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Article ; Online: Anastomosing haemangioma of adrenal gland: an unusual vascular tumour.

Rewari, Harshit / Wadhwa, Pankaj / Talwar, Harkirat / Taneja, Divya

BMJ case reports

2024 Volume 17, Issue 4

Abstract: With only 15 reported cases, anastomosing haemangioma of adrenal is a rare entity and usually presents as adrenal incidentaloma. A hypertensive, diabetic, non-smoker man in his late 60s presented with irritative voiding symptoms. On evaluation, he was ... ...

Abstract	With only 15 reported cases, anastomosing haemangioma of adrenal is a rare entity and usually presents as adrenal incidentaloma. A hypertensive, diabetic, non-smoker man in his late 60s presented with irritative voiding symptoms. On evaluation, he was found to have a urinary bladder mass and left adrenal incidentaloma measuring 8 cm. Metabolic evaluation confirmed it to be non-functional.The patient underwent transurethral resection of bladder tumour with left laparoscopic adrenalectomy. Intraoperatively, the adrenal tumour was highly vascular with multiple feeder vessels. Grossly it was soft, encapsulated with focal grey-brown areas. Microscopically, most of adrenal gland was replaced by anastomosing proliferating capillary vessels within framework of non-endothelial supporting cells reminiscent of splenic sinusoids. The tumour was positive for CD-31, CD-34, Glut-1 and SMA.Anastomosing haemangioma is a benign entity but it must be differentiated from angiosarcoma. Characteristic imaging features are not yet defined and is, therefore, difficult to diagnose preoperatively.
MeSH term(s)	Humans ; Male ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/surgery ; Adrenal Gland Neoplasms/pathology ; Hemangioma/surgery ; Hemangioma/diagnosis ; Hemangioma/complications ; Adrenalectomy/methods ; Diagnosis, Differential ; Middle Aged ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-259092
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Article ; Online: Dental students' attitudes on cardiopulmonary resuscitation training via virtual reality: an exploratory study.

Bjelovucic, Ruza / Bak, Jesper / Wolff, Jan / Taneja, Pankaj

British dental journal

2023 Volume 235, Issue 8, Page(s) 607–612

Abstract: Purpose Resuscitation guidelines have advocated the use of virtual learning as a form of pre-course e-learning. Virtual reality (VR) has been identified to provide a method of constructive learning with instant feedback. There are increasing publications ...

Abstract	Purpose Resuscitation guidelines have advocated the use of virtual learning as a form of pre-course e-learning. Virtual reality (VR) has been identified to provide a method of constructive learning with instant feedback. There are increasing publications of VR use in cardiopulmonary resuscitation (CPR) training; however, there is a dearth from the dental profession. Therefore, the aim of this exploratory study was to investigate dental students' opinions in CPR training using VR.Methods In total, 120 dental students undertook both conventional (manikin) and VR CPR training in a cross-over design. The VR scenario was in a hospital setting. Following, students completed a questionnaire evaluating their experiences.Results The majority of students (n = 88) reported that this was the first time that they had utilised VR. The experience of using VR in CPR training was rated as very good. Most students felt that the inclusion of VR in CPR training created a better learning experience and had a high learning potential. However, the hospital setting was not entirely relevant.Conclusion Dental students recommended that VR CPR training should be used as an adjunct to conventional training in dental education, but the VR scenario would benefit being a virtual dental environment.
MeSH term(s)	Humans ; Cardiopulmonary Resuscitation/education ; Cardiopulmonary Resuscitation/methods ; Students, Dental ; Learning ; Curriculum ; Virtual Reality
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-023-6388-2
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Ul III Zs.143: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 447: Show issues

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Article ; Online: Phenotypic and genotypic characterization of multi-drug resistant, biofilm forming, human invasive strain of Salmonella Typhimurium SMC25 isolated from poultry meat in India.

Bhardwaj, Dinesh Kumar / Taneja, Neetu Kumra / Taneja, Pankaj / Patel, Pravin

Microbial pathogenesis

2022 Volume 173, Issue Pt A, Page(s) 105830

Abstract: Emergence of highly virulent and multi-drug resistant (MDR) strains of Salmonella in food products significantly impacts public health and demands continuous monitoring for their presence in the food chain. The ability of Salmonella to form biofilms ... ...

Abstract	Emergence of highly virulent and multi-drug resistant (MDR) strains of Salmonella in food products significantly impacts public health and demands continuous monitoring for their presence in the food chain. The ability of Salmonella to form biofilms under harsh environmental conditions accompanied by MDR serotypes underscores an important food safety threat. This study aimed to isolate, identify and characterize MDR, biofilm-forming Salmonella from local Indian dairy and meat products (n = 60). All of the 24 isolates of Salmonella produced biofilm and were categorized as strong (16.6%), moderate (58.3%), and weak (25%) biofilm producers. Multiple antimicrobial resistance (MAR) index of all the Salmonella isolates was ≥0.2. The strongest biofilm forming poultry meat isolate, Salmonella SMC25 demonstrated intermediate to complete resistance to 14 of 22 different antibiotics tested. Epifluorescence microscopy showed that biofilm formation initiated as early as 4 h, reaching zenith within 96 h and much denser and robust biofilm is formed on rough stainless steel (SS316) surface compared to smooth glass surface. The results corroborated with increased temporal production of exopolysaccharides (EPS), high cell surface hydrophobicity and upregulation of marker genes vital to biofilm-formation in Salmonella. Significantly, SMC25 was found to adhere and invade mammalian cell lines Caco2 and HepG2, thus posing a serious food safety threat. This study is important in comprehending the prevalence of multidrug resistant, biofilm-forming, invasive strains of foodborne Salmonella in Indian food products and is important for effective risk assessment besides ensuring better food safety and public health.
MeSH term(s)	Animals ; Humans ; Salmonella typhimurium ; Poultry ; Caco-2 Cells ; Biofilms ; Meat Products ; Anti-Bacterial Agents/pharmacology ; Meat ; Food Microbiology ; Mammals
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105830
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Zs.A 2136: Show issues

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Article: Iatrosedation: a holistic tool in the armamentarium of anxiety control.

Taneja, Pankaj

SAAD digest

2015 Volume 31, Page(s) 23–25

Abstract: Identifying the causes of dental anxiety by taking a history and carrying out investigations for patients attending for any type of dental procedure, can be time consuming. Common causative factors of dental anxiety can be previous adverse dental ... ...

Abstract	Identifying the causes of dental anxiety by taking a history and carrying out investigations for patients attending for any type of dental procedure, can be time consuming. Common causative factors of dental anxiety can be previous adverse dental experiences, age, temperament or socioeconomic factors. These factors can lead to patients falling into a cycle of dental avoidance and greater treatment need with attendance for symptomatic relief only. Treatment using pharmacological methods such as conscious sedation or general anaesthesia can help overcome these obstacles, however, although a successful treatment outcome may result, how is the patient to gain trust and overcome their anxiety or fear, if they do not learn from the experience? In 1967 Nathan Friedman described a method he termed 'Iatrosedation' consisting of two components, the interview and the clinical encounter. His method relies on the communication skills and behaviour of the practitioner to identify the causes of anxiety or fear and then to provide a bespoke approach to help overcome them. The result can be that the patient not only has successful treatment, but also learns and gains confidence from their experience, as well as gains increased faith in their practitioner.
MeSH term(s)	Attitude to Health ; Communication ; Conscious Sedation ; Dental Anxiety/prevention & control ; Dental Anxiety/psychology ; Dental Care/psychology ; Dentist-Patient Relations ; Empathy ; Humans ; Interviews as Topic ; Nonverbal Communication ; Patient Education as Topic ; Trust
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1043253-x
ISSN	0049-1160
ISSN	0049-1160
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Zs.A 3005: Show issues

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Article ; Online: Pleasantness and unpleasantness in somatosensory investigation.

Taneja, Pankaj / Svendsen, Antilla Egeris / Kristensen, Ellen / Jensen, Frederik Teilmann / Vestergaard, Mathias / Nørholt, Sven Erik / Baad-Hansen, Lene

Journal of oral rehabilitation

2024 Volume 51, Issue 3, Page(s) 593–600

Abstract: Background: Qualitative sensory testing (QualST) is a simple, standardised, chairside method for evaluating somatosensory function; however, testing focuses on detection of cold, touch and pain with no recognition of perceptions of pleasantness and ... ...

Abstract	Background: Qualitative sensory testing (QualST) is a simple, standardised, chairside method for evaluating somatosensory function; however, testing focuses on detection of cold, touch and pain with no recognition of perceptions of pleasantness and unpleasantness. Objectives: The study aimed to utilise the stimuli in QualST, with the addition of a soft brush, to investigate stimulus-evoked perceptions of pleasantness and unpleasantness on the facial skin and if any side-to-side differences. Additional aims were to determine the inter- and intra-rater reliability using the modified QualST protocol and in the side-to-side differences. Methods: Thirty healthy adult female participants underwent three sessions of sensitivity testing as per the modified QualST protocol. Stimuli were applied bilaterally to the facial skin, and participants provided separate yes/no responses for presence of stimulus-evoked pleasantness, unpleasantness and/or differences between sides. Results: The stimuli were able to evoke sensations of pleasantness and unpleasantness with little differences in responses between the Q-tip and goat hair brush for the perceptions. Side-to-side differences in evoked perceptions were observed and greatest, when evaluating for pinprick-evoked unpleasantness (range between sessions = 18-19 participants). Acceptable percentage (≥90%) and excellent Cohen's Kappa (≥0.762) inter- and intra-rater agreements were identified for one or more positive responses for each stimulus modality and the targeted perception. Conclusion: The modified QualST protocol provides a simple, reproducible method for the investigation of perceptions of pleasantness and unpleasantness, with readily accessible instrumentation to dental professionals and allowing for a more holistic approach in somatosensory testing.
MeSH term(s)	Adult ; Humans ; Female ; Reproducibility of Results ; Pain ; Touch ; Pain Measurement ; Face
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13613
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Zs.A 991: Show issues

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Article: Does cone beam CT change the treatment decision for maxillary second and third molars? A prospective study.

Hermann, Louise / Nørholt, Sven Erik / Wenzel, Ann / Taneja, Pankaj / Matzen, Louise Hauge

Dento maxillo facial radiology

2023 Volume 52, Issue 7, Page(s) 20230128

Abstract: Objectives: To evaluate whether information from CBCT changes the treatment plan for maxillary second and third molars and to examine clinical and radiographic parameters with an impact on treatment decision.: Methods: This prospective study included ...

Abstract	Objectives: To evaluate whether information from CBCT changes the treatment plan for maxillary second and third molars and to examine clinical and radiographic parameters with an impact on treatment decision. Methods: This prospective study included 260 maxillary third molars with superimposition onto the second molar in panoramic images (170 patients; mean age 28 years, range 16-63). An initial treatment plan was based on clinical findings and panoramic images. After CBCT, a final treatment plan was decided. Treatment was undertaken based on the final treatment plan. Through logistic regression analyses, impact of clinical and radiographic parameters on change in treatment plan, removal of the third molar Results: The treatment plan changed in 82 cases (32%). Sixteen cases (6%) changed from removal of the third molar to removal of the second molar. Regression analyses showed that severe resorption in the second molar was significantly related to a change in treatment plan. Removal of a third molar was decided in 180 cases and regression analyses identified that mesioangulation of the third molar, marginal bone loss, superficial resorption, and age were significantly related to removal of the third molar Conclusions: Parameters such as resorption evaluated in CBCT can modify the treatment decision, resulting in removal of the second and/or the third molar.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Molar, Third/diagnostic imaging ; Prospective Studies ; Molar ; Cone-Beam Computed Tomography ; Bone Diseases, Metabolic
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article
ZDB-ID	221323-0
ISSN	1476-542X ; 0250-832X ; 0349-490X
ISSN (online)	1476-542X
ISSN	0250-832X ; 0349-490X
DOI	10.1259/dmfr.20230128
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Zs.B 2620: Show issues

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Article ; Online: Recent developments in CCR5 regulation for HIV cure.

Garg, Krati / Khan, Amir Riyaz / Taneja, Pankaj

Advances in protein chemistry and structural biology

2021 Volume 126, Page(s) 123–149

Abstract: Acquired immunodeficiency syndrome (AIDS) has affected millions of people worldwide. The human immunodeficiency virus (HIV) which infects T cells by using CD4 as its main receptor. Currently different treatments are available against HIV infection which ... ...

Abstract	Acquired immunodeficiency syndrome (AIDS) has affected millions of people worldwide. The human immunodeficiency virus (HIV) which infects T cells by using CD4 as its main receptor. Currently different treatments are available against HIV infection which can improve life expectancy of the patient but still it remains incurable. CCR5, which is also required as a co-receptor by majority of HIV strains for entry into the target cells, is now being targeted for gene therapy to develop HIV resistance in patients. In this review, we discuss different strategies that are being adapted for CCR5-gene disruption in CD4
MeSH term(s)	Acquired Immunodeficiency Syndrome/genetics ; Acquired Immunodeficiency Syndrome/immunology ; Acquired Immunodeficiency Syndrome/therapy ; CD4-Positive T-Lymphocytes/immunology ; Genetic Therapy ; HIV-1/genetics ; HIV-1/immunology ; Hematopoietic Stem Cells/immunology ; Humans ; Receptors, CCR5/genetics ; Receptors, CCR5/immunology
Chemical Substances	CCR5 protein, human ; Receptors, CCR5
Language	English
Publishing date	2021-02-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2021.01.004
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Article ; Online: Identification and optimization of pyridine carboxamide-based scaffold as a drug lead for

Singh, Padam / Kumar, Arun / Sharma, Pankaj / Chugh, Saurabh / Kumar, Ashish / Sharma, Nidhi / Gupta, Sonu / Singh, Manisha / Kidwai, Saqib / Sankar, Jishnu / Taneja, Neha / Kumar, Yashwant / Dhiman, Rohan / Mahajan, Dinesh / Singh, Ramandeep

Antimicrobial agents and chemotherapy

2024 Volume 68, Issue 2, Page(s) e0076623

Abstract: New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture ... ...

Abstract	New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture against
MeSH term(s)	Mice ; Animals ; Mycobacterium tuberculosis ; Antitubercular Agents/pharmacology ; Mycobacterium bovis ; Isoniazid ; Tuberculosis/prevention & control
Chemical Substances	Antitubercular Agents ; Isoniazid (V83O1VOZ8L)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00766-23
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Molecular docking, synthesis and anticancer activity of thiosemicarbazone derivatives against MCF-7 human breast cancer cell line.

Sibuh, Belay Zeleke / Khanna, Sonia / Taneja, Pankaj / Sarkar, Paratpar / Taneja, Neetu Kumra

Life sciences

2021 Volume 273, Page(s) 119305

Abstract: Background: The aim of this study was to synthesize and evaluate anticancer activity of 2-hydroxy benzaldehyde and 4-hydroxy benzaldehyde thiosemicarbazone (2-HBTSc and 4-HBTSc) against MCF-7 breast cancer cell line.: Materials and methods: The ... ...

Abstract	Background: The aim of this study was to synthesize and evaluate anticancer activity of 2-hydroxy benzaldehyde and 4-hydroxy benzaldehyde thiosemicarbazone (2-HBTSc and 4-HBTSc) against MCF-7 breast cancer cell line. Materials and methods: The ligands were prepared and characterized by UV vis, IR and NMR. MTT assay was used to assess viability of cells. RNA isolation, extraction and cDNA synthesis were done. Then all groups were subjected to RT-qPCR using Gene expression specific primers. Also, western blot protein expression and molecular docking were done. Two-way ANOVA with Tukey post-hoc test was employed to test the significance using GraphPad Prism. Results: The IC Conclusion: The findings of this study imply that the test compound has potential for further study.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apoptosis ; Benzaldehydes/chemical synthesis ; Benzaldehydes/pharmacology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Thiosemicarbazones/chemical synthesis ; Thiosemicarbazones/chemistry ; Thiosemicarbazones/pharmacology
Chemical Substances	2-hydroxybenzaldehyde thiosemicarbazone ; Antineoplastic Agents ; Benzaldehydes ; Ligands ; Thiosemicarbazones
Language	English
Publishing date	2021-03-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119305
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Article ; Online: Robotic Stroking on the Face and Forearm: Touch Satiety and Effects on Mechanical Pain.

Taneja, Pankaj / Baad-Hansen, Lene / Shaikh, Sumaiya / Svensson, Peter / Olausson, Håkan

Frontiers in pain research (Lausanne, Switzerland)

2021 Volume 2, Page(s) 693987

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-561X
ISSN (online)	2673-561X
DOI	10.3389/fpain.2021.693987
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