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Article ; Online: Eventration of diaphragm with ectopic thoracic kidney: A cause of chronic debilitating flank pain, managed via robot-assisted approach.

Kumar, Santosh / Deshpande, Rohit Sanjay

2023 Volume 16, Issue 4, Page(s) 786–789

Abstract: Usually, flank pain signifies the presence of a renal/ureteric pathology. Here, we highlight an unusual cause of flank pain, which can be an important differential to be borne in mind while evaluating the causes of flank pain. Anatomical variants of the ... ...

Abstract	Usually, flank pain signifies the presence of a renal/ureteric pathology. Here, we highlight an unusual cause of flank pain, which can be an important differential to be borne in mind while evaluating the causes of flank pain. Anatomical variants of the kidneys are very common, but rarely do they cause flank pain unless associated with an ongoing pathological process within them. We describe a case wherein an anatomical variant of the kidney, without any pathology, led to unremitting flank pain, purely due to its location and associated "vascular drag." Correction of the underlying anatomical defect afforded significant symptomatic relief.
Language	English
Publishing date	2023-07-25
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13236
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Article ; Online: Confronting urethrorrhagia after Otis urethrotomy: a case report.

Mete, Uttam Kumar / Deshpande, Rohit Sanjay

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 522

Abstract: Background: Otis urethrotomy can sometimes lead to troublesome bleeding after seemingly uneventful procedures. This case report highlights one such case which went unnoticed initially; the bleeding was erroneously ascribed to the prostate, thereby ... ...

Abstract	Background: Otis urethrotomy can sometimes lead to troublesome bleeding after seemingly uneventful procedures. This case report highlights one such case which went unnoticed initially; the bleeding was erroneously ascribed to the prostate, thereby falsely indicting the "decoy" prostate. Case presentation: A 78-year-old Asian gentleman was referred to our hospital with complaint of intractable bleeding after undergoing laser enucleation of prostate at another institute, wherein he further underwent unsuccessful bilateral angioembolization of pudendal arteries. On endoscopy (for hemostasis), we found a spurting vessel in the navicular fossa, which was effectively controlled. Conclusions: This case report highlights the importance of performing prompt endoscopy in case of uncontrolled bleeding after prostate endoscopic surgery.
MeSH term(s)	Male ; Humans ; Aged ; Urethra/surgery ; Urethral Diseases/etiology ; Urethral Diseases/therapy ; Hemorrhage ; Endoscopy, Gastrointestinal
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04261-w
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Article: Effects of Antibodies in the Serum After the Administration of COVID Vaccines and Their Hematological and Cardiovascular Complications.

Haq, Mehreen / Deshpande, Sanjay V

Cureus

2023 Volume 15, Issue 10, Page(s) e47984

Abstract: The outbreak of COVID-19 was seen first in Wuhan, China, on December 31, 2019. Following this, the virus has emerged, mutated, and spread to all parts of the world, taking many lives. Scientists and healthcare workers all over the world have been ... ...

Abstract	The outbreak of COVID-19 was seen first in Wuhan, China, on December 31, 2019. Following this, the virus has emerged, mutated, and spread to all parts of the world, taking many lives. Scientists and healthcare workers all over the world have been involved in developing vaccines and drugs to prevent the deadly virus from spreading. In this review article, we focus on how the human body responds to immune responses by producing antibodies against our immune system and serum levels in different age groups. Few studies are being considered, which include data collected from adults in the UK community, health workers from Oxfordshire, studies from the UK, healthcare workers at a university healthcare center in Turkey, and lastly, non-seropositive and seronegative healthcare workers in the USA children's hospital, respectively, and their responses to the goal. In addition to focusing on this study and its results, we also discuss the role of different vaccines and their development and antibody responses in the body due to natural and post-vaccine infections that include both doses in humans. We focus mainly on immunoglobulin M (IgM) and immunoglobulin G (IgG) levels in the serum produced by plasma cells, as they are involved in the first line of defense against the disease. With the development of effective vaccines and their production, trial, and market distribution to needy people, there are certain prospects for slowing down the progression of the virus, reducing mortality, and preventing re-infection in humans. However impactful and beneficial these vaccines have proven, they also carry a certain amount of danger to the people taking them. We also discuss in this article certain infrequent hematological and cardiovascular complications of the vaccine and their effect on the population.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47984
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Article ; Online: Role of physical therapy intervention in acute disseminated encephalomyelitis.

Parmar, Sanjay Tejraj / Deshpande, Charulata / Kadam, Dipti Sambhajirao

BMJ case reports

2024 Volume 17, Issue 4

Abstract: We reported a case of a school-going child, diagnosed with acute disseminated encephalomyelitis (ADEM) who presented with symptoms such as high fever, acute hemiplegia and ataxia and was referred for physiotherapeutic intervention. This case report aims ... ...

Abstract	We reported a case of a school-going child, diagnosed with acute disseminated encephalomyelitis (ADEM) who presented with symptoms such as high fever, acute hemiplegia and ataxia and was referred for physiotherapeutic intervention. This case report aims to document the assessment and management of ADEM from the intensive care unit to the home setting by physical therapy. Also, the child developed ventilator-associated pneumonia and a right lower motor neuron facial injury for which the child was referred to paediatric physical therapy. Since then, continuing for 8 months has helped the child to be independent in all aspects of mobility with no complaints. The child showed improvement in WeeFIM scores and Sunnybrook facial grading after 99 sessions of intensive physical therapy for approximately 83 hours along with the home programme. It has been proven an efficient treatment method along with other medical lines of treatment for neurological impairment associated with ADEM.
MeSH term(s)	Child ; Humans ; Encephalomyelitis, Acute Disseminated/diagnosis ; Encephalomyelitis, Acute Disseminated/therapy ; Physical Therapy Modalities
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-257339
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Article ; Online: Development of a diagnostic support system for distal humerus fracture using artificial intelligence.

Kekatpure, Aashay / Kekatpure, Aditya / Deshpande, Sanjay / Srivastava, Sandeep

International orthopaedics

2024 Volume 48, Issue 5, Page(s) 1303–1311

Abstract: Purpose: AI has shown promise in automating and improving various tasks, including medical image analysis. Distal humerus fractures are a critical clinical concern that requires early diagnosis and treatment to avoid complications. The standard ... ...

Abstract	Purpose: AI has shown promise in automating and improving various tasks, including medical image analysis. Distal humerus fractures are a critical clinical concern that requires early diagnosis and treatment to avoid complications. The standard diagnostic method involves X-ray imaging, but subtle fractures can be missed, leading to delayed or incorrect diagnoses. Deep learning, a subset of artificial intelligence, has demonstrated the ability to automate medical image analysis tasks, potentially improving fracture identification accuracy and reducing the need for additional and cost-intensive imaging modalities (Schwarz et al. 2023). This study aims to develop a deep learning-based diagnostic support system for distal humerus fractures using conventional X-ray images. The primary objective of this study is to determine whether deep learning can provide reliable image-based fracture detection recommendations for distal humerus fractures. Methods: Between March 2017 and March 2022, our tertiary hospital's PACS data were evaluated for conventional radiography images of the anteroposterior (AP) and lateral elbow for suspected traumatic distal humerus fractures. The data set consisted of 4931 images of patients seven years and older, after excluding paediatric images below seven years due to the absence of ossification centres. Two senior orthopaedic surgeons with 12 + years of experience reviewed and labelled the images as fractured or normal. The data set was split into training sets (79.88%) and validation tests (20.1%). Image pre-processing was performed by cropping the images to 224 × 224 pixels around the capitellum, and the deep learning algorithm architecture used was ResNet18. Results: The deep learning model demonstrated an accuracy of 69.14% in the validation test set, with a specificity of 95.89% and a positive predictive value (PPV) of 99.47%. However, the sensitivity was 61.49%, indicating that the model had a relatively high false negative rate. ROC analysis showed an AUC of 0.787 when deep learning AI was the reference and an AUC of 0.580 when the most senior orthopaedic surgeon was the reference. The performance of the model was compared with that of other orthopaedic surgeons of varying experience levels, showing varying levels of diagnostic precision. Conclusion: The developed deep learning-based diagnostic support system shows potential for accurately diagnosing distal humerus fractures using AP and lateral elbow radiographs. The model's specificity and PPV indicate its ability to mark out occult lesions and has a high false positive rate. Further research and validation are necessary to improve the sensitivity and diagnostic accuracy of the model for practical clinical implementation.
MeSH term(s)	Humans ; Child ; Artificial Intelligence ; Humeral Fractures, Distal ; Fractures, Bone/diagnostic imaging ; Radiography ; Algorithms ; Retrospective Studies
Language	English
Publishing date	2024-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-024-06125-4
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Zs.A 1324: Show issues

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Article: Subcutaneous Angiofibroma of the Ankle: A Rare, Undescribed Clinical Entity.

Deshpande, Sanjay V / Jadawala, Vivek H / Ahmed, Salahuddin / Goel, Sachin

Cureus

2024 Volume 16, Issue 1, Page(s) e53033

Abstract: Soft tissue angiofibroma is a pathology consisting of a benign fibrous vascularized tumor that mimics low-grade sarcoma. Such tumors frequently arise in the extremities, more commonly in the lower extremities, presenting as a slow-growing, painless ... ...

Abstract	Soft tissue angiofibroma is a pathology consisting of a benign fibrous vascularized tumor that mimics low-grade sarcoma. Such tumors frequently arise in the extremities, more commonly in the lower extremities, presenting as a slow-growing, painless swelling. Females are more commonly affected than males. We present the case of a 42-year-old male with a slow-growing, painless mass on the extensor aspect of his left foot. Differential diagnoses considered were soft tissue fibrosarcoma, liposarcoma, and sebaceous cysts. Surgical excision of the tumor was done, and upon histopathology, there were multiple lobules with well-circumscribed, alternating areas of collagenous and myxoid tissues. There was a prominent small vascular network with uniformly arranged spindle cells consisting of pale eosinophil-rich cytoplasm and small ovoid nuclei, fine chromatin, and an indistinct nucleolus. There are not many reported cases of this clinical entity, and every new case reported brings light to the pathology and progression of this tumor. Understanding this pathology is necessary since it mimics many other skin and soft tissue tumors.
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53033
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Article ; Online: Polysome-bound mRNAs and translational mechanisms regulate drought tolerance in rice.

Dawane, Akashata / Deshpande, Sanjay / Vijayaraghavreddy, Preethi / Vemanna, Ramu S

Plant physiology and biochemistry : PPB

2024 Volume 208, Page(s) 108513

Abstract: Plants evolved several acquired tolerance traits for drought stress adaptation to maintain the cellular homeostasis. Drought stress at the anthesis stage in rice affects productivity due to the inefficiency of protein synthesis machinery. The effect of ... ...

Abstract	Plants evolved several acquired tolerance traits for drought stress adaptation to maintain the cellular homeostasis. Drought stress at the anthesis stage in rice affects productivity due to the inefficiency of protein synthesis machinery. The effect of translational mechanisms on different pathways involved in cellular tolerance plays an important role. We report differential responses of translation-associated mechanisms in rice using polysome bound mRNA sequencing at anthesis stage drought stress in resistant Apo and sensitive IR64 genotypes. Apo maintained higher polysomes with 60 S-to-40 S and polysome-to-monosome ratios which directly correlate with protein levels under stress. IR64 has less protein levels under stress due to defective translation machinery and reduced water potential. Many polysome-bound long non-coding RNAs (lncRNA) were identified in both genotypes under drought, influencing translation. Apo had higher levels of N
MeSH term(s)	Drought Resistance ; Oryza/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Photosynthesis ; Droughts ; Polyribosomes/metabolism ; Stress, Physiological/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2024-03-18
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2024.108513
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Article: The Miraculous Diagnostic Role of Indocyanine Green in a Diabetic Foot Ulcer: A Rare Case Report.

Wadgaonkar, Apurv S / Deshpande, Sanjay V / Rahate, Nachiket P / Rahate, Prashant V

Cureus

2024 Volume 16, Issue 3, Page(s) e55525

Abstract: Diabetes is a chronic metabolic disorder characterized by elevated levels of glucose in the blood. This causes small nerve polyneuropathy resulting in diabetic foot ulcers. A diabetic foot ulcer is an open sore or wound that develops as a result of ... ...

Abstract	Diabetes is a chronic metabolic disorder characterized by elevated levels of glucose in the blood. This causes small nerve polyneuropathy resulting in diabetic foot ulcers. A diabetic foot ulcer is an open sore or wound that develops as a result of chronic diabetes. Indocyanine green angiography (ICGA) near-infrared (NIR) can provide real-time visualization of blood flow within the microvasculature of the underlying organ. Here, we discuss a 63-year-old patient who came with a diabetic foot ulcer over his right great toe. His blood glucose level was 208 mg/dl. He drinks alcohol occasionally and smokes regularly. The tissue perfusion of his right foot was checked using the indocyanine green dye, after which orthopedic surgeons were consulted, and the gangrenous part was amputated.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55525
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Article: Relevance of Tumor Budding and Pattern of Invasion in Oral Squamous Cell Carcinoma.

Deshpande, Nikhil Sanjay / Munemane, Anil B / Karle, Ravindra Raosaheb / Dongre, Suryakant Dattatreya

International journal of applied & basic medical research

2024 Volume 14, Issue 1, Page(s) 29–34

Abstract: Background: Standard histopathological parameters such as depth of invasion (DOI), lymphovascular invasion (LVI), and perineural invasion (PNI) are known parameters that can correlate with the prognosis and aggressiveness of oral squamous cell ... ...

Abstract	Background: Standard histopathological parameters such as depth of invasion (DOI), lymphovascular invasion (LVI), and perineural invasion (PNI) are known parameters that can correlate with the prognosis and aggressiveness of oral squamous cell carcinomas (OSCCs). Tumor budding (TB) (≤5 tumor cells at infiltrating borders) and pattern of invasion (POI) are emerging histopathological parameters that have shown promising results as reliable risk factors in predicting nodal metastasis in early OSCCs. Aim: The aim of the study was to assess TB and POI in OSCCs. Materials and methods: A total of 33 surgical resection specimens of OSCC, including buccal mucosa and tongue with neck dissection, were selected. TB and POI along with standard parameters such as grade, DOI, LVI, PNI, lymph node status, and pathological staging were evaluated. These parameters were analyzed in comparison with lymph node involvement and pathological stage of the tumor using the Chi-square and Fischer's exact test. The SPSS software, v21, was used for statistical analyses. Results: Most of OSCC were moderately differentiated tumors (63.64%). TB was present in 23 cases, in which 69.57% of cases showed low TB (<5 buds), while 30.43% of cases had higher TB (>5 buds). The worst POI (Patterns 4 and 5) was seen in 75.76% of cases. TB, POI, grade, PNI, DOI, and stromal pattern were significantly associated with the pathological stage of the tumor. Conclusion: TB and POI are important and reliable in histopathological parameters in OSCCs.
Language	English
Publishing date	2024-02-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2645750-7
ISSN	2248-9606 ; 2229-516X
ISSN (online)	2248-9606
ISSN	2229-516X
DOI	10.4103/ijabmr.ijabmr_391_23
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Article: A Young Male With an Active Giant Cell Tumor: A Case Report.

Thakur, Avantika / Deshpande, Sanjay V

Cureus

2022 Volume 14, Issue 10, Page(s) e30389

Abstract: A giant cell tumor (GCT) is a benign but locally aggressive tumor usually present over the knee joint. Its etiology is unknown but some studies have shown that it appears due to overexpression in RANK/RANKL by neoplastic mononuclear stromal cells ... ...

Abstract	A giant cell tumor (GCT) is a benign but locally aggressive tumor usually present over the knee joint. Its etiology is unknown but some studies have shown that it appears due to overexpression in RANK/RANKL by neoplastic mononuclear stromal cells signaling pathway, which results in hyperproliferation of osteoclasts. This is a case of a 25-year-old male who presented with swelling associated with pain over his left distal femur since eight months. The range of motion (ROM) at the knee joint was painful from 0 to 110 degrees and no knee effusion was observed. Examination revealed a slightly mobile mass present over the knee joint. Additional preoperative workup such as Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) was done. Histopathological findings showed the presence of large multinucleated osteoclast-like giant cells. Radiographs showed a permeative lytic lesion within the distal femur with surrounding cortical destruction. Surgical excision by curettage and bone grafting was done. The patient did well, without clinical recurrence at one-year follow-up. A local recurrence rate of 2.5 to 45% is observed. Aggressive operative excision, use of adjuvants at the time of resection, and ongoing postoperative monitoring can decrease patient morbidity.
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.30389
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