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  1. Article ; Online: Obstetric Indications for Progestin Therapy.

    Boelig, Rupsa C

    Obstetrics and gynecology clinics of North America

    2023  Volume 50, Issue 1, Page(s) 101–107

    Abstract: Specifically, meta-analyses of randomized trials demonstrate that vaginal progesterone reduces the risk of preterm birth in selected high-risk singleton pregnancies. 17-OHPC may also reduce the risk of recurrent preterm birth in singletons. Finally, one ... ...

    Abstract Specifically, meta-analyses of randomized trials demonstrate that vaginal progesterone reduces the risk of preterm birth in selected high-risk singleton pregnancies. 17-OHPC may also reduce the risk of recurrent preterm birth in singletons. Finally, one trial suggests that vaginal progesterone may also be beneficial in improving live birth rates in singletons with prior miscarriages and early pregnancy bleeding.
    MeSH term(s) Pregnancy ; Female ; Infant, Newborn ; Humans ; Progesterone ; 17 alpha-Hydroxyprogesterone Caproate ; Progestins ; Hydroxyprogesterones ; Premature Birth
    Chemical Substances Progesterone (4G7DS2Q64Y) ; 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5) ; Progestins ; Hydroxyprogesterones
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1004315-9
    ISSN 1558-0474 ; 0889-8545
    ISSN (online) 1558-0474
    ISSN 0889-8545
    DOI 10.1016/j.ogc.2022.10.004
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  2. Article ; Online: Should singleton gestations without prior preterm birth receive an ultrasound-indicated cerclage? Tempting, but we must wait for more level 1 data.

    Boelig, Rupsa C

    American journal of obstetrics & gynecology MFM

    2021  Volume 3, Issue 5, Page(s) 100431

    MeSH term(s) Cerclage, Cervical ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth/epidemiology ; Ultrasonography
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2021.100431
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  3. Article ; Online: Reply: Quality assessment of studies included in systematic reviews.

    Boelig, Rupsa C / Saccone, Gabriele / Berghella, Vincenzo

    American journal of obstetrics & gynecology MFM

    2022  Volume 4, Issue 5, Page(s) 100665

    MeSH term(s) Systematic Reviews as Topic
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2022.100665
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  4. Article ; Online: The dilemma of hyperemesis gravidarum: more answers, and more questions.

    Boelig, Rupsa C

    The American journal of clinical nutrition

    2017  Volume 106, Issue 3, Page(s) 711–712

    MeSH term(s) Enteral Nutrition ; Female ; Humans ; Hyperemesis Gravidarum ; Mothers ; Pregnancy
    Language English
    Publishing date 2017-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.3945/ajcn.117.164194
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  5. Article ; Online: All That Is Left Unsaid.

    Boelig, Rupsa C

    Obstetrics and gynecology

    2017  Volume 130, Issue 2, Page(s) 377–378

    MeSH term(s) Abortion, Spontaneous/psychology ; Bereavement ; Female ; Hospice Care/methods ; Hospice Care/psychology ; Humans ; Physician's Role/psychology ; Physician-Patient Relations ; Pregnancy ; Premature Birth/psychology
    Language English
    Publishing date 2017-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000002148
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  6. Article ; Online: Vaginal progesterone for the prevention of recurrent spontaneous preterm birth.

    Berghella, Vincenzo / Gulersen, Moti / Roman, Amanda / Boelig, Rupsa C

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 10, Page(s) 101116

    Abstract: After the United States Food and Drug Administration pulled 17-alpha hydroxyprogesterone caproate from the market for its use in prevention of recurrent spontaneous preterm birth, national societies have had mixed recommendations regarding the management ...

    Abstract After the United States Food and Drug Administration pulled 17-alpha hydroxyprogesterone caproate from the market for its use in prevention of recurrent spontaneous preterm birth, national societies have had mixed recommendations regarding the management of patients with a singleton pregnancy and previous spontaneous preterm birth. Herein we highlight the randomized trial data and translational evidence supporting the use of vaginal progesterone for prevention of recurrent spontaneous preterm birth in singleton pregnancies. Prophylactic vaginal progesterone starting at 16 weeks and 0 days every night should be offered to patients with singletons and previous singleton spontaneous preterm birth regardless of cervical length, and continued along with placement of cerclage if a transvaginal ultrasound cervical length ≤25 mm is detected at <24 weeks.
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101116
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  7. Article ; Online: Impact of telehealth implementation on diagnosis of hypertensive disorders of pregnancy.

    Abelman, Sarah H / Svetec, Sarah / Felder, Laura / Boelig, Rupsa C

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 8, Page(s) 101043

    Abstract: Background: COVID-19 caused a rapid integration of telehealth into prenatal care. This raises questions about the ability to screen for hypertensive disorders of pregnancy when caring for patients remotely.: Objective: This study aimed to assess the ... ...

    Abstract Background: COVID-19 caused a rapid integration of telehealth into prenatal care. This raises questions about the ability to screen for hypertensive disorders of pregnancy when caring for patients remotely.
    Objective: This study aimed to assess the effect of telehealth adaptation on the timing and severity of diagnosis of hypertensive disorders of pregnancy.
    Study design: This was a retrospective study of patients with hypertensive disorders of pregnancy who delivered from April 2019 to October 2019 (before the pandemic) and April 2020 to October 2020 (during the pandemic) at 1 urban tertiary care center. The primary outcome was mean gestational age at diagnosis of a hypertensive disorder of pregnancy. The secondary outcomes included severity of diagnosis, both initially and at the time of delivery. The results were adjusted for baseline characteristic difference at P<.10, using multivariable logistic regression and analysis of covariance, as appropriate. The sample size was calculated based on a previous cohort study of patients who developed preeclampsia, with a mean gestational age at delivery of 36.3 weeks and a standard deviation of 2.8 weeks. A sample size of 124 patients would be needed per group to detect a gestational age difference of 1 week with 80% power and a 95% confidence interval.
    Results: Overall, 498 patients were included, with 231 from 2019 and 267 from 2020. Of note, 17.1% of patients had preeclampsia with severe features initially, and 29.3% of patients met the criteria at delivery. In 2020, 80.5% of patients used telehealth (vs 0.9% of patients in 2019), doing so for a mean of 29.0% of prenatal appointments. Unadjusted and adjusted analyses showed no significant difference in gestational age at diagnosis or diagnosis severity between cohorts. In the adjusted analysis, cohort year was not significantly associated with severity of initial diagnosis (adjusted odds ratio, 0.86; 95% confidence interval, 0.53-1.39; P=.53) or severity of diagnosis at delivery (adjusted odds ratio, 0.97; 95% confidence interval, 0.64-1.46; P=.87). However, Black race was significantly associated with increased risk of having severe preeclampsia at initial diagnosis (adjusted odds ratio, 1.70; 95% confidence interval, 1.01-2.85; P=.046). In addition, Black race (adjusted odds ratio, 2.62; 95% confidence interval, 1.60-4.28; P<.001), Hispanic ethnicity (adjusted odds ratio for non-Hispanic, 0.40; 95% confidence interval, 0.19-0.82; P=.01), and initial body mass index (adjusted odds ratio, 1.04; 95% confidence interval, 1.01-1.06; P=.005) were significantly associated with a diagnosis of severe preeclampsia at delivery.
    Conclusion: The adaptation of telehealth was not associated with delays in the diagnosis of hypertensive disorders of pregnancy or with increased severity of diagnoses.
    MeSH term(s) Pregnancy ; Female ; Humans ; Infant, Newborn ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Hypertension, Pregnancy-Induced/diagnosis ; Hypertension, Pregnancy-Induced/epidemiology ; Retrospective Studies ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cohort Studies ; COVID-19 Testing
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101043
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  8. Article ; Online: Reply to Letter to Editor 'Vaginal progesterone should be offered to patients with a singleton gestation and a history of spontaneous preterm birth only if a cervical length ≤25 mm is detected at midtrimester'.

    Rana, Tanvi / Gulersen, Moti / Roman, Amanda / Boelig, Rupsa C / Berghella, Vincenzo

    American journal of obstetrics & gynecology MFM

    2023  Volume 6, Issue 1, Page(s) 101216

    MeSH term(s) Pregnancy ; Female ; Humans ; Infant, Newborn ; Progesterone ; Premature Birth/diagnosis ; Premature Birth/epidemiology ; Premature Birth/etiology ; Pregnancy Trimester, Second ; Progestins ; Cervix Uteri
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Progestins
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Letter
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101216
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  9. Article ; Online: Reply: Screening for preterm birth prevention: more than just 1 number?

    Boelig, Rupsa C / Roman, Amanda / Berghella, Vincenzo

    American journal of obstetrics and gynecology

    2021  Volume 226, Issue 3, Page(s) 450–451

    MeSH term(s) Cervical Length Measurement ; Cervix Uteri/diagnostic imaging ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Mass Screening ; Pregnancy ; Premature Birth/prevention & control
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2021.10.010
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  10. Article ; Online: Pregnancy as an Opportunity for Hepatitis C Virus Elimination and Eradication.

    Boudova, Sarah / Tholey, Danielle / Fenkel, Jonathan M / Derman, Richard / Boelig, Rupsa C

    The American journal of tropical medicine and hygiene

    2023  Volume 110, Issue 2, Page(s) 199–201

    Abstract: ... of hepatitis C virus (HCV) elimination by 2030. Key to this strategy is increased screening and treatment. Pregnancy ...

    Abstract Since the development of highly effective direct-acting antivirals, the WHO has set a goal of hepatitis C virus (HCV) elimination by 2030. Key to this strategy is increased screening and treatment. Pregnancy and the postpartum period represent a unique time when underserved populations have increased contact with the healthcare system. We propose using antenatal care to maximize case identification, treatment, and prevention. Pregnant individuals are an ideal sentinel population for HCV surveillance. Universal screening in pregnancy can provide population-level data. Once cases are identified, pregnancy presents an opportunity for intervention. Although not currently WHO approved, clinical trials are examining treatment during pregnancy. In the interim, identification of infection during pregnancy allows for optimization of the treatment cascade postpartum. Pregnancy can be used as a time for prevention. Taking advantage of patient engagement and existing infrastructure, pregnancy presents an opportunity to intervene in the fight for HCV eradication.
    MeSH term(s) Humans ; Female ; Pregnancy ; Hepacivirus ; Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/epidemiology ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Prenatal Care
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.23-0629
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