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  1. Article ; Online: Academician Qi-Yi Xing (Chi-Yi Hsing): pioneer organic chemist of synthetic insulin.

    Qiu, Ming-Hua

    Protein & cell

    2021  Volume 13, Issue 9, Page(s) 627–630

    MeSH term(s) Insulin
    Chemical Substances Insulin
    Language English
    Publishing date 2021-11-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-800X
    ISSN (online) 1674-8018
    ISSN 1674-800X
    DOI 10.1007/s13238-021-00891-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systems pharmacology dissection of the anti-stroke mechanism for the Chinese traditional medicine Xing-Nao-Jing.

    Chen, Yuhua / Sun, Yue / Li, Wende / Wei, Hong / Long, Tianlin / Li, Hua / Xu, Quanhua / Liu, Wei

    Journal of pharmacological sciences

    2018  Volume 136, Issue 1, Page(s) 16–25

    Abstract: Xing-Nao-Jing (XNJ) is a well-known injection that has been extensively applied in clinical ...

    Abstract Xing-Nao-Jing (XNJ) is a well-known injection that has been extensively applied in clinical treatment of stroke in China. However, the underlying mechanism of clinical administration of XNJ in stroke remains unclear. In this study, a systems pharmacology strategy based on pharmacokinetic and pharmacodynamics data was applied to analyze the pharmacological effect of XNJ on stroke. Sixteen active compounds were filtered from XNJ through Drug-likeness (DL) and Brain-blood-barrier (BBB) evaluations. Ninety-four potential targets of these active components were identified by SysDT and SEA. Biological process and pathway enrichment analyses of these targets demonstrated that XNJ exerted anti-stroke effects by biological processes and pathways, such as the response to oxidative stress, regulation of blood pressure, calcium signaling pathway, and apoptosis. Integrating the compound-target network and stroke-related PPI network, we found that Akt1, HIF-1α and ITGB2 may play key roles in the treatment of stroke. The experiments demonstrated that oxycurcumenol may prevent PC12 cells from oxidative stress-induced cell damage. Our study indicates that XNJ has an effect on stroke by protecting neuro cells from oxidative stress-induced cell damage via HIF1α, and the research strategy at the systems pharmacology level is feasible to reveal the mechanisms of novel lead compounds from natural products.
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Hypoxia-Inducible Factor 1, alpha Subunit/physiology ; Oxidative Stress/drug effects ; PC12 Cells ; Phytotherapy ; Rats ; Sesquiterpenes/pharmacology ; Sesquiterpenes/therapeutic use ; Stroke/drug therapy ; Stroke/genetics ; Structure-Activity Relationship
    Chemical Substances Drugs, Chinese Herbal ; Hif1a protein, rat ; Hypoxia-Inducible Factor 1, alpha Subunit ; Sesquiterpenes ; curcumenol ; oxycurcumenol
    Language English
    Publishing date 2018-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2017.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Zhe lie ya yuan yin, fen xing ji bao cun

    Zhang, Hua

    The etiology, classification and conservation of fractured tooth

    2013  

    Title variant Etiology, classification and conservation of fractured tooth
    Author's details zhu bian Zhang Hua, Yang Xuejin, Wang Yufeng
    MeSH term(s) Tooth Fractures ; Dental Care/methods
    Language Chinese
    Size 122 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787509167526 ; 7509167523
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: [Characteristics of coarse woody debris in Huzhong area of Great Xing' an Mountains].

    Wang, Wen-Juan / Chang, Yu / Liu, Zhi-Hua / Chen, Hong-Wei / Jing, Guo-Zhi / Zhang, Hong-Xin / Zhang, Chang-Meng

    Ying yong sheng tai xue bao = The journal of applied ecology

    2009  Volume 20, Issue 8, Page(s) 1805–1810

    Abstract: ... of Great Xing' an Mountains. The loading capacity of CWD in the burned forestlands was 24.9-181.0 m3 x hm ...

    Abstract An investigation was made on the coarse woody debris (CWD) in burned forestlands in Huzhong area of Great Xing' an Mountains. The loading capacity of CWD in the burned forestlands was 24.9-181.0 m3 x hm(-2), among which, snag and log occupied 24.3%-85.9% and 14.0%-75.7%, being 6.0-93.9 m3 x hm(-2) and 15.3-138.4 m3 x hm(-2), respectively. Significant differences were observed among burned forestlands and among years. The predominant DBH class of snag and log was 2.5-20 cm and 1.5-15 m, and the height of most snags and logs was 2.5-15 m and 5-20 cm, respectively. The loading capacity of CWD had no obvious change with the recovery of forest vegetation. The characteristics of CWD had a close relationship with pre-fire forest stand conditions and burn intensity.
    MeSH term(s) China ; Ecosystem ; Fires ; Regeneration ; Trees/physiology ; Wood/analysis
    Language Chinese
    Publishing date 2009-08
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Yan jiu xing Zhong yi yuan jian she de li lun yu shi jian

    Zhou, Hua

    2014  

    Institution Shuguang yi yuan
    Author's details zhu bian Zhou Hua
    MeSH term(s) Hospitals, Public ; Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 2, 2, 257 pages, 10 pages of plates :, illustrations, portraits
    Edition Di 1 ban.
    Document type Book
    ISBN 9787811213195 ; 7811213192
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book: Xin xing nong cun he zuo yi liao de ke chi xu fa zhan yan jiu

    Chen, Hua

    2014  

    Title variant Research on sustainable development of new rural cooperative medical scheme based on farmers' behavior
    Author's details Chen Hua, Shen Shuguang zhu
    MeSH term(s) Rural Health Services ; Health Services Research ; Cooperative Behavior
    Keywords China
    Language Chinese
    Size 5, 239 p. :, ill.
    Edition Di 1 ban.
    Publisher Jing ji ke xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787514153132 ; 7514153136
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: [Coarse woody debris loading capacity and its environmental gradient in Huzhong forest area of Great Xing' an Mountains].

    Wang, Wen-Juan / Chang, Yu / Liu, Zhi-Hua / Chen, Hong-Wei / Jing, Guo-Zhi / Zhang, Hong-Xin / Wang, Jin-Hai

    Ying yong sheng tai xue bao = The journal of applied ecology

    2009  Volume 20, Issue 4, Page(s) 773–778

    Abstract: ... of Great Xing' an Mountains. ... forest communities in Huzhong area of Great Xing'an Mountains was investigated, with its environmental gradient ...

    Abstract The coarse woody debris (CWD) loading capacity of main forest types and of different larch forest communities in Huzhong area of Great Xing'an Mountains was investigated, with its environmental gradient analyzed by Detrended Canonical Correspondence Analysis (DCCA). The CWD loading capacity varied significantly with forest type, being the highest (0.20 m3 x hm(-2)) in spruce forest (Picea koraiensis). Different larch forest (Larix gmelinii) communities had a CWD loading capacity from 0 to 0.28 m3 x hm(-2), with the highest in Pinus pumila-Larix gmelinii (0.28 m3 x hm(-2)) and the lowest in Sphagnum magellanicum-Ledum palustre-Larix gmelinii (0), but the differences were not significant. The CWD loading capacity across the study area was complicated, which might result from the complex interplay of affecting factors. The main factors affecting the spatial pattern of the CWD loading capacity were topographic factors (elevation and slope position) and stand structure (age, canopy cover, and others), and the interaction between topographic factors and stand structure expressed the spatial gradient of CWD loading capacity in Huzhong area of Great Xing' an Mountains.
    MeSH term(s) China ; Ecosystem ; Environment ; Forestry ; Geography ; Plant Stems/microbiology ; Trees/growth & development
    Language Chinese
    Publishing date 2009-04
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Primary study on the mechanism of Ma Xing Shi Gan decoction on the Th1/Th2 response in a murine model of asthma].

    Huang, Feng / Tong, Xiao-Yun / Zhang, Rong-Hua / Cai, Yu

    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

    2008  Volume 31, Issue 10, Page(s) 1519–1522

    Abstract: Objective: To study the mechanism of Ma Xing Shi Gan decoction on the cytokines of Th1/Th2 ... Xing Shi Gan decoction were orally administered to the mice respectively. The spleen cells were ... STAT-6 were analyzed by RT-PCR.: Results: After the treatment with Ma Xing Shi Gan decoction ...

    Abstract Objective: To study the mechanism of Ma Xing Shi Gan decoction on the cytokines of Th1/Th2 in a murine model of asthma.
    Methods: The murine model of asthma was induced by OVA. Various doses of Ma Xing Shi Gan decoction were orally administered to the mice respectively. The spleen cells were cultured 3 days for measurement of IFN-gamma, IL4 and IL-5 by ELISA. After 2 days' culture, the spleen cells were treated with Trizol for extraction of total RNA. The gene expression of T-bet, GATA-3 and STAT-6 were analyzed by RT-PCR.
    Results: After the treatment with Ma Xing Shi Gan decoction, the production of IL-4 and IL-5 and the gene expression of GATA-3, STAT-6 obviously decreased.
    Conclusion: Ma Xing Shi Gan decoction may modulate Thl/Th2 balance by suppressing the gene expression of GATA-3 and STAT-6 in vivo.
    MeSH term(s) Animals ; Asthma/chemically induced ; Asthma/immunology ; Asthma/pathology ; Cells, Cultured ; Cytokines/biosynthesis ; Disease Models, Animal ; Drug Combinations ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Female ; GATA3 Transcription Factor/biosynthesis ; Gene Expression Regulation/drug effects ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Plants, Medicinal/chemistry ; Random Allocation ; Reverse Transcriptase Polymerase Chain Reaction ; Spleen/cytology ; Spleen/immunology ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th2 Cells/drug effects ; Th2 Cells/immunology ; Transcription Factors/biosynthesis
    Chemical Substances Cytokines ; Drug Combinations ; Drugs, Chinese Herbal ; GATA3 Transcription Factor ; Transcription Factors
    Language Chinese
    Publishing date 2008-10
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1001-4454
    ISSN 1001-4454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Long-term effects of Dendrolimus superans Bulter disturbance on forest landscape in Huzhong Forest Bureau of Great xing' an Mountains: a simulation study].

    Chen, Hong-wei / Han, Yuan-man / Chang, Yu / Bu, Ren-cang / He, Hong-shi / Liu, Miao / Liu, Zhi-hua / Han, Wenquan

    Ying yong sheng tai xue bao = The journal of applied ecology

    2010  Volume 21, Issue 5, Page(s) 1090–1096

    Abstract: ... of Dendrolimus superans Bulter disturbance on the forest landscape in Huzhong Forest Bureau of Great Xing' ...

    Abstract A spatially explicit landscape model LANDIS was applied to simulate the long-term effects of Dendrolimus superans Bulter disturbance on the forest landscape in Huzhong Forest Bureau of Great Xing' an Mountains. The statistical software pakage APACK was used to calculate the distribution area of D. superans and representative tree species, the aggregation index reflecting the spatial pattern, and the average area of forest patchs. The dynamics of forest landscape in the study region was simulated under two scenarios, i.e., with and without D. superans disturbance for 300 years (from 1990 to 2290). In the region, the distribution area of D. superans showed a trend of increased first and decreased then. Under D. superans disturbance scenario, the distribution area and the average patch size of Larix gmelinii in 0-150 years and the aggregation index of L. gmelinii in 0-190 years, the distribution area and the average patch size of Betula platyphylla and its aggregation index in 80-190 years, as well as the distribution area, average patch size, and aggregation index of Pinus sylvestris var. mongolica were lower or slightly lower than those under no disturbance scenario. D. superans disturbance led to the fragmentation of forest landscape to some extent.
    MeSH term(s) Animals ; China ; Computer Simulation ; Conservation of Natural Resources ; Ecosystem ; Models, Theoretical ; Moths/physiology ; Pinus/parasitology ; Time Factors ; Trees/growth & development ; Trees/parasitology
    Language Chinese
    Publishing date 2010-05
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of Ma-Xing-Shi-Gan-Tang on Bleomycin- Induced Lung Fibrosis in Rats

    Chang, Chen-Wei / Lin, Chih-Chan / Lien, Hsiao-Yin / Lin, Yung-Chang / Chen, Yung-Husan / Chang, Fang-Rong / Li, Zhen-Hua

    Journal of food and drug analysis

    2011  Volume 19, Issue 2, Page(s) 139

    Language Chinese ; English
    Document type Article
    ISSN 1021-9498
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6601: Show issues

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