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  1. Book ; Online ; E-Book: Morgan and Mikhail's clinical anesthesiology

    Butterworth, John F. / Mackey, David C. / Wasnick, John D.

    (Lange medical book)

    2022  

    Abstract: Morgan & Mikhail's Clinical Anesthesiology, Seventh Edition is an essential resource for all anesthesia students and practitioners. Hailed as the best primer on the topic, this trusted classic delivers comprehensive coverage of the field's must-know ... ...

    Author's details John F. Butterworth, David C. Mackey, John D. Wasnick
    Series title Lange medical book
    Abstract "Morgan & Mikhail's Clinical Anesthesiology, Seventh Edition is an essential resource for all anesthesia students and practitioners. Hailed as the best primer on the topic, this trusted classic delivers comprehensive coverage of the field's must-know basic science and clinical topics in a clear, easy-to-understand presentation. The text is also ideal for coursework, review, or as a clinical refresher"--Publisher's description.
    Keywords Anesthesiology
    Subject code 617.96
    Language English
    Size 1 online resource (1458 pages) :, illustrations.
    Edition Seventh edition.
    Publisher McGraw Hill
    Publishing place New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-1-260-47379-7 ; 1-260-47379-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Making glaucoma genetic studies more diverse.

    Mackey, David A / Staffieri, Sandra E

    Cell

    2024  Volume 187, Issue 2, Page(s) 273–275

    Abstract: Although the blinding eye disease glaucoma is more common in people of African ancestry, previous genetic studies predominantly involved European subjects. In this issue of Cell, O'Brien et al. report a genome-wide association study for glaucoma in ... ...

    Abstract Although the blinding eye disease glaucoma is more common in people of African ancestry, previous genetic studies predominantly involved European subjects. In this issue of Cell, O'Brien et al. report a genome-wide association study for glaucoma in individuals of African ancestry, showing overlap with European studies and refining an African polygenic risk score.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Glaucoma/genetics ; Black People/genetics ; Research ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.12.023
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  3. Article ; Online: Emerging Role of Axial Length Trajectories in the Management of Myopia.

    Mackey, David A / Lee, Samantha S

    JAMA ophthalmology

    2023  Volume 142, Issue 2, Page(s) 94–95

    MeSH term(s) Humans ; Myopia/therapy ; Refraction, Ocular ; Axial Length, Eye
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.6087
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  4. Article ; Online: "Eye genetics at the fork in the road" 2017 Franceschetti Lecture, Leeds UK.

    Mackey, David

    Ophthalmic genetics

    2020  Volume 41, Issue 3, Page(s) 201–207

    Abstract: Inherited retinal diseases - a disparate group of eye disorders with over 200 known genetic causes - are now the leading cause of blindness in working-age adults in developed countries. Until recently there was no cure for genetic eye diseases. After ... ...

    Abstract Inherited retinal diseases - a disparate group of eye disorders with over 200 known genetic causes - are now the leading cause of blindness in working-age adults in developed countries. Until recently there was no cure for genetic eye diseases. After over a century of defining inherited retinal diseases with their phenotypes, and then several decades of discovering associated genes and their mutations, we now have gene therapy, stem cell therapy, predictive DNA testing and a revolution in adaptive computer technology. With the explosion of expensive treatment options, we need to consider whether finite resources should go towards treatment, prevention or rehabilitation or an amalgamation of all three. In addition, although evidence-based medicine is the goal, how do we direct our desperate patients towards genuine clinical trials and away from quackery? How do we provide scientifically valid treatments for eye diseases too rare to run proper trials and then capture the results of "off label treatments"?
    MeSH term(s) Eye Diseases/diagnosis ; Eye Diseases/genetics ; Eye Diseases/therapy ; Eye Proteins/genetics ; Genetic Therapy ; Humans ; Mutation
    Chemical Substances Eye Proteins
    Language English
    Publishing date 2020-05-03
    Publishing country England
    Document type Journal Article ; Lecture ; Research Support, Non-U.S. Gov't
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2020.1755988
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  5. Article ; Online: What colour are your eyes? Teaching the genetics of eye colour & colour vision. Edridge Green Lecture RCOphth Annual Congress Glasgow May 2019.

    Mackey, David A

    Eye (London, England)

    2021  Volume 36, Issue 4, Page(s) 704–715

    Abstract: Eye colour and colour perception are excellent examples to use when teaching genetics as they encompass not simply the basic Mendelian genetics of dominant, recessive and X-linked disorders, but also many of the new concepts such as non-allelic diseases, ...

    Abstract Eye colour and colour perception are excellent examples to use when teaching genetics as they encompass not simply the basic Mendelian genetics of dominant, recessive and X-linked disorders, but also many of the new concepts such as non-allelic diseases, polygenic disease, phenocopies, genome-wide association study (GWAS), founder effects, gene-environment interaction, evolutionary drivers for variations, copy number variation, insertions deletions, methylation and gene inactivation. Beyond genetics, colour perception touches on concepts involving optics, physics, physiology and psychology and can capture the imagination of the population, as we saw with social media trend of "#the dress". Television shows such as Game of Thrones focused attention on the eye colour of characters, as well as their Dire-wolves and Dragons. These themes in popular culture can be leveraged as tools to teach and engage everyone in genetics, which is now a key component in all eye diseases. As the explosion of data from genomics, big data and artificial intelligence transforms medicine, ophthalmologists need to be genetically literate. Genetics is relevant, not just for Inherited Retinal Diseases and congenital abnormalities but also for the leading causes of blindness: age-related macular degeneration, glaucoma, myopia, diabetic retinopathy and cataract. Genetics should be part of the armamentarium of every practicing ophthalmologist. We need to ask every patient about their family history. In the near future, patients will attend eye clinics with genetic results showing they are at high risk of certain eye diseases and ophthalmologists will need to know how to screen, follow and treat these patients.
    MeSH term(s) Artificial Intelligence ; Color Vision ; DNA Copy Number Variations ; Eye Color ; Genome-Wide Association Study ; Glaucoma ; Humans
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01749-x
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  6. Article ; Online: Protein phosphatase 2A: a high-value target of virulence factors.

    Gohmann, Reid / Mackey, David

    Trends in parasitology

    2023  Volume 39, Issue 10, Page(s) 803–805

    Abstract: Pathogen-encoded virulence factors perturb host physiology and immune function to promote infection. Reinforcing the concept that protein phosphatase 2A (PP2A) is convergently targeted by virulence factors from diverse pathogens, Li et al. demonstrate ... ...

    Abstract Pathogen-encoded virulence factors perturb host physiology and immune function to promote infection. Reinforcing the concept that protein phosphatase 2A (PP2A) is convergently targeted by virulence factors from diverse pathogens, Li et al. demonstrate that PP2A is coopted by members of a modular family of effector proteins from a plant-pathogenic oomycete.
    MeSH term(s) Virulence Factors/metabolism ; Protein Phosphatase 2/metabolism ; Virulence ; Plants ; Protein Processing, Post-Translational
    Chemical Substances Virulence Factors ; Protein Phosphatase 2 (EC 3.1.3.16)
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.07.010
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  7. Article ; Online: When 2 Epidemics Collide-COVID-19 and Myopia.

    Mackey, David A / Lee, Samantha S Y

    JAMA ophthalmology

    2023  Volume 141, Issue 4, Page(s) 340–341

    MeSH term(s) Humans ; COVID-19/epidemiology ; Epidemics ; Myopia/epidemiology
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.0074
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  8. Article ; Online: Implications of preferential access to land and clean energy for Sustainable Aviation Fuels.

    Becken, Susanne / Mackey, Brendan / Lee, David S

    The Science of the total environment

    2023  Volume 886, Page(s) 163883

    Abstract: Aviation is highly dependent on liquid fossil fuel, and the production of 'sustainable aviation fuels' (SAF) is being proposed as a solution to removing the fossil carbon component, especially for long-haul flights. An analysis of 12 aviation roadmaps ... ...

    Abstract Aviation is highly dependent on liquid fossil fuel, and the production of 'sustainable aviation fuels' (SAF) is being proposed as a solution to removing the fossil carbon component, especially for long-haul flights. An analysis of 12 aviation roadmaps for net zero 2050 reveals heavy reliance on biogenic SAF in the medium-term and synthetic e-kerosene in the longer term. Realising these roadmaps could require 9 % of global renewable electricity and 30 % of sustainably available biomass in 2050, with significant energy 'losses'. The continued use of hydrocarbon fuel in the roadmaps generates 1.35 GtCO
    MeSH term(s) Fossil Fuels ; Hydrocarbons ; Climate ; Aviation ; Carbon
    Chemical Substances Fossil Fuels ; Hydrocarbons ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-05-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163883
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  9. Article ; Online: Evaluating the effectiveness of cascade clinical screening for familial glaucoma in rural Western Australia.

    Stevenson, Louis / Blaszkowska, Magdalena / Turner, Angus / Mackey, David A

    Clinical & experimental ophthalmology

    2023  Volume 51, Issue 4, Page(s) 395–396

    MeSH term(s) Humans ; Western Australia/epidemiology ; Mass Screening ; Glaucoma/diagnosis ; Glaucoma/epidemiology ; Rural Population
    Language English
    Publishing date 2023-03-12
    Publishing country Australia
    Document type Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14216
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  10. Article ; Online: Protein phosphatase 2A: a high-value target of virulence factors

    Gohmann, Reid / Mackey, David

    Trends in Parasitology.

    2023  

    Abstract: Pathogen-encoded virulence factors perturb host physiology and immune function to promote infection. Reinforcing the concept that protein phosphatase 2A (PP2A) is convergently targeted by virulence factors from diverse pathogens, Li et al. demonstrate ... ...

    Abstract Pathogen-encoded virulence factors perturb host physiology and immune function to promote infection. Reinforcing the concept that protein phosphatase 2A (PP2A) is convergently targeted by virulence factors from diverse pathogens, Li et al. demonstrate that PP2A is coopted by members of a modular family of effector proteins from a plant-pathogenic oomycete.
    Keywords Oomycetes ; immune response ; parasitology ; phosphoprotein phosphatase ; physiology ; virulence ; PP2A ; pathogen ; virulence factor ; effector
    Language English
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.07.010
    Database NAL-Catalogue (AGRICOLA)

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