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Book ; Online: Covid-19, Older Adults and the Ageing Society

Chatterjee, Suhita Chopra / Chatterjee, Debolina

2022

Keywords	Popular medicine & health ; Coping with illness & specific conditions ; Health systems & services ; Illness & addiction: social aspects ; Popular medicine and health;Coping with illness and specific health conditions;Health systems and services;Health, illness and addiction: social aspects
Language	English
Size	1 electronic resource (162 pages)
Publisher	Taylor and Francis
Document type	Book ; Online
Note	English
HBZ-ID	HT030382677
ISBN	9781032261720 ; 1032261722
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet.

Lin, Li / Basu, Rashmita / Chatterjee, Debolina / Templin, Andrew T / Flak, Jonathan N / Johnson, Travis S

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12919

Abstract: High-fat diet (HFD) is associated with Alzheimer's disease (AD) and type 2 diabetes risk, which share features such as insulin resistance and amylin deposition. We examined gene expression associated with astrocytes and microglia since dysfunction of ... ...

Abstract	High-fat diet (HFD) is associated with Alzheimer's disease (AD) and type 2 diabetes risk, which share features such as insulin resistance and amylin deposition. We examined gene expression associated with astrocytes and microglia since dysfunction of these cell types is implicated in AD pathogenesis. We hypothesize gene expression changes in disease-associated astrocytes (DAA), disease-associated microglia and human Alzheimer's microglia exist in diabetic and obese individuals before AD development. By analyzing bulk RNA-sequencing (RNA-seq) data generated from brains of mice fed HFD and humans with AD, 11 overlapping AD-associated differentially expressed genes were identified, including Kcnj2, C4b and Ddr1, which are upregulated in response to both HFD and AD. Analysis of single cell RNA-seq (scRNA-seq) data indicated C4b is astrocyte specific. Spatial transcriptomics (ST) revealed C4b colocalizes with Gfad, a known astrocyte marker, and the colocalization of C4b expressing cells with Gad2 expressing cells, i.e., GABAergic neurons, in mouse brain. There also exists a positive correlation between C4b and Gad2 expression in ST indicating a potential interaction between DAA and GABAergic neurons. These findings provide novel links between the pathogenesis of obesity, diabetes and AD and identify C4b as a potential early marker for AD in obese or diabetic individuals.
MeSH term(s)	Mice ; Humans ; Animals ; Astrocytes/metabolism ; Diet, High-Fat/adverse effects ; Diabetes Mellitus, Type 2/metabolism ; Microglia/metabolism ; Alzheimer Disease/metabolism
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39890-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring self-care abilities among women in prisons of West Bengal, India.

Chatterjee, Debolina / Chopra Chatterjee, Suhita / Bhattacharyya, Tulika

International journal of prisoner health

2020 Volume 16, Issue 2, Page(s) 185–198

Abstract: Purpose: Self-care is defined as the ability to take care of one's body and health with or without the help of healthcare personnel. The purpose of this paper is to explore the opportunities for self-care among imprisoned women within the constraints of ...

Abstract	Purpose: Self-care is defined as the ability to take care of one's body and health with or without the help of healthcare personnel. The purpose of this paper is to explore the opportunities for self-care among imprisoned women within the constraints of a confined life, which, in turn, affect their health. Design/methodology/approach: Primary data have been collected through semi-structured interviews with 90 women in three prisons in the Indian state of West Bengal. Findings: Findings reveal that a majority of the women cited the inability to self-care was due to factors such as constricted architecture, specific penal policies that thwarted relational contexts in prisons and also the loss of control over their consumptive choices. However, it was found that coping mechanisms also existed among some women who actively constituted penal spaces for self-care. Many long-term imprisoned women tried to actively engage themselves in daily activities such as the "labour" allotted to them. Practical implications: The paper concludes that abilities to self-care have a deep impact on the health of women, which if not facilitated will lead to a health depleting experience. At a time when Indian prisons are focussing on rehabilitation, the recommendations for providing opportunities for self-care in prisons can minimize the "pains" of imprisonment and pave the way for rehabilitation. Originality/value: The research is based on data collected during original fieldwork conducted in three prisons in West Bengal, India. It provides valuable insights on how penal environments affect self-care opportunities of imprisoned women.
MeSH term(s)	Adaptation, Psychological ; Adult ; Female ; Health Promotion ; Humans ; India ; Interviews as Topic ; Middle Aged ; Prisoners ; Prisons ; Qualitative Research ; Self Care ; Women's Health ; Young Adult
Language	English
Publishing date	2020-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2220160-9
ISSN	1744-9219 ; 1744-9200
ISSN (online)	1744-9219
ISSN	1744-9200
DOI	10.1108/IJPH-04-2019-0025
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Survey of Meat Collected from Commercial Broiler Processing Plants Suggests Low Levels of Semicarbazide Can Be Created during Immersion Chilling.

Mitchell, Trevor R / Berrang, Mark E / Gold, Scott E / Lawrence, Kurt C / Glenn, Anthony E / Gamble, Gary R / Feldner, Peggy W / Hawkins, Jaci A / Miller, Christine E / Olson, Drew E / Chatterjee, Debolina / McDonough, Callie M / Pokoo-Aikins, Anthony

Journal of food protection

2022 Volume 85, Issue 5, Page(s) 798–802

MeSH term(s)	Animals ; Chickens ; Immersion ; Meat/analysis ; Nitrofurazone ; Semicarbazides/analysis ; United States
Chemical Substances	Semicarbazides ; Nitrofurazone (X8XI70B5Z6)
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/JFP-22-012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: End-of-life Characteristics of the Elderly: An Assessment of Home-based Palliative Services in Two Panchayats of Kerala.

Jayalakshmi, R / Chatterjee, Suhita Chopra / Chatterjee, Debolina

Indian journal of palliative care

2016 Volume 22, Issue 4, Page(s) 491–498

Abstract: Background: Home-based palliative services form the cornerstone of Kerala's palliative program. However, two issues need research: (a) whether family-homes can be considered as the locus of ageing and dying for marginal populations who experience ... ...

Abstract	Background: Home-based palliative services form the cornerstone of Kerala's palliative program. However, two issues need research: (a) whether family-homes can be considered as the locus of ageing and dying for marginal populations who experience deprivation and poverty and (b) whether the present delivery structure meets the needs of elderly population. These issues are examined in the context of two rural areas. The study explores end-of-life characteristics of the elderly - their sociodemographic status and living patterns, morbidity profile, and functional status. It also looks into the accessibility and utilization of palliative services and respondents' satisfaction with different components of the services. Materials and methods: A descriptive cross-sectional survey design is used. Data were collected based on the interviews of sixty service users sampled randomly from a roster of palliative care services. Semi-structured interviews were substantiated by personal field observations. Results: The study has found people living under extreme financial distress with inadequate shelter and poor social security provisions. The health profile is characterized by high level of functional dependence. Many dependent widowed women were living alone without appropriate care and shelter. The palliative program as perceived by the respondents is characterized by few doctor visitations and poor frequency. Conclusion: The study concludes that home-based palliation in its present form does not promote good end-of-life care. It lacks an integrated approach with good service-mix. It raises serious questions on family-home as the locus of ageing and dying for marginal populations, and suggests need for restructuring of the palliative program.
Language	English
Publishing date	2016-11-01
Publishing country	India
Document type	Journal Article
ISSN	0973-1075
ISSN	0973-1075
DOI	10.4103/0973-1075.191857
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Descriptive texture analyses of cooked patties made of chicken breast with the woody breast condition.

Brambila, G Sanchez / Chatterjee, Debolina / Bowker, B / Zhuang, H

Poultry science

2017 Volume 96, Issue 9, Page(s) 3489–3494

Abstract: The woody breast (WB) condition negatively influences the texture characteristics and quality of intact broiler breast fillets (Pectoralis major). But the impact of WB on ground meat is unknown. The objective of this study was to evaluate the effects of ... ...

Abstract	The woody breast (WB) condition negatively influences the texture characteristics and quality of intact broiler breast fillets (Pectoralis major). But the impact of WB on ground meat is unknown. The objective of this study was to evaluate the effects of WB on the texture and cook loss of ground meat made of broiler breast fillets. Broiler breasts (deboned 3 h postmortem) were collected on 3 separate trial d from the commercial deboning line and classified into normal and severe WB fillet categories. Individual fillets were either ground and formed into patties or left intact prior to being stored for 7 d at -20°C. Samples were then cooked directly from the frozen state to an endpoint temperature of 76 °C for cook loss, instrumental (patties: Allo-Kramer shear; fillets: Warner-Bratzler shear), and descriptive sensory analysis of texture. Cook loss was greater (P < 0.05) in intact WB fillets compared to that in intact normal fillets, but there was no difference (P > 0.05) between WB and normal patties. There was no difference (P > 0.05) in shear force between normal and WB samples regardless of meat type. Sensory analysis showed that average scores of springiness and hardness of intact WB fillets were greater than those of normal fillets (P < 0.05). However, there were no significant differences (P > 0.05) in average scores for sensory attributes cohesiveness, hardness, juiciness, fibrous, and rate of breakdown between WB and normal patties. WB patties exhibited lower springiness and chewiness scores (P < 0.05) than normal patties. Data suggest that undesirable differences in sensory texture characteristics between cooked intact WB and normal breast meat can be minimized in a ground product.
MeSH term(s)	Animals ; Chickens/abnormalities ; Cooking ; Meat/analysis ; Pectoralis Muscles/abnormalities ; Pectoralis Muscles/physiology
Language	English
Publishing date	2017-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.3382/ps/pex118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment of Private Homes as Spaces for the Dying Elderly.

Bhattacharyya, Tulika / Chatterjee, Suhita Chopra / Chand, Dipannita / Chatterjee, Debolina / Sengupta, Jaydeep

Indian journal of palliative care

2017 Volume 23, Issue 3, Page(s) 325–330

Abstract: Aim: This study makes an assessment of end-of-life care of the elderly in private homes in Kolkata, West Bengal, India.: Participants and methods: Primary data were collected from private homes which supported elder care through observation and semi- ... ...

Abstract	Aim: This study makes an assessment of end-of-life care of the elderly in private homes in Kolkata, West Bengal, India. Participants and methods: Primary data were collected from private homes which supported elder care through observation and semi-structured interviews with primary family caregivers of the elderly. Results: The study finds that the major factors preventing private homes from providing adequate care to the elderly were architecturally inadequate housing conditions, paucity of financial support, and scarcity of skilled caregivers. Besides, considerable neglect and domestic abuse of the elderly was also found in some private homes. In addition, the peripheral location of private homes within public health framework and inadequate state palliative policy, including stringent narcotic regulations, accentuated the problems of home care. Conclusion: The study concludes by questioning the rhetoric of private homes as spaces for the dying elderly in Kolkata and suggests remedial measures to improve their capacity to deliver care.
Language	English
Publishing date	2017-04-21
Publishing country	India
Document type	Journal Article
ISSN	0973-1075
ISSN	0973-1075
DOI	10.4103/IJPC.IJPC_148_16
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: MICROFLUIDIC DEVICES FOR LABEL-FREE AND NON-INSTRUMENTED QUANTITATION OF UNAMPLIFIED NUCLEIC ACIDS BY FLOW DISTANCE MEASUREMENT.

Chatterjee, Debolina / Mansfield, Danielle S / Woolley, Adam T

Analytical methods : advancing methods and applications

2014 Volume 6, Issue 20, Page(s) 8173–8179

Abstract: Timely biomarker quantitation has potential to improve human health but current methods have disadvantages either in terms of cost and complexity for benchtop instruments, or reduced performance in quantitation and/or multiplexing for point-of-care ... ...

Abstract	Timely biomarker quantitation has potential to improve human health but current methods have disadvantages either in terms of cost and complexity for benchtop instruments, or reduced performance in quantitation and/or multiplexing for point-of-care systems. We previously developed microfluidic devices wherein visually observed flow distances correlated with a model analyte's concentration.
Language	English
Publishing date	2014-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/C4AY01845A
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of private homes as spaces for the dying elderly

Tulika Bhattacharyya / Suhita Chopra Chatterjee / Dipannita Chand / Debolina Chatterjee / Jaydeep Sengupta

Indian Journal of Palliative Care, Vol 23, Iss 3, Pp 325-

2017 Volume 330

Abstract: Aim: This study makes an assessment of end-of-life care of the elderly in private homes in Kolkata, West Bengal, India. Participants and Methods: Primary data were collected from private homes which supported elder care through observation and semi- ... ...

Abstract	Aim: This study makes an assessment of end-of-life care of the elderly in private homes in Kolkata, West Bengal, India. Participants and Methods: Primary data were collected from private homes which supported elder care through observation and semi-structured interviews with primary family caregivers of the elderly. Results: The study finds that the major factors preventing private homes from providing adequate care to the elderly were architecturally inadequate housing conditions, paucity of financial support, and scarcity of skilled caregivers. Besides, considerable neglect and domestic abuse of the elderly was also found in some private homes. In addition, the peripheral location of private homes within public health framework and inadequate state palliative policy, including stringent narcotic regulations, accentuated the problems of home care. Conclusion: The study concludes by questioning the rhetoric of private homes as spaces for the dying elderly in Kolkata and suggests remedial measures to improve their capacity to deliver care.
Keywords	Care of the elderly at private homes ; continuum of care ; end-of-life care of the elderly ; palliative care ; public health ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Microfluidic devices for label-free and non-instrumented quantitation of unamplified nucleic acids by flow distance measurement

Chatterjee, Debolina / Mansfield, Danielle S / Woolley, Adam T

Analytical methods. 2014 Sept. 25, v. 6, no. 20

2014

Abstract: ... wherein visually observed flow distances correlated with a model analyte's concentration (Chatterjee et al ...

Abstract	Timely biomarker quantitation has potential to improve human health but current methods have disadvantages either in terms of cost and complexity for benchtop instruments, or reduced performance in quantitation and/or multiplexing for point-of-care systems. We previously developed microfluidic devices wherein visually observed flow distances correlated with a model analyte's concentration (Chatterjee et al., Anal. Chem., 2012, 84, 7057). Here, we significantly expand over this prior result to demonstrate the measurement of unamplified DNA analogues of microRNAs (miRNAs), biomarkers whose levels can be altered in disease states. We have developed a method for covalently attaching nucleic acid receptors on poly(dimethylsiloxane) microchannel surfaces by silane and cross-linker treatments. We found a flow distance dependence on target concentrations from 10 μg mL−1 to 10 pg mL−1 for DNA in both buffer and synthetic urine. Moreover, flow time in addition to flow distance is correlated with target concentration. We also observed longer flow distances for single-base mismatches compared to the target sequence at the same concentration, indicating that our approach can be used to detect point mutations. Finally, experiments with DNA analogues of miRNA biomarkers for kidney disease (mir-200c-3p) and prostate cancer (mir-107) in synthetic urine showed the ability to detect these analytes near clinically relevant levels. Our results demonstrate that these novel microfluidic assays offer a simple route to sensitive, amplification-free nucleic acid quantitation, with strong potential for point-of-care application.
Keywords	DNA ; analytical methods ; biomarkers ; chemical bonding ; chemical species ; human health ; kidney diseases ; microRNA ; models ; point mutation ; point-of-care systems ; prostatic neoplasms ; receptors ; silane ; urine
Language	English
Dates of publication	2014-0925
Size	p. 8173-8179.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/c4ay01845a
Database	NAL-Catalogue (AGRICOLA)

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