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Article ; Online: Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis.

Li, Jun / Cheng, Cui / Zhang, Jiajun

2024 Volume 146, Page(s) 103231

Abstract: Objective: To investigate the association between autoimmune diseases (AIDs) and bladder cancer (BC) at the genetic level using Mendelian randomization (MR).: Methods: Single nucleotide polymorphisms (SNPs) associated with the seven AIDs were ... ...

Abstract	Objective: To investigate the association between autoimmune diseases (AIDs) and bladder cancer (BC) at the genetic level using Mendelian randomization (MR). Methods: Single nucleotide polymorphisms (SNPs) associated with the seven AIDs were extracted from the IEU GWAS database, and the SNPs were quality-controlled using strict screening criteria. The association between AIDs and BC risk was assessed by inverse-variance weighted (IVW), MR-Egger regression and Weighted median method. The heterogeneity of SNPs was evaluated by Cochran Q test. MR-Egger intercept test and MR-PRESSO global test were used to test the horizontal pleiotropy of SNPs. Both sides with potential causal associations were validated using the validation set. Results: Our result showed that genetically predicted RA was significantly associated with an increased risk of BC (IVW OR = 1.214, 95 % CI = 1.062-1.388, P = 0.005). MS nominally increased the risk of BC (IVW OR = 1.095, 95 % CI = 1.005-1.193, P = 0.037), consistent with the results of the MR analysis of the BC validation cohort. However SLE, T1D, UC, CD, and MG were not causally associated with BC risk (P > 0.05). The sensitivity analyses showed that there was no heterogeneity or horizontal pleiotropy in our findings. Conclusion: This study provides evidence of a causal relationship between AIDs and BC risk at the genetic level, confirming a causal relationship between RA and MS in increasing the risk of BC.
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2024.103231
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Article ; Online: Radical chemistry in polymer science

Zixiao Wang / Feichen Cui / Yang Sui / Jiajun Yan

Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1580-

an overview and recent advances

2023 Volume 1603

Abstract: Radical chemistry is one of the most important methods used in modern polymer science and industry. Over the past century, new knowledge on radical chemistry has both promoted and been generated from the emergence of polymer synthesis and modification ... ...

Abstract	Radical chemistry is one of the most important methods used in modern polymer science and industry. Over the past century, new knowledge on radical chemistry has both promoted and been generated from the emergence of polymer synthesis and modification techniques. In this review, we discuss radical chemistry in polymer science from four interconnected aspects. We begin with radical polymerization, the most employed technique for industrial production of polymeric materials, and other polymer synthesis involving a radical process. Post-polymerization modification, including polymer crosslinking and polymer surface modification, is the key process that introduces functionality and practicality to polymeric materials. Radical depolymerization, an efficient approach to destroy polymers, finds applications in two distinct fields, semiconductor industry and environmental protection. Polymer chemistry has largely diverged from organic chemistry with the fine division of modern science but polymer chemists constantly acquire new inspirations from organic chemists. Dialogues on radical chemistry between the two communities will deepen the understanding of the two fields and benefit the humanity.
Keywords	crosslinking ; polymer surface modification ; post-polymerization modification ; radical chemistry ; radical polymerization ; Science ; Q ; Organic chemistry ; QD241-441
Subject code	540 ; 660
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Beilstein-Institut
Document type	Article ; Online
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Article: Radical chemistry in polymer science: an overview and recent advances.

Wang, Zixiao / Cui, Feichen / Sui, Yang / Yan, Jiajun

Beilstein journal of organic chemistry

2023 Volume 19, Page(s) 1580–1603

Abstract	Radical chemistry is one of the most important methods used in modern polymer science and industry. Over the past century, new knowledge on radical chemistry has both promoted and been generated from the emergence of polymer synthesis and modification techniques. In this review, we discuss radical chemistry in polymer science from four interconnected aspects. We begin with radical polymerization, the most employed technique for industrial production of polymeric materials, and other polymer synthesis involving a radical process. Post-polymerization modification, including polymer crosslinking and polymer surface modification, is the key process that introduces functionality and practicality to polymeric materials. Radical depolymerization, an efficient approach to destroy polymers, finds applications in two distinct fields, semiconductor industry and environmental protection. Polymer chemistry has largely diverged from organic chemistry with the fine division of modern science but polymer chemists constantly acquire new inspirations from organic chemists. Dialogues on radical chemistry between the two communities will deepen the understanding of the two fields and benefit the humanity.
Language	English
Publishing date	2023-10-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2192461-2
ISSN	1860-5397
ISSN	1860-5397
DOI	10.3762/bjoc.19.116
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Article ; Online: Comparison of clinical outcome after implantation of two toric intraocular lenses with different haptic type: a prospective randomized controlled trial.

Sun, Jiajun / Bai, Huiran / Cui, Wei / Wu, Xiaoming

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 262, Issue 3, Page(s) 847–855

Abstract: Objective: To study the effect of astigmatism correction, rotational stability, and related factors of two different haptic type toric intraocular lenses.: Methods: A prospective, randomized, controlled trial. Cataract patients with preoperative ... ...

Abstract	Objective: To study the effect of astigmatism correction, rotational stability, and related factors of two different haptic type toric intraocular lenses. Methods: A prospective, randomized, controlled trial. Cataract patients with preoperative corneal astigmatism of > 1 D were randomly implanted with C-loop haptic toric IOL (AcrySof-toric IOL) (group A) or plate-haptic toric IOL (AT TORBI 709 M IOL) (group B). The residual astigmatism, intraocular lens rotation, and visual quality were determined and compared between the two groups at 3 months after surgery. Results: Seventy-nine eyes were included in this study, including 40 eyes in the group A and 39 eyes in the group B. No significant difference in preoperative visual acuity, intraocular pressure, and ophthalmic biological parameters was found between the two groups. There was no significant difference in residual astigmatism between the two groups at 3 months after surgery (P > 0.05). The rotation degree in the group A was 3.85 ± 2.92°, the rotation degree in the group B was 2.33 ± 2.31°, and a significant difference in intraocular lens rotation was identified between the two groups (P < 0.05). Upon exploring the rotation-related factors of the two different haptic type toric intraocular lenses, the rotation after implanting C-loop haptic toric IOL was positively correlated with axial length (Pearson r = 0.522, P = 0.01) and corneal white-to-white distance (Pearson correlation analysis r = 0.356, P = 0.024). Conclusions: The two different haptic type toric intraocular lenses effectively corrected regular corneal astigmatism and provided a good rotational stability after surgery. But the stability of plate-haptic toric IOL was better than that of C-loop haptic toric IOL. The rotational stability of C-loop haptic toric IOL was often related to axial length and corneal white-to-white distance.
MeSH term(s)	Humans ; Astigmatism/surgery ; Haptic Technology ; Prospective Studies ; Lenses, Intraocular ; Cornea ; Corneal Diseases
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06232-9
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Article ; Online: Liver Transplantation Reverses Hepatic Myelopathy in the Decompensated Phase of Cirrhosis: Case Report and Literature Review.

Li, Jiajun / Wan, Sile / Wen, Fukai / Li, Qingyu / Cui, Yifeng / Lu, Zhaoyang / Lin, Han

Journal of clinical and translational hepatology

2024 Volume 12, Issue 4, Page(s) 436–442

Abstract: Hepatic myelopathy (HM) is a rare neurological complication in the end stage of many liver diseases and is characterized by bilateral spastic paraparesis without sensory and sphincter dysfunction. It occurs owing to metabolic disorders and central ... ...

Abstract	Hepatic myelopathy (HM) is a rare neurological complication in the end stage of many liver diseases and is characterized by bilateral spastic paraparesis without sensory and sphincter dysfunction. It occurs owing to metabolic disorders and central nervous system dysfunction associated with cirrhosis. Without timely and effective clinical intervention, the prognosis of these patients is devastating. Although liver transplantation (LT) is an effective treatment for HM, the prognosis of these patients remains unsatisfactory. Early recognition and diagnosis of this disease are essential for improving patient prognosis. Here, we report a case of hepatitis B virus-associated decompensated cirrhosis with HM. The patient recovered well after LT. We also summarize the clinical characteristics and post-transplant outcomes of 25 patients with HM treated by LT through 2023, including this case.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2023.00487
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Article ; Online: Bloom’s Classification of Educational Objectives Based on Deep Learning Theory Teaching Design of Nursing Specialty

Jia zheng / Jarrent Tayag / Yingai Cui / Jiajun Chen

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: Through the effective integration of various teaching resources, carry out the teaching design of “basic nursing technology” for the nursing specialty in the information environment based on Bloom’s education objective classification. Select 200 nursing ... ...

Abstract	Through the effective integration of various teaching resources, carry out the teaching design of “basic nursing technology” for the nursing specialty in the information environment based on Bloom’s education objective classification. Select 200 nursing students from two natural classes in the third year of undergraduate nursing major as the research objects with100 students in the experimental group and 100 students in the control group. The experimental group adopted Bloom’s objective classification teaching mode, and the control group adopted the traditional teaching model. They have carried out the teaching intervention to ensure the consistency of teachers, textbook use, teaching hours, and teaching progress between the two groups. The evaluation model of the teaching design results is the RBF neural network. The model improves the convergence ability of the RBF network by dynamically changing the control parameters of the L-M algorithm. RBF realizes the goal of the comprehensive analysis of course teaching effects evaluation and various influencing factors. The results showed that the differences in self-management ability, information ability, cooperation score, and total score of the experimental group were significantly higher than those of the control group, with statistical significance P<0.01. The teaching of Bloom’s educational objective model can enhance students’ subjective consciousness and effectively improve their independent learning ability. The learning effect is improved obviously. This paper studies the teaching approaches to improve nursing students’ comprehensive ability and humanistic care quality and provides a reference for deepening nursing undergraduate teaching reform.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	370
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article: Increased selenium and decreased iron levels in relation to risk of coronary artery disease in patients with diabetes.

Tian, Mengyun / Hu, Teng / Ying, Jiajun / Cui, Hanbin / Huangfu, Ning

Frontiers in nutrition

2023 Volume 10, Page(s) 1103330

Abstract: Background: Observational studies have reported inconsistent associations between micronutrient levels and the risk of coronary artery disease (CAD) in diabetic patients. We aim to explore the causal association between genetically predicted ... ...

Abstract	Background: Observational studies have reported inconsistent associations between micronutrient levels and the risk of coronary artery disease (CAD) in diabetic patients. We aim to explore the causal association between genetically predicted concentrations of micronutrients (phosphorus, magnesium, selenium, iron, zinc, and copper) and CAD in patients with diabetes. Methods: Single nucleotide polymorphisms (SNPs) connected to serum micronutrient levels were extracted from the corresponding published genome-wide association studies (GWASs). Summary-level statistics for CAD in diabetic patients were obtained from a GWAS of 15,666 patients with diabetes. The primary analysis was carried out with the inverse variance weighted approach, and sensitivity analyses using other statistical methods were further employed to assess the robustness of the results. Results: Genetically predicted selenium level was causally associated with a higher risk of CAD in diabetic patients (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.10-1.42; Conclusion: We provide consistent evidence for the causal effect of increased selenium and decreased iron levels on CAD in patients with diabetes, highlighting the necessity of micronutrient monitoring and application in these patients.
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1103330
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Article ; Online: Endoscopic Suture With Chemocauterization: An Effective Treatment of Congenital Pyriform Sinus Fistula.

Tian, Jiajun / Cui, Peng / Zhang, Haiyan / Lv, Zhenghua / Xu, Wei

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2023 Volume 169, Issue 6, Page(s) 1624–1630

Abstract: Objective: Endoscopic cauterization is an effective method for treating pyriform sinus fistula (PSF). However, these approaches sometimes result in a higher failure rate. We present an effective technique utilizing suture combined with ... ...

Abstract	Objective: Endoscopic cauterization is an effective method for treating pyriform sinus fistula (PSF). However, these approaches sometimes result in a higher failure rate. We present an effective technique utilizing suture combined with chemocauterization as first-line treatment in patients with PSF and evaluate the safety and efficacy of its use in 126 patients. Study design: Retrospective study. Setting: Tertiary referral center. Methods: Retrospective case review of patients treated between March 2012 and June 2021 at our institution with descriptive statistical analysis. Results: A total of 126 patients with PSF were included in this study with a mean age of 14.7 years. There was no sex predilection. The majority of patients presented with a left-sided neck lesion (89.7%). Ten patients presented following prior attempts at the surgery of the PSF at another institution; 8 via open surgery and 2 following endoscopic CO Conclusion: Endoscopic suture combined with chemocauterization is a safe and effective treatment of PSF. Surgery can be performed during the acute cervical inflammatory period without increased risk of complication or recurrence, however, patients found to have acute changes affecting the pyriform sinus should be treated with a staged surgery strategy.
MeSH term(s)	Humans ; Adolescent ; Retrospective Studies ; Pyriform Sinus/surgery ; Pyriform Sinus/abnormalities ; Recurrence ; Cautery ; Fistula/congenital ; Fistula/surgery ; Sutures
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.382
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Book ; Online: Differentiating Student Feedbacks for Knowledge Tracing

Cui, Jiajun / Zhang, Wei

2022

Abstract: In computer-aided education and intelligent tutoring systems, knowledge tracing (KT) raises attention due to the development of data-driven learning methods, which aims to predict students' future performance given their past question response sequences ... ...

Abstract	In computer-aided education and intelligent tutoring systems, knowledge tracing (KT) raises attention due to the development of data-driven learning methods, which aims to predict students' future performance given their past question response sequences to trace their knowledge states. However, current deep learning approaches only focus on enhancing prediction accuracy, but neglecting the discrimination imbalance of responses. That is, a considerable proportion of question responses are weak to discriminate students' knowledge states, but equally considered compared to other discriminative responses, thus hurting the ability of tracing students' personalized knowledge states. To tackle this issue, we propose DR4KT for Knowledge Tracing, which reweights the contribution of different responses according to their discrimination in training. For retaining high prediction accuracy on low discriminative responses after reweighting, DR4KT also introduces a discrimination-aware score fusion technique to make a proper combination between student knowledge mastery and the questions themselves. Comprehensive experimental results show that our DR4KT applied on four mainstream KT methods significantly improves their performance on three widely-used datasets.
Keywords	Computer Science - Computers and Society ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
Subject code	004
Publishing date	2022-12-16
Publishing country	us
Document type	Book ; Online
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Article ; Online: Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin.

Zang, Xinxin / Zhang, Jiajun / Jiang, Yanyan / Feng, Tingting / Cui, Yingying / Wang, Hui / Cui, Ziyin / Dang, Guanghui / Liu, Siguo

PLoS pathogens

2024 Volume 20, Issue 5, Page(s) e1012214

Abstract: Epithelial cells function as the primary line of defense against invading pathogens. However, bacterial pathogens possess the ability to compromise this barrier and facilitate the transmigration of bacteria. Nonetheless, the specific molecular mechanism ... ...

Abstract	Epithelial cells function as the primary line of defense against invading pathogens. However, bacterial pathogens possess the ability to compromise this barrier and facilitate the transmigration of bacteria. Nonetheless, the specific molecular mechanism employed by Mycobacterium tuberculosis (M.tb) in this process is not fully understood. Here, we investigated the role of Rv2569c in M.tb translocation by assessing its ability to cleave E-cadherin, a crucial component of cell-cell adhesion junctions that are disrupted during bacterial invasion. By utilizing recombinant Rv2569c expressed in Escherichia coli and subsequently purified through affinity chromatography, we demonstrated that Rv2569c exhibited cell wall-associated serine protease activity. Furthermore, Rv2569c was capable of degrading a range of protein substrates, including casein, fibrinogen, fibronectin, and E-cadherin. We also determined that the optimal conditions for the protease activity of Rv2569c occurred at a temperature of 37°C and a pH of 9.0, in the presence of MgCl2. To investigate the function of Rv2569c in M.tb, a deletion mutant of Rv2569c and its complemented strains were generated and used to infect A549 cells and mice. The results of the A549-cell infection experiments revealed that Rv2569c had the ability to cleave E-cadherin and facilitate the transmigration of M.tb through polarized A549 epithelial cell layers. Furthermore, in vivo infection assays demonstrated that Rv2569c could disrupt E-cadherin, enhance the colonization of M.tb, and induce pathological damage in the lungs of C57BL/6 mice. Collectively, these results strongly suggest that M.tb employs the serine protease Rv2569c to disrupt epithelial defenses and facilitate its systemic dissemination by crossing the epithelial barrier.
MeSH term(s)	Cadherins/metabolism ; Mycobacterium tuberculosis/pathogenicity ; Mycobacterium tuberculosis/metabolism ; Animals ; Humans ; Mice ; Serine Proteases/metabolism ; Serine Proteases/genetics ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; A549 Cells ; Tuberculosis/microbiology ; Tuberculosis/metabolism ; Female
Chemical Substances	Cadherins ; Serine Proteases (EC 3.4.-) ; Bacterial Proteins
Language	English
Publishing date	2024-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1012214
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