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  1. Book ; Online ; E-Book: Neuroimmune interactions in pain

    Ji, Ru-Rong / Cheng, Jianguo / Ji, Jasmine

    mechanisms and therapeutics

    2023  

    Author's details Ru-Rong Ji, Jianguo Cheng, Jasmine Ji editors
    Keywords Neurosciences ; Pain medicine ; Neurology ; Anesthesiology
    Language English
    Size 1 Online-Ressource (x, 364 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030016704
    ISBN 978-3-031-29231-6 ; 9783031292309 ; 3-031-29231-6 ; 3031292308
    DOI 10.1007/978-3-031-29231-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Third Special Issue on Mechanisms of Pain and Itch.

    Ji, Ru-Rong

    Neuroscience bulletin

    2022  Volume 38, Issue 4, Page(s) 339–341

    MeSH term(s) Humans ; Pain ; Pruritus
    Language English
    Publishing date 2022-04-25
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-022-00851-8
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  3. Article ; Online: Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.

    Ji, Ru-Rong

    Annual review of pharmacology and toxicology

    2022  Volume 63, Page(s) 273–293

    Abstract: Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic ... ...

    Abstract Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and cancer pain. Furthermore, endogenous SPMs are produced by sham surgery and neuromodulation (e.g., vagus nerve stimulation). SPMs produce their beneficial actions through multiple G protein-coupled receptors, expressed by immune cells, glial cells, and neurons. Notably, loss of SPM receptors impairs the resolution of pain. I also highlight the emerging role of SPMs in the control of itch. Pharmacological targeting of SPMs or SPM receptors has the potential to lead to novel therapeutics for pain and itch as emerging approaches in resolution pharmacology.
    MeSH term(s) Humans ; Inflammation/drug therapy ; Pain/drug therapy
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051921-084047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Targeting Hv1 proton channel for pain control.

    Furutani, Kenta / Ji, Ru-Rong

    Cell research

    2022  Volume 32, Issue 5, Page(s) 419–420

    MeSH term(s) Humans ; Ion Channels ; Microglia ; Pain ; Protons
    Chemical Substances Ion Channels ; Protons
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00648-4
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  5. Article ; Online: The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain

    Aidan McGinnis / Ru-Rong Ji

    Cells, Vol 12, Iss 965, p

    2023  Volume 965

    Abstract: Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the ... ...

    Abstract Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the dorsal root and trigeminal ganglia of the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) express similar molecular markers and are protective under physiological conditions. They also serve similar functions in the genesis and maintenance of neuropathic pain, downregulating some of their homeostatic functions and driving pro-inflammatory neuro-glial interactions in the PNS and CNS, i.e., “gliopathy”. However, the role of SGCs in neuropathic pain is not simply as “peripheral astrocytes”. We delineate how these peripheral and central glia participate in neuropathic pain by producing different mediators, engaging different parts of neurons, and becoming active at different stages following nerve injury. Finally, we highlight the recent findings that SGCs are enriched with proteins related to fatty acid metabolism and signaling such as Apo-E, FABP7, and LPAR1. Targeting SGCs and astrocytes may lead to novel therapeutics for the treatment of neuropathic pain.
    Keywords dorsal root ganglia ; fatty acids ; gliopathy ; nerve injury ; spinal cord ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Pain management by chemogenetic control of sensory neurons.

    Li, Yize / Ge, Xin / Ji, Ru-Rong

    Cell reports. Medicine

    2023  Volume 4, Issue 12, Page(s) 101338

    Abstract: In this study, Perez-Sanchez et al. ...

    Abstract In this study, Perez-Sanchez et al.
    MeSH term(s) Mice ; Animals ; Humans ; Pain Management ; Sensory Receptor Cells ; Pain/drug therapy ; alpha7 Nicotinic Acetylcholine Receptor/agonists ; alpha7 Nicotinic Acetylcholine Receptor/physiology
    Chemical Substances alpha7 Nicotinic Acetylcholine Receptor
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain?

    Xu, Jing / McGinnis, Aidan / Ji, Ru-Rong

    Neuron

    2023  Volume 111, Issue 4, Page(s) 450–452

    Abstract: Mechanical distension/stretch in the colon provokes visceral hypersensitivity and pain. In this issue of Neuron, Xie et al. report that mechanosensitive Piezo2 channels, expressed by TRPV1-lineage nociceptors, are involved in visceral mechanical ... ...

    Abstract Mechanical distension/stretch in the colon provokes visceral hypersensitivity and pain. In this issue of Neuron, Xie et al. report that mechanosensitive Piezo2 channels, expressed by TRPV1-lineage nociceptors, are involved in visceral mechanical nociception and hypersensitivity.
    MeSH term(s) Colon/physiology ; Ion Channels/physiology ; Neurons ; Nociceptors/physiology ; Pain ; TRPV Cation Channels/genetics
    Chemical Substances Ion Channels ; TRPV Cation Channels
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.01.011
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    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  8. Article ; Online: Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.

    Chen, Ouyang / Luo, Xin / Ji, Ru-Rong

    Medical review (2021)

    2023  Volume 3, Issue 5, Page(s) 381–407

    Abstract: Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types, representing immune cells and glial cells, respectively, but they share ... ...

    Abstract Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types, representing immune cells and glial cells, respectively, but they share similar roles in pain regulation. Macrophages are key regulators of inflammation and pain. Macrophage polarization plays different roles in inducing and resolving pain. Notably, macrophage polarization and phagocytosis can be induced by specialized pro-resolution mediators (SPMs). SPMs also potently inhibit inflammatory and neuropathic pain via immunomodulation and neuromodulation. In this review, we discuss macrophage signaling involved in pain induction and resolution, as well as in maintaining physiological pain. Microglia are macrophage-like cells in the central nervous system (CNS) and drive neuroinflammation and pathological pain in various inflammatory and neurological disorders. Microglia-produced inflammatory cytokines can potently regulate excitatory and inhibitory synaptic transmission as neuromodulators. We also highlight sex differences in macrophage and microglial signaling in inflammatory and neuropathic pain. Thus, targeting macrophage and microglial signaling in distinct locations via pharmacological approaches, including immunotherapies, and non-pharmacological approaches will help to control chronic inflammation and chronic pain.
    Language English
    Publishing date 2023-11-01
    Publishing country Germany
    Document type Journal Article
    ISSN 2749-9642
    ISSN (online) 2749-9642
    DOI 10.1515/mr-2023-0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain.

    McGinnis, Aidan / Ji, Ru-Rong

    Cells

    2023  Volume 12, Issue 6

    Abstract: Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the ... ...

    Abstract Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the dorsal root and trigeminal ganglia of the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) express similar molecular markers and are protective under physiological conditions. They also serve similar functions in the genesis and maintenance of neuropathic pain, downregulating some of their homeostatic functions and driving pro-inflammatory neuro-glial interactions in the PNS and CNS, i.e., "gliopathy". However, the role of SGCs in neuropathic pain is not simply as "peripheral astrocytes". We delineate how these peripheral and central glia participate in neuropathic pain by producing different mediators, engaging different parts of neurons, and becoming active at different stages following nerve injury. Finally, we highlight the recent findings that SGCs are enriched with proteins related to fatty acid metabolism and signaling such as Apo-E, FABP7, and LPAR1. Targeting SGCs and astrocytes may lead to novel therapeutics for the treatment of neuropathic pain.
    MeSH term(s) Humans ; Astrocytes ; Ganglia, Spinal/metabolism ; Neuroglia/metabolism ; Neuralgia/metabolism ; Neurons/metabolism
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12060965
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  10. Article ; Online: Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue.

    Ji, Ru-Rong

    Neuroscience bulletin

    2018  Volume 34, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Humans ; Pain/physiopathology ; Pruritus/physiopathology
    Language English
    Publishing date 2018-01-16
    Publishing country Singapore
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-018-0204-z
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