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Article ; Online: A population-based analysis of the presentation and outcomes of pediatric patients with osteosarcoma in Canada: a report from CYP-C.

Horkoff, Michael J / Kendal, Joseph K / Blackmore, Christopher / Truong, Tony H / Guilcher, Gregory M T / Brindle, Mary E

Canadian journal of surgery. Journal canadien de chirurgie

2022 Volume 65, Issue 4, Page(s) E527–E533

Abstract: ... with osteosarcoma between 2001 and 2017, using The Cancer in Young People in Canada (CYP-C) national database. Data ...

Abstract	Background: Frequently occurring in adolescents, osteosarcoma is the most common primary malignant bone disease, with a reported 15% of patients who present with metastasis. With advances in imaging and improvements in surgical care, an updated analysis is warranted on the outcomes of pediatric patients with osteosarcoma. Methods: We completed a retrospective review of pediatric patients who presented with osteosarcoma between 2001 and 2017, using The Cancer in Young People in Canada (CYP-C) national database. Data on 304 patients aged younger than 15 years were analyzed. Results: The proportion of patients who presented with metastasis was 23.0%. The overall 5-year survival (OS) for patients who presented with metastasis was 37.4%. Overall survival and event-free survival (EFS) were lower in these patients than in patients with localized disease (hazard ratio [HR] 4.3, Conclusion: The proportion of patients who presented with metastatic osteosarcoma in our population is higher than previously reported. Overall outcomes of patients with metastatic disease have not changed. Our data reaffirm a role for surgical resection in patients with metastasis with a need to explore new treatment strategies to improve the overall prognosis of these patients.
MeSH term(s)	Adolescent ; Aged ; Bone Neoplasms/surgery ; Child ; Humans ; Osteosarcoma/pathology ; Osteosarcoma/surgery ; Prognosis ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2022-08-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.008220
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Article ; Online: 7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons.

Gottfried-Blackmore, Andres / Jellinck, Peter H / Vecchiarelli, Haley A / Masheeb, Zahrah / Kaufmann, Martin / McEwen, Bruce S / Bulloch, Karen

The Journal of steroid biochemistry and molecular biology

2013 Volume 138, Page(s) 290–297

Abstract: ... with a preference to its 7-hydroxylated products. The E(t)C cerebellar granule cell line converts DHEA almost ... in intact brain cells, we examined whether E(t)C cerebellar neurons, which are avid producers of 7α-OH-DHEA ... could also metabolize glucocorticoids. We report that E(t)C neuronal cells exhibit 11β-HSD1 reductase ...

Abstract	The neuroprotective action of dehydroepiandrosterone (DHEA) in the absence of a known specific receptor has been attributed to its metabolism by different cell types in the brain to various steroids, with a preference to its 7-hydroxylated products. The E(t)C cerebellar granule cell line converts DHEA almost exclusively to 7α-hydroxy-DHEA (7α-OH-DHEA). It has been postulated that DHEA's 7-OH and 7-oxo metabolites can decrease glucocorticoid levels by an interactive mechanism involving 11β-hydroxysteroid dehydrogenase (11β-HSD). In order to study the relationship of 7-hydroxylation of DHEA and glucocorticoid metabolism in intact brain cells, we examined whether E(t)C cerebellar neurons, which are avid producers of 7α-OH-DHEA, could also metabolize glucocorticoids. We report that E(t)C neuronal cells exhibit 11β-HSD1 reductase activity, and are able to convert 11-dehydrocorticosterone into corticosterone, whereas they do not demonstrate 11β-HSD2 dehydrogenase activity. Consequently, E(t)C cells incubated with DHEA did not yield 7-oxo- or 7β-OH-DHEA. Our findings are supported by the reductive environment of E(t)C cells through expression of hexose-6-phosphate dehydrogenase (H6PDH), which fosters 11β-HSD1 reductase activity. To further explore the role of 7α-OH-DHEA in E(t)C neuronal cells, we examined the effect of preventing its formation using the CYP450 inhibitor ketoconazole. Treatment of the cells with this drug decreased the yield of 7α-OH-DHEA by about 75% without the formation of alternate DHEA metabolites, and had minimal effects on glucocorticoid conversion. Likewise, elevated levels of corticosterone, the product of 11β-HSD1, had no effect on the metabolic profile of DHEA. This study shows that in a single population of whole-cells, with a highly reductive environment, 7α-OH-DHEA is unable to block the reducing activity of 11β-HSD1, and that 7-hydroxylation of DHEA does not interfere with the activation of glucocorticoids. Our investigation on the metabolism of DHEA in E(t)C neuronal cells suggest that other alternate mechanisms must be at play to explain the in vivo anti-glucocorticoid properties of DHEA and its 7-OH-metabolites.
MeSH term(s)	11-beta-Hydroxysteroid Dehydrogenases/metabolism ; Animals ; Cell Line ; Cerebellum/cytology ; Dehydroepiandrosterone/analogs & derivatives ; Dehydroepiandrosterone/metabolism ; Glucocorticoids/metabolism ; Mice ; Neurons/enzymology ; Neurons/metabolism ; Real-Time Polymerase Chain Reaction
Chemical Substances	Glucocorticoids ; Dehydroepiandrosterone (459AG36T1B) ; 7-hydroxydehydroepiandrosterone (53-00-9) ; 11-beta-Hydroxysteroid Dehydrogenases (EC 1.1.1.146)
Language	English
Publishing date	2013-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2013.07.001
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Article: Collagenous Gastritis: A Cause of Pediatric Iron Deficiency Anemia.

Blackmore, Conner / Leach, Margaret

ACG case reports journal

2023 Volume 10, Issue 2, Page(s) e01000

Abstract: Collagenous gastritis (CG) is a rare histopathological condition characterized by subepithelial collagen deposition and inflammatory infiltrates in the gastric mucosa. With less than 100 cases reported in current literature, clinical presentation is ... ...

Abstract	Collagenous gastritis (CG) is a rare histopathological condition characterized by subepithelial collagen deposition and inflammatory infiltrates in the gastric mucosa. With less than 100 cases reported in current literature, clinical presentation is highly variable. We report a case of isolated CG in an 11-year-old girl who presented with a 6-month history of symptomatic severe iron deficiency anemia (nonexertional shortness of breath, palpitations, chest pain, and lethargy). CG is a rare condition in children require long-term follow-up and monitoring of their disease; and because of its rarity, a targeted treatment does not exist. The current therapeutic strategy is focused on symptom control and monitoring iron studies, in conjunction with regular follow-up.
Language	English
Publishing date	2023-03-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000001000
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Article ; Online: Clinical Decision Support: Opportunity or Armageddon?

Blackmore, C Craig

AJR. American journal of roentgenology

2019 Volume 213, Issue 5, Page(s) 1021–1022

Abstract: OBJECTIVE. ...

Abstract	OBJECTIVE.
MeSH term(s)	Decision Support Systems, Clinical ; Medicine ; Software ; Workflow
Language	English
Publishing date	2019-07-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.19.21765
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Article ; Online: The Relationship Between Medicare Outpatient Efficiency Measure OP8 and Lumbar MRI Utilization.

Blackmore, C Craig

Journal of the American College of Radiology : JACR

2018 Volume 16, Issue 3, Page(s) 276–281

Abstract: Introduction: Quality-based reporting and payment are predicated on using valid metrics. We sought to determine the relationship between widely used lumbar imaging quality metric OP8 and underlying quality as measured through actual utilization of ... ...

Abstract	Introduction: Quality-based reporting and payment are predicated on using valid metrics. We sought to determine the relationship between widely used lumbar imaging quality metric OP8 and underlying quality as measured through actual utilization of lumbar MRI. Methods: We performed a multi-institutional cross-sectional study using hospital-level billing data from a major commercial insurance company, including 23 Washington State hospitals from July 1, 2014, to June 30, 2015, with more than 25 eligible visits. For each hospital, we determined the OP8 score using the CMS published specifications. We calculated actual utilization rate from the proportion of patients visiting primary care (internal medicine or family medicine, including physicians, nurse practitioners, and physician assistants) for uncomplicated low back pain who underwent lumbar MRI. For both measures, patients under age 18 or with complicated conditions (eg, infection, cancer, inflammatory arthropathy) were excluded. OP8 scores and utilization were compared using linear regression and correlation coefficients. Results: Hospital scores ranged from 28.0% to 55.3% on OP8 and from 0.7% to 4.2% on MRI utilization (with lower scores indicating better performance). There was no association between score on OP8 and actual utilization of lumbar MRI across hospitals in Washington State (attributable risk 0.00016, 95% confidence interval: -0.00026, 0.00059, P = .43). Discussion: Widely used imaging efficiency measure OP8 does not correlate with actual utilization of lumbar MRI. Better OP8 scores reflect use of antecedent conservative therapy regardless of whether MRI is overutilized. OP8 scores may be worse for institutions with aggressive control of inappropriate imaging.
MeSH term(s)	Cross-Sectional Studies ; Efficiency, Organizational ; Humans ; Insurance, Health/economics ; Low Back Pain/diagnostic imaging ; Lumbar Vertebrae/diagnostic imaging ; Magnetic Resonance Imaging/economics ; Medicare/economics ; Outpatients ; United States ; Utilization Review ; Washington
Language	English
Publishing date	2018-12-28
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	2274861-1
ISSN	1558-349X ; 1546-1440
ISSN (online)	1558-349X
ISSN	1546-1440
DOI	10.1016/j.jacr.2018.10.026
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Zs.A 6636: Show issues

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Article: Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors.

García-Sáinz, J A / Gottfried-Blackmore, A / Vázquez-Prado, J / Romero-Avila, M T

European journal of pharmacology

1999 Volume 385, Issue 2-3, Page(s) 263–271

Abstract: ... in response to noradrenaline. Activation of protein kinase C desensitized the alpha(1b)-adrenergic-mediated ... downregulation of protein kinase C also blocked the action of the tumor promoter on the adrenergic effects ... receptor-G protein uncoupling. The results indicate that activation of protein kinase C blocked ...

Abstract	Human alpha(1b)-adrenoceptors stably expressed (B(max) approximately 800 fmol/mg membrane protein) in mouse fibroblasts were able to increase intracellular Ca(2+) and inositol phosphate production in response to noradrenaline. Activation of protein kinase C desensitized the alpha(1b)-adrenergic-mediated actions but did not block the ability of the cells to respond to lysophosphatidic acid. Inhibition or downregulation of protein kinase C also blocked the action of the tumor promoter on the adrenergic effects. Photolabeling experiments indicated that the receptor has an apparent molecular weight of approximately 80 kDa. The receptors were phosphorylated in the basal state and such phosphorylation was increased when the cells were incubated with phorbol myristate acetate or noradrenaline. Incubation of the cells with phorbol myristate acetate or noradrenaline blocked noradrenaline-promoted [35S]GTP-gamma-S binding to membranes, suggesting receptor-G protein uncoupling. The results indicate that activation of protein kinase C blocked/desensitized human alpha(1b)-adrenoceptors and that such effect was associated to receptor phosphorylation.
MeSH term(s)	Animals ; Binding, Competitive ; Calcium/metabolism ; Cell Line ; Dose-Response Relationship, Drug ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Humans ; Indoles/pharmacology ; Inositol Phosphates/metabolism ; Membranes/drug effects ; Membranes/metabolism ; Norepinephrine/pharmacology ; Phentolamine/metabolism ; Phosphorylation/drug effects ; Piperazines/metabolism ; Prazosin/metabolism ; Precipitin Tests ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Kinase C/physiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Radioligand Assay ; Receptors, Adrenergic, alpha-1/genetics ; Receptors, Adrenergic, alpha-1/metabolism ; Sulfur Radioisotopes ; Tetradecanoylphorbol Acetate/pharmacology ; Tritium
Chemical Substances	ADRA1B protein, human ; Adra1b protein, mouse ; Indoles ; Inositol Phosphates ; Piperazines ; RNA, Messenger ; Receptors, Adrenergic, alpha-1 ; Sulfur Radioisotopes ; Tritium (10028-17-8) ; 5-methylurapidil (1HLS600135) ; Guanosine 5'-O-(3-Thiotriphosphate) (37589-80-3) ; Protein Kinase C (EC 2.7.11.13) ; BMY 7378 (KC07KV8T5O) ; Tetradecanoylphorbol Acetate (NI40JAQ945) ; Calcium (SY7Q814VUP) ; Ro 31-8220 (W9A0B5E78O) ; Norepinephrine (X4W3ENH1CV) ; Prazosin (XM03YJ541D) ; Phentolamine (Z468598HBV)
Language	English
Publishing date	1999-12-03
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/s0014-2999(99)00629-9
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Zs.A 522: Show issues

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Article ; Online: Flu vaccination: an opt-out system for healthcare workers.

Blackmore, Noah C V

BMJ (Clinical research ed.)

2018 Volume 360, Page(s) k1143

Language	English
Publishing date	2018--15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.k1143
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Book: Evidence based imaging

Medina, L. Santiago / Blackmore, Christopher C. / Applegate, Kimberly E.

improving the quality of imaging in patient care

2011

Title variant	Evidence-based imaging
Author's details	L. Santiago Medina ; C. Craig Blackmore ; Kimberly E. Applegate
Keywords	Diagnostic Imaging ; Evidence-Based Medicine
Language	English
Size	XX, 680 S. : Ill., graph. Darst.
Edition	Rev. ed.
Publisher	Springer
Publishing place	New York, NY u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT016839622
ISBN	978-1-4419-7776-2 ; 9781441977779 ; 1-4419-7776-7 ; 1441977775
Database	Catalogue ZB MED Medicine, Health

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Article: Endoscopic Management of Bouveret Syndrome With Electrohydraulic Lithotripsy.

Wang, Hunter / Blackmore, Conner / Bonnichsen, Mark / Ermerak, George / Bassan, Milan

ACG case reports journal

2023 Volume 10, Issue 5, Page(s) e01051

Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000001051
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Article: Alexithymia in Adult Autism Clinic Service-Users: Relationships with Sensory Processing Differences and Mental Health.

Josyfon, Emily / Spain, Debbie / Blackmore, Charlotte / Murphy, Declan / Oakley, Bethany

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 24

Abstract: Mental health difficulties commonly co-occur with autism, especially in autistic people accessing clinic services, impacting substantially on quality-of-life. Alexithymia (difficulty describing/identifying feelings) and sensory processing differences are ...

Abstract	Mental health difficulties commonly co-occur with autism, especially in autistic people accessing clinic services, impacting substantially on quality-of-life. Alexithymia (difficulty describing/identifying feelings) and sensory processing differences are prevalent traits in autism that have been associated with depression/anxiety in autistic community samples. However, it is important to better understand interrelationships between these traits in clinical populations to improve identification of service-user needs. In this study, 190 autistic adults (65.3% male), seen in a tertiary autism clinic, completed self-report measures of alexithymia (20-item Toronto Alexithymia Scale), sensory processing differences (Adolescent/Adult Sensory Profile) and depression/anxiety (Hospital Anxiety and Depression Scale). Multiple linear regression models and mediation analyses were used to examine associations between alexithymia, sensory processing differences, and depression/anxiety severity. Across the sample, 66.3% of individuals (
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11243114
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