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Thesis ; Online: A Mixed Methods Study of the Relationship Between Emotional Intelligence and Academic Advisor’s Influence on Student Engagement and Persistence

Manz, Maria Nora

2020

Abstract: Student retention takes a national spotlight as institutions of higher education seek ways in which to help students persist. Research has touted academic advising as the cornerstone of student retention, which provides students with an opportunity to ... ...

Abstract	Student retention takes a national spotlight as institutions of higher education seek ways in which to help students persist. Research has touted academic advising as the cornerstone of student retention, which provides students with an opportunity to meet with an advising professional that can guide them through an individualized academic journey. This is particularly important at community colleges, where over 6.5 million students begin their academic journey. Therefore, it is necessary to determine the essential interpersonal skills that academic advisors must possess in order to assist students through this journey. As a result, this study looked at the emotional and social intelligence competencies of academic advisors at one community college utilizing the Emotional and Social Competency Inventory (ESCI). To assess whether an academic advisor’s emotional intelligence improved student engagement and persistence, this mixed methods study analyzed quantitative data from the ESCI against student grade point average, number of visits students made to their advisor, and student enrollment into the subsequent academic semester. Qualitative data from student interviews was analyzed using a thematic analysis. The major findings identified that: (a) students expect academic advisors to have mastered the essential competencies of advising which include knowledge about majors and programmatic requirements, knowledge about registration and the use of technology, and knowledge about institutional resources; (b) students want an individualized approach taken during their academic advising sessions, open communication, respect, and compassion exhibited by the academic advisor, in addition to an opportunity to build a lasting rapport with the advisor. The last finding (c) identified no significant correlation between the different dimensions of emotional intelligence as rated on the ESCI and student engagement and persistence. This research has implications for improving academic advisor training, increasing professional development opportunities for community college advisors, and revamping the advising structures at community colleges.
Keywords	Higher education\|Educational psychology\|Educational administration\|School counseling\|Community college education
Subject code	027 ; 302
Language	ENG
Publishing date	2020-01-01 00:00:01.0
Publisher	University of Pennsylvania
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Long-Term Outcomes of Acute Osteoarticular Infections in Children.

Manz, Nora / Krieg, Andreas H / Buettcher, Michael / Ritz, Nicole / Heininger, Ulrich

Frontiers in pediatrics

2020 Volume 8, Page(s) 587740

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.587740
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Article: MIS-C-Implications for the Pediatric Surgeon: An Algorithm for Differential Diagnostic Considerations.

Manz, Nora / Höfele-Behrendt, Claudia / Bielicki, Julia / Schmid, Hanna / Matter, Matthias S / Bielicki, Isabella / Holland-Cunz, Stefan / Gros, Stephanie J

Children (Basel, Switzerland)

2021 Volume 8, Issue 8

Abstract: Background: multisystem inflammatory syndrome in children (MIS-C) is a new disease associated with a recent infection with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Affected children can present predominantly with abdominal ... ...

Abstract	Background: multisystem inflammatory syndrome in children (MIS-C) is a new disease associated with a recent infection with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Affected children can present predominantly with abdominal symptoms, fever and high inflammatory parameters that might lead to a consult by the pediatric surgeon and an indication for surgery. Methods: clinical data of three patients with MIS-C that underwent surgery were collected. Histopathological analysis of the appendix was performed. Results: we present the clinical course of three children with fever, abdominal pain and vomiting for several days. Clinical examination and highly elevated inflammation markers led to indication for laparoscopy; appendectomy was performed in two patients. Because of intraoperative findings or due to lack of postoperative improvement, all patients were reevaluated and tested positive for MIS-C associated laboratory parameters and were subsequently treated with corticosteroids, intravenous immunoglobulins, acetyl salicylic acid and/or light molecular weight heparin. Conclusions: we discuss the implications of MIS-C as a new differential diagnosis and stress the importance of assessing the previous medical history, identifying patterns of symptoms and critically surveilling the clinical course. We implemented an algorithm for pediatric surgeons to consider MIS-C as a differential diagnosis for acute abdomen that can be integrated into the surgical workflow.
Language	English
Publishing date	2021-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children8080712
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Article ; Online: Evaluation of the current use of imaging modalities and pathogen detection in children with acute osteomyelitis and septic arthritis.

Manz, Nora / Krieg, Andreas H / Heininger, Ulrich / Ritz, Nicole

European journal of pediatrics

2018 Volume 177, Issue 7, Page(s) 1071–1080

Abstract: Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a ... ...

Abstract	Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA between 2005 and 2014 were identified using ICD-10 discharge codes. Ninety-six children were identified: OM, n = 45; SA, n = 42; and OM + SA, n = 9. Diagnostic imaging was performed in 100% of OM or OM + SA and 95% of SA patients. MRI was performed in 85% of OM patients, 26% of SA patients and 100% OM + SA patients. In patients with OM or SA, concomitant joint/bone involvement was detected in 24 and 36% of patients, respectively. In 58% of patients, a pathogen was detected (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae being most common). Blood and tissue culture were positive in 41 and 86% for OM patients and in 14 and 41%, respectively, for SA patients. In 42% of patients, no pathogen was identified, of which 40% had no material for blood or tissue culture/NAT taken. Conclusion: Optimal use of imaging modalities including MRI and systematic pathogen detection including NAT should be advocated to limit use of broad spectrum antibiotics and treatment duration. What is Known: • Magnetic resonance imaging and sonography have the best sensitivity for detection of acute osteomyelitis and septic arthritis in children. • Systematic use of blood cultures, tissue cultures and nucleic acid testing improves pathogen detection in children with acute osteomyelitis and septic arthritis. What is New: • The added value of imaging modalities other than magnetic resonance and sonography for detection of osteomyelitis and septic arthritis is limited, and their routine use should be questioned. • Despite availability of optimal pathogen detection methods, missed opportunities to improve pathogen detection are frequent.
MeSH term(s)	Acute Disease ; Anti-Bacterial Agents/administration & dosage ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/therapy ; Biomarkers ; Child ; Child, Preschool ; Cohort Studies ; Diagnostic Imaging/statistics & numerical data ; Female ; Humans ; Male ; Microbiological Techniques/statistics & numerical data ; Osteomyelitis/diagnosis ; Osteomyelitis/microbiology ; Osteomyelitis/therapy ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Biomarkers
Language	English
Publishing date	2018-05-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-018-3157-3
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Article ; Online: Effect of a MUC5AC Antibody (NPC-1C) Administered With Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients With Advanced Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial.

Huffman, Brandon M / Basu Mallick, Atrayee / Horick, Nora K / Wang-Gillam, Andrea / Hosein, Peter Joel / Morse, Michael A / Beg, Muhammad Shaalan / Murphy, Janet E / Mavroukakis, Sharon / Zaki, Anjum / Schlechter, Benjamin L / Sanoff, Hanna / Manz, Christopher / Wolpin, Brian M / Arlen, Philip / Lacy, Jill / Cleary, James M

JAMA network open

2023 Volume 6, Issue 1, Page(s) e2249720

Abstract: Importance: Treatment options are limited for patients with advanced pancreatic ductal adenocarcinoma (PDAC) beyond first-line 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX), with such individuals commonly being treated with ... ...

Abstract	Importance: Treatment options are limited for patients with advanced pancreatic ductal adenocarcinoma (PDAC) beyond first-line 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX), with such individuals commonly being treated with gemcitabine and nab-paclitaxel. Objective: To determine whether NPC-1C, an antibody directed against MUC5AC, might increase the efficacy of second-line gemcitabine and nab-paclitaxel in patients with advanced PDAC. Design, setting, and participants: This multicenter, randomized phase II clinical trial enrolled patients with advanced PDAC between April 2014 and March 2017 whose disease had progressed on first-line FOLFIRINOX. Eligible patients had tumors with at least 20 MUC5AC staining by centralized immunohistochemistry review. Statistical analysis was performed from April to May 2022. Interventions: Patients were randomly assigned to receive gemcitabine (1000 mg/m2) and nab-paclitaxel (125 mg/m2) administered intravenously on days 1, 8, and 15 of every 4-week cycle, with or without intravenous NPC-1C 1.5 mg/kg every 2 weeks. Main outcomes and measures: The primary end point was overall survival (OS). Secondary end points were progression-free survival (PFS), objective response rate (ORR), and safety. Pretreatment clinical variables were explored with Cox proportional hazards analysis. Results: A total of 78 patients (median [range] age, 62 [36-78] years; 32 [41%] women; 9 [12%] Black; 66 [85%] White) received second-line treatment with gemcitabine plus nab-paclitaxel (n = 40) or gemcitabine plus nab-paclitaxel and NPC-1C (n = 38). Median OS was 6.6 months (95% CI, 4.7-8.4 months) with gemcitabine plus nab-paclitaxel vs 5.0 months (95% CI, 3.3-6.5 months; P = .22) with gemcitabine plus nab-paclitaxel and NPC-1C. Median PFS was 2.7 months (95% CI, 1.9-4.1 months) with gemcitabine plus nab-paclitaxel vs 3.4 months (95% CI, 1.9-5.3 months; P = .80) with gemcitabine plus nab-paclitaxel and NPC-1C. The ORR was 3.1% (95% CI, 0.4%-19.7%) in the gemcitabine plus nab-paclitaxel and NPC-1C group and 2.9% (95% CI, 0.4%-18.7%) in the gemcitabine plus nab-paclitaxel group. No differences in toxicity were observed between groups, except that grade 3 or greater anemia occurred more frequently in patients treated with gemcitabine plus nab-paclitaxel and NPC-1C than gemcitabine plus nab-paclitaxel (39% [15 of 38] vs 10% [4 of 40]; P = .003). The frequency of chemotherapy dose reductions was similar in both groups (65% vs 74%; P = .47). Lower performance status, hypoalbuminemia, PDAC diagnosis less than or equal to 18 months before trial enrollment, lymphocyte-to-monocyte ratio less than 2.8, and CA19-9 greater than 2000 IU/mL were independently associated with poorer survival. Conclusions and relevance: In this randomized clinical trial of advanced PDAC, NPC-1C did not enhance the efficacy of gemcitabine/nab-paclitaxel. These data provide a benchmark for future trials investigating second-line treatment of PDAC. Trial registration: ClinicalTrials.gov Identifier: NCT01834235.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Adenocarcinoma/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Pancreatic Ductal/drug therapy ; Gemcitabine/therapeutic use ; Mucin 5AC/therapeutic use ; Paclitaxel/therapeutic use ; Pancreatic Neoplasms ; Adult ; Aged ; Pancreatic Neoplasms
Chemical Substances	130-nm albumin-bound paclitaxel ; Antibodies, Monoclonal ; ensituximab (F988K568V2) ; Gemcitabine ; MUC5AC protein, human ; Mucin 5AC ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase II ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.49720
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Article ; Online: The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support.

Irmisch, Anja / Bonilla, Ximena / Chevrier, Stéphane / Lehmann, Kjong-Van / Singer, Franziska / Toussaint, Nora C / Esposito, Cinzia / Mena, Julien / Milani, Emanuela S / Casanova, Ruben / Stekhoven, Daniel J / Wegmann, Rebekka / Jacob, Francis / Sobottka, Bettina / Goetze, Sandra / Kuipers, Jack / Sarabia Del Castillo, Jacobo / Prummer, Michael / Tuncel, Mustafa A /

Menzel, Ulrike / Jacobs, Andrea / Engler, Stefanie / Sivapatham, Sujana / Frei, Anja L / Gut, Gabriele / Ficek, Joanna / Miglino, Nicola / Aebersold, Rudolf / Bacac, Marina / Beerenwinkel, Niko / Beisel, Christian / Bodenmiller, Bernd / Dummer, Reinhard / Heinzelmann-Schwarz, Viola / Koelzer, Viktor H / Manz, Markus G / Moch, Holger / Pelkmans, Lucas / Snijder, Berend / Theocharides, Alexandre P A / Tolnay, Markus / Wicki, Andreas / Wollscheid, Bernd / Rätsch, Gunnar / Levesque, Mitchell P

Cancer cell

2021 Volume 39, Issue 3, Page(s) 288–293

Abstract: The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational trial combining a prospective diagnostic approach to assess the ... ...

Abstract	The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational trial combining a prospective diagnostic approach to assess the relevance of in-depth tumor profiling to support clinical decision-making with an exploratory approach to improve the biological understanding of the disease.
MeSH term(s)	Clinical Decision-Making/methods ; Computational Biology/methods ; Decision Support Systems, Clinical ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Precision Medicine/methods ; Prospective Studies
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2021.01.004
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Book: Berichte aus der Oecotrophologie

Merker, Nora / Kress, Barbara / Manz, Rolf

2001 Volume 01/4, Page(s) 101 S.

Language	German
Document type	Book
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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Article ; Online: NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Bioinformatics (Oxford, England)

2017 Volume 34, Issue 1, Page(s) 107–108

Abstract: Motivation: Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, ... ...

Abstract	Motivation: Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, but the agreement of results from different facilities is often small. General standards for quality control, reproducibility and documentation are missing. Results: We developed NGS-pipe, a flexible, transparent and easy-to-use framework for the design of pipelines to analyze whole-exome, whole-genome and transcriptome sequencing data. NGS-pipe facilitates the harmonization of genomic data analysis by supporting quality control, documentation, reproducibility, parallelization and easy adaptation to other NGS experiments. Availability and implementation: https://github.com/cbg-ethz/NGS-pipe. Contact: niko.beerenwinkel@bsse.ethz.ch.
MeSH term(s)	Gene Expression Profiling/methods ; Gene Expression Profiling/standards ; Genomics/methods ; High-Throughput Nucleotide Sequencing/methods ; High-Throughput Nucleotide Sequencing/standards ; Humans ; Neoplasms/genetics ; Reproducibility of Results ; Sequence Analysis, DNA/methods ; Sequence Analysis, DNA/standards ; Sequence Analysis, RNA/methods ; Sequence Analysis, RNA/standards ; Software
Language	English
Publishing date	2017-10-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btx540
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Article: Evaluation eines Ernährungserziehungsprogramms für Kinder

Merker, Nora / Kress, Barbara / Manz, Rolf / Kirch, Wilhelm

Zeitschrift für Pädagogische Psychologie

2006 Volume 16, Issue 1

Abstract: Die vorliegende Arbeit stellt Ergebnisse der Evaluation eines in Sachsen durchgeführten Ernährungserziehungsprogrammes für Kinder vor. Mittels eines quasiexperimentellen Designs mit Follow-up-Untersuchung nach sechs Monaten wurde die Wirkung der Maßnahme ...

Institution	Medizinische Fakultät, Forschungsverbund Public Health Sachsen Dresden Falkenstein-Klinik Bad Schandau Institut für Klinische Pharmakologie Dresden
Abstract	Die vorliegende Arbeit stellt Ergebnisse der Evaluation eines in Sachsen durchgeführten Ernährungserziehungsprogrammes für Kinder vor. Mittels eines quasiexperimentellen Designs mit Follow-up-Untersuchung nach sechs Monaten wurde die Wirkung der Maßnahme auf ernährungsbezogene Wissensinhalte, Präferenzen/Einstellungen und Verhaltensweisen untersucht. Die verwendeten Methoden umfassten einen Wissens- und Einstellungsfragebogen und standardisierte Beobachtungssituationen zur Erfassung von Verhaltensintentionen. Die Auswertung erfolgte mittels einer Varianzanalyse mit Messwiederholung. In allen drei Bereichen (Wissen, Einstellung, Verhalten) konnte ein signifikanter Zeit-Intervention-Interaktionseffekt beobachtet werden. Die Auswirkungen sind in den Bereichen Wissen und Einstellung am größten und auch über einen mittelfristigen Zeitraum von sechs Monaten annähernd stabil. Im Verhalten konnten nur kleine und eher kurzfristige Effekte der Maßnahme nachgewiesen werden. This article reports results from an evaluation study of a nutrition education program for children in Saxony. The efficacy of the education program in the areas of nutrition-related knowledge, attitudes, and behavior was investigated by using a quasi-experimental design with a follow-up after six months. The investigation instruments included knowledge and attitude questionnaires and standardized observation sessions to assess behavioral intentions. In all areas (nutrition-related knowledge, attitudes, and behavior) a significant time-treatment-interaction was observed. For knowledge and attitudes, the effects were more distinctive and nearly stable over the investigation period, whereas the behavioral effects were smaller and short-term.
Keywords	Ernährungserziehung ; Evaluation ; Wissen ; Einstellung ; Verhalten ; Nutrition education ; evaluation ; knowledge ; attitudes ; behavior
Publishing date	2006-09-01
Document type	Article
ZDB-ID	2076176-4
ISSN	1664-2910 ; 1010-0652 ; 1010-0652
ISSN (online)	1664-2910
ISSN	1010-0652
DOI	10.1024//1010-0652.16.1.43
Database	Hogrefe publisher's database

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Article: NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis

Singer, Jochen / Ruscheweyh, Hans-Joachim / Hofmann, Ariane L / Thurnherr, Thomas / Singer, Franziska / Toussaint, Nora C / Ng, Charlotte K Y / Piscuoglio, Salvatore / Beisel, Christian / Christofori, Gerhard / Dummer, Reinhard / Hall, Michael N / Krek, Wilhelm / Levesque, Mitchell P / Manz, Markus G / Moch, Holger / Papassotiropoulos, Andreas / Stekhoven, Daniel J / Wild, Peter /

Wüst, Thomas / Rinn, Bernd / Beerenwinkel, Niko / Berger, Bonnie

Bioinformatics. 2018 Jan. 01, v. 34, no. 1

2018

Abstract: Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, but the ... ...

Abstract	Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, but the agreement of results from different facilities is often small. General standards for quality control, reproducibility and documentation are missing. We developed NGS-pipe, a flexible, transparent and easy-to-use framework for the design of pipelines to analyze whole-exome, whole-genome and transcriptome sequencing data. NGS-pipe facilitates the harmonization of genomic data analysis by supporting quality control, documentation, reproducibility, parallelization and easy adaptation to other NGS experiments. https://github.com/cbg-ethz/NGS-pipe
Keywords	bioinformatics ; genomics ; high-throughput nucleotide sequencing ; quality control ; transcriptomics
Language	English
Dates of publication	2018-0101
Size	p. 107-108.
Publishing place	Oxford University Press
Document type	Article
ZDB-ID	1468345-3
ISSN	1460-2059 ; 1367-4811 ; 1367-4803
ISSN (online)	1460-2059 ; 1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btx540
Database	NAL-Catalogue (AGRICOLA)

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