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Article ; Online: Cardioneuroablation for pediatric patients with functional sinus node dysfunction and paroxysmal atrioventricular block.

Choi, Nak Hyun / Hong, Jeff / Moak, Jeffrey P

Journal of cardiovascular electrophysiology

2023 Volume 35, Issue 2, Page(s) 221–229

Abstract: Introduction: Severe transitory episodes of bradycardia with subsequent syncope in children are common, and generally portend a benign prognosis. Rarely, patients may experience prolonged asystolic episodes secondary to significant sinus pauses (SP) or ... ...

Abstract	Introduction: Severe transitory episodes of bradycardia with subsequent syncope in children are common, and generally portend a benign prognosis. Rarely, patients may experience prolonged asystolic episodes secondary to significant sinus pauses (SP) or paroxysmal atrioventricular block (AVB). Cardioneuroablation (CNA) is a catheter-based intervention, used to identify and ablate the epicardial ganglionated plexi (GP), which results in disruption of the vagal-mediated parasympathetic input to the sinus and atrioventricular node. Objective: Describe the methodology and role of CNA for treatment of pediatric patients with functional AVB or SP. Methods: This is a single-center, case series study. Patients with SP or AVB, 21 years of age or younger, who underwent CNA between 2015 and 2021 were included. CNA was performed via anatomically guided and high-frequency stimulation methods. Results: Six patients were included. The median age was 18.9 years (range 12.3-20.9 years), 33% female. Two patients had prolonged SP, two had paroxysmal AVB, and two had both SP and AVB. Four patients had prior syncope. The median longest pause was 8.9 s (range 3.9-16.8) with 11 total documented pauses (range 2-231) during the 6 months pre-CNA. Post-CNA, the median longest pause was 1.3 s (range 0.8-2.2) with one documented SP after termination of atrial tachycardia at the 3-month follow-up. At 6 months, the median longest pause was 1.1 s (0.8-1.3) with 0 documented pauses. No patients had syncope post-CNA. Conclusion: CNA may be an effective alternative to pacemaker implantation in pediatric patients with syncope or significant symptoms secondary to functional SP or AVB.
MeSH term(s)	Humans ; Female ; Child ; Adolescent ; Young Adult ; Adult ; Male ; Atrioventricular Block/diagnosis ; Atrioventricular Block/etiology ; Atrioventricular Block/therapy ; Sick Sinus Syndrome/diagnosis ; Sick Sinus Syndrome/surgery ; Atrioventricular Node/surgery ; Syncope/diagnosis ; Syncope/etiology ; Syncope/surgery ; Heart Atria/abnormalities ; Heart Block ; Cardiomyopathies ; Genetic Diseases, Inborn
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16145
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Article ; Online: Assessing the utility of atrial fibrillation induction to risk stratify children with Wolff-Parkinson-White syndrome.

Apfel, Gabriel / Choi, Nak Hyun / Silver, Eric S / Liberman, Leonardo

Cardiology in the young

2023 , Page(s) 1–5

Abstract: Background: Wolff-Parkinson-White syndrome is associated with sudden cardiac death from rapid conduction through the accessory pathway in atrial fibrillation. Adult patients are at higher risk for sudden cardiac death if the shortest-pre-excited-RR- ... ...

Abstract	Background: Wolff-Parkinson-White syndrome is associated with sudden cardiac death from rapid conduction through the accessory pathway in atrial fibrillation. Adult patients are at higher risk for sudden cardiac death if the shortest-pre-excited-RR-interval in atrial fibrillation (SPERRI) is ≤250 milliseconds (msec) during electrophysiologic study. Exclusive conduction through the atrioventricular node in atrial fibrillation is presumed to convey lower risk. The shortest-pre-excited-paced-cycle-length with atrial pacing has also served as a marker for risk stratification. Objective: To determine accessory pathway characteristic of patients undergoing induction of atrial fibrillation during electrophysiologic study. Methods: We reviewed 321 pediatric patients that underwent electrophysiologic study between 2010 and 2019. Induction of atrial fibrillation was attempted on patients while on isoproterenol and SPERRI was measured if atrial fibrillation was induced. Shortest-pre-excited-paced-cycle-length (SPPCL) was determined while on isoproterenol. Results: Atrial fibrillation was induced in 233 (73%) patients. Of those, 104 (45%) patients conducted exclusively through the atrioventricular node during atrial fibrillation (Group A). The remaining 129 (55%) patients had some conduction through the accessory pathway (Group B). In Group A, SPPCL was 260 msec with 48 (46%) conducting through the accessory pathway at ≤250 msec. In Group B, SPPCL was 240 msec with 92 patients (71%) conducting at ≤250 msec (p < 0.05). In Group B, SPERRI was 250 msec and had a positive correlation with SPPCL (p < 0.001, Conclusion: Conduction in atrial fibrillation during electrophysiologic study on isoproterenol via the atrioventricular node may not exclude high-risk accessory pathways in pediatric patients.
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123001415
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Article: Translucency and masking ability of translucent zirconia; comparison with conventional zirconia and lithium disilicate.

Park, Joon Hee / Bang, Hyun Ji / Choi, Nak-Hyun / Park, Eun-Jin

The journal of advanced prosthodontics

2022 Volume 14, Issue 5, Page(s) 324–333

Abstract: Purpose: The purpose of this study is to evaluate translucency and masking ability of translucent zirconia compared to conventional zirconia and lithium disilicate materials.: Materials and methods: Three types of zirconia blocks with different ... ...

Abstract	Purpose: The purpose of this study is to evaluate translucency and masking ability of translucent zirconia compared to conventional zirconia and lithium disilicate materials. Materials and methods: Three types of zirconia blocks with different yttria contents (3Y, 4Y, 5.5Y) and LS blocks (Rosetta SM) were used. Ten specimens for each group were fabricated with 10 mm diameter, with both 0.8 mm and 1.5 mm thicknesses (± 0.02 mm). All groups of zirconia specimens were sintered and polished according to the manufacturer's instructions. To calculate the translucency parameter (TP), CIELAB value was measured with a spectrophotometer on black and white backgrounds. To investigate the color masking abilities, background shades of A2, normal dentin, discolored dentin, and titanium were used. The color difference (ΔE) was calculated with the CIELAB values of A2 shade background as a reference compared with the values in the various backgrounds. One-way ANOVA and Bonferroni tests were conducted ( Results: The TP values of zirconia specimens increased as the yttria content increased. All materials used in the study were able to adequately mask normal dentin shade (ΔE < 5.5), but were incapable of masking severely discolored dentin (ΔE > 5.5). On the titanium background, all materials of 1.5 mm thickness were able to mask the background shade, but with a thickness of 0.8 mm, only 3Y-TZP and 4Y-PSZ were able to mask titanium background. Conclusion: All zirconia materials and lithium disilicate specimens used in this study were unable to adequately mask the shade of severely discolored dentin. It is recommended to use 3Y-TZP or 4Y-PSZ with a sufficient thickness of 0.8 mm or more to mask titanium.
Language	English
Publishing date	2022-10-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2575831-7
ISSN	2005-7814 ; 2005-7806
ISSN (online)	2005-7814
ISSN	2005-7806
DOI	10.4047/jap.2022.14.5.324
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Article: Application of the Korean Framework of Wetland Management Effectiveness Evaluation

Choi, Nak-Hyun / Yeum, Jung-Hun / Kim, Han

Wetlands. 2022 Mar., v. 42, no. 3

2022

Abstract: This study applied the Korean framework of wetland management effectiveness evaluation to national wetland protected areas and identified key insights into developing a national wetland management policy. The framework is based on the basic evaluation ... ...

Abstract	This study applied the Korean framework of wetland management effectiveness evaluation to national wetland protected areas and identified key insights into developing a national wetland management policy. The framework is based on the basic evaluation framework of the International Union for Conservation of Nature and reflects the characteristics of South Korea’s wetland management policy. The evaluation framework comprises a total of 29 items and 21 detailed items in the design, appropriateness, and delivery sectors. Based on a cluster analysis, which considered the management levels of 22 sites that conducted first-stage self-assessment, the sites were divided into Groups A, B, and C. The second and third stages of qualitative evaluation were conducted on the representative target sites of each group by external research teams. The average score for the overall management level was the highest for Group B, followed by Groups C and A. Significant differences were observed among the groups for five items in the design sector, seven items in the appropriateness sector, and two items in the delivery sector. The management levels in the pilot sites were 43.9% in Yongneup of Mt. Daeam, 37.4% in the Damyang riverine wetland, and 59.8% in the Upo wetland, compared to the ideal condition. Important suggestions were derived through the evaluation framework. First, management effectiveness evaluation should consider national environmental and management policy characteristics based on an international framework. Second, an integrated management system should be established. Third, stakeholders should participate in building governance. Lastly, the participation of an external expert is essential.
Keywords	cluster analysis ; governance ; issues and policy ; management systems ; riparian areas ; stakeholders ; wetland management ; wetlands ; South Korea
Language	English
Dates of publication	2022-03
Size	p. 22.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1097341-2
ISSN	1943-6246 ; 0277-5212
ISSN (online)	1943-6246
ISSN	0277-5212
DOI	10.1007/s13157-022-01536-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Implementation of oxide vertical channel TFTs with sub-150 nm channel length using atomic-layer deposited IGZO active and HfO

Ryoo, Hyun-Joo / Seong, Nak-Jin / Choi, Kyu-Jeong / Yoon, Sung-Min

Nanotechnology

2021 Volume 32, Issue 25

Abstract: We fabricated vertical channel thin film transistors (VTFTs) with a channel length of 130 nm using an ALD In-Ga-Zn-O (IGZO) active channel and high-k ... ...

Abstract	We fabricated vertical channel thin film transistors (VTFTs) with a channel length of 130 nm using an ALD In-Ga-Zn-O (IGZO) active channel and high-k HfO
Language	English
Publishing date	2021-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/abcbc4
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Article ; Online: Supraventricular Tachycardia Without Preexcitation as a Cause of Sudden Cardiac Arrest in Pediatric Patients.

Choi, Nak Hyun / Silver, Eric S / Liberman, Leonardo

Pediatric cardiology

2021 Volume 43, Issue 1, Page(s) 218–224

Abstract: Sudden cardiac arrest in pediatric patients is a rare occurrence. Supraventricular tachycardia without the presence of ventricular preexcitation in pediatric patients with a structurally normal heart is generally considered benign. Previous literature in ...

Abstract	Sudden cardiac arrest in pediatric patients is a rare occurrence. Supraventricular tachycardia without the presence of ventricular preexcitation in pediatric patients with a structurally normal heart is generally considered benign. Previous literature in adults reported a subset of patients in whom SVT was suspected to be the primary trigger of sudden cardiac arrest. We performed a single-center, retrospective cohort study of pediatric patients without known heart disease, 1-21 years of age, presenting with aborted SCA between 2009 and 2019. We collected diagnostic studies in all patients to identify the etiology of the aborted SCA. Thirty patients met the inclusion criteria. The median age at the time of SCA was 15.2 years. The etiology of SCA was identified in 23 (77%) patients. Of the seven patients with unknown diagnosis after initial diagnostic studies, three patients subsequently developed fast SVT that was presumed to be the etiology of the initial SCA. These three patients had varying diagnoses of atrioventricular nodal reentry tachycardia, ectopic atrial tachycardia, and a concealed accessory pathway with atrioventricular reentrant tachycardia. After ablation or medical treatment of the SVT substrate, no further tachyarrhythmias were observed. Pediatric patients presenting with an aborted SCA of unknown etiology ought to be considered for electrophysiology testing to elicit occult SVT substrates that may lead to a malignant ventricular tachyarrhythmia.
MeSH term(s)	Adult ; Catheter Ablation ; Child ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Humans ; Retrospective Studies ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Atrioventricular Nodal Reentry/surgery ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/etiology ; Tachycardia, Supraventricular/surgery
Language	English
Publishing date	2021-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-021-02720-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combination of

Lee, Na-Rae / Kwon, Tae-Jun / Chung, Eui-Chun / Bae, Jaewoong / Soung, Song-Hui / Tak, Hyun-Ji / Choi, Jun-Young / Lee, Young-Eun / Won Hwang, Nak / Lee, Jong Seo / Shin, Kum-Joo / Lee, Choong Hwan / Kim, KilSoo / Kim, Seokjin

Food & function

2024 Volume 15, Issue 2, Page(s) 647–662

Abstract: This study evaluated the effects of formulations ... ...

Abstract	This study evaluated the effects of formulations with
MeSH term(s)	Animals ; Mice ; Diet, High-Fat/adverse effects ; Lacticaseibacillus paracasei ; Gastrointestinal Microbiome ; Peroxisome Proliferator-Activated Receptors/metabolism ; Obesity/genetics ; Metabolome ; Mice, Inbred C57BL
Chemical Substances	Peroxisome Proliferator-Activated Receptors
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo03557c
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Article ; Online: Correlations between H

Jung, Jae K / Lee, Ji H / Jeon, Sang K / Tak, Nae H / Chung, Nak K / Baek, Un B / Lee, Si H / Lee, Chang H / Choi, Myung C / Kang, Hyun M / Bae, Jong W / Moon, Won J

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: ... ...

Abstract	H
MeSH term(s)	Polymers/chemistry ; Soot ; Silicon Dioxide ; Hydrogen ; Ethylenes
Chemical Substances	Polymers ; Soot ; Silicon Dioxide (7631-86-9) ; propylene (AUG1H506LY) ; ethylene-propylene-diene-monomer ; Hydrogen (7YNJ3PO35Z) ; Ethylenes
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032865
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Article ; Online: COVID-19 reveals Brugada pattern in an adolescent patient.

Choi, Nak Hyun / Silver, Eric S / Fremed, Michael / Liberman, Leonardo

Cardiology in the young

2020 Volume 30, Issue 11, Page(s) 1735–1737

Abstract: A diagnosis of Brugada pattern in paediatric or adolescent patients is rare. COVID-19 is characterised by fevers and a pro-inflammatory state, which may serve as inciting factors for Brugada pattern. Recently described in two adult patients, we report ... ...

Abstract	A diagnosis of Brugada pattern in paediatric or adolescent patients is rare. COVID-19 is characterised by fevers and a pro-inflammatory state, which may serve as inciting factors for Brugada pattern. Recently described in two adult patients, we report the first case of Brugada pattern in an adolescent with COVID-19.
MeSH term(s)	Antiviral Agents/therapeutic use ; Brugada Syndrome/diagnosis ; Brugada Syndrome/etiology ; Brugada Syndrome/physiopathology ; C-Reactive Protein/metabolism ; COVID-19/complications ; COVID-19/metabolism ; COVID-19/physiopathology ; COVID-19/therapy ; Chest Pain/physiopathology ; Consanguinity ; Cough/physiopathology ; Disease Progression ; Dyspnea/physiopathology ; Electrocardiography ; Fever/physiopathology ; Humans ; Hydroxychloroquine/therapeutic use ; Hyperferritinemia/metabolism ; Hypertension/physiopathology ; Hypoxia/physiopathology ; Hypoxia/therapy ; Interleukin-6/metabolism ; Intubation, Intratracheal ; Male ; Obesity/complications ; Procalcitonin/metabolism ; Respiration, Artificial ; Respiratory Insufficiency/physiopathology ; Respiratory Insufficiency/therapy ; Shoulder Pain/physiopathology ; Sleep Apnea, Obstructive/complications ; Young Adult ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Interleukin-6 ; Procalcitonin ; Hydroxychloroquine (4QWG6N8QKH) ; C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951120002619
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Article ; Online: Roles of Oxygen Interstitial Defects in Atomic-Layer Deposited InGaZnO Thin Films with Controlling the Cationic Compositions and Gate-Stack Processes for the Devices with Subμm Channel Lengths.

Bae, Soo-Hyun / Yang, Jong-Heon / Kim, Yong-Hae / Kwon, Young Ha / Seong, Nak-Jin / Choi, Kyu-Jeong / Hwang, Chi-Sun / Yoon, Sung-Min

ACS applied materials & interfaces

2022 Volume 14, Issue 27, Page(s) 31010–31023

Abstract: Roles of oxygen interstitial defects located in the In-Ga-Zn-O (IGZO) thin films prepared by atomic layer deposition were investigated with controlling the cationic compositions and gate-stack process conditions. It was found from the spectroscopic ... ...

Abstract	Roles of oxygen interstitial defects located in the In-Ga-Zn-O (IGZO) thin films prepared by atomic layer deposition were investigated with controlling the cationic compositions and gate-stack process conditions. It was found from the spectroscopic ellipsometry analysis that the excess oxygens increased with increasing the In contents within the IGZO channels. While the device using the IGZO channel with an In/Ga ratio of 0.2 did not show marked differences with the variations in the oxidant types during the gate-stack formation, the device characteristics were severely deteriorated with increasing the In/Ga ratio to 1.4, when the Al
Language	English
Publishing date	2022-07-02
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c07258
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