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Article ; Online: The role of ANXA1 in the tumor microenvironment.

Li, Lanxin / Wang, Baiqi / Zhao, Shuang / Xiong, Qinglin / Cheng, Ailan

2024 Volume 131, Page(s) 111854

Abstract: Annexin A1 (ANXA1) is widely expressed in a variety of body tissues and cells and is also involved in tumor development through multiple pathways. The invasion, metastasis, and immune escape of tumor cells depend on the interaction between tumor cells ... ...

Abstract	Annexin A1 (ANXA1) is widely expressed in a variety of body tissues and cells and is also involved in tumor development through multiple pathways. The invasion, metastasis, and immune escape of tumor cells depend on the interaction between tumor cells and their surrounding environment. Research shows that ANXA1 can act on a variety of cells in the tumor microenvironment (TME), and subsequently affect the proliferation, invasion and metastasis of tumors. This article describes the role of ANXA1 in the various components of the tumor microenvironment and its mechanism of action, as well as the existing clinical treatment measures related to ANXA1. These findings provide insight for the further design of strategies targeting ANXA1 for the diagnosis and treatment of malignant tumors.
MeSH term(s)	Annexin A1/genetics ; Annexin A1/metabolism ; Cell Line, Tumor ; Tumor Microenvironment ; Humans ; Animals
Chemical Substances	Annexin A1 ; ANXA1 protein, human
Language	English
Publishing date	2024-03-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111854
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Article: Pediatric dumbbell-shaped orbital schwannoma with extension to the cranial cavity: A case report and literature review.

Shao, Yongjia / Xi, Qian / Cheng, Ailan / Qian, Minghui / Chu, Shuguang

Frontiers in neurology

2023 Volume 13, Page(s) 1071632

Abstract: Orbital schwannomas are rare in children, especially those with intracranial extension. Herein, our report refers to a 12-year-old boy who had a cranial-orbital mass with a dumbbell-like appearance. The total neoplasms was successfully ... ...

Abstract	Orbital schwannomas are rare in children, especially those with intracranial extension. Herein, our report refers to a 12-year-old boy who had a cranial-orbital mass with a dumbbell-like appearance. The total neoplasms was successfully removed
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.1071632
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Article ; Online: Correlation Between Apparent Diffusion Coefficient and the Ki-67 Proliferation Index in Grading Pediatric Glioma.

Yao, Rong / Cheng, Ailan / Zhang, Zhengwei / Jin, Biao / Yu, Hong

Journal of computer assisted tomography

2023 Volume 47, Issue 2, Page(s) 322–328

Abstract: Objective: This study aimed to investigate the correlation between apparent diffusion coefficient (ADC) and the Ki-67 proliferation index with the pathologic grades of pediatric glioma and to compare their diagnostic performance in differentiating ... ...

Abstract	Objective: This study aimed to investigate the correlation between apparent diffusion coefficient (ADC) and the Ki-67 proliferation index with the pathologic grades of pediatric glioma and to compare their diagnostic performance in differentiating grades of pediatric glioma. Patients and methods: Magnetic resonance imaging examinations and histopathologies of 121 surgically treated pediatric gliomas (87 low-grade gliomas [LGGs; grades 1 and 2] and 34 high-grade gliomas [HGGs; grades 3 and 4]) were retrospectively reviewed. The mean tumor ADC (ADCmean), minimum tumor ADC (ADCmin), tumor/normal brain ADC ratio (ADC ratio), and value of the Ki-67 proliferation index of LGGs and HGGs were compared. Correlation coefficients were calculated for ADC parameters and Ki-67 values. The receiver operating characteristic curve was used to determine the diagnostic value of ADCmean, ADCmin, ADC ratio, and Ki-67 proliferation index for differentiating LGGs and HGGs. Results: The ADC values were significantly negatively correlated with glioma grade, and the Ki-67 proliferation index had a significant positive correlation with glioma grade. A significant negative correlation was observed between ADCmean and Ki-67 proliferation index, between ADCmin and Ki-67 proliferation index, and between ADC ratio and Ki-67 proliferation index. The receiver operating characteristic analysis demonstrated moderate to good accuracy for ADCmean in discriminating LGGs from HGGs (area under the curve [AUC], 0.875; sensitivity, 79.3%; specificity, 82.4%; accuracy, 80.2%; positive predictive value [PPV], 92.0%; and negative predictive value [NPV], 60.9% [cutoff value, 1.187] [×10-3 mm2/s]). Minimum tumor ADC showed very good to excellent accuracy with AUC of 0.946, sensitivity of 86.2%, specificity of 94.1%, accuracy of 88.4%, PPV of 97.4%, and NPV of 72.7% (cutoff value, 0.970) (×10-3 mm2/s). The ADC ratio showed moderate to good accuracy with AUC of 0.854, sensitivity of 72.4%, specificity of 88.2%, accuracy of 76.9%, PPV of 94.0%, and NPV of 55.6% (cutoff value, 1.426). For the parameter of the Ki-67 proliferation index, in discriminating LGGs from HGGs, very good to excellent diagnostic accuracy was observed (AUC, 0.962; sensitivity, 94.1%; specificity, 89.7%; accuracy, 90.9%; PPV, 97.5%; and NPV, 78.0% [cutoff value, 7]). Conclusions: Apparent diffusion coefficient parameters and the Ki-67 proliferation index were significantly correlated with histological grade in pediatric gliomas. Apparent diffusion coefficient was closely correlated with the proliferative potential of pediatric gliomas. In addition, ADCmin showed superior performance compared with ADCmean and ADC ratio in differentiating pediatric glioma grade, with a close diagnostic efficacy to the Ki-67 proliferation index.
MeSH term(s)	Child ; Humans ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Cell Proliferation ; Diffusion Magnetic Resonance Imaging/methods ; Glioma/diagnostic imaging ; Glioma/pathology ; Ki-67 Antigen ; Neoplasm Grading ; Retrospective Studies ; Sensitivity and Specificity
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001400
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Article ; Online: Evaluation method on seismic risk of substation in strong earthquake area.

Jiawei Cui / Ailan Che / Sheng Li / Yongfeng Cheng

PLoS ONE, Vol 16, Iss 12, p e

2021 Volume 0258792

Abstract: Frequent earthquakes in strong earthquake areas pose a great threat to the safety operation of electric power facilities. There exists a pressing research need to develop an assessment method for the seismic risk of substations, i.e., the hubs of power ... ...

Abstract	Frequent earthquakes in strong earthquake areas pose a great threat to the safety operation of electric power facilities. There exists a pressing research need to develop an assessment method for the seismic risk of substations, i.e., the hubs of power system networks. In this study, based on Incremental Dynamic Analysis (IDA), Probabilistic Seismic Demand Model (PSDM) and reliability theory, a vulnerability model for a substation is obtained, based on considering the relationships between Peak Ground Acceleration (PGA) and four seismic damage states (complete, extensive, moderate, and slight.) via a probabilistic approach. After an earthquake, the scope of influence and PGA distribution are evaluated using information recorded by the seismic observation stations, based on using interpolation or an empirical formula for the PGA attenuation. Therefore, the seismic risk can be evaluated by combining ground motion evaluation and the pre-built vulnerability model. The Wuqia- Kashgar area of Xinjiang was selected as the study area; it is an Earthquake-prone area, and one of the starting points for new energy transmission projects in China. Under a hypothetical earthquake (MS 7.9), the seismic risk of the substations was evaluated. The results show that: this method is able to give the probabilities of the four damage states of the substations, four substations close to the epicenter only have a probability of slight damage (45%-88%) and other substations are safer.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Magnetic resonance imaging characteristics of brain metastases in small cell lung cancer.

Zhu, Dan / Shao, Yongjia / Yang, Zhangwei / Cheng, Ailan / Xi, Qian / Liang, Xiaohua / Chu, Shuguang

Cancer medicine

2023 Volume 12, Issue 14, Page(s) 15199–15206

Abstract: Background: Lung is the most common primary site of brain metastases (BMs). For different pathological types of BMs have some similar characteristics, it is still a challenge to confirm the origin based on their characteristics directly. BMs of small ... ...

Abstract	Background: Lung is the most common primary site of brain metastases (BMs). For different pathological types of BMs have some similar characteristics, it is still a challenge to confirm the origin based on their characteristics directly. BMs of small cell lung cancer (SCLC) have favorable therapeutic expectations due to their high sensitivity to radiotherapy. This study sought to identify unique characteristics of BMs in SCLC, aiming to assist in clinical decision-making. Methods: Patients diagnosed with BMs of lung cancer who received radiotherapy from January 2017 to January 2022 were reviewed (N = 284). Definitive diagnosis of BMs of SCLC was reached for 36 patients. All patients underwent head examination using magnetic resonance imaging. The number, size, location, and signal characteristics of lesions were analyzed. Results: There were 7 and 29 patients with single focus and non-single focus, respectively. Ten patients had diffuse lesions, and the remaining 26 patients had a total of 90 lesions. These lesions were divided into three groups according to size: <1, 1-3, and >3 cm (43.33%, 53.34%, and 3.33%, respectively). Sixty-six lesions were located in the supratentorial area, primarily including cortical and subcortical lesions (55.56%) and deep brain lesions (20%). Moreover, 22 lesions were located in the infratentorial area. According to diffusion-weighted imaging and T1-weighted contrast enhancement, the imaging characteristics were classified into six patterns. Hyperintensity in diffusion-weighted imaging and homogeneous enhancement was the most common pattern of BMs in SCLC (46.67%), while partial lesions showed hyperintensity in diffusion-weighted imaging without enhancement (7.78%). Conclusions: The manifestations of BMs in SCLC were multiple lesions (diameter: 1-3 cm), hyperintensity in diffusion-weighted imaging, and homogeneous enhancement. Interestingly, hyperintensity in diffusion-weighted imaging without enhancement was also one of the characteristics.
MeSH term(s)	Humans ; Small Cell Lung Carcinoma/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/secondary ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6206
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Article ; Online: Evaluation method on seismic risk of substation in strong earthquake area.

Cui, Jiawei / Che, Ailan / Li, Sheng / Cheng, Yongfeng

PloS one

2021 Volume 16, Issue 12, Page(s) e0258792

Abstract	Frequent earthquakes in strong earthquake areas pose a great threat to the safety operation of electric power facilities. There exists a pressing research need to develop an assessment method for the seismic risk of substations, i.e., the hubs of power system networks. In this study, based on Incremental Dynamic Analysis (IDA), Probabilistic Seismic Demand Model (PSDM) and reliability theory, a vulnerability model for a substation is obtained, based on considering the relationships between Peak Ground Acceleration (PGA) and four seismic damage states (complete, extensive, moderate, and slight.) via a probabilistic approach. After an earthquake, the scope of influence and PGA distribution are evaluated using information recorded by the seismic observation stations, based on using interpolation or an empirical formula for the PGA attenuation. Therefore, the seismic risk can be evaluated by combining ground motion evaluation and the pre-built vulnerability model. The Wuqia- Kashgar area of Xinjiang was selected as the study area; it is an Earthquake-prone area, and one of the starting points for new energy transmission projects in China. Under a hypothetical earthquake (MS 7.9), the seismic risk of the substations was evaluated. The results show that: this method is able to give the probabilities of the four damage states of the substations, four substations close to the epicenter only have a probability of slight damage (45%-88%) and other substations are safer.
MeSH term(s)	China ; Disasters/prevention & control ; Earthquakes/prevention & control ; Humans ; Physical Phenomena ; Research Design
Language	English
Publishing date	2021-12-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0258792
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NIR-II light evokes DNA cross-linking for chemotherapy and immunogenic cell death.

Huang, Yun / Wei, Dengshuai / Wang, Bin / Tang, Dongsheng / Cheng, Ailan / Xiao, Shengjun / Yu, Yingjie / Huang, Weiguo

Acta biomaterialia

2023 Volume 160, Page(s) 198–210

Abstract: As a DNA damaging agent, oxaliplatin (OXA) can induce immunogenic cell death (ICD) in tumors to activate the immune system. However, the DNA damage induced by OXA is limited and the ICD effect is not strong enough to enhance anti-tumor efficacy. Here, we ...

Abstract	As a DNA damaging agent, oxaliplatin (OXA) can induce immunogenic cell death (ICD) in tumors to activate the immune system. However, the DNA damage induced by OXA is limited and the ICD effect is not strong enough to enhance anti-tumor efficacy. Here, we propose a strategy to maximize the ICD effect of OXA through the mild hyperthermia generated by nanoparticles with a platinum (IV) prodrug of OXA (Pt(IV)-C16) and a near-infrared-II (NIR-II) photothermal agent IR1061 upon the irradiation of NIR-II light. The mild hyperthermia (43 °C) holds advantages in two aspects: 1) increase the Pt-DNA cross-linking, leading to enhanced DNA damage and apoptosis; 2) induce stronger ICD effects for cancer immunotherapy. We demonstrated that, compared with OXA and photothermal therapy of IR1061 alone, these nanoparticles under NIR-II light irradiation can significantly improve the anti-cancer efficacy against triple-negative breast cancer 4T1 tumor. This new strategy provides an effective way to improve the therapeutic outcome of OXA. STATEMENT OF SIGNIFICANCE: OXA could induce immunogenic cell death (ICD) via stimulating immune responses by increasing tumor cell stress and death, which triggers tumor-specific immune responses to achieve immunotherapy. However, due to the insufficient Pt-DNA crosslinks, the ICD effect triggered by OXA cannot induce robust immune response. Mild hyperthermia has great potential to maximize the therapeutic outcome of oxaliplatin by increasing the Pt-DNA cross-linking to augment the immunoresponse for enhanced cancer immunotherapy.
MeSH term(s)	Humans ; Oxaliplatin/pharmacology ; Immunogenic Cell Death ; Borates ; Neoplasms/drug therapy ; Nanoparticles ; Immunotherapy ; DNA ; Cell Line, Tumor
Chemical Substances	Oxaliplatin (04ZR38536J) ; IR1061 ; Borates ; DNA (9007-49-2)
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2023.02.012
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Article ; Online: The rosette-forming glioneuronal tumor mimicked cerebral cysticercosis: a case report.

Zhu, Dan / Cheng, Ailan / Benons, Nickita T L / Chu, Shuguang

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 42, Issue 10, Page(s) 4301–4308

Abstract: Introduction: Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region. This is a comprehensive analysis of a 22-year-old woman with RGNT composed of mainly cystic ...

Abstract	Introduction: Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region. This is a comprehensive analysis of a 22-year-old woman with RGNT composed of mainly cystic components. In addition, the case showed multiple lesions located in brain parenchyma which mimicked cerebral cysticercosis. Here, we analyzed this case and listed some characteristics of RGNTs in reported literature which occurring in atypical locations for further understanding it. Case report: A 22-year-old woman presented with a history of transient dizziness, nausea, and vomiting. Magnetic resonance imaging (MRI) showed multiple cystic lesions in brain parenchyma and then the patient was diagnosed with cerebral cysticercosis possibility. Empirical anti-infective therapy in addition to a follow-up post 2 weeks of MRI examination showed the lesions unchanged. Finally, a biopsy of the right cerebellar hemisphere lesions verified RGNT. Conclusion: RGNT is an uncommon tumor classified as grade I glioma by World Health Organization (WHO) with slightly longer course. The imaging findings of RGNT are not specific especially in atypical areas. RGNT is rare, but we should also consider the possibility in diagnosis and differential diagnosis.
MeSH term(s)	Cerebral Ventricle Neoplasms ; Female ; Fourth Ventricle ; Glioma ; Humans ; Magnetic Resonance Imaging ; Neurocysticercosis/diagnostic imaging ; Young Adult
Language	English
Publishing date	2021-05-20
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05199-x
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Zs.A 1877: Show issues

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Article ; Online: miR-33b in human cancer: Mechanistic and clinical perspectives.

Zhang, Wenlong / Jiang, Bincan / Zhu, Hecheng / Cheng, Ailan / Li, Can / Huang, Haoxuan / Li, Xuewen / Kuang, Yirui

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114432

Abstract: The microRNAs (miRNAs), an extensive class of small noncoding RNAs (∼22 nucleotides), have been shown to have critical functions in various biological processes during development. miR-33b (or hsa-miR-33b) is down-regulated in cancer of multiple systems. ...

Abstract	The microRNAs (miRNAs), an extensive class of small noncoding RNAs (∼22 nucleotides), have been shown to have critical functions in various biological processes during development. miR-33b (or hsa-miR-33b) is down-regulated in cancer of multiple systems. Notably, at least 27 protein-coding genes can be targeted by miR-33b. miR-33b regulates the cell cycle, cell proliferation, various metabolism pathways, epithelial-mesenchymal transition (EMT), cancer cell invasion and migration, etc. In prostate cancer, Cullin 4B (CUL4B) can be recruited to the promoter to inhibit the expression of miR-33b. In gastric cancer, the hypermethylation of the CpG island regulated the expression of miR-33b. Besides, miR-33b could be negatively regulated by 7 competing-endogenous RNAs (ceRNAs), which are all long non-coding RNAs (lncRNAs). There are at least 4 signaling pathways, including NF-κB, MAP8, Notch1, and Wnt/β-catenin signaling pathways, which could be regulated partially by miR-33b. Additionally, low expression of miR-33b was associated with clinicopathology and prognosis in cancer patients. In addition, the aberrant expression of miR-33b was connected with the resistance of cancer cells to 5 anticancer drugs (cisplatin, docetaxel, bortezomib, paclitaxel, and daunorubicin). Importantly, our work systematically summarizes the aberrant expression of miR-33b in various neoplastic diseases and the effect of its downregulation on the biological behavior of cancer cells. Furthermore, this review focuses on recent advances in understanding the molecular regulation mechanisms of miR-33b. Moreso, the relationship between the miR-33b expression levels and the clinicopathological data and prognosis of tumor patients was summarized for the first time. Overall, we suggest that the current studies of miR-33b are insufficient but provide potential hints and direction for future miR-33b-related research.
MeSH term(s)	Male ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cisplatin/metabolism ; Stomach Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Wnt Signaling Pathway ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Cell Movement ; Cell Line, Tumor ; RNA, Long Noncoding ; Cullin Proteins/metabolism
Chemical Substances	MicroRNAs ; Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents ; RNA, Long Noncoding ; CUL4B protein, human ; Cullin Proteins
Language	English
Publishing date	2023-02-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114432
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Article ; Online: The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma.

Liu, Xiwu / Jiang, Bincan / Cheng, Ailan / Guo, Youwei / Wang, Lei / Liu, Weidong / Yin, Wen / Li, Yihan / Jiang, Xingjun / Ren, Caiping

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

2023 Volume 52, Issue 1, Page(s) 79

Abstract: Objective: Our research group in the early stage identified CD109 as the target of aptamer S3 in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron (DT) and load doxorubicin (Dox) onto DT to develop a targeted delivery ... ...

Abstract	Objective: Our research group in the early stage identified CD109 as the target of aptamer S3 in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron (DT) and load doxorubicin (Dox) onto DT to develop a targeted delivery system, and explore whether S3-DT-Dox can achieve targeted therapy for NPC. Methods: Aptamer S3-conjugated DT was synthesized and loaded with Dox. The effects of S3-DT-Dox on NPC cells were investigated with laser confocal microscopy, flow cytometry, and MTS assays. A nude mouse tumor model was established from NPC 5-8F cells, and the in vivo anti-tumor activity of S3-DT-Dox was examined by using fluorescent probe labeling and hematoxylin-eosin staining. Results: The synthesized S3-DT had high purity and stability. S3-DT specifically recognized 5-8F cells and NPC tissues in vitro. When the ratio of S3-DT to Dox was 1:20, S3-DT had the best Dox loading efficiency. The drug release rate reached the maximum (0.402 ± 0.029) at 48 h after S3-DT-Dox was prepared and mixed with PBS. S3-DT did not affect Dox toxicity to 5-8F cells, but reduced Dox toxicity to non-target cells. Meanwhile, S3-DT-Dox was able to specifically target the transplanted tumors and inhibit their growth in nude mice, with minor damage to normal tissues. Conclusion: Our study highlights the ability and safety of S3-DT-Dox to target NPC cells and inhibit the development NPC.
MeSH term(s)	Animals ; Mice ; Nasopharyngeal Carcinoma/drug therapy ; Mice, Nude ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; DNA ; Nasopharyngeal Neoplasms/drug therapy
Chemical Substances	Doxorubicin (80168379AG) ; DNA (9007-49-2)
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2434004-2
ISSN	1916-0216 ; 1916-0208 ; 0381-6605
ISSN (online)	1916-0216
ISSN	1916-0208 ; 0381-6605
DOI	10.1186/s40463-023-00673-2
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