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  1. Article ; Online: Standardization in the Diagnosis of Invasive Lobular Carcinoma of the Breast.

    Christgen, Matthias / Kreipe, Hans

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2023  Volume 36, Issue 5, Page(s) 100163

    MeSH term(s) Humans ; Female ; Carcinoma, Lobular/diagnosis ; Carcinoma, Lobular/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast/pathology ; Reference Standards ; Carcinoma, Ductal, Breast/pathology
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1016/j.modpat.2023.100163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2450: Show issues Location:
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  2. Book ; Thesis: Die Rolle des mitochondrialen Apoptose-Signalweges in der Chemotherapie des Pankreaskarzinoms mit Gemcitabine

    Christgen, Matthias

    2005  

    Author's details vorgelegt von Matthias Christgen
    Language German
    Size 76 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2005
    HBZ-ID HT014719807
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 D 162 order for loan Magazin

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  3. Article ; Online: Malignant phyllodes tumor and invasive lobular breast carcinoma: Morpho-molecular characterization of an uncommon collision tumor and review of the literature.

    Schaumann, Nora / Bartels, Stephan / Kuehnle, Elna / Kreipe, Hans / Christgen, Matthias

    Pathology, research and practice

    2024  Volume 254, Page(s) 155100

    Abstract: Phyllodes tumor (PT) of the breast is a biphasic neoplasia composed of mesenchymal and epithelial cells. PTs are graded as benign, borderline or malignant according to histological criteria. Invasive lobular carcinoma (ILC) is a special breast cancer ... ...

    Abstract Phyllodes tumor (PT) of the breast is a biphasic neoplasia composed of mesenchymal and epithelial cells. PTs are graded as benign, borderline or malignant according to histological criteria. Invasive lobular carcinoma (ILC) is a special breast cancer subtype defined by non-cohesive growth and loss of E-cadherin. PT is treated by resection. ILC is treated by resection and adjuvant endocrine therapy with or without chemotherapy. Collision tumors composed of PT and concurrent ILC are rare. Due to their dissociated growth, ILC cells may escape histologic detection when admixed with PTs. Here we report the case of a 71-years-old female diagnosed with a PT/ILC collision tumor. The patient presented with a tumor in the right breast. A core needle biopsy showed mesenchymal spindle cell proliferates suspicious for a PT. The resection specimen confirmed a malignant PT with stromal overgrowth. Unexpectedly, the resection specimen also revealed sparse infiltrates of ILC admixed with the PT. Immunohistochemistry of mesenchymal PT cells and ILC cells was consistent with the histomorphological diagnosis. Molecular analyses demonstrated a IDH1 variant of unknown significance and GNAS gene mutation in microdissected PT tissue. ILC tissue showed wild-type IDH1 and GNAS, but harbored CDH1/E-cadherin and TP53 gene mutations, arguing against clonal relatedness of the two lesions. Review of the literature identified six reported PT/ILC collision tumors, involving three benign, two borderline and one malignant PT. In summary, this is the second report on a malignant PT/ILC collision tumor. Correct histologic diagnosis of PT/ILC collision tumors is clinically relevant, because adjuvant endocrine therapy is mandatory for ILC.
    MeSH term(s) Female ; Humans ; Aged ; Phyllodes Tumor/genetics ; Phyllodes Tumor/pathology ; Breast Neoplasms/pathology ; Breast/pathology ; Biopsy, Large-Core Needle ; Cadherins/genetics ; Carcinoma, Lobular/genetics ; Carcinoma, Lobular/therapy ; Carcinoma, Lobular/pathology
    Chemical Substances Cadherins
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Review ; Case Reports
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Untersuchungen zur Molekularpathologie der Mikroglandulären Adenose der weiblichen Brustdrüse

    Radner, Martin [Verfasser] / Christgen, Matthias [Akademischer Betreuer]

    2023  

    Author's details Martin Radner ; Akademischer Betreuer: Matthias Christgen ; Institut für Pathologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Parasitic Worms in the Appendix: Incidental Finding of Concomitant Schistosomiasis in Suspected and Confirmed Endometriosis.

    Hussein, Kais / Kreipe, Hans / Christgen, Matthias

    Deutsches Arzteblatt international

    2022  Volume 118, Issue 43, Page(s) 740

    MeSH term(s) Animals ; Appendix/diagnostic imaging ; Endometriosis/complications ; Endometriosis/diagnosis ; Female ; Helminths ; Incidental Findings ; Schistosomiasis/complications ; Schistosomiasis/diagnosis
    Language English
    Publishing date 2022-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical validity and clinical utility of Ki67 in early breast cancer.

    Kreipe, Hans / Harbeck, Nadia / Christgen, Matthias

    Therapeutic advances in medical oncology

    2022  Volume 14, Page(s) 17588359221122725

    Abstract: Ki67 represents an immunohistochemical nuclear localized marker that is widely used in surgical pathology. Nuclear immunoreactivity for Ki67 indicates that cells are cycling and are in G1- to S-phase. The percentage of Ki67-positive tumor cells (Ki67 ... ...

    Abstract Ki67 represents an immunohistochemical nuclear localized marker that is widely used in surgical pathology. Nuclear immunoreactivity for Ki67 indicates that cells are cycling and are in G1- to S-phase. The percentage of Ki67-positive tumor cells (Ki67 index) therefore provides an estimate of the growth fraction in tumor specimens. In breast cancer (BC), tumor cell proliferation rate is one of the most relevant prognostic markers and Ki67 is consequently helpful in prognostication similar to histological grading and mRNA profiling-based BC risk stratification. In BCs treated with short-term preoperative endocrine therapy, Ki67 dynamics enable distinguishing between endocrine sensitive and resistant tumors. Despite its nearly universal use in pathology laboratories worldwide, no internationally accepted consensus has yet been achieved for some methodological details related to Ki67 immunohistochemistry (IHC). Controversial issues refer to choice of IHC antibody clones, scoring methods, inter-laboratory reproducibility, and the potential value of computer-assisted imaging analysis and/or artificial intelligence for Ki67 assessment. Prospective clinical trials focusing on BC treatment have proven that Ki67, as determined by standardized central pathology assessment, is of clinical validity. Clinical utility has been demonstrated in huge observational studies.
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359221122725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma.

    Sflomos, George / Schaumann, Nora / Christgen, Matthias / Christgen, Henriette / Bartels, Stephan / Kreipe, Hans / Battista, Laura / Brisken, Cathrin

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Invasive lobular carcinoma (ILC) is a common breast cancer subtype that is often diagnosed at advanced stages and causes significant morbidity. Late-onset secondary tumor recurrence affects up to 30% of ILC patients, posing a therapeutic challenge if ... ...

    Abstract Invasive lobular carcinoma (ILC) is a common breast cancer subtype that is often diagnosed at advanced stages and causes significant morbidity. Late-onset secondary tumor recurrence affects up to 30% of ILC patients, posing a therapeutic challenge if resistance to systemic therapy develops. Nonetheless, there is a lack of preclinical models for ILC, and the current models do not accurately reproduce the complete range of the disease. We created clinically relevant metastatic xenografts to address this gap by grafting the triple-negative IPH-926 cell line into mouse milk ducts. The resulting intraductal xenografts accurately recapitulate lobular carcinoma in situ (LCIS), invasive lobular carcinoma, and metastatic ILC in relevant organs. Using a panel of 15 clinical markers, we characterized the intratumoral heterogeneity of primary and metastatic lesions. Interestingly, intraductal IPH-926 xenografts express low but actionable HER2 and are not dependent on supplementation with the ovarian hormone estradiol for their growth. This model provides a valuable tool to test the efficiency of potential new ILC therapeutics, and it may help detect vulnerabilities within ILC that can be exploited for therapeutic targeting.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immunohistochemical marker profiles for the differentiation of collagenous spherulosis from adenoid cystic carcinoma of the breast.

    Warm, Henriette L / Kandt, Leonie D / Schaumann, Nora / Werlein, Christopher / Gronewold, Malte / Christgen, Henriette / Hellmann, Malin / Lafos, Marcel / Auber, Bernd / Hillemanns, Peter / Kreipe, Hans / Christgen, Matthias

    Human pathology

    2024  

    Abstract: Collagenous spherulosis (CS) is a rare breast lesion of unknown histogenesis. Adenoid cystic carcinoma (ACC) is a rare basal-like breast carcinoma with low histological grade. CS is a benign lesion but resembles ACC. Both lesions show a similar ... ...

    Abstract Collagenous spherulosis (CS) is a rare breast lesion of unknown histogenesis. Adenoid cystic carcinoma (ACC) is a rare basal-like breast carcinoma with low histological grade. CS is a benign lesion but resembles ACC. Both lesions show a similar histomorphology and feature bilineage differentiation. This study compared immunohistochemical markers in CS and ACC. We compiled n=13 CS cases and n=18 mammary ACCs. Fourteen marker proteins (ER, PR, HER2, GATA3, CK7, E-cadherin, CD117, CK5/14, p40, p63, SMA, CD10, calponin, P-cadherin) were evaluated by immunohistochemistry (IHC). MYB rearrangement, a common alteration in ACC, was assessed by fluorescence in situ hybridization. Patient age ranged between 40-60 years for CS lesions and 30-90 years for ACCs. 7/13 (54%) CS cases harbored a lobular carcinoma in situ (LCIS) in the luminal component. One CS/LCIS lesion occurred in a carrier of a pathogenic germline variant in CDH1/E-cadherin. MYB rearrangement was detected in 0/11 (0%) CS and 6/16 (37%) ACC cases (P=0.054). CS was associated with expression of ER in the luminal component (P<0.001), E-cadherin loss in the luminal component (P=0.045), and expression of CD10 and calponin in the basal component (P<0.001). Furthermore, CS was associated with GATA3 expression in the luminal component (12/13 [92%] versus 5/18 [27%], P<0.001). In summary, IHC for GATA3 and E-cadherin may contribute to the differential diagnosis between CS and ACC, although these markers are not exclusively expressed in either lesion. Histologic evaluation has to take into account that CS is frequently colonized by LCIS, requiring thorough correlation of histomorphology and immunohistochemical features.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2024.04.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 722: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Molecular Characterization and Subtyping of Breast Cancer Cell Lines Provide Novel Insights into Cancer Relevant Genes.

    Pommerenke, Claudia / Nagel, Stefan / Haake, Josephine / Koelz, Anne Leena / Christgen, Matthias / Steenpass, Laura / Eberth, Sonja

    Cells

    2024  Volume 13, Issue 4

    Abstract: Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics. To characterize BC cell line ... ...

    Abstract Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics. To characterize BC cell line models in depth, we profiled a panel of 29 authenticated and publicly available BC cell lines by mRNA-sequencing, mutation analysis, and immunoblotting. Gene expression profiles separated BC cell lines in two major clusters that represent basal-like (mainly triple-negative BC) and luminal BC subtypes, respectively. HER2-positive cell lines were located within the luminal cluster. Mutation calling highlighted the frequent aberration of
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Carcinoma, Hepatocellular ; Cell Line, Tumor ; Liver Neoplasms ; Breast/metabolism ; Carrier Proteins ; Mitochondrial Proteins/metabolism
    Chemical Substances RTN4IP1 protein, human ; Carrier Proteins ; Mitochondrial Proteins
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040301
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  10. Article ; Online: Frequency of genetic alterations differs in advanced breast cancer between metastatic sites.

    Grote, Isabel / Poppe, Alexandra / Lehmann, Ulrich / Christgen, Matthias / Kreipe, Hans / Bartels, Stephan

    Genes, chromosomes & cancer

    2023  Volume 63, Issue 1, Page(s) e23199

    Abstract: About 20%-30% of breast cancer (BC) patients will develop distant metastases, preferentially in bones, liver, lung, and brain. BCs with different intrinsic subtypes prefer different sites for metastasis. These subtypes vary in the abundance of genetic ... ...

    Abstract About 20%-30% of breast cancer (BC) patients will develop distant metastases, preferentially in bones, liver, lung, and brain. BCs with different intrinsic subtypes prefer different sites for metastasis. These subtypes vary in the abundance of genetic alterations which may influence the localization of metastases. Currently, information about the relation between metastatic site and mutational profile of BC is limited. In this study, n = 521 BC metastases of the most frequently affected sites (bone, brain, liver, and lung) were investigated for the frequency of AKT1, ERBB2, ESR1, PIK3CA, and TP53 mutations via NGS and pyrosequencing. Somatic mutations were present in 64% cases. PIK3CA and TP53 were the most frequently mutated genes under study. We provide an analysis of the mutational profile of BCs and the affected metastatic site. Genetic alterations differed significantly depending on the organ site affected by metastases. TP53 mutations were mostly observed in brain metastases (51.0%), metastases outside of the brain revealed a much lower proportion of TP53 mutated samples. PIK3CA mutations are frequent in liver (40.6%), lung (36.8%), and bone metastases (35.7%), whereas less common in brain metastases (18.4%). The highest percentage of ESR1 mutations was observed in liver and lung metastases (about 30% each), whereas metastatic lesions in the brain showed significantly less ESR1 mutations, only in 2.0% of the cases. In summary, we found significant differences of mutational status in mBC depending on the affected organ and intrinsic subtype. Organotropism of metastatic cancer spread may be influenced by the mutational profile of individual BCs.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Mutation ; Bone Neoplasms/genetics ; Bone Neoplasms/secondary ; Brain Neoplasms/genetics ; Class I Phosphatidylinositol 3-Kinases/genetics
    Chemical Substances Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137)
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018988-9
    ISSN 1098-2264 ; 1045-2257
    ISSN (online) 1098-2264
    ISSN 1045-2257
    DOI 10.1002/gcc.23199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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