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  1. Article ; Online: Food is Medicine for HIV: Improved health and hospitalizations in the Changing Health through Food Support (CHEFS-HIV) pragmatic randomized trial.

    Palar, Kartika / Sheira, Lila A / Frongillo, Edward A / O'Donnell, Asher A / Nápoles, Tessa M / Ryle, Mark / Pitchford, Simon / Madsen, Kim / Phillips, Beth / Riley, Elise D / Weiser, Sheri D

    The Journal of infectious diseases

    2024  

    Abstract: Background: Policy support for "Food is Medicine"-medically tailored meals or groceries to improve health-is rapidly growing. No randomized trials have heretofore investigated the benefits of medically tailored food programs for people living with HIV ( ... ...

    Abstract Background: Policy support for "Food is Medicine"-medically tailored meals or groceries to improve health-is rapidly growing. No randomized trials have heretofore investigated the benefits of medically tailored food programs for people living with HIV (PLHIV).
    Methods: The CHEFS-HIV pragmatic randomized trial included PLHIV who were clients of Project Open Hand (POH), a San Francisco-based nonprofit food organization. The intervention arm (n = 93) received comprehensive medically tailored meals, groceries, and nutritional education. Control participants (n = 98) received less intensive (POH "standard of care") food services. Health, nutrition, and behavioral outcomes were assessed at baseline and 6 months later. Primary outcomes measured were viral non-suppression and health related quality of life. Mixed models estimated treatment effects as differences-in-differences between arms.
    Results: The intervention arm had lower odds of hospitalization (odds ratio [OR] = 0.11), food insecurity (OR = 0.23), depressive symptoms (OR = 0.32), antiretroviral therapy adherence <90% (OR = 0.18), and unprotected sex (OR = 0.18), and less fatty food consumption (β= -0.170 servings/day) over 6 months, compared to the control arm. There was no difference between study arms in viral non-suppression and health-related quality of life over 6 months.
    Conclusions: A "Food-is-Medicine" intervention reduced hospitalizations and improved mental and physical health among PLHIV, despite no impact on viral suppression.
    Clinical trials registration: NCT03191253.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae195
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  2. Article ; Online: Provider Use of, Attitudes Towards, and Self-efficacy with Key Measurement-based Care Practices in Youth Mental Health Treatment: A Multi-site Examination.

    Jensen-Doss, Amanda / Casline, Elizabeth / Woodard, Grace S / Phillips, Dominique A / Lane, Elizabeth / Palafu, Tessa / Waye, Catherine / Ramirez, Vanessa / Cheron, Daniel M / Okamura, Kelsie

    Administration and policy in mental health

    2024  

    Abstract: Measurement-based care (MBC) is an underutilized evidence-based practice, and current implementation efforts demonstrate limited success in increasing MBC use. A better understanding of MBC implementation determinants is needed to improve these efforts, ... ...

    Abstract Measurement-based care (MBC) is an underutilized evidence-based practice, and current implementation efforts demonstrate limited success in increasing MBC use. A better understanding of MBC implementation determinants is needed to improve these efforts, particularly from studies examining the full range of MBC practices and that span multiple samples of diverse providers using different MBC systems. This study addressed these limitations by conducting a multi-site survey examining MBC predictors and use in youth treatment. Participants were 159 clinicians and care coordinators working in youth mental health care settings across the United States. Participants were drawn from three program evaluations of MBC implementation. Providers completed measures assessing use of five MBC practices (administering measures, viewing feedback, reviewing feedback in supervision, sharing feedback with clients in session, and using feedback to plan treatment), MBC self-efficacy, and MBC attitudes. Despite expectations that MBC should be standard care for all clients, providers reported only administering measures to 40-60% of clients on average, with practices related to the use of feedback falling in the 1-39% range. Higher MBC self-efficacy and more positive views of MBC practicality predicted higher MBC use, although other attitude measures were not significant predictors. Effects of predictors were not moderated by site, suggesting consistent predictors across implementation settings. Implications of study findings for future research and for the implementation of MBC are discussed.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025319-1
    ISSN 1573-3289 ; 0894-587X
    ISSN (online) 1573-3289
    ISSN 0894-587X
    DOI 10.1007/s10488-024-01354-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New manual qPCR assay validated on tongue swabs collected and processed in Uganda shows sensitivity that rivals sputum-based molecular TB diagnostics.

    Steadman, Amy / Andama, Alfred / Ball, Alexey / Mukwatamundu, Job / Khimani, Khushboo / Mochizuki, Tessa / Asege, Lucy / Bukirwa, Alice / Kato, John Baptist / Katumba, David / Kisakye, Esther / Mangeni, Wilson / Mwebe, Sandra / Nakaye, Martha / Nassuna, Irene / Nyawere, Justine / Nakaweesa, Annet / Cook, Catherine / Phillips, Patrick /
    Nalugwa, Talemwa / Bachman, Christine M / Semitala, Fred Collins / Weigl, Bernhard H / Connelly, John / Worodria, William / Cattamanchi, Adithya

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: Reliance on sputum-based testing is a key barrier to increasing access to molecular diagnostics for tuberculosis (TB). Many people with TB are unable to produce sputum, and sputum processing increases the complexity and cost of molecular ... ...

    Abstract Background: Reliance on sputum-based testing is a key barrier to increasing access to molecular diagnostics for tuberculosis (TB). Many people with TB are unable to produce sputum, and sputum processing increases the complexity and cost of molecular assays. Tongue swabs are emerging as an alternative to sputum, but performance limits are uncertain.
    Methods: From June 2022 to July 2023, we enrolled 397 consecutive adults with cough >2 weeks at two health centers in Kampala, Uganda. We collected routine demographic and clinical information, sputum for routine TB testing (Xpert MTB/RIF Ultra® and two liquid cultures), and up to four tongue swabs for same-day qPCR. We evaluated tongue swab qPCR diagnostic accuracy in reference to sputum TB test results, quantified TB targets per swab, assessed the impact of serial swabbing, and compared two swab types (Copan FLOQSWAB® and Steripack® spun polyester).
    Results: Among 397 participants, 43.1% were female, median age was 33 years, 23.5% were living with HIV (PLHIV) and 32.0% had confirmed TB. Sputum Xpert Ultra and tongue swab qPCR results were concordant for 98.2% [96.2-99.1] of participants. Tongue swab qPCR sensitivity was 92.6% [95%CI: 86.5, 96.0] and specificity 99.1% [96.9-99.8] vs. microbiological reference standard (MRS). A single tongue swab recovered a seven-log range of TB copies, with a decreasing recovery trend among four serial swabs. We found no difference between swab types.
    Conclusions: Tongue swabs are a promising alternative to sputum for molecular diagnosis of TB, with sensitivity approaching sputum-based molecular tests. Our results provide valuable insights for developing successful tongue swab-based TB diagnostics.
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae041
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  4. Article: MMP2 and MMP9 associate with crescentic glomerulonephritis.

    Phillips, Tessa M / Fadia, Mitali / Lea-Henry, Tom N / Smiles, Jonathan / Walters, Giles D / Jiang, Simon H

    Clinical kidney journal

    2016  Volume 10, Issue 2, Page(s) 215–220

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2016-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfw111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Insights from a workplace SARS-CoV-2 specimen collection program, with genomes placed into global sequence phylogeny.

    Leiser, Owen P / Auberry, Deanna L / Bakker, Erica / Chrisler, Will / Engbrecht, Kristin / Engelmann, Heather / Fansler, Sarah / Gerbasi, Vincent / Hansen, Joshua / Hutchinson, Chelsea / Hutchison, Janine / Lancaster, Mary J / Lawrence, Kathleen / Melville, Angela / Mobberley, Jennifer / O'Bryon, Isabelle / Oxford, Kristie L / Oxford, Tessa / Phillips, Shelby /
    Rodda, Kabrena E / Sanford, James A / Schepmoes, Athena / Staley, Brian E / Terrell, Kelcey / Victry, Kristin / Warner, Cynthia / Omberg, Kristin M

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0285042

    Abstract: In 2020, the Department of Energy established the National Virtual Biotechnology Laboratory (NVBL) to address key challenges associated with COVID-19. As part of that effort, Pacific Northwest National Laboratory (PNNL) established a capability to ... ...

    Abstract In 2020, the Department of Energy established the National Virtual Biotechnology Laboratory (NVBL) to address key challenges associated with COVID-19. As part of that effort, Pacific Northwest National Laboratory (PNNL) established a capability to collect and analyze specimens from employees who self-reported symptoms consistent with the disease. During the spring and fall of 2021, 688 specimens were screened for SARS-CoV-2, with 64 (9.3%) testing positive using reverse-transcriptase quantitative PCR (RT-qPCR). Of these, 36 samples were released for research. All 36 positive samples released for research were sequenced and genotyped. Here, the relationship between patient age and viral load as measured by Ct values was measured and determined to be only weakly significant. Consensus sequences for each sample were placed into a global phylogeny and transmission dynamics were investigated, revealing that the closest relative for many samples was from outside of Washington state, indicating mixing of viral pools within geographic regions.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Clinical Laboratory Techniques ; Phylogeny ; RNA, Viral/analysis ; Specimen Handling ; Workplace ; Washington
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Onset of bell's palsy in late pregnancy and early puerperium is associated with worse long-term outcomes.

    Phillips, Katie M / Heiser, Alyssa / Gaudin, Robert / Hadlock, Tessa A / Jowett, Nate

    The Laryngoscope

    2017  Volume 127, Issue 12, Page(s) 2854–2859

    Abstract: Introduction: The incidence of Bell's palsy (BP) is elevated in the late phases of pregnancy. Controversy exists as to whether pregnancy is a risk factor for worse outcomes in BP, and whether such outcomes are the result of factors intrinsic to ... ...

    Abstract Introduction: The incidence of Bell's palsy (BP) is elevated in the late phases of pregnancy. Controversy exists as to whether pregnancy is a risk factor for worse outcomes in BP, and whether such outcomes are the result of factors intrinsic to pregnancy or the tendency to withhold medical therapy in this cohort.
    Methods: Long-term facial function outcomes in cases of pregnancy-associated BP (PABP) were compared against outcomes in cases affecting nonpregnant adult women of child-bearing age by a blinded expert using the electronic clinician-graded facial function scale (eFACE) facial grading system.
    Results: Fifty-one pregnancy-associated cases and 58 nonpregnancy-associated cases were included. Among patients who received early corticosteroid therapy, significantly worse static, synkinesis, and composite facial function eFACE scores were demonstrated among cases of PABP compared to nonpregnancy-associated cases (static median = 86 vs. 92.5, P = 0.005; synkinesis median = 79 vs. 86, P = 0.007; composite median = 78 vs. 84, P = 0.023). Among those not treated with corticosteroids, significantly worse dynamic and composite facial function eFACE scores were demonstrated in cases of PABP compared to those for nonpregnancy-associated cases (dynamic median = 74 vs. 92.5, P = 0.038; composite median = 73 vs. 86.5, P = 0.038). A trend toward improved outcomes was demonstrated within both groups for those treated with corticosteroids compared to those who were not.
    Conclusion: In comparison to cases unrelated to pregnancy, late-term PABP is associated with worse long-term outcomes to a degree that cannot solely be explained by differences in medical therapy.
    Level of evidence: 4. Laryngoscope, 127:2854-2859, 2017.
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.26569
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  7. Article ; Online: Australian Genomics: Outcomes of a 5-year national program to accelerate the integration of genomics in healthcare.

    Stark, Zornitza / Boughtwood, Tiffany / Haas, Matilda / Braithwaite, Jeffrey / Gaff, Clara L / Goranitis, Ilias / Spurdle, Amanda B / Hansen, David P / Hofmann, Oliver / Laing, Nigel / Metcalfe, Sylvia / Newson, Ainsley J / Scott, Hamish S / Thorne, Natalie / Ward, Robyn L / Dinger, Marcel E / Best, Stephanie / Long, Janet C / Grimmond, Sean M /
    Pearson, John / Waddell, Nicola / Barnett, Christopher P / Cook, Matthew / Field, Michael / Fielding, David / Fox, Stephen B / Gecz, Jozef / Jaffe, Adam / Leventer, Richard J / Lockhart, Paul J / Lunke, Sebastian / Mallett, Andrew J / McGaughran, Julie / Mileshkin, Linda / Nones, Katia / Roscioli, Tony / Scheffer, Ingrid E / Semsarian, Christopher / Simons, Cas / Thomas, David M / Thorburn, David R / Tothill, Richard / White, Deborah / Dunwoodie, Sally / Simpson, Peter T / Phillips, Peta / Brion, Marie-Jo / Finlay, Keri / Quinn, Michael Cj / Mattiske, Tessa / Tudini, Emma / Boggs, Kirsten / Murray, Sean / Wells, Kathy / Cannings, John / Sinclair, Andrew H / Christodoulou, John / North, Kathryn N

    American journal of human genetics

    2023  Volume 110, Issue 3, Page(s) 419–426

    Abstract: Australian Genomics is a national collaborative partnership of more than 100 organizations piloting a whole-of-system approach to integrating genomics into healthcare, based on federation principles. In the first five years of operation, Australian ... ...

    Abstract Australian Genomics is a national collaborative partnership of more than 100 organizations piloting a whole-of-system approach to integrating genomics into healthcare, based on federation principles. In the first five years of operation, Australian Genomics has evaluated the outcomes of genomic testing in more than 5,200 individuals across 19 rare disease and cancer flagship studies. Comprehensive analyses of the health economic, policy, ethical, legal, implementation and workforce implications of incorporating genomics in the Australian context have informed evidence-based change in policy and practice, resulting in national government funding and equity of access for a range of genomic tests. Simultaneously, Australian Genomics has built national skills, infrastructure, policy, and data resources to enable effective data sharing to drive discovery research and support improvements in clinical genomic delivery.
    MeSH term(s) Humans ; Australia ; Genomics ; Health Policy ; Rare Diseases ; Delivery of Health Care
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2023.01.018
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  8. Article ; Online: Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease.

    Nlandu-Khodo, Stellor / Osaki, Yosuke / Scarfe, Lauren / Yang, Haichun / Phillips-Mignemi, Melanie / Tonello, Jane / Saito-Diaz, Kenyi / Neelisetty, Surekha / Ivanova, Alla / Huffstater, Tessa / McMahon, Robert / Taketo, M Mark / deCaestecker, Mark / Kasinath, Balakuntalam / Harris, Raymond C / Lee, Ethan / Gewin, Leslie S

    JCI insight

    2020  Volume 5, Issue 10

    Abstract: The Wnt/β-catenin signaling pathway plays an important role in renal development and is reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in acute kidney injury (AKI) through actions on the proximal tubule, but the ... ...

    Abstract The Wnt/β-catenin signaling pathway plays an important role in renal development and is reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in acute kidney injury (AKI) through actions on the proximal tubule, but the current dogma is that Wnt/β-catenin signaling promotes fibrosis and development of chronic kidney disease (CKD). As the role of proximal tubular β-catenin signaling in CKD remains unclear, we genetically stabilized (i.e., activated) β-catenin specifically in murine proximal tubules. Mice with increased tubular β-catenin signaling were protected in 2 murine models of AKI to CKD progression. Oxidative stress, a common feature of CKD, reduced the conventional T cell factor/lymphoid enhancer factor-dependent β-catenin signaling and augmented FoxO3-dependent activity in proximal tubule cells in vitro and in vivo. The protective effect of proximal tubular β-catenin in renal injury required the presence of FoxO3 in vivo. Furthermore, we identified cystathionine γ-lyase as a potentially novel transcriptional target of β-catenin/FoxO3 interactions in the proximal tubule. Thus, our studies overturned the conventional dogma about β-catenin signaling and CKD by showing a protective effect of proximal tubule β-catenin in CKD and identified a potentially new transcriptional target of β-catenin/FoxO3 signaling that has therapeutic potential for CKD.
    MeSH term(s) Acute Kidney Injury/genetics ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Animals ; Forkhead Box Protein O3/genetics ; Forkhead Box Protein O3/metabolism ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Male ; Mice ; Mice, Transgenic ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Signal Transduction ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances Forkhead Box Protein O3 ; FoxO3 protein, mouse ; beta Catenin
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.135454
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  9. Article ; Online: IHC4 score plus clinical treatment score predicts locoregional recurrence in early breast cancer.

    Lakhanpal, Roopa / Sestak, Ivana / Shadbolt, Bruce / Bennett, Genevieve M / Brown, Michael / Phillips, Tessa / Zhang, Yanping / Bullman, Amanda / Rezo, Angela

    Breast (Edinburgh, Scotland)

    2016  Volume 29, Page(s) 147–152

    Abstract: Purpose: Immunohistochemical 4 (IHC4) score plus Clinical Treatment Score (CTS) is an inexpensive tool predicting risk of distant recurrence in women with early breast cancer (EBC). IHC4 score is based on ER, PR, HER2 and Ki67 index. This study explores ...

    Abstract Purpose: Immunohistochemical 4 (IHC4) score plus Clinical Treatment Score (CTS) is an inexpensive tool predicting risk of distant recurrence in women with early breast cancer (EBC). IHC4 score is based on ER, PR, HER2 and Ki67 index. This study explores the role of the combined score (IHC4 + CTS) in predicting risk of locoregional recurrence (LRR) in women with EBC who had breast conservation surgery (BCS) without adjuvant radiotherapy (study group). The secondary objective was to evaluate the clinicopathological differences between our study group and women who had adjuvant radiation following BCS (control group).
    Methods and materials: Patients were selected from the local database over a 13-year period. IHC testing was done where results were missing. Combined scores were calculated using the appropriate formulae.
    Results: Patients in the study group (81 patients) had favorable clinicopathological features compared to the control group (1406 patients). The Cox regression indicated a statistically significant association between the combined score and the risk of LRR (p = 0.03). The incidence of LRR was zero, 20% and 33.3% in the low, intermediate and high risk groups respectively (p = 0.007). Margin status was the only variable not included in the combined score. The Cox regression analysis demonstrated that the combined score (p = 0.02) and the ordinal measure of margins (p = 0.03) were significant independent predictors of LRR.
    Conclusion: This is the first study of its kind. The IHC4 score + CTS can be used to identify low risk women who can potentially avoid adjuvant radiotherapy.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Australia ; Case-Control Studies ; Female ; Health Status Indicators ; Humans ; Immunohistochemistry ; Incidence ; Ki-67 Antigen/analysis ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/chemistry ; Neoplasm Recurrence, Local/epidemiology ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Radiotherapy, Adjuvant/statistics & numerical data ; Receptor, ErbB-2/analysis ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Regression Analysis ; Risk Assessment/methods ; Risk Factors ; Treatment Outcome ; Unilateral Breast Neoplasms/chemistry ; Unilateral Breast Neoplasms/pathology ; Unilateral Breast Neoplasms/therapy
    Chemical Substances Ki-67 Antigen ; Receptors, Estrogen ; Receptors, Progesterone ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2016-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1143210-x
    ISSN 1532-3080 ; 0960-9776
    ISSN (online) 1532-3080
    ISSN 0960-9776
    DOI 10.1016/j.breast.2016.06.019
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  10. Article ; Online: Prenatal Undernutrition and Autonomic Function in Adulthood.

    de Rooij, Susanne R / Jones, Alexander / Phillips, David I / Osmond, Clive / Karemaker, John M / Roseboom, Tessa J / Painter, Rebecca C

    Psychosomatic medicine

    2016  Volume 78, Issue 9, Page(s) 991–997

    Abstract: Objectives: Early-life adversity has been shown to be associated with cardiovascular disease and mortality in later life, but little is known about the mechanisms that underlie this association. Prenatal undernutrition, a severe early-life stressor, is ... ...

    Abstract Objectives: Early-life adversity has been shown to be associated with cardiovascular disease and mortality in later life, but little is known about the mechanisms that underlie this association. Prenatal undernutrition, a severe early-life stressor, is associated with double the risk of coronary heart disease and increased blood pressure responses to psychological stress. In the present study, we tested the hypothesis that prenatal undernutrition induces alterations in the autonomic nervous system, which may increase the risk of developing heart disease.
    Methods: We studied autonomic function in 740 men and women (mean [SD] age, 58 [0.9] years) who were members of the Dutch famine birth cohort. We compared those exposed to famine during early (n = 64), mid (n = 107), or late gestation (n = 127) to those unexposed to famine in utero (n = 442). Participants underwent a series of 3 psychological stressors (Stroop, mirror tracing, and speech) while their blood pressure and heart rate were recorded continuously.
    Results: Data had sufficient quality in 602 participants for derivation of autonomic function indices by spectral analysis. The stress protocol led to significant sample-level changes in systolic blood pressure, heart rate, and all cardiovascular control measures (all p values < .001). None of the autonomic function parameters, at rest or in response to stress, differed significantly (all p values > .050) according to prenatal famine exposure.
    Conclusions: Prenatal undernutrition was not associated with autonomic function in late adulthood. We conclude that altered autonomic function does not seem to explain our previous findings of increased coronary heart disease risk among those exposed to famine prenatally.
    MeSH term(s) Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/physiopathology ; Blood Pressure/physiology ; Female ; Gestational Age ; Heart Rate/physiology ; Humans ; Middle Aged ; Netherlands ; Pregnancy ; Pregnancy Complications ; Prenatal Exposure Delayed Effects/physiopathology ; Starvation/complications
    Language English
    Publishing date 2016-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0000000000000393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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