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Book: Radiology of the post surgical abdomen

Brittenden, John / Tolan, Damian J. M.

2012

Author's details	John Brittenden ; Damian J. M. Tolan, ed
Language	English
Size	XV, 326 S. : zahlr. Ill.
Publisher	Springer
Publishing place	London u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT017211390
ISBN	978-1-4471-2774-1 ; 9781447127758 ; 1-4471-2774-9 ; 1447127757
Database	Catalogue ZB MED Medicine, Health

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2012 A 1737	order for loan	Magazin

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Article ; Online: The impact of mismatch repair status and systemic inflammatory markers on radiological staging in colon cancer.

Platt, James R / Ansett, Jennifer / Seligmann, Jenny F / West, Nicholas P / Tolan, Damian J M

The British journal of radiology

2023 Volume 96, Issue 1150, Page(s) 20230098

Abstract: Objective: Mismatch repair (MMR) deficient (dMMR) colon cancer (CC) is distinct from MMR proficient (pMMR) CC, yet the impact of MMR status on radiological staging is unclear. The purpose of this study was to investigate how MMR status impacts CC CT ... ...

Abstract	Objective: Mismatch repair (MMR) deficient (dMMR) colon cancer (CC) is distinct from MMR proficient (pMMR) CC, yet the impact of MMR status on radiological staging is unclear. The purpose of this study was to investigate how MMR status impacts CC CT staging. Methods: We retrospectively compared CT staging accuracy between dMMR and pMMR CC patients undergoing curative resection. Accuracy was assessed as individual tumour (T)/nodal (N) stages and as dichotomous "statuses" (T1/2 Results: There was no significant difference in overall staging accuracy between the dMMR (44 patients) and pMMR (57 patients) groups. dMMR tumours with incorrect N stage/"status" were more likely to be overstaged than pMMR tumours (90% Conclusion: Whilst overall staging accuracy was similar between groups, incorrectly N staged dMMR tumours were more likely to be overstaged than pMMR tumours, risking inappropriate surgical or neoadjuvant treatment. We describe novel relationships between several inflammatory markers and pathological "N status" in dMMR CC, which if integrated into routine practice may improve CT staging accuracy. Advances in knowledge: Compared to pMMR CC, dMMR CC is at significant risk of N overstaging. Platelet count, CRP and neutrophil count are higher in dMMR CC patients with nodal metastases than those without, and their role in refining clinical staging requires further investigation.
MeSH term(s)	Humans ; Retrospective Studies ; DNA Mismatch Repair ; Neoplasm Staging ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Prognosis
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20230098
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Article ; Online: Magnetic Resonance Imaging for Perianal Fistula.

Tolan, Damian J M

Seminars in ultrasound, CT, and MR

2016 Volume 37, Issue 4, Page(s) 313–322

Abstract: Perianal fistulas and other inflammatory diseases of the anus and perianal soft tissues are a cause of substantial morbidity, and are a major part of the practice of any colorectal surgeon. Magnetic resonance imaging (MRI) has a key role in the ... ...

Abstract	Perianal fistulas and other inflammatory diseases of the anus and perianal soft tissues are a cause of substantial morbidity, and are a major part of the practice of any colorectal surgeon. Magnetic resonance imaging (MRI) has a key role in the assessment of patients for the extent of fistulizing Crohn disease, complications related to fistulas, and to assist in confirming the diagnosis or proposing an alternative. Technique is critical and in particular, the selection of sequences for diagnosis and characterization of abnormalities with the main choices being between standard anatomical sequences (T1 or T2), assessing for edema (FS T2 or STIR), assessing abnormal contrast enhancement (FS T1), and assessing for abnormal diffusion or a combination of these. Guidance on MRI sequence selection, classification of fistulas, the current guidance on the role of MRI in assessing patients, and advice on how to provide useful structured reports, as well as how to detect complications of perianal sepsis are included.
MeSH term(s)	Contrast Media ; Humans ; Magnetic Resonance Imaging/methods ; Rectal Fistula/classification ; Rectal Fistula/diagnostic imaging ; Rectal Fistula/etiology
Chemical Substances	Contrast Media
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1353113-x
ISSN	1558-5034 ; 0887-2171
ISSN (online)	1558-5034
ISSN	0887-2171
DOI	10.1053/j.sult.2016.04.004
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Article ; Online: CT colonography remains an important test for colorectal cancer.

Burr, Nicholas Ewin / Plumb, Andrew / Sood, Ruchit / Rembacken, Bjorn / Tolan, Damian J M

Gut

2021 Volume 71, Issue 1, Page(s) 217–218

MeSH term(s)	Colonic Polyps/diagnostic imaging ; Colonography, Computed Tomographic ; Colonoscopy ; Colorectal Neoplasms/diagnostic imaging ; Humans
Language	English
Publishing date	2021-03-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2021-324399
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Book: Radiology of the post surgical abdomen

Brittenden, John / Tolan, Damian J. M

2012

Author's details	John Brittenden, Damian J.M. Tolan, editors
MeSH term(s)	Radiography, Abdominal/methods ; Abdomen/surgery ; Postoperative Complications/diagnostic imaging ; Postoperative Period ; Radiography
Language	English
Size	xv, 326 p. :, ill.
Publisher	Springer
Publishing place	London
Document type	Book
ISBN	9781447127741 ; 9781447127758 ; 1447127749 ; 1447127757
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Current controversies in TNM for the radiological staging of rectal cancer and how to deal with them: results of a global online survey and multidisciplinary expert consensus.

European radiology

2022 Volume 32, Issue 7, Page(s) 4991–5003

Abstract: Objectives: To identify the main problem areas in the applicability of the current TNM staging system (8: Methods: A global case-based online survey was conducted including 41 image-based rectal cancer cases focusing on various items included in the ... ...

Abstract	Objectives: To identify the main problem areas in the applicability of the current TNM staging system (8 Methods: A global case-based online survey was conducted including 41 image-based rectal cancer cases focusing on various items included in the TNM system. Cases reaching < 80% agreement among survey respondents were identified as problem areas and discussed among an international expert panel, including 5 radiologists, 6 colorectal surgeons, 4 radiation oncologists, and 3 pathologists. Results: Three hundred twenty-one respondents (from 32 countries) completed the survey. Sixteen problem areas were identified, related to cT staging in low-rectal cancers, definitions for cT4b and cM1a disease, definitions for mesorectal fascia (MRF) involvement, evaluation of lymph nodes versus tumor deposits, and staging of lateral lymph nodes. The expert panel recommended strategies on how to handle these, including advice on cT-stage categorization in case of involvement of different layers of the anal canal, specifications on which structures to include in the definition of cT4b disease, how to define MRF involvement by the primary tumor and other tumor-bearing structures, how to differentiate and report lymph nodes and tumor deposits on MRI, and how to anatomically localize and stage lateral lymph nodes. Conclusions: The recommendations derived from this global survey and expert panel discussion may serve as a practice guide and support tool for radiologists (and other clinicians) involved in the staging of rectal cancer and may contribute to improved consistency in radiological staging and reporting. Key points: • Via a case-based online survey (incl. 321 respondents from 32 countries), we identified 16 problem areas related to the applicability of the TNM staging system for the radiological staging and reporting of rectal cancer. • A multidisciplinary panel of experts recommended strategies on how to handle these problem areas, including advice on cT-stage categorization in case of involvement of different layers of the anal canal, specifications on which structures to include in the definition of cT4b disease, how to define mesorectal fascia involvement by the primary tumor and other tumor-bearing structures, how to differentiate and report lymph nodes and tumor deposits on MRI, and how to anatomically localize and stage lateral lymph nodes. • These recommendations may serve as a practice guide and support tool for radiologists (and other clinicians) involved in the staging of rectal cancer and may contribute to improved consistency in radiological staging and reporting.
MeSH term(s)	Consensus ; Extranodal Extension ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasm Staging ; Rectal Neoplasms/pathology ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-08591-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A young woman with recurrent perianal sepsis.

Kaye, Tom L / O'Connor, Anthony / Burke, Dermot / Tolan, Damian J M

BMJ (Clinical research ed.)

2015 Volume 350, Page(s) h1969

MeSH term(s)	Abscess ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Crohn Disease/immunology ; Drainage ; Female ; Humans ; Magnetic Resonance Imaging ; Mesalamine/therapeutic use ; Perineum/pathology ; Proctitis/complications ; Proctitis/immunology ; Proctitis/pathology ; Rectal Fistula/immunology ; Rectal Fistula/pathology ; Rectal Fistula/surgery ; Recurrence ; Sepsis/drug therapy ; Sepsis/etiology ; Sepsis/immunology ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Mesalamine (4Q81I59GXC)
Language	English
Publishing date	2015-04-23
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h1969
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Article ; Online: Standard of reporting for studies on inflammatory Bowel disease.

Oates, Adam J / Tolan, Damian J M

Radiology

2008 Volume 249, Issue 1, Page(s) 390; author reply 390–1

MeSH term(s)	Humans ; Inflammatory Bowel Diseases/classification
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2491080770
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Article ; Online: Non-invasive, vagus nerve stimulation to reduce ileus after colorectal surgery: protocol for a feasibility trial with nested mechanistic studies.

Chapman, Stephen J / Naylor, Maureen / Czoski Murray, Carolyn J / Tolan, Damian / Stocken, Deborah D / Jayne, David G

BMJ open

2021 Volume 11, Issue 7, Page(s) e046313

Abstract: Introduction: Ileus is a common and distressing condition characterised by gut dysfunction after surgery. While a number of interventions have aimed to curtail its impact on patients and healthcare systems, ileus is still an unmet challenge. Electrical ... ...

Abstract	Introduction: Ileus is a common and distressing condition characterised by gut dysfunction after surgery. While a number of interventions have aimed to curtail its impact on patients and healthcare systems, ileus is still an unmet challenge. Electrical stimulation of the vagus nerve is a promising new treatment due to its role in modulating the neuro-immune axis through a novel anti-inflammatory reflex. The protocol for a feasibility study of non-invasive vagus nerve stimulation (nVNS), and a programme of mechanistic and qualitative studies, is described. Methods and analysis: This is a participant-blinded, parallel-group, randomised, sham-controlled feasibility trial (IDEAL Stage 2b) of self-administered nVNS. One hundred forty patients planned for elective, minimally invasive, colorectal surgery will be randomised to four schedules of nVNS before and after surgery. Feasibility outcomes include assessments of recruitment and attrition, adequacy of blinding and compliance to the intervention. Clinical outcomes include bowel function and length of hospital stay. A series of mechanistic substudies exploring the impact of nVNS on inflammation and bowel motility will inform the design of the final stimulation schedule. Semistructured interviews with participants will explore experiences and perceptions of the intervention, while interviews with patients who decline participation will explore barriers to recruitment. Ethics and dissemination: The protocol has been approved by the Tyne and Wear South National Health Service (NHS) Research Ethics Committee (19/NE/0217) on 2 July 2019. Feasibility, mechanistic and qualitative findings will be disseminated to national and international partners through peer-reviewed publications, academic conferences, social media channels and stakeholder engagement activities. The findings will build a case for or against progression to a definitive randomised assessment as well as informing key elements of study design. Trial registration number: ISRCTN62033341.
MeSH term(s)	Colorectal Surgery ; Feasibility Studies ; Humans ; Ileus/etiology ; Ileus/prevention & control ; Randomized Controlled Trials as Topic ; State Medicine ; Treatment Outcome ; Vagus Nerve Stimulation
Language	English
Publishing date	2021-07-21
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-046313
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CT assessment of right colonic arterial anatomy pre and post cancer resection - a potential marker for quality and extent of surgery?

Kaye, Tom L / West, Nick P / Jayne, David G / Tolan, Damian J M

Acta radiologica (Stockholm, Sweden : 1987)

2015 Volume 57, Issue 4, Page(s) 394–400

Abstract: Background: There is conflicting opinion as to the optimum extent of resection for right-sided colonic cancer, which is currently graded by pathological analysis of the resected specimen. It is not known if computed tomography (CT) analysis of residual ... ...

Abstract	Background: There is conflicting opinion as to the optimum extent of resection for right-sided colonic cancer, which is currently graded by pathological analysis of the resected specimen. It is not known if computed tomography (CT) analysis of residual post-resection arterial stump length could be used as an alternative in vivo marker for extent of mesenteric resection. Ileocolic artery stumps have been demonstrated previously on CT after right hemicolectomy, but only in the early postoperative period. Purpose: To analyze preoperative right colonic arterial anatomy using portal venous colorectal cancer staging CT and subsequently determine if post-resection arterial stumps (a potential in vivo marker of surgical resection) could be consistently identified using routine follow-up CT scans many months after cancer resection. Material and methods: A retrospective analysis of routine staging and follow-up CT scans for 151 patients with right-sided colorectal cancer was performed. Preoperative right colonic arterial anatomy and postoperative arterial stumps were analyzed and measured. Results: Preoperative ileocolic (98.8%), middle (94.7%), and right colic artery (23.8%) identification was comparable to catheter angiogram studies. Postoperative ileocolic stumps were consistently demonstrated (88.3%) many months (average, 2 years and 42 days) after resection and were significantly longer than expected for a standard D2 resection (paired t-test, t(127) = -11.45, P ≤ 0.001). Conclusion: This is the first study to successfully demonstrate ileocolic arterial stumps many months (and years) after cancer resection using routine portal venous CT. Further prospective research should assess whether arterial stumps can be used as an in vivo marker of surgical quality and extent.
MeSH term(s)	Colon/blood supply ; Colon/diagnostic imaging ; Colon/surgery ; Colonic Neoplasms/blood supply ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Follow-Up Studies ; Humans ; Pilot Projects ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185115583033
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