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  1. Article ; Online: Neutrophil granulocytes influence on extracellular matrix in cancer progression.

    Strøbech, Jan E / Giuriatti, Pietro / Erler, Janine T

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 2, Page(s) C486–C493

    Abstract: One in three persons will develop cancer in their lifetime (Siegel RL, Miller KD, Fuchs HE, Jemal A. ...

    Abstract One in three persons will develop cancer in their lifetime (Siegel RL, Miller KD, Fuchs HE, Jemal A.
    MeSH term(s) Extracellular Matrix/pathology ; Granulocytes/pathology ; Humans ; Neoplasms/pathology ; Neutrophils/pathology ; Tumor Microenvironment/physiology
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00122.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Framing cancer progression: influence of the organ- and tumour-specific matrisome.

    Rafaeva, Maria / Erler, Janine T

    The FEBS journal

    2020  Volume 287, Issue 8, Page(s) 1454–1477

    Abstract: The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It provides mechanical and biochemical cues directing cellular behaviour and, therefore, has control over the progression of diseases such as cancer. Recent efforts have ...

    Abstract The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It provides mechanical and biochemical cues directing cellular behaviour and, therefore, has control over the progression of diseases such as cancer. Recent efforts have greatly enhanced our knowledge of the protein composition of the ECM and its regulators, the so-called matrisome, in healthy and cancerous tissues; yet, an overview of the common signatures and organ-specific ECM in cancer is missing. Here, we address this by taking a detailed approach to review why cancer grows in certain organs, and focus on the influence of the matrisome at primary and metastatic tumour sites. Our in-depth and comprehensive review of the current literature and general understanding identifies important commonalities and distinctions, providing insight into the biology of metastasis, which could pave the way to improve future diagnostics and therapies.
    MeSH term(s) Disease Progression ; Extracellular Matrix/metabolism ; Homeostasis ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Interdisciplinary research: Bold alliances aid translational work.

    Erler, Janine T

    Nature

    2015  Volume 517, Issue 7535, Page(s) 438

    MeSH term(s) Biological Science Disciplines/manpower ; Biological Science Disciplines/organization & administration ; Europe ; Interdisciplinary Communication ; Research Support as Topic ; Translational Medical Research/economics ; Translational Medical Research/manpower ; Translational Medical Research/organization & administration
    Language English
    Publishing date 2015-01-22
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/517438e
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  4. Article ; Online: Cancer: Disabling defences in the brain.

    Erler, Janine T

    Nature

    2014  Volume 508, Issue 7494, Page(s) 46–47

    MeSH term(s) Animals ; Brain/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Female ; Fibrinolysin/metabolism ; Humans ; Neuropeptides/metabolism ; Plasminogen Activator Inhibitor 2/metabolism ; Serpins/metabolism ; Neuroserpin
    Chemical Substances Neuropeptides ; Plasminogen Activator Inhibitor 2 ; Serpins ; Fibrinolysin (EC 3.4.21.7)
    Language English
    Publishing date 2014-04-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/508046a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Extracting, quantifying, and comparing dynamical and biomechanical properties of living matter through single particle tracking.

    Scott, Shane / Weiss, Matthias / Selhuber-Unkel, Christine / Barooji, Younes F / Sabri, Adal / Erler, Janine T / Metzler, Ralf / Oddershede, Lene B

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 3, Page(s) 1513–1537

    Abstract: A panoply of new tools for tracking single particles and molecules has led to an explosion of experimental data, leading to novel insights into physical properties of living matter governing cellular development and function, health and disease. In this ... ...

    Abstract A panoply of new tools for tracking single particles and molecules has led to an explosion of experimental data, leading to novel insights into physical properties of living matter governing cellular development and function, health and disease. In this Perspective, we present tools to investigate the dynamics and mechanics of living systems from the molecular to cellular scale
    MeSH term(s) Single Molecule Imaging ; Biophysics ; Biological Science Disciplines/methods
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp01384c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hypoxic Signalling in Tumour Stroma.

    Laitala, Anu / Erler, Janine T

    Frontiers in oncology

    2018  Volume 8, Page(s) 189

    Abstract: Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The ... ...

    Abstract Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.
    Language English
    Publishing date 2018-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2018.00189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: FES null mice demonstrate a reduction in neutrophil dependent pancreatic cancer metastatic burden.

    Strøbech, Jan E / Giuriatti, Pietro / Stagaard, Rikke / De Sepulveda, Paulo / Nielsen, Sebastian R / Erler, Janine T

    Frontiers in oncology

    2023  Volume 13, Page(s) 1096499

    Abstract: Patients with pancreatic ductal adenocarcinoma (PDAC) have a dismal 5-year survival rate of less than 10%, predominantly due to delayed diagnosis and a lack of effective treatment options. In the PDAC tumor microenvironment (TME), neutrophils are among ... ...

    Abstract Patients with pancreatic ductal adenocarcinoma (PDAC) have a dismal 5-year survival rate of less than 10%, predominantly due to delayed diagnosis and a lack of effective treatment options. In the PDAC tumor microenvironment (TME), neutrophils are among the immune cell types that are most prevalent and are linked to a poor clinical prognosis. However, treatments that target tumor-associated neutrophils are limited despite recent developments in our understanding of neutrophil function in cancer. The feline sarcoma oncogene (FES) is a nonreceptor tyrosine kinase previously associated with leukemia and hematopoietic homeostasis. Here we describe a newly derived FES null mouse with no distinct phenotype and no defects in hematopoietic homeostasis including neutrophil viability. The immune cell composition and neutrophil population were analyzed with flow cytometry, colony-forming unit (CFU) assay, and a neutrophil viability assay, while the response to PDAC was examined with an
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1096499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Framing cancer progression: influence of the organ‐ and tumour‐specific matrisome

    Rafaeva, Maria / Erler, Janine T

    FEBS journal. 2020 Apr., v. 287, no. 8

    2020  

    Abstract: The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It provides mechanical and biochemical cues directing cellular behaviour and, therefore, has control over the progression of diseases such as cancer. Recent efforts have ...

    Abstract The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It provides mechanical and biochemical cues directing cellular behaviour and, therefore, has control over the progression of diseases such as cancer. Recent efforts have greatly enhanced our knowledge of the protein composition of the ECM and its regulators, the so‐called matrisome, in healthy and cancerous tissues; yet, an overview of the common signatures and organ‐specific ECM in cancer is missing. Here, we address this by taking a detailed approach to review why cancer grows in certain organs, and focus on the influence of the matrisome at primary and metastatic tumour sites. Our in‐depth and comprehensive review of the current literature and general understanding identifies important commonalities and distinctions, providing insight into the biology of metastasis, which could pave the way to improve future diagnostics and therapies.
    Keywords diagnostic techniques ; extracellular matrix ; homeostasis ; metastasis ; neoplasm progression ; neoplasms ; protein composition
    Language English
    Dates of publication 2020-04
    Size p. 1454-1477.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15223
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2006/704: Show issues

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  9. Article ; Online: Fibrosis and Cancer: Partners in Crime or Opposing Forces?

    Cox, Thomas R / Erler, Janine T

    Trends in cancer

    2016  Volume 2, Issue 6, Page(s) 279–282

    Abstract: The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. ... ...

    Abstract The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2016.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Quantification of Lung Metastases from In Vivo Mouse Models.

    Chang, Joan / Erler, Janine T

    Advances in experimental medicine and biology

    2016  Volume 899, Page(s) 245–251

    Abstract: Cancer research has made significant progress in terms of understanding and targeting primary tumors; however, the challenge remains for the successful treatment of metastatic cancers. This highlights the importance to use in vivo models to study the ... ...

    Abstract Cancer research has made significant progress in terms of understanding and targeting primary tumors; however, the challenge remains for the successful treatment of metastatic cancers. This highlights the importance to use in vivo models to study the metastatic process, as well as for preclinical testing of compounds that could inhibit metastasis. As a result, proper quantification of metastases from in vivo models is of the utmost significance. Here, we provide a detailed protocol for collecting and handling lung tissues from mice, and guidance for subsequent analysis of metastases, as well as interpretation of data.
    MeSH term(s) Animals ; Disease Models, Animal ; Image Processing, Computer-Assisted ; Lung/pathology ; Lung Neoplasms/secondary ; Mice
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-26666-4_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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