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Article ; Online: Enhanced hydrogen storage of alkaline earth metal-decorated B

Duraisamy, Parimala Devi / S, Prince Makarios Paul / Gopalan, Praveena / Angamuthu, Abiram

2024 Volume 30, Issue 2, Page(s) 55

Abstract: ... with hydrogen molecules. In this paper, boron-based B: Methods: Density functional theory (DFT) approach ...

Abstract	Context: Boron-based nanostructures hold significant promise for revolutionizing hydrogen storage technologies due to their exceptional properties and potential in efficiently accommodating and interacting with hydrogen molecules. In this paper, boron-based B Methods: Density functional theory (DFT) approach at ωB97XD/6-311++G(d,p) level of theory is employed to investigate the possibility of storing H
Language	English
Publishing date	2024-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-024-05847-x
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Article ; Online: Identification of B- and T-cell epitopes on HtrA protein of Orientia tsutsugamushi.

Sankar, Sathish / Saravanan, Nithiyanandan / Rajendiran, Prashanth / Ramamurthy, Mageshbabu / Nandagopal, Balaji / Sridharan, Gopalan

Journal of cellular biochemistry

2018 Volume 120, Issue 4, Page(s) 5869–5879

Abstract: ... scrub typhus. This study was undertaken to predict the peptide vaccine that elicits both B- and T-cell immunity ... for the identification of protective antigen(s). Using BepiPred2 program, the potential B-cell epitope PNSSWGRYGLKMGLR ... by the reticuloendothelial system. The T-cell epitopes would generate T-helper function. The B-cell epitope(s) identified ...

Abstract	Orientia tsutsugamushi, a cause of scrub typhus is emerging as an important pathogen in several parts of the tropics. The control of this infection relies on rapid diagnosis, specific treatment, and prevention through vector control. Development of a vaccine for human use would be very important as a public health measure. Antibody and T-cell response have been found to be important in the protection against scrub typhus. This study was undertaken to predict the peptide vaccine that elicits both B- and T-cell immunity. The outer-membrane protein, 47-kDa high-temperature requirement A was used as the target protein for the identification of protective antigen(s). Using BepiPred2 program, the potential B-cell epitope PNSSWGRYGLKMGLR with high conservation among O. tsutsugamushi and the maximum surface exposed residues was identified. Using IEDB, NetMHCpan, and NetCTL programs, T-cell epitopes MLNELTPEL and VTNGIISSK were identified. These peptides were found to have promiscuous class-I major histocompatibility complex (MHC) binding affinity to MHC supertypes and high proteasomal cleavage, transporter associated with antigen processing prediction, and antigenicity scores. In the I-TASSER generated model, the C-score was -0.69 and the estimated TM-score was 0.63 ± 0.14. The location of the epitope in the 3D model was external. Therefore, an antibody to this outer-membrane protein epitope could opsonize the bacterium for clearance by the reticuloendothelial system. The T-cell epitopes would generate T-helper function. The B-cell epitope(s) identified could be evaluated as antigen(s) in immunodiagnostic assays. This cocktail of three peptides would elicit both B- and T-cell immune response with a suitable adjuvant and serve as a vaccine candidate.
MeSH term(s)	Adjuvants, Immunologic ; Amino Acid Sequence ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/immunology ; Epitopes, B-Lymphocyte ; Epitopes, T-Lymphocyte/immunology ; Histocompatibility Antigens Class I/metabolism ; Orientia tsutsugamushi/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Conformation ; Scrub Typhus/immunology ; Scrub Typhus/prevention & control ; Sequence Homology ; Serine Endopeptidases/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Adjuvants, Immunologic ; Bacterial Proteins ; Epitopes, B-Lymphocyte ; Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Peptide Fragments ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2018-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.27872
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Article ; Online: Genomic surveillance of omicron B.1.1.529 SARS-CoV-2 and its variants between December 2021 and March 2023 in Tamil Nadu, India-A state-wide prospective longitudinal study.

Selvavinayagam, Sivaprakasam T / Suvaithenamudhan, Suvaiyarasan / Yong, Yean K / Hemashree, Kannan / Rajeshkumar, Manivannan / Kumaresan, Anandhazhvar / Arthydevi, Parthiban / Kannan, Meganathan / Gopalan, Natarajan / Vignesh, Ramachandran / Murugesan, Amudhan / Sivasankaran, Munusamy P / Sankar, Sathish / Cheedarla, Narayanaiah / Anshad, Abdul R / Govindaraj, Sakthivel / Zhang, Ying / Tan, Hong Y / Larsson, Marie /

Saravanan, Shanmugam / Balakrishnan, Pachamuthu / Kulanthaivel, Langeswaran / Singh, Kamalendra / Joseph, Narcisse / Velu, Vijayakumar / Byrareddy, Siddappa N / Shankar, Esaki M / Raju, Sivadoss

Journal of medical virology

2024 Volume 96, Issue 2, Page(s) e29456

Abstract: A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1 ...

Abstract	A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their mutational patterns and their genetic interrelationship in the Indian population. The study identified several unique mutations at different time-points, which likely could attribute to the changing disease characteristics, transmission, and pathogenicity attributes of omicron variants. The study found that the omicron variant is highly competent in its mutating potentials, and that it continues to evolve in the general population, likely escaping from natural as well as vaccine-induced immune responses. Our findings suggest that continuous surveillance of viral variants at the global scenario is warranted to undertake intervention measures against potentially precarious SARS-CoV-2 variants and their evolution.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; India/epidemiology ; Longitudinal Studies ; Prospective Studies ; COVID-19/epidemiology ; Genomics
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29456
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Article: Design of peptide epitope from the neuraminidase protein of influenza A and influenza B towards short peptide vaccine development.

Sankar, Sathish / Ramamurthy, Mageshbabu / Suganya, Subramanian / Nandagopal, Balaji / Sridharan, Gopalan

Bioinformation

2018 Volume 14, Issue 5, Page(s) 183–189

Abstract: Influenza viruses A and B are important human respiratory pathogens causing seasonal, endemic and ... the peptide DKTSVTLAGNSSLCS of seasonal influenza and the peptide DILLKFSPTEITAPT of influenza B were ... identified as potential linear cell mediated epitopes. The epitopes predicted by BepiPred (B-cell epitope ...

Abstract	Influenza viruses A and B are important human respiratory pathogens causing seasonal, endemic and pandemic infections in several parts of the globe with high morbidity and considerable mortality. The current inactivated and live attenuated vaccines are not effective. Therefore, it is of interest to design universal influenza virus vaccines with high efficacy. The peptide GQSVVSVKLAGNSSL of pandemic influenza, the peptide DKTSVTLAGNSSLCS of seasonal influenza and the peptide DILLKFSPTEITAPT of influenza B were identified as potential linear cell mediated epitopes. The epitopes predicted by BepiPred (B-cell epitope designer) program was subjected to docking experiment-using HexDock and CABS dock programs. The epitopes of pandemic H1N1 influenza A gave similar score of high affinity in docking. The epitope DKTSVTLAGNSSLCS of seasonal influenza A and epitope DILLKFSPTEITAPT of influenza B had high binding energy. It is further observed that the peptides GQSVVSVKLAGNSSL (pandemic influenza), DKTSVTLAGNSSLCS (seasonal influenza) DILLKFSPTEITAPT (influenza B) are found to interact with some known MHC class II alleles. These peptides have high-affinity binding with known MHC class II alleles. Thus, they have the potential to elicit cell immune response. These vaccines have to be further evaluated in animal models and human volunteers. These findings have application in the development of peptide B-cell epitope vaccines against influenza viruses.
Language	English
Publishing date	2018-05-31
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630014183
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Article ; Online: B cell epitopes in the intrinsically disordered regions of neuraminidase and hemagglutinin proteins of H5N1 and H9N2 avian influenza viruses for peptide-based vaccine development.

Ramamurthy, Mageshbabu / Sankar, Sathish / Abraham, Asha Mary / Nandagopal, Balaji / Sridharan, Gopalan

Journal of cellular biochemistry

2019 Volume 120, Issue 10, Page(s) 17534–17544

Abstract: ... of PONDR program. Linear B cell epitope was predicted using BepiPred 2 program for NA and HA of H5N1 and ... highly immunogenic linear and conformational B-cell epitopes towards developing a vaccine against AIV ...

Abstract	Avian influenza viruses (AIV) are very active in several parts of the globe and are the cause of huge economic loss for the poultry industry and also human fatalities. Three dimensional modeling was carried out for neuraminidase (NA) and hemagglutinin (HA) proteins of AIV. The C-score, estimated TM-Score, and estimated root-mean-square deviation (RMSD) score for NA of H5N1 were -1.18, 0.57 ± 0.15, and 9.8 ± 7.6, respectively. The C-score, estimated TM-Score, and estimated RMSD score for NA of H9N2 were -1.43, 0.54 ± 0.15, and 10.5 ± 4.6, respectively. The C-score, estimated TM-Score, and estimated RMSD score for HA of H5N1 were -0.03, 0.71 ± 0.12, and 7.7 ± 4.3, respectively. The C-score, estimated TM-Score, and estimated RMSD score for HA of H9N2 were -0.57, 0.64 ± 0.13, and 8.9 ± 4.6, respectively. Intrinsically disordered regions were identified for the NA and HA proteins of H5N1 and H9N2 with the use of PONDR program. Linear B cell epitope was predicted using BepiPred 2 program for NA and HA of H5N1 and H9N2 avian influenza strains. Discontinuous epitopes were predicted by Discotope 2 program. The linear epitopes that were considered likely to be immunogenic and within the intrinsically disordered region for the NA of H5N1 was TKSTNSRSGFEMIWDPNGWTGTDSSFSVK, and for H9N2 it was VGDTPRNDDSSSSSNCRDPNNERGAP. In the case of HA of H5N1, it was QRLVPKIATRSKVNGQSG and ATGLRNSPQRERRRKK; for H9N2 it was INRTFKPLIGPRPLVNGLQG and SLKLAVGLRNVPARSSR. The discontinuous epitopes of NA of H5N1 and H9N2 were identified at various regions of the protein structure spanning from amino acid residue positions 90 to 449 and 107 to 469, respectively. Similarly, the discontinuous epitopes of HA of H5N1 and H9N2 were identified in the amino acid residue positions 27 to 517 and 136 to 521, respectively. This study has identified potential and highly immunogenic linear and conformational B-cell epitopes towards developing a vaccine against AIV both for human and poultry use.
MeSH term(s)	Animals ; Chickens/genetics ; Chickens/virology ; Epitopes, B-Lymphocyte/immunology ; Epitopes, B-Lymphocyte/therapeutic use ; Hemagglutinins/immunology ; Hemagglutinins/therapeutic use ; Humans ; Influenza A Virus, H5N1 Subtype ; Influenza A Virus, H9N2 Subtype/immunology ; Influenza A Virus, H9N2 Subtype/pathogenicity ; Influenza in Birds/genetics ; Influenza in Birds/immunology ; Influenza in Birds/virology ; Influenza, Human/genetics ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Intrinsically Disordered Proteins/immunology ; Intrinsically Disordered Proteins/therapeutic use ; Neuraminidase/immunology ; Neuraminidase/therapeutic use ; Poultry/genetics ; Poultry/virology ; Vaccines, Subunit/immunology ; Vaccines, Subunit/therapeutic use
Chemical Substances	Epitopes, B-Lymphocyte ; Hemagglutinins ; Intrinsically Disordered Proteins ; Vaccines, Subunit ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.29017
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Article ; Online: Overexpression of family with sequence similarity 134, member B (FAM134B) in colon cancers and its tumor suppressive properties in vitro.

Lee, Katherine Ting-Wei / Islam, Farhadul / Vider, Jelena / Martin, Jeremy / Chruścik, Anna / Lu, Cu-Tai / Gopalan, Vinod / Lam, Alfred Kin-Yan

Cancer biology & therapy

2020 Volume 21, Issue 10, Page(s) 954–962

Abstract: This study aims to investigate the overexpression-induced properties of tumor ... ...

Abstract	This study aims to investigate the overexpression-induced properties of tumor suppressor
MeSH term(s)	Apoptosis/physiology ; Cell Proliferation/physiology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Female ; Genes, Tumor Suppressor ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Transfection
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; RETREG1 protein, human
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2020.1810535
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Article ; Online: Prediction of Pan-Specific B-Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome.

Kalaiselvan, Sagadevan / Sankar, Sathish / Ramamurthy, Mageshbabu / Ghosh, Asit Ranjan / Nandagopal, Balaji / Sridharan, Gopalan

Journal of cellular biochemistry

2017 Volume 118, Issue 8, Page(s) 2320–2324

Abstract: ... devices and vaccines incorporating pan-specific epitopes of genotypes. We predicted linear B-cell epitopes ... candidate B-cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified ... in the C-terminal of the protein. Our study for the first time has reported pan-specific B-cell epitopes ...

Abstract	Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG-based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan-specific epitopes of genotypes. We predicted linear B-cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers. We modeled the Andes and Sin Nombre hantavirus nucleocapsid protein to locate the identified epitopes. Based on the mean percent prediction probability score, epitope IMASKSVGS/TAEEKLKKKSAF was identified as the best candidate B-cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified in the C-terminal of the protein. Our study for the first time has reported pan-specific B-cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan-specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools toward pan-detection of hantavirus antibodies in ELISA. J. Cell. Biochem. 118: 2320-2324, 2017. © 2017 Wiley Periodicals, Inc.
Keywords	covid19
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.25887
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Article ; Online: Prediction of B Cell Epitopes Among Hantavirus Strains Causing Hemorragic Fever With Renal Syndrome.

Kalaiselvan, Sagadevan / Sankar, Sathish / Ramamurthy, Mageshbabu / Ghosh, Asit Ranjan / Nandagopal, Balaji / Sridharan, Gopalan

Journal of cellular biochemistry

2017 Volume 118, Issue 5, Page(s) 1182–1188

Abstract: ... of the sequence diversity of HFRS strains, 3D structure of Hantaan N protein, and B-cell epitopes on this molecule ...

Abstract	Hantavirus infections are now recognized to be a global problem. The hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. The virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. They primarily include HFRS, HCPS, febrile illness with or without mild involvement of renal diseases. In the course of our study on hantavirus etiology of febrile illnesses, we recovered a hantavirus strain identified by nPCR. This has been sequenced to be Hantaan-like virus (partial S segment). The current manuscript is focused on understanding the N protein coded by S segment in terms of variation of amino acid sequences of the virus genotypes associated with HFRS. The diagnosis of this infection is achieved by PCR testing of serum/plasma or demonstration of IgM/IgG in serum. The limitations of PCR are temporal often not positive after 7 days of onset of infection. IgM detection is possible around this period and up to 21 days. IgG detection is less definitive in acute infections. Here, we report characterization of the sequence diversity of HFRS strains, 3D structure of Hantaan N protein, and B-cell epitopes on this molecule. We predicted a 20 amino acid sequence length peptide by using BepiPred online server in IEDB analysis resource program. We suggest this peptide may be used for development of geographic region-specific immunoassays like EIAs for antibody detection, monoclonal antibody development, and immunoblots (line immunoassay). J. Cell. Biochem. 118: 1182-1188, 2017. © 2016 Wiley Periodicals, Inc.
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.25765
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Article ; Online: Adverse histology, homozygous loss of CDKN2A/B, and complex genomic alterations in locally advanced/metastatic renal mucinous tubular and spindle cell carcinoma.

Yang, Chen / Cimera, Robert S / Aryeequaye, Ruth / Jayakumaran, Gowtham / Sarungbam, Judy / Al-Ahmadie, Hikmat A / Gopalan, Anuradha / Sirintrapun, S Joseph / Fine, Samson W / Tickoo, Satish K / Epstein, Jonathan I / Reuter, Victor E / Zhang, Yanming / Chen, Ying-Bei

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2020 Volume 34, Issue 2, Page(s) 445–456

Abstract: ... loss of CDKN2A/B was observed in 3 (38%) locally advanced/metastatic MTSCCs. Tumor necrosis, solid ... through clonal evolution; CDKN2A/B deletion and additional complex genomic abnormalities may contribute to this process ...

Abstract	Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare subtype of renal cell carcinoma with characteristic histologic features and chromosomal alterations. Although typically indolent, a small subset of cases has been reported to exhibit aggressive clinical behavior. We retrospectively identified 33 patients with MTSCC, consisting of 10 cases of locally advanced/metastatic MTSCC (pT3 or N1 or M1) and 23 kidney-confined MTSCC (pT1/T2) without disease recurrence or progression. Utilizing a single-nucleotide polymorphism array and a targeted next-generation sequencing platform, we examined genome-wide molecular alterations in 24 cases, including 11 available samples from 8 patients with locally advanced/metastatic MTSCC. Ten patients with locally advanced/metastatic MTSCC were 8 females (80%) and 2 males (20%). At nephrectomy, 7 of these 10 cases (70%) were pT3 or pN1 while the remaining 3 (30%) were pT1/T2. Eight patients (80%) developed metastases and common sites included lymph node (4, 40%), bone (4, 40%), and retroperitoneum (3, 30%). Four patients died of disease (40%) during follow-up. Locally advanced/metastatic MTSCCs shared typical MTSCC genomic profiles with loss of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22, while some exhibited additional complex genomic alterations, most frequently a relative gain of 1q (7/8). Homozygous loss of CDKN2A/B was observed in 3 (38%) locally advanced/metastatic MTSCCs. Tumor necrosis, solid nested/sheet pattern, irregular trabecular/single-file infiltration in a desmoplastic stroma, lymphovascular space invasion, and increased mitotic activity were associated with locally advanced/metastatic MTSCCs (all p < 0.05). Our findings reveal that MTSCCs with aggressive clinical behavior have progressed through clonal evolution; CDKN2A/B deletion and additional complex genomic abnormalities may contribute to this process. Recognizing the morphologic presentation of high-grade MTSCC and evaluating adverse histologic features seen in these tumors can help establish a definitive diagnosis and stratify patients for treatment and prognostication.
MeSH term(s)	Adenocarcinoma, Mucinous/genetics ; Adenocarcinoma, Mucinous/pathology ; Aged ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Female ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Retrospective Studies
Chemical Substances	CDKN2A protein, human ; CDKN2B protein, human ; Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2020-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/s41379-020-00667-9
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Article ; Online: Irreducible Tibial Pilon Fracture Treated with Single-Stage Closed Ilizarov Fixation and Gradual Correction: A Case Report.

Gopalan, Balachandar

JBJS case connector

2023 Volume 13, Issue 2

Abstract: Case: A young polytrauma victim of a road traffic accident was diagnosed with comminuted articular fracture of the left distal tibial pilon and open segmental fracture of the fibula. The comminuted distal tibial metaphysis was translocated into the ... ...

Abstract	Case: A young polytrauma victim of a road traffic accident was diagnosed with comminuted articular fracture of the left distal tibial pilon and open segmental fracture of the fibula. The comminuted distal tibial metaphysis was translocated into the interosseous space and, hence, was irreducible. He underwent single-stage closed Ilizarov device stabilization and gradual postoperative closed reduction to obtain good functional outcome at 9 months. The lung and scapular injuries were treated conservatively. Conclusion: Acute complex irreducible tibial pilon fracture can be treated according to principles of deformity correction with the Ilizarov device.
MeSH term(s)	Male ; Humans ; Treatment Outcome ; Fracture Fixation, Internal ; Tibia ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Ankle Fractures ; Fractures, Open/surgery ; Fractures, Comminuted/diagnostic imaging ; Fractures, Comminuted/surgery
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	e23.00029
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