based on literature and expert consensus. These can begin to be used to support development of research priorities and outcomes measurements.
MeSH term(s)	Humans ; Delphi Technique ; Delivery of Health Care ; Medical Informatics ; Consensus ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3500-2
ISSN	2511-705X ; 0026-1270
ISSN (online)	2511-705X
ISSN	0026-1270
DOI	10.1055/a-2035-3008
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Article ; Online: [Empirically Supported Psychological Treatments for Children and Adolescents: State of the Art].

Fonseca-Pedrero, Eduardo / Pérez-Álvarez, Marino / Al-Halabí, Susana / Inchausti, Félix / López-Navarro, Emilio R / Muñiz, José / Lucas-Molina, Beatriz / Pérez-Albéniz, Alicia / Baños Rivera, Rosa / Cano-Vindel, Antonio / Gimeno-Peón, Alberto / Prado-Abril, Javier / González-Menéndez, Ana / Valero, Ana V / Priede, Amador / González-Blanch, César / Ruiz-Rodríguez, Paloma / Moriana, Juan A / Gómez, Laura E /

Navas, Patricia / Saldaña, David / Murphy, Carol-Anne / Ortiz Gómez, Marta / Rivero Contreras, Miriam / Valdés-Coronel, Marta / Martos, Juan / Ayuda, Raquel / Freire, Sandra / González, Ana / Llorente, María / Rodríguez, Celestino / Areces, Débora / Cueli, Marisol / García, Trinidad / González-Castro, Paloma / Izquierdo Elizo, Amaia / Cuéllar Flores, Isabel / Padilla Torres, Diego / Cerezo, Rebeca / Fernández, Estrella / Tuero, Ellián / Suárez Fernández, Natalia / Núñez, José C / Caballero-Peláez, Carmen / Sánchez-Reales, Sergio / Ortuño-Sierra, Javier / Alonso Fernández, Irene / Gutiérrez López, Mª I / Rodríguez Pereira, Carlamarina / Bobes Bascarán, Teresa / Roncero, María / Carrasco Tornero, Ángel / García-Soriano, Gemma / Quiles-Sebastián, María J / Quiles Marcos, Yolanda / López-Núñez, Carla / Fernández-Artamendi, Sergio / Senín-Calderón, Crsitina / Santesteban-Echarri, Olga / Bellido Zanin, Gloria / Perona Garcelán, Salvador / Rodríguez-Testal, Juan F / Postigo Claros, Montserrat / Colmenero Navarrete, Lidia / Gavino Lázaro, Aurora / Pastor Morales, Joaquín M / Barros Albarrán, María D / Rufo Benavente, Sergio / García Haro, Juan M / Gutiérrez López, Beatriz / Martín Babarro, Javier / Coloma-Carmona, Ainhoa / Carballo, José L / Fumero, Ascensión / Marrero, Rosario J / de Miguel, Adelia / Peñate, Wenceslao / Debbané, Martin / Valero-Moreno, Selene / de la Barrera, Usue / Postigo-Zegarra, Silvia / Montoya-Castilla, Inmaculada

Psicothema

2021 Volume 33, Issue 3, Page(s) 386–398

Abstract: Empirically Supported Psychological Treatments for Children and Adolescents: State of the Art.: Background: The empirical evidence accumulated on the efficacy, effectiveness, and efficiency of psychotherapeutic treatments in children and adolescents ... ...

Abstract	Empirically Supported Psychological Treatments for Children and Adolescents: State of the Art. Background: The empirical evidence accumulated on the efficacy, effectiveness, and efficiency of psychotherapeutic treatments in children and adolescents calls for an update. The main goal of this paper objective was to carry out a selective review of empirically supported psychological treatments for a variety of common psychological disorders and problems in childhood and adolescence. Method: A review was carried out of the psychological treatments for different psychological disorders and problems in social-emotional or behavioral adjustment in the child-adolescent population according to the Spanish National Health System (Clinical Practice Guidelines) levels of evidence and degrees of recommendation. Results: The findings suggest that psychological treatments have empirical support for addressing a wide range of psychological problems in these developmental stages. The degree of empirical support ranges from low to high depending on the phenomenon analyzed. The review suggests unequal progress in the different fields of intervention. Conclusions: From this update, psychologists will be able to make informed decisions when implementing those empirically supported treatments to address the problems that occur in childhood and adolescence.
MeSH term(s)	Adolescent ; Humans ; Mental Disorders/therapy
Language	Spanish
Publishing date	2021-07-22
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2421645-8
ISSN	1886-144X ; 0214-9915
ISSN (online)	1886-144X
ISSN	0214-9915
DOI	10.7334/psicothema2021.56
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Article: Efficacy of Neoadjuvant Carboplatin plus Docetaxel in Triple-Negative Breast Cancer: Combined Analysis of Two Cohorts.

Sharma, Priyanka / López-Tarruella, Sara / García-Saenz, Jose Angel / Ward, Claire / Connor, Carol S / Gómez, Henry L / Prat, Aleix / Moreno, Fernando / Jerez-Gilarranz, Yolanda / Barnadas, Augusti / Picornell, Antoni C / Del Monte-Millán, Maria / Gonzalez-Rivera, Milagros / Massarrah, Tatiana / Pelaez-Lorenzo, Beatriz / Palomero, María Isabel / González Del Val, Ricardo / Cortes, Javier / Fuentes Rivera, Hugo /

Bretel Morales, Denisse / Márquez-Rodas, Iván / Perou, Charles M / Wagner, Jamie L / Mammen, Joshua M V / McGinness, Marilee K / Klemp, Jennifer R / Amin, Amanda L / Fabian, Carol J / Heldstab, Jaimie / Godwin, Andrew K / Jensen, Roy A / Kimler, Bruce F / Khan, Qamar J / Martin, Miguel

Clinical cancer research : an official journal of the American Association for Cancer Research

2017 Volume 23, Issue 3, Page(s) 649–657

Abstract: ... prescribed NA chemotherapy regimen of carboplatin (AUC 6) + docetaxel (75 mg/m: Results: Among 190 ...

Abstract	Purpose: Recent studies demonstrate that addition of neoadjuvant (NA) carboplatin to anthracycline/taxane chemotherapy improves pathologic complete response (pCR) in triple-negative breast cancer (TNBC). Effectiveness of anthracycline-free platinum combinations in TNBC is not well known. Here, we report efficacy of NA carboplatin + docetaxel (CbD) in TNBC. Experimental design: The study population includes 190 patients with stage I-III TNBC treated uniformly on two independent prospective cohorts. All patients were prescribed NA chemotherapy regimen of carboplatin (AUC 6) + docetaxel (75 mg/m Results: Among 190 patients, median tumor size was 35 mm, 52% were lymph node positive, and 16% had germline BRCA1/2 mutation. The overall pCR and RCB 0 + 1 rates were 55% and 68%, respectively. pCRs in patients with BRCA-associated and wild-type TNBC were 59% and 56%, respectively (P = 0.83). On multivariable analysis, stage III disease was the only factor associated with a lower likelihood of achieving a pCR. Twenty-one percent and 7% of patients, respectively, experienced at least one grade 3 or 4 adverse event. Conclusions: The CbD regimen was well tolerated and yielded high pCR rates in both BRCA-associated and wild-type TNBC. These results are comparable with pCR achieved with the addition of carboplatin to anthracycline-taxane chemotherapy. Our study adds to the existing data on the efficacy of platinum agents in TNBC and supports further exploration of the CbD regimen in randomized studies. Clin Cancer Res; 23(3); 649-57. ©2016 AACR.
Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-16-0162
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Article ; Online: Notes from the Field: Mucormycosis Cases During the COVID-19 Pandemic - Honduras, May-September 2021.

Mejía-Santos, Homer / Montoya, Sandra / Chacón-Fuentes, Rafael / Zielinski-Gutierrez, Emily / Lopez, Beatriz / Ning, Mariangeli F / Farach, Nasim / García-Coto, Fany / Rodríguez-Araujo, David S / Rosales-Pavón, Karla / Urbina, Gustavo / Rivera, Ana Carolina / Peña, Rodolfo / Tovar, Amy / Paz, Mitzi Castro / Lopez, Roque / Pardo-Cruz, Fabian / Mendez, Carol / Flores, Angel /

Varela, Mirna / Chiller, Tom / Jackson, Brendan R / Jordan, Alexander / Lyman, Meghan / Toda, Mitsuru / Caceres, Diego H / Gold, Jeremy A W

MMWR. Morbidity and mortality weekly report

2021 Volume 70, Issue 50, Page(s) 1747–1749

MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; Female ; Honduras/epidemiology ; Humans ; Male ; Middle Aged ; Mucormycosis/epidemiology ; Pandemics
Language	English
Publishing date	2021-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7050a2
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Article: Defining and Scoping Participatory Health Informatics: An eDelphi Study

Methods of Information in Medicine

2023 Volume 62, Issue 03/04, Page(s) 90–99

Abstract	Background: Health care has evolved to support the involvement of individuals in decision making by, for example, using mobile apps and wearables that may help empower people to actively participate in their treatment and health monitoring. While the term “participatory health informatics” (PHI) has emerged in literature to describe these activities, along with the use of social media for health purposes, the scope of the research field of PHI is not yet well defined. Objective: This article proposes a preliminary definition of PHI and defines the scope of the field. Methods: We used an adapted Delphi study design to gain consensus from participants on a definition developed from a previous review of literature. From the literature we derived a set of attributes describing PHI as comprising 18 characteristics, 14 aims, and 4 relations. We invited researchers, health professionals, and health informaticians to score these characteristics and aims of PHI and their relations to other fields over three survey rounds. In the first round participants were able to offer additional attributes for voting. Results: The first round had 44 participants, with 28 participants participating in all three rounds. These 28 participants were gender-balanced and comprised participants from industry, academia, and health sectors from all continents. Consensus was reached on 16 characteristics, 9 aims, and 6 related fields. Discussion: The consensus reached on attributes of PHI describe PHI as a multidisciplinary field that uses information technology and delivers tools with a focus on individual-centered care. It studies various effects of the use of such tools and technology. Its aims address the individuals in the role of patients, but also the health of a society as a whole. There are relationships to the fields of health informatics, digital health, medical informatics, and consumer health informatics. Conclusion: We have proposed a preliminary definition, aims, and relationships of PHI based on literature and expert consensus. These can begin to be used to support development of research priorities and outcomes measurements.
Keywords	participatory health informatics ; Delphi study ; social media ; mHealth ; shared decision making
Language	English
Publishing date	2023-02-14
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	3500-2
ISSN	2511-705X ; 0026-1270
ISSN (online)	2511-705X
ISSN	0026-1270
DOI	10.1055/a-2035-3008
Database	Thieme publisher's database

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Article ; Online: An Easy Assessment of Frailty at Baseline Independently Predicts Prognosis in Very Elderly Patients With Acute Coronary Syndromes.

Journal of the American Medical Directors Association

2017 Volume 19, Issue 4, Page(s) 296–303

Abstract: Background: Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS.: Methods: The ... ...

Abstract	Background: Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS. Methods: The prospective multicenter LONGEVO-SCA registry included unselected patients with ACS aged 80 years or older. A comprehensive geriatric assessment was performed during hospitalization, including frailty assessment by the FRAIL scale. The primary endpoint was mortality at 6 months. Results: A total of 532 patients were included. Mean age was 84.3 years, 61.7% male. Most patients had positive troponin levels (84%) and high GRACE risk score values (mean 165). A total of 205 patients were classified as prefrail (38.5%) and 145 as frail (27.3%). Frail and prefrail patients had a higher prevalence of comorbidities, lower left ventricle ejection fraction, and higher mean GRACE score value. A total of 63 patients (11.8%) were dead at 6 months. Both prefrailty and frailty were associated with higher 6-month mortality rates (P < .001). After adjusting for potential confounders, this association remained significant (hazard ratio [HR] 2.71; 95% confidence interval [CI] 1.09-6.73 for prefrailty and HR 2.99; 95% CI 1.20-7.44 for frailty, P = .024). The other independent predictors of mortality were age, Charlson Index, and GRACE risk score. Conclusions: The FRAIL scale is a simple tool that independently predicts mortality in unselected very elderly patients with ACS. The presence of prefrailty criteria also should be taken into account when performing risk stratification of these patients.
MeSH term(s)	Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Aged, 80 and over ; Cause of Death ; Comorbidity ; Female ; Frail Elderly/statistics & numerical data ; Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Kaplan-Meier Estimate ; Male ; Prevalence ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Registries ; Risk Assessment ; Spain ; Survival Analysis ; Time Factors
Language	English
Publishing date	2017-11-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2017.10.007
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