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  1. AU=Li Liwu
  2. AU="Akamine, Yuko"
  3. AU=Pereira Carlos
  4. AU=Roosa Kimberlyn
  5. AU=Rodrguez-Garca-de-Cortzar Ainhoa AU=Rodrguez-Garca-de-Cortzar Ainhoa
  6. AU="Eltan, Sevgi Bilgic"
  7. AU=Shibley I A Jr
  8. AU="Shin Ohta"
  9. AU="Herrera, José M."
  10. AU="Bolanle, Ogunyemi Folasade"
  11. AU="Spezialetti, Matteo"
  12. AU=Rosas Lucia E
  13. AU="Spadotto, Valeria"
  14. AU="Jimenez-Macias, Jorge L"

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  1. Artikel ; Online: Regularities of element migration based on rock spectral features: a case study of the Liwu copper deposit.

    Wang, Jiaxian / He, Li / He, Zhengwei / Hou, Yun / Wang, Chaowei / Zhang, Chengjiang

    Analytical methods : advancing methods and applications

    2021  Band 13, Heft 14, Seite(n) 1720–1730

    Abstract: The Liwu copper-zinc mining area has a complex topographical environment. Using traditional ...

    Abstract The Liwu copper-zinc mining area has a complex topographical environment. Using traditional prospecting methods, it is difficult and costly to carry out traditional prospecting research on a large scale. This study used portable X-ray fluorescence (pXRF) spectrometry and hyperspectral imaging for analysing rock samples in the B
    Sprache Englisch
    Erscheinungsdatum 2021-03-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d1ay00004g
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Regularities of element migration based on rock spectral features: a case study of the Liwu copper deposit

    Wang, Jiaxian / He, Li / He, Zhengwei / Hou, Yun / Wang, Chaowei / Zhang, Chengjiang

    Analytical methods. 2021 Apr. 15, v. 13, no. 14

    2021  

    Abstract: The Liwu copper–zinc mining area has a complex topographical environment. Using traditional ... samples in the B₂ ore body of the Liwu copper–zinc deposit. The hyperspectral imaging data and ...

    Abstract The Liwu copper–zinc mining area has a complex topographical environment. Using traditional prospecting methods, it is difficult and costly to carry out traditional prospecting research on a large scale. This study used portable X-ray fluorescence (pXRF) spectrometry and hyperspectral imaging for analysing rock samples in the B₂ ore body of the Liwu copper–zinc deposit. The hyperspectral imaging data and the measured indoor spectral characteristic curve of the same lithological rock have a certain similarity. The absorption or reflection characteristics in the same waveband were similar. The main elements were Cu and Zn in the ore body, Pb which was obviously brought out, and Cd, Sn and Sb which were brought in. It is believed that the mass migration of Cd, Sn, Sb and Pb elements plays an important role in the precipitation and enrichment of Cu and Zn elements. This method can be used to quickly determine element migration. The combination of the two analytical methods of pXRF and hyperspectral analysis, the low requirements of the work site and the fast and efficient characteristics, mean this method has unique advantages in analysing and monitoring environmental pollution, rock and mineral analysing and prospecting.
    Schlagwörter X-radiation ; absorption ; case studies ; fluorescence ; hyperspectral imagery ; pollution
    Sprache Englisch
    Erscheinungsverlauf 2021-0415
    Umfang p. 1720-1730.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d1ay00004g
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Buch ; Online: Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation

    Li, Liwu / McCall, Charles E. / Hu, Xiaoyu

    2020  

    Schlagwörter Medicine ; Immunology ; innate immune memory ; inflammation dynamics ; resolving and non-resolving inflammation ; acute disease ; chronic disease
    Umfang 1 electronic resource (139 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021231196
    ISBN 9782889635825 ; 2889635821
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  4. Artikel ; Online: Epigenetic regulation of innate immune dynamics during inflammation.

    Caldwell, Blake A / Li, Liwu

    Journal of leukocyte biology

    2024  Band 115, Heft 4, Seite(n) 589–606

    Abstract: Innate immune cells play essential roles in modulating both immune defense and inflammation by expressing a diverse array of cytokines and inflammatory mediators, phagocytizing pathogens to promote immune clearance, and assisting with the adaptive immune ...

    Abstract Innate immune cells play essential roles in modulating both immune defense and inflammation by expressing a diverse array of cytokines and inflammatory mediators, phagocytizing pathogens to promote immune clearance, and assisting with the adaptive immune processes through antigen presentation. Rudimentary innate immune "memory" states such as training, tolerance, and exhaustion develop based on the nature, strength, and duration of immune challenge, thereby enabling dynamic transcriptional reprogramming to alter present and future cell behavior. Underlying transcriptional reprogramming are broad changes to the epigenome, or chromatin alterations above the level of DNA sequence. These changes include direct modification of DNA through cytosine methylation as well as indirect modifications through alterations to histones that comprise the protein core of nucleosomes. In this review, we will discuss recent advances in our understanding of how these epigenetic changes influence the dynamic behavior of the innate immune system during both acute and chronic inflammation, as well as how stable changes to the epigenome result in long-term alterations of innate cell behavior related to pathophysiology.
    Mesh-Begriff(e) Humans ; Epigenesis, Genetic ; Histones/metabolism ; DNA Methylation ; Inflammation/genetics ; Immunity, Innate
    Chemische Substanzen Histones
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiae026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: CRISPR-Cas9-Induced Gene Editing in Primary Human Monocytes.

    Liao, Xiaofeng / Li, Liwu

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2782, Seite(n) 189–193

    Abstract: Monocytes play important and diverse roles in both homeostatic and inflammatory immune responses. The CRISPR-Cas9 system in lentiviral vectors has been widely used to manipulate specific genes of immortal monocyte cell lines to study monocyte functions. ... ...

    Abstract Monocytes play important and diverse roles in both homeostatic and inflammatory immune responses. The CRISPR-Cas9 system in lentiviral vectors has been widely used to manipulate specific genes of immortal monocyte cell lines to study monocyte functions. However, human primary monocytes are refractory to this method with low gene knockout (KO) efficiency. In this chapter, we developed an in vitro gene-editing procedure for primary human monocytes with a consistent and high-gene KO efficiency via a ribonucleoprotein (RNP) complex consisting of Cas9 protein and single-guide RNA (sgRNA). This method can be adapted to study the functions of targeted signaling molecules involved in modulating monocyte polarization in primary human monocytes.
    Mesh-Begriff(e) Humans ; Gene Editing/methods ; CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems ; Monocytes/metabolism ; CRISPR-Associated Protein 9/genetics
    Chemische Substanzen RNA, Guide, CRISPR-Cas Systems ; CRISPR-Associated Protein 9 (EC 3.1.-)
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3754-8_15
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Editorial: Plasticity of monocytes/macrophages: phenotypic changes during disease progression.

    Yuan, Ruoxi / Ma, Yanan / Yang, Chao / Li, Liwu

    Frontiers in immunology

    2023  Band 14, Seite(n) 1328382

    Mesh-Begriff(e) Humans ; Monocytes ; Macrophages ; Cytokines ; Leukocytes ; Disease Progression
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2023-11-13
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1328382
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Alleviation of monocyte exhaustion by BCG derivative mycolic acid.

    Wu, Yajun / Caldwell, Blake / Wang, Jing / Zhang, Yao / Li, Liwu

    iScience

    2024  Band 27, Heft 2, Seite(n) 108978

    Abstract: Monocyte exhaustion with sustained pathogenic inflammation and immune-suppression, a hallmark of sepsis resulting from systemic infections, presents a challenge with limited therapeutic solutions. This study identified Methoxy-Mycolic Acid (M-MA), a ... ...

    Abstract Monocyte exhaustion with sustained pathogenic inflammation and immune-suppression, a hallmark of sepsis resulting from systemic infections, presents a challenge with limited therapeutic solutions. This study identified Methoxy-Mycolic Acid (M-MA), a branched mycolic acid derived from
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108978
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Immune Homeostasis Maintenance Through Advanced Immune Therapeutics to Target Atherosclerosis.

    Geng, Shuo / Wu, Yajun / Li, Liwu

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2782, Seite(n) 25–37

    Abstract: Atherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development approaches have been focused on small molecule-based compounds that aim to lower plasma lipids and reduce ... ...

    Abstract Atherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development approaches have been focused on small molecule-based compounds that aim to lower plasma lipids and reduce systemic inflammation, two primary causes of atherosclerosis. However, despite the widely available lipid-lowering and anti-inflammatory small compounds and biologic agents, CHD prevalence still remains high. Based on recent advances revealing disrupted immune homeostasis during atherosclerosis pathogenesis, novel strategies aimed at rejuvenating immune homeostasis with engineered immune leukocytes are being developed. This chapter aims to assess basic and translational efforts on these emerging strategies for the effective development of atherosclerosis treatment, as well as key challenges in this important translational field.
    Mesh-Begriff(e) Humans ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Inflammation/pathology ; Anti-Inflammatory Agents/therapeutic use ; Homeostasis
    Chemische Substanzen Anti-Inflammatory Agents
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3754-8_2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A Robust In Vitro Culture Model and Generation of Memory Monocytes.

    Wang, Jing / Geng, Shuo / Wu, Yajun / Li, Liwu

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2782, Seite(n) 81–88

    Abstract: Innate monocytes can be trained or reprogrammed to adopt distinct memory states, such as low-grade inflammation and immune exhaustion, bearing fundamental relevance to the pathogenesis of both acute diseases such as sepsis as well as chronic diseases ... ...

    Abstract Innate monocytes can be trained or reprogrammed to adopt distinct memory states, such as low-grade inflammation and immune exhaustion, bearing fundamental relevance to the pathogenesis of both acute diseases such as sepsis as well as chronic diseases such as atherosclerosis. Therefore, it is critically important to develop a regimen for generating memory monocytes in vitro in order to better define key monocyte memory states with diverse potentials for proliferation, differentiation, and activation, as well as underlying mechanisms. Here, we describe an efficient in vitro system to propagate a large number of highly purified murine memory monocytes through sustaining bone marrow-derived monocytes with macrophage colony-stimulating factor (M-CSF, 10 ng/mL)-containing medium, together with other polarization agents such as lipopolysaccharide (LPS) for a 5-day period. This method can yield high-purity monocytes, capable of exhibiting dynamic memory behaviors upon training with various polarizing agents.
    Mesh-Begriff(e) Animals ; Mice ; Monocytes ; Macrophage Colony-Stimulating Factor ; Bone Marrow Cells ; Granulocyte-Macrophage Colony-Stimulating Factor ; Bone Marrow ; Lipopolysaccharides/pharmacology ; Cell Differentiation
    Chemische Substanzen Macrophage Colony-Stimulating Factor (81627-83-0) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Lipopolysaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3754-8_5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Differential training of innate leukocytes getting compartmentalized.

    Geng, Shuo / Li, Liwu

    Journal of leukocyte biology

    2021  Band 111, Heft 1, Seite(n) 7–8

    Mesh-Begriff(e) Immunity, Innate ; Leukocytes
    Sprache Englisch
    Erscheinungsdatum 2021-10-12
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4CE0821-421
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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