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  1. Article: Treatment of Resistant Glomerular Diseases with Adrenocorticotropic Hormone Gel: A Prospective Trial

    Bomback, Andrew S. / Canetta, Pietro A. / Beck Jr., Laurence H. / Ayalon, Rivka / Radhakrishnan, Jai / Appel, Gerald B.

    American Journal of Nephrology

    2012  Volume 36, Issue 1, Page(s) 58–67

    Abstract: Background: Adrenocorticotropic hormone (ACTH) has shown promising results in glomerular diseases resistant to conventional therapies, but the reported data have solely been from retrospective, observational studies. Methods: In this prospective, open- ... ...

    Institution Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, N.Y., and Section of Nephrology, Department of Medicine, Boston University School of Medicine, Boston, Mass., USA
    Abstract Background: Adrenocorticotropic hormone (ACTH) has shown promising results in glomerular diseases resistant to conventional therapies, but the reported data have solely been from retrospective, observational studies. Methods: In this prospective, open-label study (NCT01129284), 15 subjects with resistant glomerular diseases were treated with ACTH gel (80 units subcutaneously twice weekly) for 6 months. Resistant membranous nephropathy (MN), minimal change disease (MCD), and focal segmental glomerulosclerosis (FSGS) were defined as failure to achieve sustained remission of proteinuria off immunosuppressive therapy with at least 2 treatment regimens; resistant IgA nephropathy was defined as >1 g/g urine protein:creatinine ratio despite maximally tolerated RAAS blockade. Remission was defined as stable or improved renal function with ≥50% reduction in proteinuria to <0.5 g/g (complete remission) or 0.5–3.5 g/g (partial remission). Results: The study included 5 subjects with resistant idiopathic MN, 5 subjects with resistant MCD (n = 2)/FSGS (n = 3), and 5 subjects with resistant IgA nephropathy. Two resistant MN subjects achieved partial remission on ACTH therapy, although 3 achieved immunologic remission of disease (PLA2R antibody disappeared by 4 months of therapy). One subject with resistant FSGS achieved complete remission on ACTH; one subject with resistant MCD achieved partial remission but relapsed within 4 weeks of stopping ACTH. Two subjects with resistant IgA nephropathy demonstrated >50% reductions in proteinuria while on ACTH, with proteinuria consistently <1 g/g by 6 months. Three of 15 subjects reported significant steroid-like adverse effects with ACTH, including weight gain and hyperglycemia, prompting early termination of therapy without any clinical response. Conclusions: ACTH gel is a promising treatment for resistant glomerular diseases and should be studied further in controlled trials against currently available therapies for resistant disease.
    Keywords Focal segmental glomerulosclerosis ; Membranous nephropathy ; IgA nephropathy ; Minimal change disease
    Language English
    Publishing date 2012-06-19
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Report: Patient-Oriented, Translational Research
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000339287
    Database Karger publisher's database

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  2. Article ; Online: Identification of novel candidate disease genes from de novo exonic copy number variants.

    Gambin, Tomasz / Yuan, Bo / Bi, Weimin / Liu, Pengfei / Rosenfeld, Jill A / Coban-Akdemir, Zeynep / Pursley, Amber N / Nagamani, Sandesh C S / Marom, Ronit / Golla, Sailaja / Dengle, Lauren / Petrie, Heather G / Matalon, Reuben / Emrick, Lisa / Proud, Monica B / Treadwell-Deering, Diane / Chao, Hsiao-Tuan / Koillinen, Hannele / Brown, Chester /
    Urraca, Nora / Mostafavi, Roya / Bernes, Saunder / Roeder, Elizabeth R / Nugent, Kimberly M / Bader, Patricia I / Bellus, Gary / Cummings, Michael / Northrup, Hope / Ashfaq, Myla / Westman, Rachel / Wildin, Robert / Beck, Anita E / Immken, LaDonna / Elton, Lindsay / Varghese, Shaun / Buchanan, Edward / Faivre, Laurence / Lefebvre, Mathilde / Schaaf, Christian P / Walkiewicz, Magdalena / Yang, Yaping / Kang, Sung-Hae L / Lalani, Seema R / Bacino, Carlos A / Beaudet, Arthur L / Breman, Amy M / Smith, Janice L / Cheung, Sau Wai / Lupski, James R / Patel, Ankita / Shaw, Chad A / Stankiewicz, Paweł

    Genome medicine

    2017  Volume 9, Issue 1, Page(s) 83

    Abstract: Background: Exon-targeted microarrays can detect small (<1000 bp) intragenic copy number variants (CNVs), including those that affect only a single exon. This genome-wide high-sensitivity approach increases the molecular diagnosis for conditions with ... ...

    Abstract Background: Exon-targeted microarrays can detect small (<1000 bp) intragenic copy number variants (CNVs), including those that affect only a single exon. This genome-wide high-sensitivity approach increases the molecular diagnosis for conditions with known disease-associated genes, enables better genotype-phenotype correlations, and facilitates variant allele detection allowing novel disease gene discovery.
    Methods: We retrospectively analyzed data from 63,127 patients referred for clinical chromosomal microarray analysis (CMA) at Baylor Genetics laboratories, including 46,755 individuals tested using exon-targeted arrays, from 2007 to 2017. Small CNVs harboring a single gene or two to five non-disease-associated genes were identified; the genes involved were evaluated for a potential disease association.
    Results: In this clinical population, among rare CNVs involving any single gene reported in 7200 patients (11%), we identified 145 de novo autosomal CNVs (117 losses and 28 intragenic gains), 257 X-linked deletion CNVs in males, and 1049 inherited autosomal CNVs (878 losses and 171 intragenic gains); 111 known disease genes were potentially disrupted by de novo autosomal or X-linked (in males) single-gene CNVs. Ninety-one genes, either recently proposed as candidate disease genes or not yet associated with diseases, were disrupted by 147 single-gene CNVs, including 37 de novo deletions and ten de novo intragenic duplications on autosomes and 100 X-linked CNVs in males. Clinical features in individuals with de novo or X-linked CNVs encompassing at most five genes (224 bp to 1.6 Mb in size) were compared to those in individuals with larger-sized deletions (up to 5 Mb in size) in the internal CMA database or loss-of-function single nucleotide variants (SNVs) detected by clinical or research whole-exome sequencing (WES). This enabled the identification of recently published genes (BPTF, NONO, PSMD12, TANGO2, and TRIP12), novel candidate disease genes (ARGLU1 and STK3), and further confirmation of disease association for two recently proposed disease genes (MEIS2 and PTCHD1). Notably, exon-targeted CMA detected several pathogenic single-exon CNVs missed by clinical WES analyses.
    Conclusions: Together, these data document the efficacy of exon-targeted CMA for detection of genic and exonic CNVs, complementing and extending WES in clinical diagnostics, and the potential for discovery of novel disease genes by genome-wide assay.
    MeSH term(s) Cohort Studies ; DNA Copy Number Variations ; Exons ; Genetic Diseases, Inborn ; Genome, Human ; Homeodomain Proteins/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Membrane Proteins/genetics ; Neurodevelopmental Disorders/genetics ; Protein-Serine-Threonine Kinases/genetics ; Retrospective Studies ; Transcription Factors/genetics ; Whole Genome Sequencing
    Chemical Substances ARGLU1 protein, human ; Homeodomain Proteins ; Intracellular Signaling Peptides and Proteins ; MEIS2 protein, human ; Membrane Proteins ; PTCHD1 protein, human ; Transcription Factors ; STK3 protein, human (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2017-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-017-0472-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Abu-Shawareb, H / Acree, R / Adams, P / Adams, J / Addis, B / Aden, R / Adrian, P / Afeyan, B B / Aggleton, M / Aghaian, L / Aguirre, A / Aikens, D / Akre, J / Albert, F / Albrecht, M / Albright, B J / Albritton, J / Alcala, J / Alday, C /
    Alessi, D A / Alexander, N / Alfonso, J / Alfonso, N / Alger, E / Ali, S J / Ali, Z A / Allen, A / Alley, W E / Amala, P / Amendt, P A / Amick, P / Ammula, S / Amorin, C / Ampleford, D J / Anderson, R W / Anklam, T / Antipa, N / Appelbe, B / Aracne-Ruddle, C / Araya, E / Archuleta, T N / Arend, M / Arnold, P / Arnold, T / Arsenlis, A / Asay, J / Atherton, L J / Atkinson, D / Atkinson, R / Auerbach, J M / Austin, B / Auyang, L / Awwal, A A S / Aybar, N / Ayers, J / Ayers, S / Ayers, T / Azevedo, S / Bachmann, B / Back, C A / Bae, J / Bailey, D S / Bailey, J / Baisden, T / Baker, K L / Baldis, H / Barber, D / Barberis, M / Barker, D / Barnes, A / Barnes, C W / Barrios, M A / Barty, C / Bass, I / Batha, S H / Baxamusa, S H / Bazan, G / Beagle, J K / Beale, R / Beck, B R / Beck, J B / Bedzyk, M / Beeler, R G / Behrendt, W / Belk, L / Bell, P / Belyaev, M / Benage, J F / Bennett, G / Benedetti, L R / Benedict, L X / Berger, R L / Bernat, T / Bernstein, L A / Berry, B / Bertolini, L / Besenbruch, G / Betcher, J / Bettenhausen, R / Betti, R / Bezzerides, B / Bhandarkar, S D / Bickel, R / Biener, J / Biesiada, T / Bigelow, K / Bigelow-Granillo, J / Bigman, V / Bionta, R M / Birge, N W / Bitter, M / Black, A C / Bleile, R / Bleuel, D L / Bliss, E / Blue, B / Boehly, T / Boehm, K / Boley, C D / Bonanno, R / Bond, E J / Bond, T / Bonino, M J / Borden, M / Bourgade, J-L / Bousquet, J / Bowers, J / Bowers, M / Boyd, R / Boyle, D / Bozek, A / Bradley, D K / Bradley, K S / Bradley, P A / Bradley, L / Brannon, L / Brantley, P S / Braun, D / Braun, T / Brienza-Larsen, K / Briggs, R / Briggs, T M / Britten, J / Brooks, E D / Browning, D / Bruhn, M W / Brunner, T A / Bruns, H / Brunton, G / Bryant, B / Buczek, T / Bude, J / Buitano, L / Burkhart, S / Burmark, J / Burnham, A / Burr, R / Busby, L E / Butlin, B / Cabeltis, R / Cable, M / Cabot, W H / Cagadas, B / Caggiano, J / Cahayag, R / Caldwell, S E / Calkins, S / Callahan, D A / Calleja-Aguirre, J / Camara, L / Camp, D / Campbell, E M / Campbell, J H / Carey, B / Carey, R / Carlisle, K / Carlson, L / Carman, L / Carmichael, J / Carpenter, A / Carr, C / Carrera, J A / Casavant, D / Casey, A / Casey, D T / Castillo, A / Castillo, E / Castor, J I / Castro, C / Caughey, W / Cavitt, R / Celeste, J / Celliers, P M / Cerjan, C / Chandler, G / Chang, B / Chang, C / Chang, J / Chang, L / Chapman, R / Chapman, T D / Chase, L / Chen, H / Chen, K / Chen, L-Y / Cheng, B / Chittenden, J / Choate, C / Chou, J / Chrien, R E / Chrisp, M / Christensen, K / Christensen, M / Christiansen, N S / Christopherson, A R / Chung, M / Church, J A / Clark, A / Clark, D S / Clark, K / Clark, R / Claus, L / Cline, B / Cline, J A / Cobble, J A / Cochrane, K / Cohen, B / Cohen, S / Collette, M R / Collins, G W / Collins, L A / Collins, T J B / Conder, A / Conrad, B / Conyers, M / Cook, A W / Cook, D / Cook, R / Cooley, J C / Cooper, G / Cope, T / Copeland, S R / Coppari, F / Cortez, J / Cox, J / Crandall, D H / Crane, J / Craxton, R S / Cray, M / Crilly, A / Crippen, J W / Cross, D / Cuneo, M / Cuotts, G / Czajka, C E / Czechowicz, D / Daly, T / Danforth, P / Danly, C / Darbee, R / Darlington, B / Datte, P / Dauffy, L / Davalos, G / Davidovits, S / Davis, P / Davis, J / Dawson, S / Day, R D / Day, T H / Dayton, M / Deck, C / Decker, C / Deeney, C / DeFriend, K A / Deis, G / Delamater, N D / Delettrez, J A / Demaret, R / Demos, S / Dempsey, S M / Desjardin, R / Desjardins, T / Desjarlais, M P / Dewald, E L / DeYoreo, J / Diaz, S / Dimonte, G / Dittrich, T R / Divol, L / Dixit, S N / Dixon, J / Do, A / Dodd, E S / Dolan, D / Donovan, A / Donovan, M / Döppner, T / Dorrer, C / Dorsano, N / Douglas, M R / Dow, D / Downie, J / Downing, E / Dozieres, M / Draggoo, V / Drake, D / Drake, R P / Drake, T / Dreifuerst, G / Drury, O / DuBois, D F / DuBois, P F / Dunham, G / Durocher, M / Dylla-Spears, R / Dymoke-Bradshaw, A K L / Dzenitis, B / Ebbers, C / Eckart, M / Eddinger, S / Eder, D / Edgell, D / Edwards, M J / Efthimion, P / Eggert, J H / Ehrlich, B / Ehrmann, P / Elhadj, S / Ellerbee, C / Elliott, N S / Ellison, C L / Elsner, F / Emerich, M / Engelhorn, K / England, T / English, E / Epperson, P / Epstein, R / Erbert, G / Erickson, M A / Erskine, D J / Erlandson, A / Espinosa, R J / Estes, C / Estabrook, K G / Evans, S / Fabyan, A / Fair, J / Fallejo, R / Farmer, N / Farmer, W A / Farrell, M / Fatherley, V E / Fedorov, M / Feigenbaum, E / Fehrenbach, T / Feit, M / Felker, B / Ferguson, W / Fernandez, J C / Fernandez-Panella, A / Fess, S / Field, J E / Filip, C V / Fincke, J R / Finn, T / Finnegan, S M / Finucane, R G / Fischer, M / Fisher, A / Fisher, J / Fishler, B / Fittinghoff, D / Fitzsimmons, P / Flegel, M / Flippo, K A / Florio, J / Folta, J / Folta, P / Foreman, L R / Forrest, C / Forsman, A / Fooks, J / Foord, M / Fortner, R / Fournier, K / Fratanduono, D E / Frazier, N / Frazier, T / Frederick, C / Freeman, M S / Frenje, J / Frey, D / Frieders, G / Friedrich, S / Froula, D H / Fry, J / Fuller, T / Gaffney, J / Gales, S / Le Galloudec, B / Le Galloudec, K K / Gambhir, A / Gao, L / Garbett, W J / Garcia, A / Gates, C / Gaut, E / Gauthier, P / Gavin, Z / Gaylord, J / Geddes, C G R / Geissel, M / Génin, F / Georgeson, J / Geppert-Kleinrath, H / Geppert-Kleinrath, V / Gharibyan, N / Gibson, J / Gibson, C / Giraldez, E / Glebov, V / Glendinning, S G / Glenn, S / Glenzer, S H / Goade, S / Gobby, P L / Goldman, S R / Golick, B / Gomez, M / Goncharov, V / Goodin, D / Grabowski, P / Grafil, E / Graham, P / Grandy, J / Grasz, E / Graziani, F R / Greenman, G / Greenough, J A / Greenwood, A / Gregori, G / Green, T / Griego, J R / Grim, G P / Grondalski, J / Gross, S / Guckian, J / Guler, N / Gunney, B / Guss, G / Haan, S / Hackbarth, J / Hackel, L / Hackel, R / Haefner, C / Hagmann, C / Hahn, K D / Hahn, S / Haid, B J / Haines, B M / Hall, B M / Hall, C / Hall, G N / Hamamoto, M / Hamel, S / Hamilton, C E / Hammel, B A / Hammer, J H / Hampton, G / Hamza, A / Handler, A / Hansen, S / Hanson, D / Haque, R / Harding, D / Harding, E / Hares, J D / Harris, D B / Harte, J A / Hartouni, E P / Hatarik, R / Hatchett, S / Hauer, A A / Havre, M / Hawley, R / Hayes, J / Hayes, S / Hayes-Sterbenz, A / Haynam, C A / Haynes, D A / Headley, D / Heal, A / Heebner, J E / Heerey, S / Heestand, G M / Heeter, R / Hein, N / Heinbockel, C / Hendricks, C / Henesian, M / Heninger, J / Henrikson, J / Henry, E A / Herbold, E B / Hermann, M R / Hermes, G / Hernandez, J E / Hernandez, V J / Herrmann, M C / Herrmann, H W / Herrera, O D / Hewett, D / Hibbard, R / Hicks, D G / Higginson, D P / Hill, D / Hill, K / Hilsabeck, T / Hinkel, D E / Ho, D D / Ho, V K / Hoffer, J K / Hoffman, N M / Hohenberger, M / Hohensee, M / Hoke, W / Holdener, D / Holdener, F / Holder, J P / Holko, B / Holunga, D / Holzrichter, J F / Honig, J / Hoover, D / Hopkins, D / Berzak Hopkins, L F / Hoppe, M / Hoppe, M L / Horner, J / Hornung, R / Horsfield, C J / Horvath, J / Hotaling, D / House, R / Howell, L / Hsing, W W / Hu, S X / Huang, H / Huckins, J / Hui, H / Humbird, K D / Hund, J / Hunt, J / Hurricane, O A / Hutton, M / Huynh, K H-K / Inandan, L / Iglesias, C / Igumenshchev, I V / Ivanovich, I / Izumi, N / Jackson, M / Jackson, J / Jacobs, S D / James, G / Jancaitis, K / Jarboe, J / Jarrott, L C / Jasion, D / Jaquez, J / Jeet, J / Jenei, A E / Jensen, J / Jimenez, J / Jimenez, R / Jobe, D / Johal, Z / Johns, H M / Johnson, D / Johnson, M A / Gatu Johnson, M / Johnson, R J / Johnson, S / Johnson, S A / Johnson, T / Jones, K / Jones, O / Jones, M / Jorge, R / Jorgenson, H J / Julian, M / Jun, B I / Jungquist, R / Kaae, J / Kabadi, N / Kaczala, D / Kalantar, D / Kangas, K / Karasiev, V V / Karasik, M / Karpenko, V / Kasarky, A / Kasper, K / Kauffman, R / Kaufman, M I / Keane, C / Keaty, L / Kegelmeyer, L / Keiter, P A / Kellett, P A / Kellogg, J / Kelly, J H / Kemic, S / Kemp, A J / Kemp, G E / Kerbel, G D / Kershaw, D / Kerr, S M / Kessler, T J / Key, M H / Khan, S F / Khater, H / Kiikka, C / Kilkenny, J / Kim, Y / Kim, Y-J / Kimko, J / Kimmel, M / Kindel, J M / King, J / Kirkwood, R K / Klaus, L / Klem, D / Kline, J L / Klingmann, J / Kluth, G / Knapp, P / Knauer, J / Knipping, J / Knudson, M / Kobs, D / Koch, J / Kohut, T / Kong, C / Koning, J M / Koning, P / Konior, S / Kornblum, H / Kot, L B / Kozioziemski, B / Kozlowski, M / Kozlowski, P M / Krammen, J / Krasheninnikova, N S / Krauland, C M / Kraus, B / Krauser, W / Kress, J D / Kritcher, A L / Krieger, E / Kroll, J J / Kruer, W L / Kruse, M K G / Kucheyev, S / Kumbera, M / Kumpan, S / Kunimune, J / Kur, E / Kustowski, B / Kwan, T J T / Kyrala, G A / Laffite, S / Lafon, M / LaFortune, K / Lagin, L / Lahmann, B / Lairson, B / Landen, O L / Land, T / Lane, M / Laney, D / Langdon, A B / Langenbrunner, J / Langer, S H / Langro, A / Lanier, N E / Lanier, T E / Larson, D / Lasinski, B F / Lassle, D / LaTray, D / Lau, G / Lau, N / Laumann, C / Laurence, A / Laurence, T A / Lawson, J / Le, H P / Leach, R R / Leal, L / Leatherland, A / LeChien, K / Lechleiter, B / Lee, A / Lee, M / Lee, T / Leeper, R J / Lefebvre, E / Leidinger, J-P / LeMire, B / Lemke, R W / Lemos, N C / Le Pape, S / Lerche, R / Lerner, S / Letts, S / Levedahl, K / Lewis, T / Li, C K / Li, H / Li, J / Liao, W / Liao, Z M / Liedahl, D / Liebman, J / Lindford, G / Lindman, E L / Lindl, J D / Loey, H / London, R A / Long, F / Loomis, E N / Lopez, F E / Lopez, H / Losbanos, E / Loucks, S / Lowe-Webb, R / Lundgren, E / Ludwigsen, A P / Luo, R / Lusk, J / Lyons, R / Ma, T / Macallop, Y / MacDonald, M J / MacGowan, B J / Mack, J M / Mackinnon, A J / MacLaren, S A / MacPhee, A G / Magelssen, G R / Magoon, J / Malone, R M / Malsbury, T / Managan, R / Mancini, R / Manes, K / Maney, D / Manha, D / Mannion, O M / Manuel, A M / Manuel, M J-E / Mapoles, E / Mara, G / Marcotte, T / Marin, E / Marinak, M M / Mariscal, D A / Mariscal, E F / Marley, E V / Marozas, J A / Marquez, R / Marshall, C D / Marshall, F J / Marshall, M / Marshall, S / 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/ Moreno, K / Morgan, B E / Morrow, T / Morton, J W / Moses, E / Moy, K / Muir, R / Murillo, M S / Murray, J E / Murray, J R / Munro, D H / Murphy, T J / Munteanu, F M / Nafziger, J / Nagayama, T / Nagel, S R / Nast, R / Negres, R A / Nelson, A / Nelson, D / Nelson, J / Nelson, S / Nemethy, S / Neumayer, P / Newman, K / Newton, M / Nguyen, H / Di Nicola, J-M G / Di Nicola, P / Niemann, C / Nikroo, A / Nilson, P M / Nobile, A / Noorai, V / Nora, R C / Norton, M / Nostrand, M / Note, V / Novell, S / Nowak, P F / Nunez, A / Nyholm, R A / O'Brien, M / Oceguera, A / Oertel, J A / Oesterle, A L / Okui, J / Olejniczak, B / Oliveira, J / Olsen, P / Olson, B / Olson, K / Olson, R E / Opachich, Y P / Orsi, N / Orth, C D / Owen, M / Padalino, S / Padilla, E / Paguio, R / Paguio, S / Paisner, J / Pajoom, S / Pak, A / Palaniyappan, S / Palma, K / Pannell, T / Papp, F / Paras, D / Parham, T / Park, H-S / Pasternak, A / Patankar, S / Patel, M V / Patel, P K / Patterson, R / Patterson, S / Paul, B / 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    Physical review letters

    2024  Volume 132, Issue 6, Page(s) 65102

    Abstract: ... in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129 ...

    Abstract On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.065102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

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    Physical review letters

    2021  Volume 129, Issue 7, Page(s) 75001

    Abstract: For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating ... ...

    Abstract For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.129.075001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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Alain / Poirson, Florent / Chaput, Ulriikka / Beeken, Thomas / Maxime, Leclerc / Haikel, Oueslati / Vodovar, Dominique / Chelly, Jonathan / Marteau, Philippe / Chocron, Richard / Juvin, Philippe / Loeb, Thomas / Adnet, Frederic / Lecarpentier, Eric / Riviere, Antoine / De Cagny, Bertand / Soupison, Thierry / Privat, Elodie / Escutnaire, Joséphine / Dumont, Cyrielle / Baert, Valentine / Vilhelm, Christian / Hubert, Hervé / Leteurtre, Stéphane / Fresco, Marion / Bubenheim, Michael / Beduneau, Gaetan / Carpentier, Dorothée / Grange, Steven / Artaud-Macari, Elise / Misset, Benoit / Tamion, Fabienne / Girault, Christophe / Dumas, Guillaume / Chevret, Sylvie / Lemiale, Virginie / Mokart, Djamel / Mayaux, Julien / Pène, Frédéric / Nyunga, Martine / Perez, Pierre / Moreau, Anne-Sophie / Bruneel, Fabrice / Vincent, François / Klouche, Kada / Reignier, Jean / Rabbat, Antoine / Azoulay, Elie / Frat, Jean-Pierre / Ragot, Stéphanie / Constantin, Jean-Michel / Prat, Gwenael / Mercat, Alain / Boulain, Thierry / Demoule, Alexandre / Devaquet, Jérôme / Nseir, Saad / Charpentier, Julien / Argaud, Laurent / Beuret, Pascal / Ricard, Jean-Damien / Teiten, Christelle / Marjanovic, Nicolas / Palamin, Nicola / L’Her, Erwan / Bailly, Arthur / Boisramé-Helms, Julie / Champigneulle, Benoit / Kamel, Toufik / Mercier, Emmanuelle / Le Thuaut, Aurélie / Lascarrou, Jean-Baptiste / Rolle, Amélie / De Jong, Audrey / Chanques, Gérald / Jaber, Samir / Hariri, Geoffroy / Baudel, Jean-Luc / Dubée, Vincent / Preda, Gabriel / Bourcier, Simon / Joffre, Jeremie / Bigé, Naïke / Ait-Oufella, Hafid / Maury, Eric / Mater, Houda / Merdji, Hamid / Grimaldi, David / Rousseau, Christophe / Mira, Jean-Paul / Chiche, Jean-Daniel / Sedghiani, Ines / Benabderrahim, A. / Hamdi, Dhekra / Jendoubi, Asma / Cherif, Mohamed Ali / Hechmi, Youssef Zied El / Zouheir, Jerbi / Bagate, François / Bousselmi, Radhwen / Schortgen, Frédérique / Asfar, Pierre / Guérot, Emmanuel / Fabien, Grelon / Anguel, Nadia / Sigismond, Lasocki / Matthieu, Henry-Lagarrigue / Gonzalez, Frédéric / François, Legay / Guitton, Christophe / Schenck, Maleka / Jean-Marc, Doise / Dreyfuss, Didier / Radermacher, Peter / Frère, Antoine / Martin-Lefèvre, Laurent / Colin, Gwenhaël / Fiancette, Maud / Henry-Laguarrigue, Matthieu / Lacherade, Jean-Claude / Lebert, Christine / Vinatier, Isabelle / Yehia, Aihem / Joret, Aurélie / Menunier-Beillard, Nicolas / Benzekri-Lefevre, Dalila / Desachy, Arnaud / Bellec, Fréderic / Plantefève, Gaëtan / Quenot, Jean-Pierre / Meziani, Ferhat / Tavernier, Elsa / Ehrmann, Stephan / Chudeau, Nicolas / Raveau, Tommy / Moal, Valérie / Houillier, Pascal / Rouve, Emmanuelle / Lakhal, Karim / Gandonnière, Charlotte Salmon / Jouan, Youenn / Bodet-Contentin, Laetitia / Balmier, Adrien / Messika, Jonathan / De Montmollin, Etienne / Pouyet, Victorine / Sztrymf, Benjamin / Thiagarajah, Abirami / Roux, Damien / De Chambrun, Marc Pineton / Luyt, Charles-Edouard / Beloncle, François / Zapella, Nathalie / Ledochowsky, Stanislas / Terzi, Nicolas / Mazou, Jean-Marc / Sonneville, Romain / Paulus, Sylvie / Fedun, Yannick / Landais, Mickael / Raphalen, Jean-Herlé / Combes, Alain / Amoura, Zahir / Jacquemin, Aemilia / Guerrero, Felipe / Marcheix, Bertrand / Hernandez, Nicolas / Fourcade, Olivier / Georges, Bernard / Delmas, Clément / Makoudi, Sarah / Genton, Audrey / Bernard, Rémy / Lebreton, Guillaume / Amour, Julien / Mazet, Charlotte / Bounes, Fanny / Murat, Gurbuz / Cronier, Laure / Robin, Guillaume / Biendel, Caroline / Silva, Stein / Boubeche, Samia / Abriou, Caroline / Wurtz, Véronique / Scherrer, Vincent / Rey, Nathalie / Gastaldi, Gioia / Veber, Benoit / Doguet, Fabien / Gay, Arnaud / Dureuil, Bertrand / Besnier, Emmanuel / Rouget, Antoine / Gantois, Guillaume / Magalhaes, Eric / Wanono, Ruben / Smonig, Roland / Lermuzeaux, Mathilde / Lebut, Jordane / Olivier, Andremont / Dupuis, Claire / Radjou, Aguila / Mourvillier, Bruno / Neuville, Mathilde / D’ortho, Marie Pia / Bouadma, Lila / Rouvel-Tallec, Anny / Rudler, Marika / Weiss, Nicolas / Perlbarg, Vincent / Galanaud, Damien / Thabut, Dominique / Rachdi, Emna / Mhamdi, Ghada / Trifi, Ahlem / Abdelmalek, Rim / Abdellatif, Sami / Daly, Foued / Nasri, Rochdi / Tiouiri, Hanene / Lakhal, Salah Ben / Rousseau, Geoffroy / Asmolov, Romain / Grammatico-Guillon, Leslie / Auvet, Adrien / Laribi, Said / Garot, Denis / Dequin, Pierre François / Guillon, Antoine / Fergé, Jean-Louis / Abgrall, Gwénolé / Hinault, Ronan / Vally, Shazima / Roze, Benoit / Chaplain, Agathe / Chabartier, Cyrille / Savidan, Anne-Charlotte / Marie, Sabia / Cabie, Andre / Resiere, Dabor / Valentino, Ruddy / Mehdaoui, Hossein / Benarous, Lucas / Soda-Diop, Marième / Bouzana, Fouad / Perrin, Gilles / Bourenne, Jeremy / Eon, Béatrice / Lambert, Dominique / Trebuchon, Agnes / Poncelet, Géraldine / Le Bourgeois, Fleur / Michael, Levy / Camille, Guillot / Naudin, Jérôme / Deho, Anna / Dauger, Stéphane / Sauthier, Michaël / Bergeron-Gallant, Krystale / Emeriaud, Guillaume / Jouvet, Philippe / Tiebergien, Nicolas / Jacquet-Lagrèze, Matthias / Fellahi, Jean-Luc / Baudin, Florent / Essouri, Sandrine / Javouhey, Etienne / Guérin, Claude / Lampin, Marie / Mamouri, Ouardia / Devos, Patrick / Karaca-Altintas, Yasemin / Vinchon, Matthieu / Brossier, David / Eltaani, Redha / Teyssedre, Sonia / Sabine, Meyet / Bouchut, Jean-Christophe / Peguet, Olivier / Petitdemange, Lucie / Guilbert, Anne Sophie / Aoul, Nabil Tabet / Addou, Zakaria / Aouffen, Nabil / Anas, Benqqa / Kalouch, Samira / Yaqini, Khalid / Chlilek, Aziz / Abdou, Rchi / Gravellier, Perrine / Chantreuil, Julie / Travers, Nadine / Listrat, Antoine / Le Reun, Claire / Favrais, Geraldine / Coppere, Zoe / Blanot, Stéphane / Montmayeur, Juliette / Bronchard, Régis / Rolando, Stephane / Orliaguet, Gilles / Leger, Pierre-Louis / Rambaud, Jérôme / Thueux, Emilie / De Larrard, Alexandra / Berthelot, Véronique / Denot, Julien / Reymond, Marie / Amblard, Alain / Morin-Zorman, Sarah / Lengliné, Etienne / Pichereau, Claire / Mariotte, Eric / Emmanuel, Canet / Poujade, Julien / Trumpff, Guillaume / Janssen-Langenstein, Ralf / Harlay, Marie-Line / Zaid, Noorah / Ait-Ammar, Nawel / Bonnal, Christine / Merle, Jean-Claude / Botterel, Francoise / Levesque, Eric / Riad, Zakaria / Mezidi, Mehdi / Yonis, Hodane / Aublanc, Mylène / Perinel-Ragey, Sophie / Lissonde, Floriane / Louf-Durier, Aurore / Tapponnier, Romain / Louis, Bruno / Forel, Jean-Marie / Bisbal, Magali / Lehingue, Samuel / Rambaud, Romain / Adda, Mélanie / Hraiech, Sami / Marchi, Elisa / Roch, Antoine / Guerin, Vincent / Rozencwajg, Sacha / Schmidt, Matthieu / Hekimian, Guillaume / Bréchot, Nicolas / Trouillet, Jean Louis / Besset, Sébastien / Franchineau, Guillaume / Nieszkowska, Ania / Pascal, Leprince / Loiselle, Maud / Sarah, Chemam / Laurence, Dangers / Guillemette, Thomas / Jacquens, Alice / Kerever, Sebastien / Guidet, Bertrand / Aegerter, Philippe / Das, Vincent / Fartoukh, Muriel / Hayon, Jan / Desmard, Mathieu / Fulgencio, Jean-Pierre / Zuber, Benjamin / Soufi, A. / Khaleq, K. / Hamoudi, D. / Garret, Charlotte / Peron, Matthieu / Coron, Emmanuel / Bretonnière, Cédric / Audureau, Etienne / Audrey, Winters / Christophe, Duvoux / Christian, Jacquelinet / Daniel, Azoulay / Cyrille, Feray / Aissaoui, Wissal / Rghioui, Kawtar / Haddad, Wafae / Barrou, Houcine / Carteaux-Taeib, Anna / Lupinacci, Renato / Manceau, Gilles / Jeune, Florence / Tresallet, Christophe / Habacha, Sahar / Fathallah, Ines / Zoubli, Aymen / Aloui, Rafaa / Kouraichi, Nadia / Jouet, Emilie / Badin, Julie / Fermier, Brice / Feller, Marc / Serie, Mathieu / Pillot, Jérôme / Marie, William / Gisbert-Mora, Chloé / Vinclair, Camille / Lesbordes, Pierre / Mathieu, Pascal / De Brabant, Fabienne / Muller, Emmanuel / Robaux, Marie-Aline / Giabicani, Mikhael / Marchalot, Antoine / Gelinotte, Stéphanie / Declercq, Pierre Louis / Eraldi, Jean-Pierre / Bougerol, François / Meunier-Beillard, Nicolas / Devilliers, Hervé / Rigaud, Jean-Philippe / Verrière, Camille / Ardisson, Fanny / Kentish-Barnes, Nancy / Jacq, Gwenaëlle / Chermak, Akli / Lautrette, Alexandre / Legrand, Matthieu / Soummer, Alexis / Thiery, Guillaume / Cottereau, Alice / Canet, Emmanuel / Caujolle, Marie / Allyn, Jérôme / Valance, Dorothée / Brulliard, Caroline / Martinet, Olivier / Jabot, Julien / Gallas, Thomas / Vandroux, David / Allou, Nicolas / Durand, Arthur / Nevière, Rémi / Delguste, Florian / Boulanger, Eric / Preau, Sebastien / Martin, Ruste / Cochet, Hélène / Ponthus, Jean Pierre / Amilien, Virginie / Tchir, Martial / Barsam, Elise / Ayoub, Mohsen / Georger, Jean Francois / Guillame, Izaute / Assaraf, Julie / Tripon, Simona / Mallet, Maxime / Barbara, Guilaume / Louis, Guillaume / Gaudry, Stéphane / Barbarot, Nicolas / Jamet, Angéline / Outin, Hervé / Gibot, Sébastien / Bollaert, Pierre-Edouard / Holleville, Mathilde / Legriel, Stéphane / Chateauneuf, Anne Laure / Cavelot, Sébastien / Moyer, Jean-Denis / Bedos, Jean Pierre / Merle, Philippe / Laine, Aurelie / Natalie, De Sa / Cornuault, Mathieu / Libot, Jérome / Asehnoune, Karim / Rozec, Bertrand / Dantal, Jacques / Videcoq, Michel / Degroote, Thècle / Jaillette, Emmanuelle / Zerimech, Farid / Malika, Balduyck / Llitjos, Jean-François / Amara, Marlène / Lacave, Guillaume / Pangon, Béatrice / Mavinga, José / Makunza, Joseph Nsiala / Mafuta, M. E. / Yanga, Yves / Eric, Amisi / Ilunga, Jp / Kilembe, Ma / Alby-Laurent, Fanny / Toubiana, Julie / Mokline, Amel / Laajili, Achraf / Amri, Helmi / Rahmani, Imene / Mensi, Nidhal / Gharsallah, Lazheri / Tlaili, Sofiene / Gasri, Bahija / Hammouda, Rym / Messadi, Amen Allah / Allain, Pierre-Antoine / Gault, Nathallie / Paugam-Burtz, Catherine / Foucrier, Arnaud / Chatbri, Bassem / Bourbiaa, Yousra / Thabet, Lamia / Neuschwander, Arthur / Vincent, Looten / Beck, Jennifer / Vibol, Chhor / Amelie, Yavchitz / Resche-Rigon, Matthieu / Pirracchio, Jean MantzRomain / Bureau, Côme / Decavèle, Maxens / Campion, Sébastien / Ainsouya, Roukia / Niérat, Marie-Cécile / Prodanovic, Hélène / Raux, Mathieu / Similowski, Thomas / Dubé, Bruno-Pierre / Demiri, Suela / Dres, Martin / May, Faten / Quintard, Hervé / Kounis, Ilias / Saliba, Faouzi / André, Stephane / Boudon, Marc / Ichai, Philippe / Younes, Aline / Nakad, Lionel / Coilly, Audrey / Antonini, Teresa / Sobesky, Rodolphe / De Martin, Eleonora / Samuel, Didier / Hubert, Noemie / Nay, Mai-Anh / Auchabie, Johann / Giraudeau, Bruno / Jean, Reignier / Darmon, Michaël / Ruckly, Stephane / Garrouste-Orgeas, Maïté / Gratia, Elisabeth / Goldgran-Toledano, Dany / Jamali, Samir / Dumenil, Anne Sylvie / Schwebel, Carole / Brisard, Laurent / Bizouarn, Philippe / Lepoivre, Thierry / Nicolet, Johanna / Rigal, Jean Christophe / Roussel, Jean Christian / Cheurfa, Cherifa / Abily, Julien / Lescot, Thomas / Page, Isaline / Warnier, Stéphanie / Nys, Monique / Rousseau, Anne-Françoise / Damas, Pierre / Uhel, Fabrice / Lesouhaitier, Mathieu / Grégoire, Murielle / Gaudriot, Baptiste / Gacouin, Arnaud / Le Tulzo, Yves / Flecher, Erwan / Tarte, Karin / Tadié, Jean-Marc / Georges, Quentin / Soares, M. / Jeon, Kyeongman / Oeyen, Sandra / Rhee, Chin Kook / Gruber, Pascale / Ostermann, Marlies / Hill, Quentin / Depuydt, Peter / Ferra, Christelle / Muller, Alice / Aurelie, Bourmaud / Niles, Christopher / Herbert, Fabien / Pied, Sylviane / Loridant, Séverine / François, Nadine / Bignon, Anne / Sendid, Boualem / Lemaitre, Caroline / Dupre, Celine / Zayene, Aymen / Portier, Lucie / De Freitas Caires, Nathalie / Lassalle, Philippe / Le Neindre, Aymeric / Selot, Pascal / Ferreiro, Daniel / Bonarek, Maria / Henriot, Stépahen / Rodriguez, Julie / Taddei, Mara / Di Bari, Mauro / Hickmann, Cheryl / Castanares-Zapatero, Diego / Deldicque, Louise / Van Den Bergh, Peter / Caty, Gilles / Roeseler, Jean / Francaux, Marc / Laterre, Pierre-François / Dupuis, Bastien / Machayeckhi, Sharam / Sarfati, Celine / Moore, Alex / Mendialdua, Paula / Rodet, Emilie / Pilorge, Catherine / Stephan, Francois / Rezaiguia-Delclaux, Saida / Dugernier, Jonathan / Hesse, Michel / Jumetz, Thibaud / Bialais, Emilie / Depoortere, Virginie / Michotte, Jean Bernard / Wittebole, Xavier / Jamar, François

    Ann Intensive Care

    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1186/s13613-016-0224-7
    Database COVID19

    Kategorien

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