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Article ; Online: Erratum. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience.

Schlesinger, Ilana

2020 Volume 133, Issue 2, Page(s) 596

Language	English
Publishing date	2020-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2020.1.JNS19466a
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Article ; Online: Association of health behaviors with function and health-related quality of life among patients with Parkinson’s disease

Michal Duvdevani / Galit Yogev-Seligmann / Ilana Schlesinger / Maria Nassar / Ilana Erich / Rafi Hadad / Michal Kafri

Israel Journal of Health Policy Research, Vol 13, Iss 1, Pp 1-

2024 Volume 10

Abstract: Abstract Background Current evidence on chronic conditions favors promotion of health behaviors as a mean to positively impact health outcomes. In Parkinson’s disease, performing health behaviors is indicated as a means to fight the long-lasting burden ... ...

Abstract	Abstract Background Current evidence on chronic conditions favors promotion of health behaviors as a mean to positively impact health outcomes. In Parkinson’s disease, performing health behaviors is indicated as a means to fight the long-lasting burden of the disease. Understanding actual engagement in health behaviors and patient activation and their association to function and health-related quality of life is therefore important. Our objectives were, among people with Parkinson’s disease: (1) to characterize health behaviors including utilization of rehabilitative treatments, physical activity, and patient activation levels, and (2) to test the associations between these health behaviors and health outcomes. Methods A cross-sectional study of 88 people with Parkinson’s disease (age 66.84 ± 8.8) was conducted. Participants answered questionnaires measuring health behaviors including utilization of health professions treatments, physical activity, patient activation, and health outcomes consisting of function and health-related quality of life. Linear regression models were conducted to test associations between measured health behaviors, function and health-related quality of life. Results Participants rarely engage in rehabilitative treatments, but showed high levels of patient activation. Controlled by demographics and disease severity, physical activity and patient activation were associated with function (b = 0.41, p < .001; b = 0.2, p = .02, respectively) and physical activity but not patient activation, which was associated with health-related quality of life (b = 0.19, p = .03). There was also interaction effects of physical activity and non-motor symptoms, and physical activity and motor symptoms on health-related quality of life (b = 0.19, p = .02 and b = − 0.22, p = .01, respectively). Conclusions In respect to their potential health-related benefits for people with Parkinson’s disease, health professionals’ treatments are underutilized. Findings supported the importance of health behaviors for ...
Keywords	Health behaviors ; Parkinson’s disease ; Patient activation ; Structural equation modeling ; Health related quality of life ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Association of health behaviors with function and health-related quality of life among patients with Parkinson's disease.

Duvdevani, Michal / Yogev-Seligmann, Galit / Schlesinger, Ilana / Nassar, Maria / Erich, Ilana / Hadad, Rafi / Kafri, Michal

Israel journal of health policy research

2024 Volume 13, Issue 1, Page(s) 2

Abstract: Background: Current evidence on chronic conditions favors promotion of health behaviors as a mean to positively impact health outcomes. In Parkinson's disease, performing health behaviors is indicated as a means to fight the long-lasting burden of the ... ...

Abstract	Background: Current evidence on chronic conditions favors promotion of health behaviors as a mean to positively impact health outcomes. In Parkinson's disease, performing health behaviors is indicated as a means to fight the long-lasting burden of the disease. Understanding actual engagement in health behaviors and patient activation and their association to function and health-related quality of life is therefore important. Our objectives were, among people with Parkinson's disease: (1) to characterize health behaviors including utilization of rehabilitative treatments, physical activity, and patient activation levels, and (2) to test the associations between these health behaviors and health outcomes. Methods: A cross-sectional study of 88 people with Parkinson's disease (age 66.84 ± 8.8) was conducted. Participants answered questionnaires measuring health behaviors including utilization of health professions treatments, physical activity, patient activation, and health outcomes consisting of function and health-related quality of life. Linear regression models were conducted to test associations between measured health behaviors, function and health-related quality of life. Results: Participants rarely engage in rehabilitative treatments, but showed high levels of patient activation. Controlled by demographics and disease severity, physical activity and patient activation were associated with function (b = 0.41, p < .001; b = 0.2, p = .02, respectively) and physical activity but not patient activation, which was associated with health-related quality of life (b = 0.19, p = .03). There was also interaction effects of physical activity and non-motor symptoms, and physical activity and motor symptoms on health-related quality of life (b = 0.19, p = .02 and b = - 0.22, p = .01, respectively). Conclusions: In respect to their potential health-related benefits for people with Parkinson's disease, health professionals' treatments are underutilized. Findings supported the importance of health behaviors for maintaining function and health-related quality of life among people with Parkinson's disease. They also show a differential contribution of motor and non-motor symptoms to the association between physical activity and quality of life. It is suggested that policy makers encourage opportunities for physical activity tailored for people with Parkinson's disease and adopt a proactive stance towards enhancing awareness and use of rehabilitation services. Trial registration NCT05211700, ClinicalTrials.gov ID: NCT05211700 first release 12/30/2021, https://classic. Clinicaltrials: gov/ct2/show/NCT05211700.
MeSH term(s)	Aged ; Humans ; Middle Aged ; Cross-Sectional Studies ; Health Behavior ; Israel ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Quality of Life
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2657655-7
ISSN	2045-4015 ; 2045-4015
ISSN (online)	2045-4015
ISSN	2045-4015
DOI	10.1186/s13584-023-00588-3
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Article: Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism.

Sinai, Alon / Nassar, Maria / Shornikov, Lev / Constantinescu, Marius / Zaaroor, Menashe / Schlesinger, Ilana

Parkinson's disease

2024 Volume 2024, Page(s) 6643510

Abstract: Background: Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson's disease. The efficacy and safety in patients with ... ...

Abstract	Background: Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson's disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. Objective: To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) ( Methods: Tremor was assessed in the treated hemibody using the Clinical Rating Scale for Tremor (CRST). The motor Unified MSA Rating Scale (UMSAR) was used in the MSA-P and motor sections of the Unified Parkinson's Disease Rating Scale (UPDRS-III) in DLB patients. Cognition was measured using the Montreal Cognitive Assessment (MoCA). Results: In MSA-P and DLB patients, there was immediate tremor relief. CRST scores measured on the treated side improved compared to baseline. During the follow-up of up to 1 year tremor reduction persisted. The change in CRST scores at different time points did not reach statistical significance, probably due to the small sample size. Adverse events were transient and resolved within a year. Conclusions: In our experience, FUS VIM-thalamotomy was effective in patients with MSA-P and DLB. Larger, controlled studies are needed to verify our preliminary observations.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573854-9
ISSN	2042-0080 ; 2090-8083
ISSN (online)	2042-0080
ISSN	2090-8083
DOI	10.1155/2024/6643510
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Article ; Online: Socio-Clinical factors associated with Parkinson's disease-related specific self-management behaviours.

Kafri, Michal / Abu Taieh, Maram / Duvdevani, Michal / Schlesinger, Ilana / Nassar, Maria / Erich, Ilana / Hadad, Rafi / Yogev-Seligmann, Galit

Chronic illness

2023 , Page(s) 17423953231198893

Abstract: Objective: To test associations between socio-clinical factors, self-management and patient activation among patients with Parkinson's disease (PD), and to explore the use of regression tree to find the cut-off levels of socio-clinical factors which ... ...

Abstract	Objective: To test associations between socio-clinical factors, self-management and patient activation among patients with Parkinson's disease (PD), and to explore the use of regression tree to find the cut-off levels of socio-clinical factors which associate with lower or higher self-management behaviours and patient's activation. Methods: A cross-sectional study of patients with PD ( Results: Most patients did not utilize rehabilitative treatments. Non-motor symptoms and cognitive status were significantly associated with physical activity ( Conclusion: In PD, disease-specific clinical characteristics overshadow other personal factors as determinants of self-management behaviours. The role of non-motor symptoms in reduced self-management behaviours and activation is highlighted.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2191311-0
ISSN	1745-9206 ; 1742-3953
ISSN (online)	1745-9206
ISSN	1742-3953
DOI	10.1177/17423953231198893
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Article ; Online: Sobel edge detection for quantifying the effectiveness of focused ultrasound thalamotomy for tremor relief

Aharonson Vered / Postema Michiel / Gebbie Robyn / Van Der Merwe Jesse / Schlesinger Ilana

Current Directions in Biomedical Engineering, Vol 9, Iss 1, Pp 17-

2023 Volume 20

Abstract: Focused ultrasound on the thalamus is employed to relieve tremor in movement disorders. The treatment efficacy is currently assessed by subjective observation of patient tremor during hand movements. The purpose of this study was to create a simple ... ...

Abstract	Focused ultrasound on the thalamus is employed to relieve tremor in movement disorders. The treatment efficacy is currently assessed by subjective observation of patient tremor during hand movements. The purpose of this study was to create a simple quantitative method to assess tremor based on traditional pen-and-paper spiral drawing that could be employed during treatment and follow-up visits. Image processing was employed to automatically and rapidly clean scanned spiral and line drawings and to isolate the minimal part of the drawing that could provide sufficient data for tremor detection. Sobel edge detection and easily-interpretable statistics of the distribution of edge-angle orientations in the spirals relative to the spiral centres were used as tremor measures. The method was applied to scanned drawings of 122 tremor patients before treatment and in follow-up visits. Discrimination analysis of the tremor measure between drawings in the session before treatment and the follow-up sessions was carried out. The processing yielded correctly cropped and clean spirals. The tremor measure demonstrated consistent tremor reduction in the treated hand drawings in all five follow-up visits during the first year following treatment date in 76 patients from the study cohort. In this study we developed a computational method that rapidly computed tremor severity estimate in an explainable and clinically useful manner from a traditional pen-and-paper spiral drawing. This rapid quantitative and objective tremor assessment can easily be implemented during focused ultrasound treatment and replace the subjective assessment currently employed.
Keywords	parkinson’s disease ; essential tremor ; thermal lesion ; unilateral ablation ; fus ; Medicine ; R
Subject code	150
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article ; Online: Is cognition key in paradoxical kinesia?

Schlesinger, Ilana

Movement disorders : official journal of the Movement Disorder Society

2011 Volume 26, Issue 2, Page(s) 365

MeSH term(s)	Cognition Disorders/psychology ; Earthquakes ; Humans ; Kinesis/physiology ; Parkinsonian Disorders/psychology
Language	English
Publishing date	2011-02-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.23433
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Article ; Online: A Trial of Focused Ultrasound Thalamotomy for Essential Tremor.

Schlesinger, Ilana / Zaaroor, Menashe

The New England journal of medicine

2016 Volume 375, Issue 22, Page(s) 2201–2202

Language	English
Publishing date	2016--01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1612210
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Article ; Online: Assessing Tremor and Adverse Events in Patients With Tremor-Dominant Parkinson Disease Undergoing Focused Ultrasound Thalamotomy.

Schlesinger, Ilana / Sinai, Alon / Zaaroor, Menashe

JAMA neurology

2018 Volume 75, Issue 5, Page(s) 632–633

MeSH term(s)	Humans ; Parkinson Disease ; Thalamus ; Tremor ; Ultrasonic Therapy
Language	English
Publishing date	2018-03-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2018.0263
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Article ; Online: Efficacy of Parenteral Amantadine Therapy in the Treatment of Multiple System Atrophy With Predominant Parkinsonism.

Friedberg, Adit / Erikh, Ilana / Nassar, Maria / Sprecher, Elliot / Schlesinger, Ilana

Clinical neuropharmacology

2018 Volume 41, Issue 5, Page(s) 160–163

Abstract: Objective: The aim of this study was to assess clinical response to a high-dose intravenous (IV) amantadine given for 5 consecutive days in patients with multiple system atrophy parkinsonism (MSA-P).: Methods: Subjects with a diagnosis of MSA-P ... ...

Abstract	Objective: The aim of this study was to assess clinical response to a high-dose intravenous (IV) amantadine given for 5 consecutive days in patients with multiple system atrophy parkinsonism (MSA-P). Methods: Subjects with a diagnosis of MSA-P treated with IV amantadine were included. Patients' disease severity before and after therapy was evaluated using the Unified Multiple System Atrophy Rating Scale (UMSARS). Results: Fourteen subjects (8 females) were included. In 10 subjects (71.4%), clinical improvement was noted. The UMSARS score after treatment decreased by 2 points (median [interquartile range, 0-3]) when compared with UMSARS score at baseline (P = 0.0020). Upon examining the walking parameter, a trend of improvement was shown (P = 0.0625) (range, 0-1 points). Neither specific demographic parameters nor occurrence of adverse effects was found to be a predictive factor for improvement. Adverse events were mild and transient except for one patient who experienced acute psychosis prompting treatment cessation, upon which psychosis resolved. Conclusions: Our preliminary data show that IV amantadine may be a safe and effective therapy in MSA-P. A double-blind placebo-controlled trial is needed to establish the true benefit of amantadine therapy.
MeSH term(s)	Administration, Intravenous ; Aged ; Amantadine/administration & dosage ; Amantadine/adverse effects ; Antiparkinson Agents/adverse effects ; Antiparkinson Agents/therapeutic use ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Multiple System Atrophy/drug therapy ; Parkinsonian Disorders/drug therapy ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Antiparkinson Agents ; Amantadine (BF4C9Z1J53)
Language	English
Publishing date	2018-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
DOI	10.1097/WNF.0000000000000291
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