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  1. Book: UNTERSUCHUNGEN ZUR KLINISCHEN PHARMAKOLOGIE UND PHARMAKOKINETIK DES TETRACYCLISCHEN ANTIDEPRESSIVUM MIANSERIN (ORG GB 94)

    Lund, Harald

    1981  

    Title variant UNTERSUCHUNGEN ZUR KLINISCHEN PHARMAKOLOGIE UND PHARMAKOKINETIK DES TETRACYCLISCHEN ANTIDEPRESSIVUM MIANSERIN ORG GB
    Size 111 S. : GRAPH. DARST.
    Document type Book
    Note MUENCHEN, UNIV., DISS., 1982
    HBZ-ID HT002625067
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies.

    Lund, Harald / Pieber, Melanie / Harris, Robert A

    Frontiers in aging neuroscience

    2017  Volume 9, Page(s) 234

    Abstract: While bone marrow-derived ... ...

    Abstract While bone marrow-derived Ly6C
    Language English
    Publishing date 2017-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2017.00234
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  3. Article ; Online: Students developing representational competence as producers with and of augmented reality in science

    Birgitte Lund Nielsen / Harald Brandt / Hakon Swensen

    Nordina: Nordic Studies in Science Education, Vol 14, Iss

    2018  Volume 2

    Abstract: This research aims to examine how augmented reality (AR) can be used in lower secondary science education. The focus is on outcomes as perceived by students and teachers from 3 rounds of piloting AR-resources, in the third round supporting students as ... ...

    Abstract This research aims to examine how augmented reality (AR) can be used in lower secondary science education. The focus is on outcomes as perceived by students and teachers from 3 rounds of piloting AR-resources, in the third round supporting students as producers of AR. Data sources are teacher interviews, questionnaires and video/observation from Danish, Norwegian and Spanish classrooms. Findings point to positive possibilities for supporting students’ representational competencies, however dependent of the teachers’ thorough use of scaffolding. Teachers refer to student learning of the science content through active engagement in technology-supported inquiry. Students report a high level of outcomes, e.g., by experiencing a sense of presence in the science phenomena and “seeing the invisible”. The piloting with students as AR-producers in particular revealed affordances for their creative and collaborative use of digital resources (21st century skills), stimulating also dialogue about ICT from their everyday life as produced by someone.
    Keywords Augmented reality ; science inquiry ; representational competence ; exploratory talk ; dialogue ; Special aspects of education ; LC8-6691 ; Science ; Q
    Subject code 370
    Language Danish
    Publishing date 2018-05-01T00:00:00Z
    Publisher University of Oslo
    Document type Article ; Online
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  4. Article ; Online: Students developing representational competence as producers with and of augmented reality in science

    Birgitte Lund Nielsen / Harald Brandt / Hakon Swensen

    Nordina: Nordic Studies in Science Education, Vol 14, Iss

    2018  Volume 2

    Abstract: This research aims to examine how augmented reality (AR) can be used in lower secondary science education. The focus is on outcomes as perceived by students and teachers from 3 rounds of piloting AR-resources, in the third round supporting students as ... ...

    Abstract This research aims to examine how augmented reality (AR) can be used in lower secondary science education. The focus is on outcomes as perceived by students and teachers from 3 rounds of piloting AR-resources, in the third round supporting students as producers of AR. Data sources are teacher interviews, questionnaires and video/observation from Danish, Norwegian and Spanish classrooms. Findings point to positive possibilities for supporting students’ representational competencies, however dependent of the teachers’ thorough use of scaffolding. Teachers refer to student learning of the science content through active engagement in technology-supported inquiry. Students report a high level of outcomes, e.g., by experiencing a sense of presence in the science phenomena and “seeing the invisible”. The piloting with students as AR-producers in particular revealed affordances for their creative and collaborative use of digital resources (21st century skills), stimulating also dialogue about ICT from their everyday life as produced by someone.
    Keywords Augmented reality ; science inquiry ; representational competence ; exploratory talk ; dialogue ; Special aspects of education ; LC8-6691 ; Science ; Q
    Subject code 370
    Language Danish
    Publishing date 2018-05-01T00:00:00Z
    Publisher University of Oslo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans.

    Tammen, Harald / Kömhoff, Martin / Delić, Denis / Lund, Søren S / Hocher, Berthold / Frankenreiter, Sandra / Hess, Rüdiger / von Eynatten, Maximilian / Mark, Michael / Klein, Thomas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 601

    Abstract: Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used for the treatment of type 2 diabetes, with additional beneficial effects for the kidney. Treatment of mice with linagliptin revealed increased storage of cobalamin (Cbl, Vitamin B12) in ... ...

    Abstract Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used for the treatment of type 2 diabetes, with additional beneficial effects for the kidney. Treatment of mice with linagliptin revealed increased storage of cobalamin (Cbl, Vitamin B12) in organs if a standard Cbl diet (30 µg Cbl/kg chow) is given. In order to translate these findings to humans, we determined methylmalonic acid (MMA), a surrogate marker of functional Cbl homeostasis, in human plasma and urine samples (n = 1092) from baseline and end of trial (6 months after baseline) of the previously completed MARLINA-T2D clinical trial. We found that individuals with medium Cbl levels (MMA between 50 and 270 nmol/L for plasma, 0.4 and 3.5 µmol/mmol creatinine for urine, at baseline and end of trial) exhibited higher MMA values at the end of study in placebo compared with linagliptin. Linagliptin might inhibit the N-terminal degradation of the transcobalamin receptor CD320, which is necessary for uptake of Cbl into endothelial cells. Because we demonstrate that linagliptin led to increased organ levels of Cbl in mice, sustained constant medium MMA levels in humans, and inhibited CD320 processing by DPP-4 in-vitro, we speculate that linagliptin promotes intra-cellular uptake of Cbl by prolonging half-life of CD320.
    MeSH term(s) Humans ; Animals ; Mice ; Linagliptin/pharmacology ; Linagliptin/therapeutic use ; Vitamin B 12/pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Endothelial Cells ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Homeostasis
    Chemical Substances Linagliptin (3X29ZEJ4R2) ; Vitamin B 12 (P6YC3EG204) ; Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-27648-7
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  6. Book ; Online: Norges Bank’s financial sector role in the period 1945-2013, with a particular focus on financial stability

    Haare, Harald / Lund, Arild / Solheim, Jon A

    (Staff memo / Norges Bank ; no. 2016, 9)

    2016  

    Author's details Harald Haare, Arild Lund and Jon A. Solheim
    Series title Staff memo / Norges Bank ; no. 2016, 9
    Language English
    Size 1 Online-Ressource (circa 36 Seiten), Illustrationen
    Publisher Norges Bank
    Publishing place Oslo
    Document type Book ; Online
    ISBN 9788275539197 ; 8275539196
    Database ECONomics Information System

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  7. Article ; Online: DRGquant: A new modular AI-based pipeline for 3D analysis of the DRG.

    Hunt, Matthew A / Lund, Harald / Delay, Lauriane / Dos Santos, Gilson Goncalves / Pham, Albert / Kurtovic, Zerina / Telang, Aditya / Lee, Adam / Parvathaneni, Akhil / Kussick, Emily / Corr, Maripat / Yaksh, Tony L

    Journal of neuroscience methods

    2022  Volume 371, Page(s) 109497

    Abstract: Background: The dorsal root ganglion (DRG) is structurally complex and pivotal to systems processing nociception. Whole mount analysis allows examination of intricate microarchitectural and cellular relationships of the DRG in three-dimensional (3D) ... ...

    Abstract Background: The dorsal root ganglion (DRG) is structurally complex and pivotal to systems processing nociception. Whole mount analysis allows examination of intricate microarchitectural and cellular relationships of the DRG in three-dimensional (3D) space.
    New method: We present DRGquant a set of tools and techniques optimized as a pipeline for automated image analysis and reconstruction of cells/structures within the DRG. We have developed an open source software pipeline that utilizes machine learning to identify substructures within the DRG and reliably classify and quantify them.
    Results: Our methods were sufficiently sensitive to isolate, analyze, and classify individual DRG substructures including macrophages. The activation of macrophages was visualized and quantified in the DRG following intrathecal injection of lipopolysaccharide, and in a model of chemotherapy induced peripheral neuropathy. The percent volume of infiltrating macrophages was similar to a commercial source in quantification. Circulating fluorescent dextran was visualized within DRG macrophages using whole mount preparations, which enabled 3D reconstruction of the DRG and DRGquant demonstrated subcellular spatial resolution within individual macrophages.
    Comparison with existing method(s): Here we describe a reliable and efficient methodologic pipeline to prepare cleared and whole mount DRG tissue. DRGquant allows automated image analysis without tedious manual gating to reduce bias. The quantitation of DRG macrophages was superior to commercial solutions.
    Conclusions: Using machine learning to separate signal from noise and identify individual cells, DRGquant enabled us to isolate individual structures or areas of interest within the DRG for a more granular and fine-tuned analysis. Using these 3D techniques, we are better able to appreciate the biology of the DRG under experimental inflammatory conditions.
    MeSH term(s) Ganglia, Spinal ; Image Processing, Computer-Assisted/methods ; Lipopolysaccharides ; Machine Learning ; Macrophages
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2022-02-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2022.109497
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  8. Article ; Online: Augmented Reality in science education–affordances for student learning

    Birgitte Lund Nielsen / Harald Brandt / Håkon Swensen

    Nordina: Nordic Studies in Science Education, Vol 12, Iss

    2016  Volume 2

    Abstract: Most extant studies examining augmented reality (AR) have focused on the technology itself. This paper presents findings addressing the issue of AR for educational purposes based on a sequential survey distributed to 35 expert science teachers, ICT ... ...

    Abstract Most extant studies examining augmented reality (AR) have focused on the technology itself. This paper presents findings addressing the issue of AR for educational purposes based on a sequential survey distributed to 35 expert science teachers, ICT designers and science education researchers from four countries. There was consensus among experts in relation to a focus on ‘learning before technology’, and they in particular supplemented affordances identified in literature with perspectives related to interactivity, a creator perspective and inquiry based science. Expert reflections were condensed into innovative dimensions in a framework with nine continua. The framework can be used to illustrate how, and to what extent, an innovative educational perspective, such as that focusing on engaging learners in creating and/or inquiring can be addressed in a particular AR design, and is in the paper exemplified for use in both analysis of existing educational AR and in design of new second-generation AR.
    Keywords Augmented reality ; ICT ; animations ; science learning ; Special aspects of education ; LC8-6691 ; Science ; Q
    Subject code 028
    Language Danish
    Publishing date 2016-09-01T00:00:00Z
    Publisher University of Oslo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Augmented Reality in science education–affordances for student learning

    Birgitte Lund Nielsen / Harald Brandt / Håkon Swensen

    Nordina: Nordic Studies in Science Education, Vol 12, Iss

    2016  Volume 2

    Abstract: Most extant studies examining augmented reality (AR) have focused on the technology itself. This paper presents findings addressing the issue of AR for educational purposes based on a sequential survey distributed to 35 expert science teachers, ICT ... ...

    Abstract Most extant studies examining augmented reality (AR) have focused on the technology itself. This paper presents findings addressing the issue of AR for educational purposes based on a sequential survey distributed to 35 expert science teachers, ICT designers and science education researchers from four countries. There was consensus among experts in relation to a focus on ‘learning before technology’, and they in particular supplemented affordances identified in literature with perspectives related to interactivity, a creator perspective and inquiry based science. Expert reflections were condensed into innovative dimensions in a framework with nine continua. The framework can be used to illustrate how, and to what extent, an innovative educational perspective, such as that focusing on engaging learners in creating and/or inquiring can be addressed in a particular AR design, and is in the paper exemplified for use in both analysis of existing educational AR and in design of new second-generation AR.
    Keywords Augmented reality ; ICT ; animations ; science learning ; Special aspects of education ; LC8-6691 ; Science ; Q
    Subject code 028
    Language Danish
    Publishing date 2016-09-01T00:00:00Z
    Publisher University of Oslo
    Document type Article ; Online
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  10. Article ; Online: Total late effect burden in long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplant and its effect on health-related quality of life.

    Smeland, Knut / Holte, Harald / Fagerli, Unn-Merete / Bersvendsen, Hanne / Hjermstad, Marianne J / Loge, Jon H / Murbrach, Klaus / Linnsund, Marianne D / Fluge, Oystein / Stenehjem, Jo S / Lund, May B / Kvaloy, Stein / Kiserud, Cecilie E

    Haematologica

    2022  Volume 107, Issue 11, Page(s) 2698–2707

    Abstract: Lymphoma survivors after high-dose therapy with autologous stem-cell transplant (HDT-ASCT) are at risk of several late effects, which might impair their health-related quality of life (HRQoL). We assessed the total late effect burden in this population, ... ...

    Abstract Lymphoma survivors after high-dose therapy with autologous stem-cell transplant (HDT-ASCT) are at risk of several late effects, which might impair their health-related quality of life (HRQoL). We assessed the total late effect burden in this population, and how it affects HRQoL. All lymphoma survivors treated with HDT-ASCT as adults in Norway between 1987 and 2008 were identified, and 271 (68%) attended both a comprehensive clinical assessment and completed a questionnaire. Severity of 45 conditions in 12 organ-system categories were graded as mild, moderate, severe or life-threatening, according to a modified version of CTCAEv4.03. At a median of 8 years after HDT-ASCT, 98% of survivors had at least one moderate or more severe late effect and 56% had severe or life-threatening late effects. Fourteen percent had low, 39% medium and 47% high late effect burden, defined as having moderate or more severe late effects in 0-1, 2-3 and >3 organsystems, respectively. Female sex, increasing age, B-symptoms at diagnosis and >1 treatment line prior to HDT-ASCT were independently associated with having high late effect burden. The survivors had significantly poorer physical and mental HRQoL assessed by the Short Form-36 compared to age- and sex-matched controls. The prevalence of poor physical and mental HRQoL increased with higher late effect burden (both P<0.001), and the low burden group had better physical HRQoL than controls (P<0.001). In conclusion, lymphoma survivors after HDT-ASCT have impaired HRQoL, seemingly driven by a high late effect burden. This highlights the importance of prevention, regular assessments for early detection and treatment of late effects and modifiable risk factors.
    MeSH term(s) Adult ; Female ; Humans ; Quality of Life ; Transplantation, Autologous ; Lymphoma/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Survivors
    Language English
    Publishing date 2022-11-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.280413
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