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  1. Article ; Online: m

    Wu, Xingwei / Fu, Minjie / Ge, Chang / Zhou, Hanyu / Huang, Haoyu / Zhong, Min / Zhang, Mengying / Xu, Hao / Zhu, Guoping / Hua, Wei / Lv, Kun / Yang, Hui

    Molecular neurobiology

    2024  

    Abstract: Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are dysregulated in glioma. However, the functional roles of lncRNAs in glioma remain largely unknown. In this study, we utilized the TCGA (the Cancer Genome Atlas database) and ... ...

    Abstract Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are dysregulated in glioma. However, the functional roles of lncRNAs in glioma remain largely unknown. In this study, we utilized the TCGA (the Cancer Genome Atlas database) and GEPIA2 (Gene Expression Profiling Interactive Analysis 2) databases and observed the overexpression of lncRNA CHASERR in glioma tissues. We subsequently investigated this phenomenon in glioma cell lines. The effects of lncRNA CHASERR on glioma proliferation, migration, and invasion were analyzed using in vitro and in vivo experiments. Additionally, the regulatory mechanisms among PTEN/p-Akt/mTOR and Wnt/β-catenin, lncRNA CHASERR, Micro-RNA-6893-3p(miR-6893-3p), and tripartite motif containing14 (TRIM14) were investigated via bioinformatics analyses, quantitative real-time PCR (qRT-PCR), western blot (WB), RNA immunoprecipitation (RIP), dual luciferase reporter assay, fluorescence in situ hybridization (FISH), and RNA sequencing assays. RIP and RT-qRCR were used to analyze the regulatory effect of N
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03911-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: m

    Zhu, Xiaolong / Wu, Xingwei / Yang, Hui / Xu, Qiancheng / Zhang, Mengying / Liu, Xiaocen / Lv, Kun

    Biology direct

    2023  Volume 18, Issue 1, Page(s) 27

    Abstract: ... methyladenine (m: Results: LINC01003 expression was upregulated in glioma cell lines and tissues. Higher ... LINC01003 upregulation is induced by m: Conclusion: This study characterized LINC01003 as a lncRNA ...

    Abstract Background: Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanisms.
    Methods: The GEIPA2 and Chinese Glioma Genome Atlas (CCGA) databases were employed to analyze gene expression and the overall survival curve in patients with glioma. The functions of LINC01003 in glioma growth and migration were assessed by loss-of-function experiments in vitro and in vivo. RNA sequencing was used to determine the signaling pathways effected by LINC01003. Bioinformatics analysis and RNA immunoprecipitation (RIP) assays were used to explore the mechanism underlying the N6-methyladenine (m
    Results: LINC01003 expression was upregulated in glioma cell lines and tissues. Higher LINC01003 expression predicted shorter overall survival time in glioma patients. Functionally, LINC01003 knockdown inhibited the cell cycle and cell proliferation and migration in glioma cells. Mechanistically, RNA sequencing revealed that LINC01003 mediated the focal adhesion signaling pathway. Furthermore, LINC01003 upregulation is induced by m
    Conclusion: This study characterized LINC01003 as a lncRNA that contributes to tumorigenesis in glioma and demonstrated that the LINC01003-CAV1-FAK axis serves as a potential therapeutic target for glioma.
    MeSH term(s) Humans ; Up-Regulation ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction/genetics ; Glioma/genetics ; Glioma/metabolism ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism
    Chemical Substances RNA, Long Noncoding ; MicroRNAs ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2221028-3
    ISSN 1745-6150 ; 1745-6150
    ISSN (online) 1745-6150
    ISSN 1745-6150
    DOI 10.1186/s13062-023-00386-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: m

    Hodara, Emmanuelle / Mades, Aubree / Swartz, Lisa / Iqbal, Maheen / Xu, Tong / Bsteh, Daniel / Farnham, Peggy J / Rhie, Suhn K / Goldkorn, Amir

    NAR cancer

    2023  Volume 5, Issue 4, Page(s) zcad054

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcad054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: m

    Chen, Li / Xia, Siwei / Wang, Feixia / Zhou, Yuanyuan / Wang, Shuqi / Yang, Ting / Li, Yang / Xu, Min / Zhou, Ya / Kong, Desong / Zhang, Zili / Shao, Jiangjuan / Xu, Xuefen / Zhang, Feng / Zheng, Shizhong

    Pharmacological research

    2023  Volume 189, Page(s) 106704

    Abstract: The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride ( ... ...

    Abstract The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl
    MeSH term(s) Mice ; Animals ; Hepatic Stellate Cells ; Circadian Clocks ; Methylation ; Liver Cirrhosis/metabolism ; Liver ; Nucleotidyltransferases ; Carbon Tetrachloride/metabolism ; Carbon Tetrachloride/pharmacology ; Nuclear Receptor Subfamily 1, Group D, Member 1/metabolism
    Chemical Substances Nucleotidyltransferases (EC 2.7.7.-) ; Carbon Tetrachloride (CL2T97X0V0) ; Nr1d1 protein, mouse ; Nuclear Receptor Subfamily 1, Group D, Member 1
    Language English
    Publishing date 2023-02-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: m

    Wang, Shiguan / Chen, Shanze / Sun, Jianfeng / Han, Pan / Xu, Bowen / Li, Xinying / Zhong, Youquan / Xu, Zaichao / Zhang, Peng / Mi, Ping / Zhang, Cuijuan / Li, Lixiang / Zhang, Haiyan / Xia, Yuchen / Li, Shiyang / Heikenwalder, Mathias / Yuan, Detian

    Nature metabolism

    2023  Volume 5, Issue 5, Page(s) 842–860

    Abstract: ... adenosine (m ...

    Abstract Different organs undergo distinct transcriptional, epigenetic and physiological alterations that guarantee their functional maturation after birth. However, the roles of epitranscriptomic machineries in these processes have remained elusive. Here we demonstrate that expression of RNA methyltransferase enzymes Mettl3 and Mettl14 gradually declines during postnatal liver development in male mice. Liver-specific Mettl3 deficiency causes hepatocyte hypertrophy, liver injury and growth retardation. Transcriptomic and N6-methyl-adenosine (m
    MeSH term(s) Mice ; Male ; Animals ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Liver/metabolism ; Hepatocytes/metabolism ; Ceramides ; Endoplasmic Reticulum Stress ; Adenosine/metabolism ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; Ceramides ; Adenosine (K72T3FS567) ; Smpd3 protein, mouse (EC 3.1.4.12) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00808-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: m

    Wei, Huamei / Yang, Jinhun / Lu, Rongzhou / Huang, Yanyan / Huang, Zheng / Huang, Lizheng / Zeng, Min / Wei, Yunyu / Xu, Zuoming / Li, Wenchuan / Pu, Jian

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19124

    Abstract: ... ...

    Abstract N
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Interleukin-11/metabolism ; Liver Neoplasms/pathology ; RNA ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances Interleukin-11 ; RNA (63231-63-0) ; RNA-Binding Proteins ; IGF2BP1 protein, human ; IL11 protein, human
    Language English
    Publishing date 2023-11-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45449-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: m

    Xu, Wenqi / Shen, Hongjie

    Current opinion in genetics & development

    2024  Volume 86, Page(s) 102196

    Abstract: As the most well-studied modification in mRNA, m ...

    Abstract As the most well-studied modification in mRNA, m
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2024.102196
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: m

    Jin, Jian / Xu, Chao / Wu, Sen / Wu, Zhengchang / Wu, Shenglong / Sun, Mingan / Bao, Wenbin

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: Porcine epidemic diarrhea virus (PEDV) is a burdensome coronavirus for the global pig industry. Although its fecal-oral route has been well-recognized, increasing evidence suggests that PEDV can also spread through airborne routes, indicating that the ... ...

    Abstract Porcine epidemic diarrhea virus (PEDV) is a burdensome coronavirus for the global pig industry. Although its fecal-oral route has been well-recognized, increasing evidence suggests that PEDV can also spread through airborne routes, indicating that the infection may also occur in the respiratory tract. N
    MeSH term(s) Animals ; Coronavirus ; Macrophages, Alveolar ; Porcine epidemic diarrhea virus/physiology ; Swine ; Swine Diseases/genetics ; Virus Replication
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23116191
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  9. Article: M

    Xu, Menghui / Zhuo, Ruhao / Tao, Shengxiang / Liang, Yaxu / Liu, Chunru / Liu, Qingyang / Wang, Tian / Zhong, Xiang

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11101954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: m

    Guo, Feng / Zhang, Yanhong / Ma, Jinyou / Yu, Yan / Wang, Qiuxia / Gao, Pei / Wang, Li / Xu, Zhiyong / Wei, Xiaobing / Jing, Mengna

    Frontiers in genetics

    2022  Volume 13, Page(s) 818357

    Abstract: Hepatic inflammation is always accompanied with abnormal lipid metabolism. Whether ... ...

    Abstract Hepatic inflammation is always accompanied with abnormal lipid metabolism. Whether N
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.818357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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